JP2013520423A - ジアシルグリセロールリパーゼ阻害剤としての使用のためのグリシンスルホンアミド - Google Patents
ジアシルグリセロールリパーゼ阻害剤としての使用のためのグリシンスルホンアミド Download PDFInfo
- Publication number
- JP2013520423A JP2013520423A JP2012553956A JP2012553956A JP2013520423A JP 2013520423 A JP2013520423 A JP 2013520423A JP 2012553956 A JP2012553956 A JP 2012553956A JP 2012553956 A JP2012553956 A JP 2012553956A JP 2013520423 A JP2013520423 A JP 2013520423A
- Authority
- JP
- Japan
- Prior art keywords
- acetic acid
- phenylsulfonamido
- cyclobutyl
- difluoromethoxy
- dichlorobiphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 COC(C*(C1(CCC1)c1cc(-c(ccc(N)c2)c2N)ccc1)[N+](*=O)(c(cc1)cc(N)c1N)[O-])=O Chemical compound COC(C*(C1(CCC1)c1cc(-c(ccc(N)c2)c2N)ccc1)[N+](*=O)(c(cc1)cc(N)c1N)[O-])=O 0.000 description 2
- ALGAZPMCTIRYFW-UHFFFAOYSA-N CC(C)(CCc1c2)Oc1ccc2N Chemical compound CC(C)(CCc1c2)Oc1ccc2N ALGAZPMCTIRYFW-UHFFFAOYSA-N 0.000 description 1
- OLXMFKAKXAAVKQ-UHFFFAOYSA-N CC(C)(CCc1c2)Oc1ccc2S(N(CC(O)=O)C1(COCC1)c(cc1)ccc1-c1cc(Cl)cc(Cl)c1)(=O)=O Chemical compound CC(C)(CCc1c2)Oc1ccc2S(N(CC(O)=O)C1(COCC1)c(cc1)ccc1-c1cc(Cl)cc(Cl)c1)(=O)=O OLXMFKAKXAAVKQ-UHFFFAOYSA-N 0.000 description 1
- PNESIPYSOZUBGI-UHFFFAOYSA-N COC(CN(C1(CCC1)c(cc1)ccc1Br)S(c(cc1)ccc1OC(F)F)(=O)=O)=O Chemical compound COC(CN(C1(CCC1)c(cc1)ccc1Br)S(c(cc1)ccc1OC(F)F)(=O)=O)=O PNESIPYSOZUBGI-UHFFFAOYSA-N 0.000 description 1
- VOFBRAMKHNPEGG-UHFFFAOYSA-N N#Cc(cccc1)c1S(N(CC(O)=O)C1(CCC1)c1cc(-c2cc(Cl)cc(Cl)c2)ccc1)(=O)=O Chemical compound N#Cc(cccc1)c1S(N(CC(O)=O)C1(CCC1)c1cc(-c2cc(Cl)cc(Cl)c2)ccc1)(=O)=O VOFBRAMKHNPEGG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30599610P | 2010-02-19 | 2010-02-19 | |
| US61/305,996 | 2010-02-19 | ||
| PCT/US2011/024726 WO2011103055A1 (en) | 2010-02-19 | 2011-02-14 | Glycine sulfonamides for use as inhibitors of diacylglycerol lipase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013520423A true JP2013520423A (ja) | 2013-06-06 |
| JP2013520423A5 JP2013520423A5 (enExample) | 2014-04-03 |
Family
ID=43755254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012553956A Withdrawn JP2013520423A (ja) | 2010-02-19 | 2011-02-14 | ジアシルグリセロールリパーゼ阻害剤としての使用のためのグリシンスルホンアミド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8404741B2 (enExample) |
| EP (1) | EP2536694B1 (enExample) |
| JP (1) | JP2013520423A (enExample) |
| CN (1) | CN102858753A (enExample) |
| WO (1) | WO2011103055A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11236055B2 (en) * | 2016-07-01 | 2022-02-01 | Venenum Biodesign, LLC | Non-systemic TGR5 agonists |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2348847A1 (en) | 2000-05-31 | 2001-11-30 | Pfizer Inc. | New isoxazole-sulfonamide endothelin antagonists |
| AU2009235634B8 (en) | 2008-04-08 | 2013-05-23 | Grunenthal Gmbh | Substituted sulfonamide derivatives |
-
2011
- 2011-02-11 US US13/025,384 patent/US8404741B2/en active Active
- 2011-02-14 WO PCT/US2011/024726 patent/WO2011103055A1/en not_active Ceased
- 2011-02-14 JP JP2012553956A patent/JP2013520423A/ja not_active Withdrawn
- 2011-02-14 CN CN2011800198869A patent/CN102858753A/zh active Pending
- 2011-02-14 EP EP11705768.7A patent/EP2536694B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| CN102858753A (zh) | 2013-01-02 |
| EP2536694B1 (en) | 2014-01-22 |
| WO2011103055A1 (en) | 2011-08-25 |
| EP2536694A1 (en) | 2012-12-26 |
| US8404741B2 (en) | 2013-03-26 |
| US20110207749A1 (en) | 2011-08-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7519221B2 (ja) | 置換ピラゾロ［１，５－ａ］ピリミジンおよび医療疾患の治療におけるその使用 | |
| CA2918365C (en) | Sulfonamides as modulators of sodium channels | |
| CA2655654C (en) | New carbonylated (aza)cyclohexanes as dopamine d3 receptor ligands | |
| US9422235B2 (en) | Sulfonamide derivatives with therapeutic indications | |
| CA3069720A1 (en) | Carboxamides as modulators of sodium channels | |
| RS20060143A (sr) | Jedinjenja fenil ili piridil amida kao antagonisti prostaglandina e2 | |
| JP2009536613A (ja) | Ｃｂ２受容体を調節する化合物 | |
| CN101550114A (zh) | 具有cb1拮抗、激动或部分激动活性的噻唑衍生物 | |
| JP2007536366A (ja) | 置換メチルアリール又はヘテロアリールアミド化合物 | |
| CA3144075A1 (en) | Pharmaceutically active pyrazolo-pyridone modulators of dcn1/2-mediated cullin neddylation | |
| WO2010076034A1 (en) | Toluidine sulfonamides and their use as-inhibitors | |
| EP2382189A1 (en) | Toluidine sulfonamides and their use | |
| JP5815033B2 (ja) | 癌治療用新規ｎ−ヒドロキシ−ベンズアミド | |
| WO2019178324A1 (en) | Amino-benzoisothiazole and amino-benzoisothiadiazole amide compounds | |
| RS57071B1 (sr) | Jedinjenja fluorofenil pirazola | |
| JP2013520423A (ja) | ジアシルグリセロールリパーゼ阻害剤としての使用のためのグリシンスルホンアミド | |
| EP2536704B1 (en) | Glycine chroman-6-sulfonamides for use as inhibitors of diacylglycerol lipase | |
| EP4043436A1 (en) | Magl inhibitor, preparation method therefor and use thereof | |
| NZ715751B2 (en) | Sulfonamides as modulators of sodium channels | |
| KR20180117016A (ko) | 신규 sirt 1 활성화제 및 이의 의학적 용도 | |
| EP2382190A1 (en) | Toluidine sulfonamides and their use as-inhibitors | |
| WO2016205031A1 (en) | Fluoropyridyl pyrazol compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140213 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20140213 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20141106 |