JP2013518978A5 - - Google Patents
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- Publication number
- JP2013518978A5 JP2013518978A5 JP2012552512A JP2012552512A JP2013518978A5 JP 2013518978 A5 JP2013518978 A5 JP 2013518978A5 JP 2012552512 A JP2012552512 A JP 2012552512A JP 2012552512 A JP2012552512 A JP 2012552512A JP 2013518978 A5 JP2013518978 A5 JP 2013518978A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- polysaccharide
- functional group
- hydrophobic
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000004804 polysaccharides Chemical class 0.000 claims 43
- 229920001282 polysaccharide Polymers 0.000 claims 41
- 239000005017 polysaccharide Substances 0.000 claims 41
- 125000000524 functional group Chemical group 0.000 claims 15
- -1 alkali metal cation Chemical class 0.000 claims 14
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 13
- 230000002209 hydrophobic effect Effects 0.000 claims 13
- 239000002243 precursor Substances 0.000 claims 9
- 239000002253 acid Substances 0.000 claims 8
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
- 230000008878 coupling Effects 0.000 claims 7
- 238000010168 coupling process Methods 0.000 claims 7
- 238000005859 coupling reaction Methods 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000003277 amino group Chemical group 0.000 claims 6
- 238000006243 chemical reaction Methods 0.000 claims 6
- 125000001165 hydrophobic group Chemical group 0.000 claims 6
- 229920006395 saturated elastomer Polymers 0.000 claims 6
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 5
- 229910052783 alkali metal Inorganic materials 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000001408 amides Chemical group 0.000 claims 5
- 150000001412 amines Chemical class 0.000 claims 5
- 150000001768 cations Chemical class 0.000 claims 5
- 150000002148 esters Chemical class 0.000 claims 5
- 150000004676 glycans Polymers 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 238000007306 functionalization reaction Methods 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 150000001298 alcohols Chemical class 0.000 claims 2
- 229920001586 anionic polysaccharide Polymers 0.000 claims 2
- 150000004836 anionic polysaccharides Chemical class 0.000 claims 2
- 150000001450 anions Chemical class 0.000 claims 2
- 150000001720 carbohydrates Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229930182470 glycoside Natural products 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 229920001218 Pullulan Polymers 0.000 claims 1
- 239000004373 Pullulan Substances 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 125000001033 ether group Chemical group 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229940099552 hyaluronan Drugs 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 239000010318 polygalacturonic acid Substances 0.000 claims 1
- 235000019423 pullulan Nutrition 0.000 claims 1
- 229920001221 xylan Polymers 0.000 claims 1
- 150000004823 xylans Chemical class 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1000537A FR2956116A1 (fr) | 2010-02-09 | 2010-02-09 | Complexes polysaccharide/bmp-7 solubles a ph physiologique |
| FR1000537 | 2010-02-09 | ||
| US28284610P | 2010-04-08 | 2010-04-08 | |
| US61/282,846 | 2010-04-08 | ||
| FR1001474 | 2010-04-08 | ||
| FR1001474A FR2958647B1 (fr) | 2010-04-08 | 2010-04-08 | Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive hydrophobe porte par un spacer au moins trivalent. |
| PCT/IB2010/002970 WO2011061615A1 (fr) | 2009-11-19 | 2010-11-19 | Complexes polysaccharide / bmp solubles a ph physiologique |
| IBPCT/IB2010/002970 | 2010-11-19 | ||
| PCT/IB2011/050554 WO2011098962A2 (fr) | 2010-02-09 | 2011-02-09 | Polysaccharides anioniques fonctionnalisés par au moins deux groupements hydrophobes portés par un spacer au moins trivalent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518978A JP2013518978A (ja) | 2013-05-23 |
| JP2013518978A5 true JP2013518978A5 (cg-RX-API-DMAC7.html) | 2014-03-27 |
| JP5950458B2 JP5950458B2 (ja) | 2016-07-13 |
Family
ID=43827580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012552512A Expired - Fee Related JP5950458B2 (ja) | 2010-02-09 | 2011-02-09 | 少なくとも３価のスペーサーにより保有される少なくとも２つの疎水性基により官能化されたアニオン性多糖類 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2533812A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5950458B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN102834117B (cg-RX-API-DMAC7.html) |
| BR (1) | BR112012019580A2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011098962A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9018190B2 (en) | 2009-03-27 | 2015-04-28 | Adocia | Functionalized oligosaccharides |
| FR2943538B1 (fr) | 2009-03-27 | 2011-05-20 | Adocia | Formulation a action rapide d'insuline recombinante humaine |
| FR2980796B1 (fr) * | 2011-09-30 | 2014-07-04 | Adocia | Oligosaccharides fonctionnalises |
| EP2828297A1 (fr) * | 2011-05-10 | 2015-01-28 | Adocia | Oligosaccharides fonctionnalisés |
| FR2984749A1 (fr) * | 2011-12-23 | 2013-06-28 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 en combinaison avec une hormone gastro-intestinale a visee therapeutique |
| BR112014002986A2 (pt) * | 2011-08-10 | 2017-06-13 | Adocia | composição sob a forma de uma solução injetável, e formulação de dose única |
| FR2978918B1 (fr) * | 2011-08-10 | 2013-12-27 | Adocia | Solution injectable a ph7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 |
| US20130231281A1 (en) | 2011-11-02 | 2013-09-05 | Adocia | Rapid acting insulin formulation comprising an oligosaccharide |
| WO2013064787A1 (fr) * | 2011-11-02 | 2013-05-10 | Adocia | Formulation à action rapide d'insuline comprenant un oligosaccharide |
| CN107583039A (zh) | 2012-01-09 | 2018-01-16 | 阿道恰公司 | Ph为7且至少含pi为5.8至8.5之基础胰岛素和取代共聚(氨基酸)的可注射溶液 |
| US20150314003A2 (en) | 2012-08-09 | 2015-11-05 | Adocia | Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer |
| US9700599B2 (en) | 2012-11-13 | 2017-07-11 | Adocia | Rapid-acting insulin formulation comprising a substituted anionic compound |
| US9795678B2 (en) | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
| FR3020947B1 (fr) | 2014-05-14 | 2018-08-31 | Adocia | Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations |
| FR3043557B1 (fr) | 2015-11-16 | 2019-05-31 | Adocia | Composition a action rapide d'insuline comprenant un citrate substitue |
| JP2021528474A (ja) * | 2018-06-29 | 2021-10-21 | ビーエイエスエフ・ソシエタス・エウロパエアＢａｓｆ Ｓｅ | エステルアミン塩 |
| CN109851683B (zh) * | 2018-12-12 | 2021-05-11 | 兰州大学 | 一种金属配合物、一种金属配合物的制备方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2387201A (en) | 1942-01-12 | 1945-10-16 | Bonneville Ltd | Mono-acyl ethylene diamines |
| US4826818A (en) | 1983-10-26 | 1989-05-02 | Kanebo Ltd. | Proteinaceous emulsifier, process for preparing same and emulsion type cosmetic compositions containing same |
| US6068697A (en) * | 1996-11-27 | 2000-05-30 | Kao Corporation | Polysaccharide derivatives and hydraulic compositions |
| US6905694B1 (en) * | 1997-05-12 | 2005-06-14 | Hercules Incorporated | Hydrophobically modified polysaccharide in personal care products |
| FR2861396B1 (fr) * | 2003-10-24 | 2005-12-16 | Commissariat Energie Atomique | Derives amphiphiles de cyclodextrines,leur procede de preparation et leurs utilisations |
| FR2891149B1 (fr) * | 2005-09-26 | 2007-11-30 | Biodex Sarl | Composition pharmaceutique a action cicatrisante comprenant un derive de dextrane soluble et un facteur de croissance derive des plaquettes. |
| EP2007816A1 (fr) * | 2006-04-07 | 2008-12-31 | Adocia | Polysaccharides bifonctionnalises |
| CN100509862C (zh) * | 2006-12-13 | 2009-07-08 | 辽宁大学 | β-环糊精-聚L-谷氨酸-苄酯接枝共聚物的合成方法 |
| CN101148480A (zh) * | 2007-07-23 | 2008-03-26 | 天津大学 | 苯基聚蔗糖微球及其制备方法 |
| FR2919188B1 (fr) * | 2007-07-27 | 2010-02-26 | Proteins & Peptides Man | Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps |
| EP2288370A1 (fr) * | 2008-04-14 | 2011-03-02 | Adocia | Composition osteogenique comprenant un complexe facteur de croissance/polymere amphiphile un sel soluble de cation e un support organique |
| FR2948573B1 (fr) * | 2009-07-31 | 2011-11-18 | Adocia | Nouvelle forme d'administration de complexes de proteines osteogeniques |
| FR2956116A1 (fr) * | 2010-02-09 | 2011-08-12 | Adocia | Complexes polysaccharide/bmp-7 solubles a ph physiologique |
-
2011
- 2011-02-09 BR BR112012019580-8A patent/BR112012019580A2/pt not_active Application Discontinuation
- 2011-02-09 WO PCT/IB2011/050554 patent/WO2011098962A2/fr not_active Ceased
- 2011-02-09 CN CN201180011939.2A patent/CN102834117B/zh not_active Expired - Fee Related
- 2011-02-09 JP JP2012552512A patent/JP5950458B2/ja not_active Expired - Fee Related
- 2011-02-09 CN CN201510615466.7A patent/CN105218685B/zh not_active Expired - Fee Related
- 2011-02-09 EP EP11710319A patent/EP2533812A2/fr not_active Withdrawn
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