JP2013518926A5 - - Google Patents
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- Publication number
- JP2013518926A5 JP2013518926A5 JP2012552893A JP2012552893A JP2013518926A5 JP 2013518926 A5 JP2013518926 A5 JP 2013518926A5 JP 2012552893 A JP2012552893 A JP 2012552893A JP 2012552893 A JP2012552893 A JP 2012552893A JP 2013518926 A5 JP2013518926 A5 JP 2013518926A5
- Authority
- JP
- Japan
- Prior art keywords
- hyaluronic acid
- high salt
- salt concentration
- solution
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 22
- 229920002674 hyaluronan Polymers 0.000 claims 22
- 229960003160 hyaluronic acid Drugs 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 239000007864 aqueous solution Substances 0.000 claims 13
- 239000000243 solution Substances 0.000 claims 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 10
- 239000011780 sodium chloride Substances 0.000 claims 5
- 239000000872 buffer Substances 0.000 claims 4
- 230000001954 sterilising effect Effects 0.000 claims 4
- 229910021538 borax Inorganic materials 0.000 claims 3
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 3
- 239000004327 boric acid Substances 0.000 claims 3
- 235000010339 sodium tetraborate Nutrition 0.000 claims 3
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims 3
- 235000010338 boric acid Nutrition 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 239000002033 PVDF binder Substances 0.000 claims 1
- 239000007983 Tris buffer Substances 0.000 claims 1
- 125000004369 butenyl group Chemical group C(=CCC)* 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 239000008213 purified water Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/702,540 US8283463B2 (en) | 2010-02-09 | 2010-02-09 | Sterile hyaluronic acid solutions |
| US12/702,540 | 2010-02-09 | ||
| PCT/US2011/022656 WO2011100114A1 (en) | 2010-02-09 | 2011-01-27 | Sterile hyaluronic acid solutions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518926A JP2013518926A (ja) | 2013-05-23 |
| JP2013518926A5 true JP2013518926A5 (cg-RX-API-DMAC7.html) | 2014-03-13 |
| JP5789271B2 JP5789271B2 (ja) | 2015-10-07 |
Family
ID=43754892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012552893A Active JP5789271B2 (ja) | 2010-02-09 | 2011-01-27 | 無菌ヒアルロン酸溶液 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8283463B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2400993B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5789271B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112012019008B8 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2531955T3 (cg-RX-API-DMAC7.html) |
| PL (1) | PL2400993T3 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI405595B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011100114A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10189773B2 (en) | 2010-05-07 | 2019-01-29 | Medicus Biosciences, Llc | In-vivo gelling pharmaceutical pre-formulation |
| US11083821B2 (en) * | 2011-08-10 | 2021-08-10 | C.P. Medical Corporation | Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules |
| US10111985B2 (en) * | 2011-08-10 | 2018-10-30 | Medicus Biosciences, Llc | Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules |
| ES2686114T3 (es) * | 2011-12-20 | 2018-10-16 | Angioclinic Ag | El ácido hialurónico y su uso para el tratamiento de la insuficiencia venosa y las venas varicosas |
| CA2873105C (en) | 2012-05-11 | 2018-01-16 | Medicus Biosciences, Llc | Biocompatible hydrogel treatments for retinal detachment |
| FR3019465B1 (fr) | 2014-04-02 | 2017-06-23 | Horus Pharma | Composition hyperosmolaire d'acide hyaluronique et son utilisation pour le traitement de l'oedeme corneen |
| EP3131521B1 (en) | 2014-04-17 | 2020-11-11 | Merz Pharma GmbH & Co. KGaA | Composition for improving the appearance of ageing skin |
| US10245324B2 (en) | 2014-10-31 | 2019-04-02 | Johnson & Johnson Consumer Inc. | Ophthalmic composition |
| US20170014339A1 (en) * | 2015-07-17 | 2017-01-19 | i.com medical GmbH | Tear Substitute, Fluid for Being Used as a Tear Substitute, and Method for Producing a Tear Substitute |
| DE102015226456A1 (de) | 2015-12-22 | 2017-06-22 | Heraeus Medical Gmbh | Verfahren zur Sterilisation von wässrigen Polysaccharidlösungen und sterile wässrige Polysaccharidlösungen |
| AR108280A1 (es) | 2016-05-05 | 2018-08-08 | Acraf | Composición oftálmica que comprende una combinación sinérgica de glucógeno y ácido hialurónico o sal del mismo |
| HUE058672T2 (hu) * | 2016-10-14 | 2022-09-28 | I Com Medical Gmbh | Eljárás a szemfelület homeosztázisának megállapítására, helyreállítására és megõrzésére |
| US12303601B2 (en) * | 2017-10-12 | 2025-05-20 | Solyplus Gmbh | Methods of fabrication of concentrated and homogeneously wetted massive polymers and applications thereof |
| CN111196917B (zh) * | 2018-11-20 | 2022-10-14 | 臧唯 | 内窥镜用视野清晰剂 |
| KR20220049525A (ko) * | 2019-08-21 | 2022-04-21 | 가부시키가이샤 시세이도 | 화장료 |
| IT201900019724A1 (it) | 2019-10-24 | 2021-04-24 | Bmg Pharma S P A | “procedimento in solvente organico per la purificazione dell’acido ialuronico sale sodico” |
| IT202000008299A1 (it) * | 2020-04-17 | 2021-10-17 | Glycores 2000 Srl | Composizione liquida oftalmica comprendente acido ialuronico lineare a basso peso molecolare |
| KR102549875B1 (ko) * | 2020-09-22 | 2023-07-03 | 주식회사 필코리아 | 필러 정제용 장치 |
| CN112255345A (zh) * | 2020-10-20 | 2021-01-22 | 山东华熙海御生物医药有限公司 | 一种测定高分子量透明质酸分子量的方法 |
| KR102762718B1 (ko) * | 2022-02-23 | 2025-02-06 | 주식회사 스카이테라퓨틱스 | 고분자 히알루론산의 구조체, 이의 제조방법 및 이를 포함하는 화장료 조성물 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4141973A (en) | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
| DE2837115A1 (de) | 1978-08-25 | 1980-03-06 | Bayer Ag | Neues verfahren zur herstellung von sterilen feststoffen |
| US5093487A (en) | 1986-01-06 | 1992-03-03 | Mobay Corporation | Low viscosity high molecular weight filter sterilizable hyaluronic acid |
| RU2067841C1 (ru) * | 1994-01-28 | 1996-10-20 | Научно-производственная фирма "Нарт" | Способ получения ароматизатора |
| IT1273011B (it) | 1994-07-25 | 1997-07-01 | Trhecnopharma S A | Preparato oftalmico per l'uso come lacrima artificiale |
| US5621093A (en) | 1995-06-06 | 1997-04-15 | Anika Research, Inc. | Steam-sterilizing solid hyaluronic acid |
| WO1997033593A1 (en) * | 1996-03-15 | 1997-09-18 | Takara Shuzo Co., Ltd. | A product of heat treatment of uronic acid, food, drink or drug including the product |
| KR19980080116A (ko) | 1997-03-27 | 1998-11-25 | 히라따 다다시 | 히알루론산 나트륨의 정제법 |
| US6149864A (en) | 1998-06-25 | 2000-11-21 | Massachusetts Institute Of Technology | Supercritical fluid sterilization method |
| CH692919A5 (fr) | 1999-01-28 | 2002-12-13 | Trb Chemedica S A | Procédé de purification de l'acide hyaluronique à poids moléculaire élevé. |
| KR100354606B1 (ko) | 2000-02-01 | 2002-09-30 | 주식회사 중외제약 | 다목적 콘택트 렌즈 관리 용액 조성물 |
| FR2811996B1 (fr) * | 2000-07-19 | 2003-08-08 | Corneal Ind | Reticulation de polysaccharide(s), preparation d'hydrogel(s) ; polysaccharide(s) et hydrogel(s) obtenus,leurs utilisations |
| WO2003002159A1 (en) | 2001-06-29 | 2003-01-09 | Biovitrum Ab | Process for bulk autoclaving |
| CA2458126C (en) * | 2001-11-21 | 2012-06-26 | Novartis Ag | Composition for stabilizing hyaluronic acid |
| DK1526859T3 (da) | 2002-08-07 | 2013-02-04 | Medidom Lab | Fremgangsmåde til fremstilling af et sterilt præparat af hyaluronsyre med høj molvægt |
| US6930077B2 (en) | 2003-09-10 | 2005-08-16 | Advanced Medical Optics, Inc. | Compositions and methods using sub-PPM combinations of polyquaternium-1 and high molecular weight PHMB |
| US7956180B2 (en) * | 2004-05-27 | 2011-06-07 | Novozymes A/S | Dried and agglomerated hyaluronic acid product |
| CN101001649B (zh) | 2004-07-09 | 2011-08-31 | 弗罗桑医疗设备公司 | 包括透明质酸的止血组合物及其制备方法 |
| DE102005030011A1 (de) | 2005-06-17 | 2006-12-21 | Aesculap Ag & Co. Kg | Verfahren zur Herstellung von sterilen Polysaccharidlösungen |
| US20090036554A1 (en) * | 2007-08-01 | 2009-02-05 | Burke Susan E | Ophthalmic compositions comprising a terpene compound |
| JP2011503047A (ja) * | 2007-11-13 | 2011-01-27 | バイオ−テクノロジー ゼネラル（イスラエル）リミテッド | 粘弾性生体高分子のための希釈濾過滅菌プロセス |
| CN102209548A (zh) * | 2008-09-15 | 2011-10-05 | 博士伦公司 | 包含具有氨基糖单元的聚合物的组合物及其制备和使用方法 |
-
2010
- 2010-02-09 US US12/702,540 patent/US8283463B2/en active Active
-
2011
- 2011-01-27 ES ES11702563.5T patent/ES2531955T3/es active Active
- 2011-01-27 EP EP11702563.5A patent/EP2400993B1/en active Active
- 2011-01-27 WO PCT/US2011/022656 patent/WO2011100114A1/en not_active Ceased
- 2011-01-27 PL PL11702563T patent/PL2400993T3/pl unknown
- 2011-01-27 TW TW100103169A patent/TWI405595B/zh active
- 2011-01-27 BR BR112012019008A patent/BR112012019008B8/pt active IP Right Grant
- 2011-01-27 EP EP20140193207 patent/EP2865395A1/en not_active Withdrawn
- 2011-01-27 JP JP2012552893A patent/JP5789271B2/ja active Active
-
2012
- 2012-08-01 US US13/564,161 patent/US8530641B2/en active Active
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