JP2013518917A5 - - Google Patents
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- Publication number
- JP2013518917A5 JP2013518917A5 JP2012552297A JP2012552297A JP2013518917A5 JP 2013518917 A5 JP2013518917 A5 JP 2013518917A5 JP 2012552297 A JP2012552297 A JP 2012552297A JP 2012552297 A JP2012552297 A JP 2012552297A JP 2013518917 A5 JP2013518917 A5 JP 2013518917A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- substituted
- compound
- group
- pharmaceutical preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- -1 aminoalkyl oxazoles Chemical class 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 210000003027 ear inner Anatomy 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000002768 hair cell Anatomy 0.000 claims 2
- 210000002985 organ of corti Anatomy 0.000 claims 2
- 230000001953 sensory effect Effects 0.000 claims 2
- 206010011878 Deafness Diseases 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000005779 cell damage Effects 0.000 claims 1
- 208000037887 cell injury Diseases 0.000 claims 1
- 230000006727 cell loss Effects 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 230000032459 dedifferentiation Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 230000010370 hearing loss Effects 0.000 claims 1
- 231100000888 hearing loss Toxicity 0.000 claims 1
- 208000016354 hearing loss disease Diseases 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102010007281A DE102010007281A1 (de) | 2010-02-08 | 2010-02-08 | Neue Aminoalkyl-oxazol- und Aminoalkyl-thiazolcarbonsäureamide und ihre Anwendung zur Stimulation der endogenen situ Regeneration von Haarsinneszellen im Corti'schen Organ des Innenohres beim Säuger |
| DE102010007281.8 | 2010-02-08 | ||
| PCT/EP2011/000502 WO2011095338A1 (de) | 2010-02-08 | 2011-02-04 | Neue aminoalkyl-oxazol- und aminoalkyl-thiazolcarbonsäureamide als regenerationsfördernde substanzen für sinnesorgane und postmitotische gewebe |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013518917A JP2013518917A (ja) | 2013-05-23 |
| JP2013518917A5 true JP2013518917A5 (https=) | 2014-01-09 |
Family
ID=43754901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012552297A Pending JP2013518917A (ja) | 2010-02-08 | 2011-02-04 | 感覚器官及び有糸分裂後組織のための再生促進物質としての新規なアミノアルキルオキサゾール及びアミノアルキルチアゾールカルボン酸アミド |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20130012514A1 (https=) |
| EP (1) | EP2534139A1 (https=) |
| JP (1) | JP2013518917A (https=) |
| CN (1) | CN102947281B (https=) |
| CA (1) | CA2789013A1 (https=) |
| DE (1) | DE102010007281A1 (https=) |
| WO (1) | WO2011095338A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2871181B1 (en) | 2013-11-12 | 2016-10-05 | Acousia Therapeutics GmbH | Novel Compounds for Regeneration of Terminally-Differentiated Cells and tissues |
| EP3366683A1 (en) * | 2017-02-28 | 2018-08-29 | Acousia Therapeutics GmbH | Cyclic amides, acteamides and ureas useful as potassium channel openers |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5378803A (en) * | 1987-12-11 | 1995-01-03 | Sterling Winthrop Inc. | Azole-fused peptides and processes for preparation thereof |
| DE19807426A1 (de) * | 1998-02-23 | 1999-10-14 | Otogene Biotechnologische Fors | Verfahren zur Behandlung von Erkrankungen oder Störungen des Innenohrs |
| EP1126855B1 (en) * | 1998-09-25 | 2007-05-09 | Cephalon, Inc. | Use of fused pyrrolocarbazoles for preventing/treating damage to sensory hair cells and cochlear neurons |
| TW502019B (en) * | 1999-03-26 | 2002-09-11 | Cocensys Inc | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
| CN1441841B (zh) * | 2000-07-11 | 2013-03-20 | 桑得医药品公司 | 对内耳的细胞再生和分化的刺激 |
| UA89035C2 (ru) * | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Эфиры гидроксамовых кислот и их фармацевтическое применение |
| JP2008502595A (ja) * | 2004-03-31 | 2008-01-31 | エグゼリクシス， インコーポレイテッド | 未分化リンパ腫キナーゼモジュレータおよびその使用方法 |
| JP5182088B2 (ja) * | 2006-04-19 | 2013-04-10 | アステラス製薬株式会社 | アゾールカルボキサミド誘導体 |
| GB0614538D0 (en) * | 2006-07-21 | 2006-08-30 | Univ Cambridge Tech | Therapeutic Compounds And Their Use |
-
2010
- 2010-02-08 DE DE102010007281A patent/DE102010007281A1/de not_active Withdrawn
-
2011
- 2011-02-04 US US13/577,503 patent/US20130012514A1/en not_active Abandoned
- 2011-02-04 CN CN201180017156.5A patent/CN102947281B/zh not_active Expired - Fee Related
- 2011-02-04 WO PCT/EP2011/000502 patent/WO2011095338A1/de not_active Ceased
- 2011-02-04 JP JP2012552297A patent/JP2013518917A/ja active Pending
- 2011-02-04 EP EP11703394A patent/EP2534139A1/de not_active Withdrawn
- 2011-02-04 CA CA2789013A patent/CA2789013A1/en not_active Abandoned
-
2014
- 2014-03-13 US US14/208,419 patent/US8889723B2/en not_active Expired - Fee Related
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