JP2010059183A5 - - Google Patents
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- Publication number
- JP2010059183A5 JP2010059183A5 JP2009256184A JP2009256184A JP2010059183A5 JP 2010059183 A5 JP2010059183 A5 JP 2010059183A5 JP 2009256184 A JP2009256184 A JP 2009256184A JP 2009256184 A JP2009256184 A JP 2009256184A JP 2010059183 A5 JP2010059183 A5 JP 2010059183A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- lipoxin
- substituent
- analog
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 239000004480 active ingredient Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 230000033115 angiogenesis Effects 0.000 claims 5
- UXVRTOKOJOMENI-ICTGYCPSSA-N (6e,8e,10e,12e)-5,14,15-trihydroxyicosa-6,8,10,12-tetraenoic acid Chemical compound CCCCCC(O)C(O)\C=C\C=C\C=C\C=C\C(O)CCCC(O)=O UXVRTOKOJOMENI-ICTGYCPSSA-N 0.000 claims 4
- IXAQOQZEOGMIQS-ORRYEOPJSA-N Lipoxin A Natural products CCCCCC(O)C=CC=C/C=C/C=C/C(O)C(O)CCCC(=O)O IXAQOQZEOGMIQS-ORRYEOPJSA-N 0.000 claims 4
- IXAQOQZEOGMIQS-SSQFXEBMSA-N lipoxin A4 Chemical compound CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O IXAQOQZEOGMIQS-SSQFXEBMSA-N 0.000 claims 4
- 230000001737 promoting effect Effects 0.000 claims 4
- 208000037803 restenosis Diseases 0.000 claims 2
- 230000015590 smooth muscle cell migration Effects 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 206010029113 Neovascularisation Diseases 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- RDLVTAMOKVDZDQ-INJLQNTRSA-N C[C@](CCCC(O)=O)(/C=C/C=C\C=C\C=C\[C@@H]([C@@H](CCCCC(F)(F)F)O)O)O Chemical compound C[C@](CCCC(O)=O)(/C=C/C=C\C=C\C=C\[C@@H]([C@@H](CCCCC(F)(F)F)O)O)O RDLVTAMOKVDZDQ-INJLQNTRSA-N 0.000 description 2
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27293101P | 2001-03-02 | 2001-03-02 | |
| US60/272,931 | 2001-03-02 | ||
| US10/086,609 US6627658B2 (en) | 2001-03-02 | 2002-03-01 | Lipoxin analogs as novel inhibitors of angiogenesis |
| US10/086,609 | 2002-03-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569237A Division JP2005508282A (ja) | 2001-03-02 | 2002-03-01 | 新規な脈管形成抑制剤としてのリポキシン類似物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012195046A Division JP2012255025A (ja) | 2001-03-02 | 2012-09-05 | 新規な脈管形成抑制剤としてのリポキシン類似物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010059183A JP2010059183A (ja) | 2010-03-18 |
| JP2010059183A5 true JP2010059183A5 (https=) | 2012-02-16 |
| JP5302856B2 JP5302856B2 (ja) | 2013-10-02 |
Family
ID=26774943
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569237A Withdrawn JP2005508282A (ja) | 2001-03-02 | 2002-03-01 | 新規な脈管形成抑制剤としてのリポキシン類似物 |
| JP2009256184A Expired - Fee Related JP5302856B2 (ja) | 2001-03-02 | 2009-11-09 | 新規な脈管形成抑制剤としてのリポキシン類似物 |
| JP2012195046A Ceased JP2012255025A (ja) | 2001-03-02 | 2012-09-05 | 新規な脈管形成抑制剤としてのリポキシン類似物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569237A Withdrawn JP2005508282A (ja) | 2001-03-02 | 2002-03-01 | 新規な脈管形成抑制剤としてのリポキシン類似物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012195046A Ceased JP2012255025A (ja) | 2001-03-02 | 2012-09-05 | 新規な脈管形成抑制剤としてのリポキシン類似物 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US6627658B2 (https=) |
| EP (2) | EP2221089A1 (https=) |
| JP (3) | JP2005508282A (https=) |
| AT (1) | ATE412448T1 (https=) |
| AU (1) | AU2002252175A1 (https=) |
| CY (1) | CY1108670T1 (https=) |
| DE (1) | DE60229640D1 (https=) |
| DK (1) | DK1406698T3 (https=) |
| ES (1) | ES2316553T3 (https=) |
| PT (1) | PT1406698E (https=) |
| WO (1) | WO2002070068A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1762557B1 (en) | 2000-02-16 | 2011-04-06 | The Brigham And Women's Hospital, Inc. | Aspirin-triggered lipid mediators |
| US7700650B2 (en) | 2000-03-20 | 2010-04-20 | Trustees Of Boston University | Lipoxin analogs and method for the treatment of periodontal disease |
| WO2002070068A2 (en) * | 2001-03-02 | 2002-09-12 | The Brigham And Women's Hospital | Lipoxin analogs as novel inhibitors of angiogenesis |
| US8722654B2 (en) | 2001-03-02 | 2014-05-13 | The Brigham And Women's Hospital, Inc. | Lipoxin analogs as novel inhibitors of angiogenesis |
| US7902257B2 (en) * | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7759395B2 (en) | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| DE60330154D1 (de) * | 2002-08-12 | 2009-12-31 | Brigham & Womens Hospital | Resolvine: biotemplate zur durchführung therapeutischer anwendungen |
| WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| EP1755537A4 (en) * | 2004-04-14 | 2009-12-09 | Univ Boston | METHOD AND COMPOSITIONS FOR PREVENTING OR TREATING PERIODONTOPATHIA |
| PL1809270T3 (pl) * | 2004-11-09 | 2010-08-31 | Alcon Inc | Kwas 5,6,7-trihydroksyheptanowy i jego analogi do leczenia chorób oczu i chorób związanych z odpowiedziami hiperproliferacyjnymi i angiogenicznymi |
| WO2007041440A2 (en) | 2005-10-03 | 2007-04-12 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers |
| US8636986B2 (en) * | 2005-11-18 | 2014-01-28 | The Forsyth Institute | Treatment and prevention of bone loss using resolvins |
| CA2650607A1 (en) * | 2006-04-28 | 2007-11-08 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of cardiovascular disease |
| MX2009000657A (es) * | 2006-07-19 | 2009-05-28 | Resolvyx Pharmaceuticals Inc | Composiciones y metodos para el tratamiento de mucositis. |
| WO2008057283A2 (en) * | 2006-10-26 | 2008-05-15 | Resolvyx Pharmaceuticals, Inc. | Use of resolvins for inhibition of bone loss |
| WO2008070129A2 (en) * | 2006-12-05 | 2008-06-12 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of inflammatory disease |
| PL2184993T3 (pl) * | 2007-08-08 | 2012-03-30 | Basf Se | Wodne mikroemulsje zawierające owadobójcze związki organiczne |
| CA2699483A1 (en) * | 2007-09-14 | 2009-03-26 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for modulating immune function |
| JP5421272B2 (ja) * | 2007-10-12 | 2014-02-19 | リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド | 眼病治療のための組成物及び方法 |
| US20100324138A1 (en) * | 2007-10-29 | 2010-12-23 | Bazan Nicolas G | Lipoxin A4 Protection for Retinal Cells |
| US7601693B2 (en) * | 2008-02-05 | 2009-10-13 | National Taiwan University | Composition for treating cancer and use thereof |
| US20100105772A1 (en) * | 2008-04-25 | 2010-04-29 | Serhan Charles N | Use of novel lipid mediators to inhibit angiogenesis |
| HK1219654A1 (zh) * | 2013-02-22 | 2017-04-13 | University Of Southern California | 用於治疗眼科疾病和病症的方法 |
| SG11201507515YA (en) | 2013-03-15 | 2015-10-29 | Marcus Kare Torleif Larsson | Cells, methods and apparatuses for umbilical cord blood collection and isolation of cells |
| EP3020398A1 (en) * | 2014-11-17 | 2016-05-18 | Nitto Denko Corporation | Compounds and formulations for reducing scarring |
| ES2827796T3 (es) | 2016-06-03 | 2021-05-24 | Thetis Pharmaceuticals Llc | Composiciones y procedimientos relativos a sales de mediadores pro-resolutivos especializados de inflamación |
| WO2018073615A1 (en) | 2016-10-21 | 2018-04-26 | Longboat Explorers Ab | Methods and compositions for generating hematopoietic cells |
| WO2018144316A1 (en) | 2017-01-31 | 2018-08-09 | The Brigham And Women's Hospital, Inc. | Alx receptor ligands define a biochemical endotype for inflammation-based diseases |
| WO2018161175A1 (en) * | 2017-03-09 | 2018-09-13 | University Health Network | Lipoxin and lipoxin analogue mediated neuroprotection and treatments |
| US12465878B2 (en) | 2019-06-20 | 2025-11-11 | Amniotics Ab | Apparatus for filtering amniotic fluid |
| EP4234019A3 (en) | 2019-10-18 | 2023-09-13 | Amniotics AB | Processes and apparatuses for obtaining amniotic mesenchymal stem cells from amniotic fluid and cells derived thereof |
| US12435308B2 (en) | 2020-11-06 | 2025-10-07 | Amniotics Ab | Immunomodulation by amniotic fluid mesenchymal stem cells |
| WO2023168245A2 (en) | 2022-03-03 | 2023-09-07 | Thetis Pharmaceuticals Llc | Cyclodextrin complexes of specialized proresolving mediators |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4560514A (en) | 1984-05-04 | 1985-12-24 | Bengt Samuelsson | Inflammatory lipoxin A and anti-anflammatory lipoxin B compounds |
| US4576758A (en) | 1984-06-01 | 1986-03-18 | The Upjohn Company | Anti-inflammatory lipoxin B analogs |
| US4780281A (en) | 1985-06-14 | 1988-10-25 | Wayne State University | Method for assay of peroxidase enzyme or reducing substrate activity |
| JPS62198677A (ja) | 1986-02-26 | 1987-09-02 | Nissan Chem Ind Ltd | テトラオ−ル誘導体 |
| JPH0739368B2 (ja) | 1986-10-01 | 1995-05-01 | 旭硝子株式会社 | ２０，２０，２０−トリフルオロアラキドン酸誘導体およびその製造法 |
| CA1329809C (en) | 1987-07-08 | 1994-05-24 | Nissan Chemical Industries, Ltd. | Optically active allyl alcohol and process for producing leucotriene b_ using thereof |
| JPH01228994A (ja) | 1988-03-10 | 1989-09-12 | Fumie Satou | γ−シリルアリルアルコール及びその製造法 |
| US5079261A (en) | 1989-04-28 | 1992-01-07 | Brigham And Women's Hospital | Use of lipoxin a4 and its derivatives as antagonists for slow-reacting substances of anaphylaxis |
| JP2834512B2 (ja) | 1990-01-30 | 1998-12-09 | 帝人株式会社 | リポキシン誘導体を有効成分とする疾患治療剤 |
| US5322699A (en) | 1991-02-04 | 1994-06-21 | The Rockefeller University | Leukocyte-derived CR3 modulator, integrin modulating factor-1 (IMF-1) |
| US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| JP3227922B2 (ja) | 1993-01-20 | 2001-11-12 | 富士電機株式会社 | 自動販売機 |
| DE69435125D1 (de) | 1993-06-15 | 2008-10-02 | Brigham & Womens Hospital | Lipoxinverbindungen mit verlängerter halbwertszeit |
| US5441951A (en) | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| US6048897A (en) * | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| WO1995001179A1 (en) * | 1993-06-29 | 1995-01-12 | Brigham & Women's Hospital | Modulation of inflammation related to columnar epithelia |
| US5750354A (en) | 1994-03-11 | 1998-05-12 | Brigham And Women's Hospital | Lipoxin transport system and uses therefor |
| EP0938557B1 (en) * | 1996-10-25 | 2000-09-13 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Methods and compositions for inhibiting inflammation and angiogenesis comprising a mammalian cd97 alpha subunit |
| US5837283A (en) * | 1997-03-12 | 1998-11-17 | The Regents Of The University Of California | Cationic lipid compositions targeting angiogenic endothelial cells |
| AU748621B2 (en) * | 1998-08-13 | 2002-06-06 | Merck & Co., Inc. | Integrin receptor antagonists |
| JP2002539181A (ja) * | 1999-03-18 | 2002-11-19 | ブリガム・アンド・ウイメンズ・ホスピタル | リポキシン化合物およびこれらの使用 |
| CA2367909C (en) * | 1999-03-18 | 2008-02-12 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of tnf-(alpha) initiated neutrophil response |
| EP1762557B1 (en) * | 2000-02-16 | 2011-04-06 | The Brigham And Women's Hospital, Inc. | Aspirin-triggered lipid mediators |
| US7700650B2 (en) | 2000-03-20 | 2010-04-20 | Trustees Of Boston University | Lipoxin analogs and method for the treatment of periodontal disease |
| WO2002070068A2 (en) | 2001-03-02 | 2002-09-12 | The Brigham And Women's Hospital | Lipoxin analogs as novel inhibitors of angiogenesis |
-
2002
- 2002-03-01 WO PCT/US2002/006404 patent/WO2002070068A2/en not_active Ceased
- 2002-03-01 EP EP10003357A patent/EP2221089A1/en not_active Ceased
- 2002-03-01 EP EP02721234A patent/EP1406698B1/en not_active Expired - Lifetime
- 2002-03-01 JP JP2002569237A patent/JP2005508282A/ja not_active Withdrawn
- 2002-03-01 AU AU2002252175A patent/AU2002252175A1/en not_active Abandoned
- 2002-03-01 PT PT02721234T patent/PT1406698E/pt unknown
- 2002-03-01 DK DK02721234T patent/DK1406698T3/da active
- 2002-03-01 DE DE60229640T patent/DE60229640D1/de not_active Expired - Lifetime
- 2002-03-01 US US10/086,609 patent/US6627658B2/en not_active Expired - Fee Related
- 2002-03-01 AT AT02721234T patent/ATE412448T1/de active
- 2002-03-01 ES ES02721234T patent/ES2316553T3/es not_active Expired - Lifetime
-
2003
- 2003-07-08 US US10/615,361 patent/US20040053998A1/en not_active Abandoned
-
2005
- 2005-09-08 US US11/222,458 patent/US8008282B2/en not_active Expired - Fee Related
-
2007
- 2007-08-13 US US11/837,657 patent/US20080064749A1/en not_active Abandoned
-
2008
- 2008-12-29 CY CY20081101498T patent/CY1108670T1/el unknown
-
2009
- 2009-11-09 JP JP2009256184A patent/JP5302856B2/ja not_active Expired - Fee Related
-
2012
- 2012-09-05 JP JP2012195046A patent/JP2012255025A/ja not_active Ceased
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