JP2013516633A5 - - Google Patents
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- Publication number
- JP2013516633A5 JP2013516633A5 JP2012548227A JP2012548227A JP2013516633A5 JP 2013516633 A5 JP2013516633 A5 JP 2013516633A5 JP 2012548227 A JP2012548227 A JP 2012548227A JP 2012548227 A JP2012548227 A JP 2012548227A JP 2013516633 A5 JP2013516633 A5 JP 2013516633A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- hpvlp
- sample
- jcv antibody
- level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 82
- 239000000523 sample Substances 0.000 claims description 47
- 241000701460 JC polyomavirus Species 0.000 claims description 41
- 239000002955 immunomodulating agent Substances 0.000 claims description 28
- 229940121354 immunomodulator Drugs 0.000 claims description 28
- 230000002584 immunomodulator Effects 0.000 claims description 28
- 239000012472 biological sample Substances 0.000 claims description 17
- 238000001514 detection method Methods 0.000 claims description 16
- 239000002245 particle Substances 0.000 claims description 15
- 238000003556 assay Methods 0.000 claims description 10
- 230000002411 adverse Effects 0.000 claims description 6
- 238000012544 monitoring process Methods 0.000 claims description 6
- 229920001184 polypeptide Polymers 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 208000024891 symptom Diseases 0.000 claims description 6
- 229960005027 natalizumab Drugs 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- 239000006228 supernatant Substances 0.000 claims description 4
- 238000012286 ELISA Assay Methods 0.000 claims description 3
- 208000014644 Brain disease Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 208000032274 Encephalopathy Diseases 0.000 claims description 2
- 101710163270 Nuclease Proteins 0.000 claims description 2
- 239000013592 cell lysate Substances 0.000 claims description 2
- 230000002490 cerebral effect Effects 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 238000011026 diafiltration Methods 0.000 claims description 2
- 238000011534 incubation Methods 0.000 claims description 2
- 238000005342 ion exchange Methods 0.000 claims description 2
- 239000006166 lysate Substances 0.000 claims description 2
- 230000002934 lysing effect Effects 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 230000001376 precipitating effect Effects 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 230000000750 progressive effect Effects 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 238000005185 salting out Methods 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 238000007689 inspection Methods 0.000 claims 1
- 230000002787 reinforcement Effects 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29404810P | 2010-01-11 | 2010-01-11 | |
| US61/294,048 | 2010-01-11 | ||
| US31619310P | 2010-03-22 | 2010-03-22 | |
| US61/316,193 | 2010-03-22 | ||
| PCT/US2011/020832 WO2011085369A1 (en) | 2010-01-11 | 2011-01-11 | Assay for jc virus antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015246985A Division JP2016040557A (ja) | 2010-01-11 | 2015-12-18 | Ｊｃウイルス抗体に対するアッセイ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013516633A JP2013516633A (ja) | 2013-05-13 |
| JP2013516633A5 true JP2013516633A5 (enExample) | 2014-02-27 |
| JP5946218B2 JP5946218B2 (ja) | 2016-07-05 |
Family
ID=44305841
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012548227A Active JP5946218B2 (ja) | 2010-01-11 | 2011-01-11 | Ｊｃウイルス抗体に対するアッセイ |
| JP2015246985A Withdrawn JP2016040557A (ja) | 2010-01-11 | 2015-12-18 | Ｊｃウイルス抗体に対するアッセイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015246985A Withdrawn JP2016040557A (ja) | 2010-01-11 | 2015-12-18 | Ｊｃウイルス抗体に対するアッセイ |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US9316641B2 (enExample) |
| EP (4) | EP3339865B9 (enExample) |
| JP (2) | JP5946218B2 (enExample) |
| KR (1) | KR101877576B1 (enExample) |
| CN (1) | CN102906278A (enExample) |
| AU (1) | AU2011203815B2 (enExample) |
| BR (1) | BR112012017014B1 (enExample) |
| CA (1) | CA2784137A1 (enExample) |
| CY (2) | CY1119972T1 (enExample) |
| DK (3) | DK4152004T3 (enExample) |
| ES (3) | ES2930469T3 (enExample) |
| FI (2) | FI4152004T3 (enExample) |
| HR (3) | HRP20221390T1 (enExample) |
| HU (3) | HUE036183T2 (enExample) |
| IN (1) | IN2012DN06139A (enExample) |
| LT (3) | LT2524060T (enExample) |
| ME (1) | ME03026B (enExample) |
| MX (1) | MX341991B (enExample) |
| NO (1) | NO2524060T3 (enExample) |
| NZ (1) | NZ600681A (enExample) |
| PL (3) | PL3339865T3 (enExample) |
| PT (3) | PT3339865T (enExample) |
| RS (3) | RS66509B1 (enExample) |
| SG (2) | SG181653A1 (enExample) |
| SI (3) | SI3339865T1 (enExample) |
| SM (3) | SMT202500065T1 (enExample) |
| WO (1) | WO2011085369A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008537595A (ja) | 2005-04-04 | 2008-09-18 | バイオジェン アイデック エムエイ インコーポレイテッド | 治療タンパク質に対する免疫反応を評価するための方法および生成物 |
| EP1988921A4 (en) | 2006-02-28 | 2010-02-10 | Elan Pharm Inc | METHOD FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES WITH NATALIZUMAB |
| EP3360900A1 (en) | 2006-03-03 | 2018-08-15 | Biogen MA Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
| CA2776756A1 (en) | 2009-10-11 | 2011-04-14 | Biogen Idec Ma Inc. | Anti-vla-4 related assays |
| AU2011203815B2 (en) | 2010-01-11 | 2015-11-26 | Biogen Ma Inc. | Assay for JC virus antibodies |
| US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| WO2012166971A2 (en) * | 2011-05-31 | 2012-12-06 | Biogen Idec Ma Inc. | Method of assessing risk of pml |
| US20150065367A1 (en) * | 2011-12-12 | 2015-03-05 | Janssen Diagnostics Bvba | Polyomavirus peptide sequences |
| WO2013158674A1 (en) * | 2012-04-16 | 2013-10-24 | Board Of Regents, The University Of Texas System | Detection of extracellular jcv micrornas |
| WO2013192100A1 (en) | 2012-06-18 | 2013-12-27 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods and compositions for detecting jc virus |
| US9771413B2 (en) | 2012-12-31 | 2017-09-26 | Neurimmune Holding Ag | Recombinant human antibodies for therapy and prevention of polyomavirus-related diseases |
| US9949671B2 (en) | 2013-03-13 | 2018-04-24 | Orthoaccel Technologies, Inc. | Diagnostic mouthpieces |
| EP3004334A4 (en) | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | METHOD FOR ASSESSING A PML RISK |
| EP3110976B1 (en) * | 2014-02-27 | 2020-05-13 | Biogen MA Inc. | Method of assessing risk of pml |
| MA40985A (fr) | 2014-11-17 | 2017-09-26 | Biogen Ma Inc | Méthodes de traitement de la sclérose en plaques |
| IT201600083859A1 (it) * | 2016-08-09 | 2018-02-09 | Univ Degli Studi Di Ferrara | Immunosaggio per l’identificazione di anticorpi contro il virus Polioma JC (JCPyV) mediante l’uso di peptidi sintetici. |
| WO2019169317A1 (en) * | 2018-03-02 | 2019-09-06 | Stueve Olaf | Methods and compositions for treating natalizumab-associated progressive multifocal encephalopathy |
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| WO2012166971A2 (en) | 2011-05-31 | 2012-12-06 | Biogen Idec Ma Inc. | Method of assessing risk of pml |
-
2011
- 2011-01-11 AU AU2011203815A patent/AU2011203815B2/en active Active
- 2011-01-11 EP EP17203178.3A patent/EP3339865B9/en active Active
- 2011-01-11 NZ NZ600681A patent/NZ600681A/en unknown
- 2011-01-11 CA CA2784137A patent/CA2784137A1/en active Pending
- 2011-01-11 HU HUE11732315A patent/HUE036183T2/hu unknown
- 2011-01-11 PT PT172031783T patent/PT3339865T/pt unknown
- 2011-01-11 HU HUE22191259A patent/HUE070903T2/hu unknown
- 2011-01-11 HR HRP20221390TT patent/HRP20221390T1/hr unknown
- 2011-01-11 SM SM20250065T patent/SMT202500065T1/it unknown
- 2011-01-11 CN CN2011800133864A patent/CN102906278A/zh active Pending
- 2011-01-11 EP EP24213770.1A patent/EP4524571A3/en active Pending
- 2011-01-11 SI SI201132069T patent/SI3339865T1/sl unknown
- 2011-01-11 RS RS20250151A patent/RS66509B1/sr unknown
- 2011-01-11 EP EP22191259.5A patent/EP4152004B9/en active Active
- 2011-01-11 DK DK22191259.5T patent/DK4152004T3/da active
- 2011-01-11 NO NO11732315A patent/NO2524060T3/no unknown
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