JP2013516633A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013516633A5 JP2013516633A5 JP2012548227A JP2012548227A JP2013516633A5 JP 2013516633 A5 JP2013516633 A5 JP 2013516633A5 JP 2012548227 A JP2012548227 A JP 2012548227A JP 2012548227 A JP2012548227 A JP 2012548227A JP 2013516633 A5 JP2013516633 A5 JP 2013516633A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- hpvlp
- sample
- jcv antibody
- level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 82
- 239000000523 sample Substances 0.000 claims description 47
- 241000701460 JC polyomavirus Species 0.000 claims description 41
- 239000002955 immunomodulating agent Substances 0.000 claims description 28
- 229940121354 immunomodulator Drugs 0.000 claims description 28
- 230000002584 immunomodulator Effects 0.000 claims description 28
- 239000012472 biological sample Substances 0.000 claims description 17
- 238000001514 detection method Methods 0.000 claims description 16
- 239000002245 particle Substances 0.000 claims description 15
- 238000003556 assay Methods 0.000 claims description 10
- 230000002411 adverse Effects 0.000 claims description 6
- 238000012544 monitoring process Methods 0.000 claims description 6
- 229920001184 polypeptide Polymers 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 208000024891 symptom Diseases 0.000 claims description 6
- 229960005027 natalizumab Drugs 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- 239000006228 supernatant Substances 0.000 claims description 4
- 238000012286 ELISA Assay Methods 0.000 claims description 3
- 208000014644 Brain disease Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 208000032274 Encephalopathy Diseases 0.000 claims description 2
- 101710163270 Nuclease Proteins 0.000 claims description 2
- 239000013592 cell lysate Substances 0.000 claims description 2
- 230000002490 cerebral effect Effects 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 238000011026 diafiltration Methods 0.000 claims description 2
- 238000011534 incubation Methods 0.000 claims description 2
- 238000005342 ion exchange Methods 0.000 claims description 2
- 239000006166 lysate Substances 0.000 claims description 2
- 230000002934 lysing effect Effects 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 230000001376 precipitating effect Effects 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 230000000750 progressive effect Effects 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 238000005185 salting out Methods 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 238000007689 inspection Methods 0.000 claims 1
- 230000002787 reinforcement Effects 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29404810P | 2010-01-11 | 2010-01-11 | |
| US61/294,048 | 2010-01-11 | ||
| US31619310P | 2010-03-22 | 2010-03-22 | |
| US61/316,193 | 2010-03-22 | ||
| PCT/US2011/020832 WO2011085369A1 (en) | 2010-01-11 | 2011-01-11 | Assay for jc virus antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015246985A Division JP2016040557A (ja) | 2010-01-11 | 2015-12-18 | Ｊｃウイルス抗体に対するアッセイ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013516633A JP2013516633A (ja) | 2013-05-13 |
| JP2013516633A5 true JP2013516633A5 (enExample) | 2014-02-27 |
| JP5946218B2 JP5946218B2 (ja) | 2016-07-05 |
Family
ID=44305841
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012548227A Active JP5946218B2 (ja) | 2010-01-11 | 2011-01-11 | Ｊｃウイルス抗体に対するアッセイ |
| JP2015246985A Withdrawn JP2016040557A (ja) | 2010-01-11 | 2015-12-18 | Ｊｃウイルス抗体に対するアッセイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015246985A Withdrawn JP2016040557A (ja) | 2010-01-11 | 2015-12-18 | Ｊｃウイルス抗体に対するアッセイ |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US9316641B2 (enExample) |
| EP (4) | EP2524060B1 (enExample) |
| JP (2) | JP5946218B2 (enExample) |
| KR (1) | KR101877576B1 (enExample) |
| CN (1) | CN102906278A (enExample) |
| AU (1) | AU2011203815B2 (enExample) |
| BR (1) | BR112012017014B1 (enExample) |
| CA (1) | CA2784137A1 (enExample) |
| CY (2) | CY1119972T1 (enExample) |
| DK (3) | DK4152004T3 (enExample) |
| ES (3) | ES2930469T3 (enExample) |
| FI (2) | FI4152004T3 (enExample) |
| HR (3) | HRP20180356T1 (enExample) |
| HU (3) | HUE036183T2 (enExample) |
| IN (1) | IN2012DN06139A (enExample) |
| LT (3) | LT4152004T (enExample) |
| ME (1) | ME03026B (enExample) |
| MX (1) | MX341991B (enExample) |
| NO (1) | NO2524060T3 (enExample) |
| NZ (1) | NZ600681A (enExample) |
| PL (3) | PL4152004T3 (enExample) |
| PT (3) | PT3339865T (enExample) |
| RS (3) | RS66509B1 (enExample) |
| SG (2) | SG10201500079YA (enExample) |
| SI (3) | SI3339865T1 (enExample) |
| SM (3) | SMT201800148T1 (enExample) |
| WO (1) | WO2011085369A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8124350B2 (en) | 2005-04-04 | 2012-02-28 | Biogen Idec Ma Inc. | Methods and products for evaluating an immune response to a therapeutic protein |
| HUE047230T2 (hu) | 2006-02-28 | 2020-04-28 | Biogen Ma Inc | Gyulladásos és autoimmun betegségek natalizumabbal való kezelésének módszerei |
| KR20080104343A (ko) | 2006-03-03 | 2008-12-02 | 엘란 파마슈티칼스, 인크. | 나탈리주마브로 염증 및 자가면역 질환을 치료하는 방법 |
| EP2485762B1 (en) | 2009-10-11 | 2017-12-13 | Biogen MA Inc. | Anti-vla-4 related assays |
| BR112012017014B1 (pt) | 2010-01-11 | 2021-07-20 | Biogen Ma Inc | Métodos para detecção de anticorpos de vírus jc |
| US11287423B2 (en) * | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| HUE061244T2 (hu) * | 2011-05-31 | 2023-06-28 | Biogen Ma Inc | A PML kockázat értékelésének módszere |
| US20150065367A1 (en) * | 2011-12-12 | 2015-03-05 | Janssen Diagnostics Bvba | Polyomavirus peptide sequences |
| US20130273549A1 (en) * | 2012-04-16 | 2013-10-17 | Board Of Regents, The University Of Texas System | Detection of extracellular jcv micrornas |
| US9631243B2 (en) | 2012-06-18 | 2017-04-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for identifying JC virus |
| EP3517545A1 (en) * | 2012-12-31 | 2019-07-31 | Neurimmune Holding AG | Recombinant human antibodies for therapy and prevention of polyomavirus-related diseases |
| US9949671B2 (en) | 2013-03-13 | 2018-04-24 | Orthoaccel Technologies, Inc. | Diagnostic mouthpieces |
| EP3004334A4 (en) | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | METHOD FOR ASSESSING A PML RISK |
| ES2818823T3 (es) * | 2014-02-27 | 2021-04-14 | Biogen Ma Inc | Método de evaluación del riesgo de LMP |
| MA40985A (fr) | 2014-11-17 | 2017-09-26 | Biogen Ma Inc | Méthodes de traitement de la sclérose en plaques |
| IT201600083859A1 (it) * | 2016-08-09 | 2018-02-09 | Univ Degli Studi Di Ferrara | Immunosaggio per l’identificazione di anticorpi contro il virus Polioma JC (JCPyV) mediante l’uso di peptidi sintetici. |
| WO2019169317A1 (en) * | 2018-03-02 | 2019-09-06 | Stueve Olaf | Methods and compositions for treating natalizumab-associated progressive multifocal encephalopathy |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4235601A (en) | 1979-01-12 | 1980-11-25 | Thyroid Diagnostics, Inc. | Test device and method for its use |
| US4391904A (en) | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4517288A (en) | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
| US4703017C1 (en) | 1984-02-14 | 2001-12-04 | Becton Dickinson Co | Solid phase assay with visual readout |
| CA1291031C (en) | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
| US5763262A (en) | 1986-09-18 | 1998-06-09 | Quidel Corporation | Immunodiagnostic device |
| ES2150428T3 (es) | 1987-04-27 | 2000-12-01 | Unilever Nv | Ensayos de union especifica. |
| US4943522A (en) | 1987-06-01 | 1990-07-24 | Quidel | Lateral flow, non-bibulous membrane assay protocols |
| US5120643A (en) | 1987-07-13 | 1992-06-09 | Abbott Laboratories | Process for immunochromatography with colloidal particles |
| US4818677A (en) | 1987-12-03 | 1989-04-04 | Monoclonal Antibodies, Inc. | Membrane assay using focused sample application |
| AU2684488A (en) | 1988-06-27 | 1990-01-04 | Carter-Wallace, Inc. | Test device and method for colored particle immunoassay |
| US5221616A (en) | 1988-07-15 | 1993-06-22 | Quidel Corporation | Prevention of spontaneous complement activation in mammalian biological fluids |
| US5118630A (en) | 1988-11-04 | 1992-06-02 | Quidel Corporation | Method for determining periodic infertility in females |
| US6352862B1 (en) | 1989-02-17 | 2002-03-05 | Unilever Patent Holdings B.V. | Analytical test device for imuno assays and methods of using same |
| US6033665A (en) | 1989-09-27 | 2000-03-07 | Elan Pharmaceuticals, Inc. | Compositions and methods for modulating leukocyte adhesion to brain endothelial cells |
| US5084828A (en) | 1989-09-29 | 1992-01-28 | Healthtech Services Corp. | Interactive medication delivery system |
| US5252496A (en) | 1989-12-18 | 1993-10-12 | Princeton Biomeditech Corporation | Carbon black immunochemical label |
| US5096837A (en) | 1990-02-08 | 1992-03-17 | Pacific Biotech, Inc. | Immunochromatographic assay and method of using same |
| US5223220A (en) | 1990-03-27 | 1993-06-29 | Pacific Biotech, Inc. | Solid phase immunoassay device and method of making same |
| US5118428A (en) | 1990-11-13 | 1992-06-02 | Quidel | Method to remove red blood cells from whole blood samples |
| DE4139840B4 (de) | 1990-12-04 | 2005-06-02 | Quidel Corp., San Diego | Antigen-Zubereitung zum Nachweis von H. pylori |
| EP0566695B1 (en) | 1991-01-11 | 1999-06-02 | Quidel Corporation | A one-step lateral flow assay and nonbibulous support used therein |
| US5213796A (en) | 1991-05-06 | 1993-05-25 | Dana Farber Cancer Institute | Assay for polyomavirus in humans and uses thereof |
| US5225328A (en) | 1991-05-30 | 1993-07-06 | Quidel Corporation | Stable alkaline phosphatase compositions with color enhancement and their use in assays |
| US5686315A (en) | 1991-06-14 | 1997-11-11 | Quidel Corporation | Assay device for one step detection of analyte |
| EP0646179A4 (en) | 1992-02-04 | 1996-10-02 | Quidel Corp | PROCESS FOR SIMPLIFIED EXTRACTION OF BACTERIAL ANTIGENS USING DEHYDRATE REAGENTS. |
| US5541069A (en) | 1992-02-28 | 1996-07-30 | Quidel Corporation | Assay having improved dose response curve |
| EP0630475B1 (en) | 1992-03-10 | 2000-09-06 | Quidel Corporation | Red blood cell separation means for specific binding assays |
| SG44845A1 (en) | 1993-01-12 | 1997-12-19 | Biogen Inc | Recombitant anti-vla4 antibody molecules |
| US5415994A (en) | 1993-08-02 | 1995-05-16 | Quidel Corporation | Lateral flow medical diagnostic assay device with sample extraction means |
| US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
| US5434057A (en) | 1994-02-02 | 1995-07-18 | Quidel Corporation | Sperm motility assay and devices |
| US5521102A (en) | 1994-08-08 | 1996-05-28 | Quidel Corporation | Controlled sensitivity immunochromatographic assay |
| US5845255A (en) | 1994-10-28 | 1998-12-01 | Advanced Health Med-E-Systems Corporation | Prescription management system |
| US6551593B1 (en) | 1995-02-10 | 2003-04-22 | Millennium Pharmaceuticals, Inc. | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam |
| US5712172A (en) | 1995-05-18 | 1998-01-27 | Wyntek Diagnostics, Inc. | One step immunochromatographic device and method of use |
| US5804452A (en) | 1995-04-27 | 1998-09-08 | Quidel Corporation | One step urine creatinine assays |
| US5786220A (en) | 1995-04-28 | 1998-07-28 | Quidel Corporation | Assays and devices for distinguishing between normal and abnormal pregnancy |
| US20010051350A1 (en) | 1995-05-02 | 2001-12-13 | Albert Nazareth | Diagnostic detection device and method |
| US5773234A (en) | 1995-08-07 | 1998-06-30 | Quidel Corporation | Method and device for chlamydia detection |
| DE19543553B4 (de) | 1995-11-22 | 2009-04-09 | Deutsches Primatenzentrum Gmbh | VP-Antigene des JC-Virus |
| US6305377B1 (en) | 1996-12-12 | 2001-10-23 | Michael T. Portwood | System and method for improving compliance of a medical regimen |
| US6229011B1 (en) | 1997-08-22 | 2001-05-08 | Hoffman-La Roche Inc. | N-aroylphenylalanine derivative VCAM-1 inhibitors |
| US6306642B1 (en) | 1997-11-24 | 2001-10-23 | Quidel Corporation | Enzyme substrate delivery and product registration in one step enzyme immunoassays |
| US6623981B2 (en) | 1998-01-27 | 2003-09-23 | Bristol-Myers Squibb Company | Detection of patients at risk for developing integrin antagonist/agonist mediated disease states |
| US6014631A (en) | 1998-04-02 | 2000-01-11 | Merck-Medco Managed Care, Llc | Computer implemented patient medication review system and process for the managed care, health care and/or pharmacy industry |
| US6045501A (en) | 1998-08-28 | 2000-04-04 | Celgene Corporation | Methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug |
| US6407066B1 (en) | 1999-01-26 | 2002-06-18 | Elan Pharmaceuticals, Inc. | Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| US7171371B2 (en) | 1999-09-03 | 2007-01-30 | Smg Trust | Method and system for providing pre and post operative support and care |
| EP1232392B2 (de) | 1999-10-12 | 2014-04-02 | Oxoid (Ely) Limited | Verbessertes verfahren zum nachweis von säure-resistenten bakterien der gattung helicobacter im stuhl |
| US6388084B1 (en) | 1999-12-06 | 2002-05-14 | Hoffmann-La Roche Inc. | 4-pyridinyl-n-acyl-l-phenylalanines |
| AU783110B2 (en) | 1999-12-16 | 2005-09-22 | Biogen Ma Inc. | Methods of treating central nervous system ischemic or hemorrhagic injury using anti alpha4 integrin antagonists |
| WO2001075449A1 (fr) | 2000-03-30 | 2001-10-11 | Nippon Kayaku Kabushiki Kaisha | Technique d'investigation du cancer par epreuve biologique d'un autoanticorps contre mdm2 et reactif |
| US6620626B1 (en) | 2000-08-09 | 2003-09-16 | Mission Research Corp. | Antigen detection device and method |
| MY129000A (en) | 2000-08-31 | 2007-03-30 | Tanabe Seiyaku Co | INHIBITORS OF a4 MEDIATED CELL ADHESION |
| AU1038402A (en) | 2000-10-17 | 2002-04-29 | Besst Test Aps | Assay for directly detecting a rs virus related biological cell in a body fluid sample |
| US6315720B1 (en) | 2000-10-23 | 2001-11-13 | Celgene Corporation | Methods for delivering a drug to a patient while avoiding the occurrence of an adverse side effect known or suspected of being caused by the drug |
| US6485460B2 (en) | 2001-01-12 | 2002-11-26 | Bracco Diagnostics, Inc. | Tamper evident syringe barrel |
| WO2003016902A1 (en) | 2001-08-20 | 2003-02-27 | Proteome Systems Intellectual Property Pty Ltd | Diagnostic testing process and apparatus |
| JP4264348B2 (ja) | 2001-08-20 | 2009-05-13 | プロテオム システムズ リミテッド | 診断検査方法および装置 |
| US6605602B1 (en) | 2001-09-28 | 2003-08-12 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Method of treating BK virus nephropathy |
| KR20040105740A (ko) | 2002-02-25 | 2004-12-16 | 엘란 파마슈티칼스, 인크. | 염증 치료제의 투여 방법 |
| TWI281470B (en) | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
| TW200307671A (en) | 2002-05-24 | 2003-12-16 | Elan Pharm Inc | Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins |
| CA2490284C (en) | 2002-06-21 | 2013-10-22 | Mckesson Information Solutions Llc | Closed loop medication use system and method |
| WO2005052567A1 (en) | 2003-11-24 | 2005-06-09 | Biogen Idec Ma Inc. | Methods for detecting half-antibodies using chip-based gel electrophoresis |
| JP4672263B2 (ja) | 2004-01-27 | 2011-04-20 | デンカ生研株式会社 | 簡便な検出法、検出装置及び検出キットとその製法 |
| US7419666B1 (en) | 2004-02-23 | 2008-09-02 | Massachusetts Eye And Ear Infirmary | Treatment of ocular disorders |
| TWI439284B (zh) | 2004-04-09 | 2014-06-01 | 艾伯維生物技術有限責任公司 | 用於治療ＴＮＦα相關失調症之多重可變劑量療法 |
| US20050283385A1 (en) | 2004-06-21 | 2005-12-22 | The Permanente Medical Group, Inc. | Individualized healthcare management system |
| CA2573245C (en) | 2004-07-08 | 2013-10-01 | Elan Pharmaceuticals, Inc. | Multivalent vla-4 antagonists comprising polymer moieties |
| CA2478458A1 (en) | 2004-08-20 | 2006-02-20 | Michael Panzara | Treatment of pediatric multiple sclerosis |
| NZ581497A (en) | 2004-12-03 | 2012-07-27 | Biogen Idec Inc | Delaying or preventing onset of multiple sclerosis by vla-4 ginding antibody |
| ES2387317T3 (es) | 2005-03-03 | 2012-09-20 | Seedlings Life Science Ventures, Llc. | Procedimiento de control de riesgos de pacientes en tratamiento con natalizumab |
| US8124350B2 (en) | 2005-04-04 | 2012-02-28 | Biogen Idec Ma Inc. | Methods and products for evaluating an immune response to a therapeutic protein |
| ATE493405T1 (de) | 2005-09-29 | 2011-01-15 | Elan Pharm Inc | Pyrimidinylamidverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren |
| EA017110B1 (ru) | 2006-02-27 | 2012-09-28 | Элан Фамэсьютикэлс, Инк. | ПИРИМИДИНИЛСУЛЬФОНАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ПОЛУЧЕНИЯ ПИРИМИДИНИЛСУЛЬФОНАМИДНЫХ СОЕДИНЕНИЙ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО ИНТЕГРИНОМ α4, СПОСОБ СНИЖЕНИЯ И/ИЛИ ПРЕДУПРЕЖДЕНИЯ ВОСПАЛИТЕЛЬНОГО КОМПОНЕНТА ЗАБОЛЕВАНИЯ ИЛИ АУТОИММУННОГО ОТВЕТА |
| US8410115B2 (en) * | 2006-02-28 | 2013-04-02 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
| HUE047230T2 (hu) | 2006-02-28 | 2020-04-28 | Biogen Ma Inc | Gyulladásos és autoimmun betegségek natalizumabbal való kezelésének módszerei |
| KR20080104343A (ko) | 2006-03-03 | 2008-12-02 | 엘란 파마슈티칼스, 인크. | 나탈리주마브로 염증 및 자가면역 질환을 치료하는 방법 |
| US7838583B2 (en) * | 2006-06-30 | 2010-11-23 | Sumitomo Rubber Industries, Ltd. | Rubber composition for cap tread and pneumatic tire having cap tread using same |
| WO2008061243A2 (en) | 2006-11-16 | 2008-05-22 | Novavax, Inc. | Respiratory syncytial virus-virus like particle (vlps) |
| EP1933140B1 (en) | 2006-12-11 | 2011-08-17 | AraGen Biotechnology Co. Ltd. | Antibody detection method involving an oligonucleotide enhanced collodial gold signal |
| AU2010210979B2 (en) * | 2009-02-05 | 2015-12-10 | Biogen Ma Inc. | Methods for the detection of JC polyoma virus |
| US9354233B2 (en) | 2009-02-20 | 2016-05-31 | The Regents Of The University Of California | A+ biomarker assays |
| BR112012017014B1 (pt) * | 2010-01-11 | 2021-07-20 | Biogen Ma Inc | Métodos para detecção de anticorpos de vírus jc |
| HUE061244T2 (hu) | 2011-05-31 | 2023-06-28 | Biogen Ma Inc | A PML kockázat értékelésének módszere |
-
2011
- 2011-01-11 BR BR112012017014-7A patent/BR112012017014B1/pt active IP Right Grant
- 2011-01-11 IN IN6139DEN2012 patent/IN2012DN06139A/en unknown
- 2011-01-11 HU HUE11732315A patent/HUE036183T2/hu unknown
- 2011-01-11 US US13/521,311 patent/US9316641B2/en active Active
- 2011-01-11 PL PL22191259.5T patent/PL4152004T3/pl unknown
- 2011-01-11 SM SM20180148T patent/SMT201800148T1/it unknown
- 2011-01-11 MX MX2012007660A patent/MX341991B/es active IP Right Grant
- 2011-01-11 EP EP11732315.4A patent/EP2524060B1/en not_active Revoked
- 2011-01-11 KR KR1020127019171A patent/KR101877576B1/ko active Active
- 2011-01-11 EP EP22191259.5A patent/EP4152004B9/en active Active
- 2011-01-11 JP JP2012548227A patent/JP5946218B2/ja active Active
- 2011-01-11 DK DK22191259.5T patent/DK4152004T3/da active
- 2011-01-11 SM SM20250065T patent/SMT202500065T1/it unknown
- 2011-01-11 PL PL17203178.3T patent/PL3339865T3/pl unknown
- 2011-01-11 SI SI201132069T patent/SI3339865T1/sl unknown
- 2011-01-11 EP EP24213770.1A patent/EP4524571A3/en active Pending
- 2011-01-11 RS RS20250151A patent/RS66509B1/sr unknown
- 2011-01-11 HU HUE22191259A patent/HUE070903T2/hu unknown
- 2011-01-11 AU AU2011203815A patent/AU2011203815B2/en active Active
- 2011-01-11 ES ES17203178T patent/ES2930469T3/es active Active
- 2011-01-11 RS RS20221053A patent/RS63744B1/sr unknown
- 2011-01-11 NZ NZ600681A patent/NZ600681A/en unknown
- 2011-01-11 HR HRP20180356TT patent/HRP20180356T1/hr unknown
- 2011-01-11 PT PT172031783T patent/PT3339865T/pt unknown
- 2011-01-11 LT LTEP22191259.5T patent/LT4152004T/lt unknown
- 2011-01-11 SG SG10201500079YA patent/SG10201500079YA/en unknown
- 2011-01-11 SM SM20220445T patent/SMT202200445T1/it unknown
- 2011-01-11 DK DK17203178.3T patent/DK3339865T5/da active
- 2011-01-11 NO NO11732315A patent/NO2524060T3/no unknown
- 2011-01-11 FI FIEP22191259.5T patent/FI4152004T3/fi active
- 2011-01-11 PT PT117323154T patent/PT2524060T/pt unknown
- 2011-01-11 SG SG2012043154A patent/SG181653A1/en unknown
- 2011-01-11 PT PT221912595T patent/PT4152004T/pt unknown
- 2011-01-11 ES ES11732315.4T patent/ES2664173T3/es active Active
- 2011-01-11 LT LTEP11732315.4T patent/LT2524060T/lt unknown
- 2011-01-11 HR HRP20221390TT patent/HRP20221390T1/hr unknown
- 2011-01-11 CA CA2784137A patent/CA2784137A1/en active Pending
- 2011-01-11 EP EP17203178.3A patent/EP3339865B9/en active Active
- 2011-01-11 SI SI201132127T patent/SI4152004T1/sl unknown
- 2011-01-11 WO PCT/US2011/020832 patent/WO2011085369A1/en not_active Ceased
- 2011-01-11 ME MEP-2018-60A patent/ME03026B/me unknown
- 2011-01-11 ES ES22191259T patent/ES3012733T3/es active Active
- 2011-01-11 LT LTEP17203178.3T patent/LT3339865T/lt unknown
- 2011-01-11 CN CN2011800133864A patent/CN102906278A/zh active Pending
- 2011-01-11 HR HRP20250210TT patent/HRP20250210T1/hr unknown
- 2011-01-11 RS RS20180245A patent/RS56977B1/sr unknown
- 2011-01-11 SI SI201131438T patent/SI2524060T1/en unknown
- 2011-01-11 HU HUE17203178A patent/HUE060312T2/hu unknown
- 2011-01-11 PL PL11732315T patent/PL2524060T3/pl unknown
- 2011-01-11 FI FIEP17203178.3T patent/FI3339865T5/fi active
- 2011-01-11 DK DK11732315.4T patent/DK2524060T3/en active
-
2015
- 2015-12-18 JP JP2015246985A patent/JP2016040557A/ja not_active Withdrawn
-
2016
- 2016-03-08 US US15/063,777 patent/US10444234B2/en active Active
-
2018
- 2018-02-28 CY CY20181100251T patent/CY1119972T1/el unknown
-
2022
- 2022-11-18 CY CY20221100739T patent/CY1126069T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Gorelik et al. | Anti‐JC virus antibodies: implications for PML risk stratification | |
| HRP20250210T1 (hr) | Analiza za antitijela jc virusa | |
| Chapenko et al. | Association of active human herpesvirus‐6,‐7 and parvovirus B19 infection with clinical outcomes in patients with myalgic encephalomyelitis/chronic fatigue syndrome | |
| Ryschkewitsch et al. | JC virus persistence following progressive multifocal leukoencephalopathy in multiple sclerosis patients treated with natalizumab | |
| Mancuso et al. | Increased prevalence of varicella zoster virus DNA in cerebrospinal fluid from patients with multiple sclerosis | |
| EP3452830A1 (en) | Assay for the diagnosis of a neurological disease | |
| RU2013158334A (ru) | Средства и способы диагностики и лечения рассеянного склероза | |
| KR20150140657A (ko) | 자간전증의 진단을 위한 방법 및 조성물 | |
| Kolcava et al. | The value of anti-JCV antibody index assessment in multiple sclerosis patients treated with natalizumab with respect to demographic, clinical and radiological findings | |
| JP7311857B2 (ja) | オートタキシン測定による神経障害性疼痛を検出する方法及び検出試薬 | |
| Al-zobaei | Comparison between haemagglutination inhibition and complement fixation tests in detecting antibodies responses following influenza viral infection | |
| Sna et al. | Cytomegalovirus and Other Herpesvirus Infections in Adult Epilepsy Patients. | |
| IT202000021235A1 (it) | Immunosaggio per l’identificazione di anticorpi contro il virus polioma delle cellule di merkel (mcpyv) mediante l’uso di peptidi sintetici | |
| Das et al. | Comparison of Xper t Xpress SARS-CoV-2 assay and RT-PCR test in diagnosis o f COVID-19 | |
| US20220397571A1 (en) | Assay for jc virus antibodies | |
| CN118897083A (zh) | 尿液mt蛋白及其多肽片段在痛风中的应用 | |
| HK40088791B (en) | Assay for jc virus antibodies | |
| HK40088791A (en) | Assay for jc virus antibodies | |
| RU2629335C1 (ru) | Способ диагностики периода инфекционного заболевания, вызванного вирусом varicella zoster у детей | |
| HK40123180A (en) | Assay for jc virus antibodies | |
| WO2014066676A1 (en) | Biomarkers for the identification of liver damage | |
| WO2018087715A1 (en) | An assay for determining hepatitis b clearance |