JP2013516479A5 - - Google Patents

Download PDF

Info

Publication number
JP2013516479A5
JP2013516479A5 JP2012548125A JP2012548125A JP2013516479A5 JP 2013516479 A5 JP2013516479 A5 JP 2013516479A5 JP 2012548125 A JP2012548125 A JP 2012548125A JP 2012548125 A JP2012548125 A JP 2012548125A JP 2013516479 A5 JP2013516479 A5 JP 2013516479A5
Authority
JP
Japan
Prior art keywords
unsaturated bond
contain
branched
lower alkyl
oxygen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012548125A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013516479A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/020414 external-priority patent/WO2011085126A2/en
Publication of JP2013516479A publication Critical patent/JP2013516479A/ja
Publication of JP2013516479A5 publication Critical patent/JP2013516479A5/ja
Pending legal-status Critical Current

Links

JP2012548125A 2010-01-06 2011-01-06 標的薬物を開発する方法および組成物 Pending JP2013516479A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29277610P 2010-01-06 2010-01-06
US61/292,776 2010-01-06
PCT/US2011/020414 WO2011085126A2 (en) 2010-01-06 2011-01-06 Methods and compositions of targeted drug development

Publications (2)

Publication Number Publication Date
JP2013516479A JP2013516479A (ja) 2013-05-13
JP2013516479A5 true JP2013516479A5 (enExample) 2014-11-06

Family

ID=44306150

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012548125A Pending JP2013516479A (ja) 2010-01-06 2011-01-06 標的薬物を開発する方法および組成物

Country Status (10)

Country Link
US (4) US8618302B2 (enExample)
EP (2) EP2521553A4 (enExample)
JP (1) JP2013516479A (enExample)
KR (1) KR20130027080A (enExample)
CN (1) CN102811723A (enExample)
AU (1) AU2011204368B2 (enExample)
CA (2) CA2786277A1 (enExample)
MX (1) MX2012007872A (enExample)
SG (1) SG182343A1 (enExample)
WO (2) WO2011085129A2 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8658170B2 (en) 2010-01-06 2014-02-25 Joseph P. Errico Combination therapy with MDM2 and EFGR inhibitors
SG182343A1 (en) * 2010-01-06 2012-08-30 Joseph P Errico Methods and compositions of targeted drug development
WO2011106226A2 (en) * 2010-02-23 2011-09-01 Cornell University Prolylhydroxylase inhibitors and methods of use
HUP1000243A2 (en) * 2010-05-06 2012-01-30 Avidin Kft 8-hidroxy-quinoline derivatives
AU2011255627A1 (en) * 2010-05-18 2012-12-06 Eastern Virginia Medical School Inhibitors of human 12-lipoxygenase
UA112517C2 (uk) 2010-07-06 2016-09-26 Новартіс Аг Тетрагідропіридопіримідинові похідні
WO2012012653A1 (en) * 2010-07-21 2012-01-26 Errico Joseph P Combination therapy with mdm2 and efgr inhibitors
JP6001650B2 (ja) * 2011-05-23 2016-10-05 昂科生物医学技術（蘇州）有限公司 Ｃｄｃ４２抑制剤およびその応用
JP2014527511A (ja) 2011-06-24 2014-10-16 アムジエン・インコーポレーテツド Ｔｒｐｍ８拮抗剤及び治療におけるそれらの使用
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
CN102503945A (zh) * 2011-11-28 2012-06-20 华东理工大学 能够抑制表皮生长因子受体的化合物及其应用
CA2873902A1 (en) * 2012-05-18 2013-11-21 Georgetown University Methods and systems for populating and searching a drug informatics database
WO2013192423A2 (en) 2012-06-20 2013-12-27 Eutropics Pharmaceuticals, Inc. Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
EP2922544B1 (en) * 2012-11-21 2018-08-01 Eutropics Pharmaceuticals, Inc. Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives
EP2925743B1 (en) 2013-05-14 2016-02-03 Active Biotech AB N-(heteroaryl)-sulfonamide derivatives useful as s100-inhibitors
US10732182B2 (en) 2013-08-01 2020-08-04 Eutropics Pharmaceuticals, Inc. Method for predicting cancer sensitivity
US20160253451A1 (en) * 2013-10-07 2016-09-01 Korea University Method of using a water-based pharmacophore
EP3063302B1 (en) 2013-10-30 2019-12-04 Eutropics Pharmaceuticals, Inc. Methods for determining chemosensitivity and chemotoxicity
CN104016908B (zh) * 2014-04-03 2016-04-20 定陶县友帮化工有限公司 一种2-氨基-3，5-二氯吡啶的合成方法
CN104402831B (zh) * 2014-10-24 2016-08-17 郑州大学 含酰脲结构单元的-5-氰基嘧啶衍生物及其制备方法和用途
CN104744439A (zh) * 2015-02-10 2015-07-01 南开大学 8-羟基喹啉类ntr1小分子拮抗剂及应用
HUP1500098A2 (hu) * 2015-03-09 2016-09-28 Avidin Kft 8-hidroxikinolin származékok új enantiomerjei és szintézisük
US10624881B2 (en) * 2015-10-12 2020-04-21 Health Research, Inc. Methods for inducing apoptosis in cancer cells
EP3388419A1 (en) * 2017-04-12 2018-10-17 Leadiant Biosciences SA Gli1 inhibitors and uses thereof
WO2019043635A1 (en) 2017-09-01 2019-03-07 Richter Gedeon Nyrt. COMPOUNDS INHIBITING THE ACTIVITY OF D-AMINO ACID OXIDASE
KR20210124187A (ko) * 2018-11-15 2021-10-14 인스티튜트 구스타브 루시 마드라신-유도체 화합물, 조성물 및 암 치료를 위한 이의 용도
TW202218665A (zh) 2020-09-21 2022-05-16 德國阿爾伯特路德維希弗萊堡大學 用於治療或預防造血細胞移植後血液科贅瘤(neoplasm)復發之mdm2抑制劑
CN112250637A (zh) * 2020-10-30 2021-01-22 中山大学 虚拟筛选的化合物在制备抗肿瘤药物中的应用及其药物
CN117645560A (zh) * 2021-12-16 2024-03-05 贵州大学 一种含酰胺的阿魏酸衍生物及其制备方法和应用
WO2024073624A2 (en) * 2022-09-28 2024-04-04 The Research Foundation For The State University Of New York Antiproliferative betti bases and prodrugs thereof
CN115572266B (zh) * 2022-10-24 2023-10-03 南方医科大学 一种蛋白抑制剂、一种试剂组及其应用
CN120463779B (zh) * 2025-07-10 2025-09-19 南京农业大学三亚研究院 真菌效应子药靶Nep1及基于该药靶的高通量药物分子筛选和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641474A (en) 1970-05-11 1972-02-08 Rca Corp Semiconductor mounting structure
ES2273688T3 (es) 1999-04-14 2007-05-16 Dana-Farber Cancer Institute, Inc. Procedimiento y composicion para el tratamiento de cancer.
US6465448B1 (en) 1999-08-13 2002-10-15 Case Western Reserve University Methoxyamine potentiation of temozolomide anti-cancer activity
US6931325B2 (en) 2001-02-07 2005-08-16 Regents Of The University Of Michigan Three dimensional protein mapping
CA2476006A1 (en) * 2002-02-05 2003-08-14 Japan Science And Technology Agency Egf/egfr complex
US6916455B2 (en) 2002-08-14 2005-07-12 The Regents Of The University Of California Protein crystallography prescreen kit
JP2008520734A (ja) 2004-11-19 2008-06-19 バイオクァンタ コーポレイション Ｐｆ４ファーマコフォア及びそれらの使用
TWI473808B (zh) 2005-06-22 2015-02-21 Plexxikon Inc 用於激酶調節的化合物及方法及其適應症
US7754724B2 (en) 2005-06-30 2010-07-13 Dow Agrosciences Llc N-substituted piperazines
AU2007234382B2 (en) 2006-04-05 2011-06-09 Novartis Ag Combinations comprising BCR-ABL/C-KIT/PDGF-R TK inhibitors for treating cancer
US20090029949A1 (en) 2006-05-25 2009-01-29 Parrill-Baker Abby L GPCR Ligands Identified by Computational Modeling
EP2079699A1 (en) 2006-07-25 2009-07-22 Envivo Pharmaceuticals, Inc. Quinoline derivatives
CN101505751A (zh) * 2006-08-23 2009-08-12 惠氏公司 8-羟基喹啉化合物和其方法
US8609649B2 (en) * 2007-03-20 2013-12-17 Brandeis University Compositions and methods for the diagnosis, treatment, and prevention of amyotrophic lateral sclerosis and related neurological diseases
US8183236B2 (en) * 2007-04-12 2012-05-22 University Of Southern California Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics
US8138356B2 (en) 2007-10-16 2012-03-20 Angiogeney, Inc. Chemical inhibitors of inhibitors of differentiation
US8119656B2 (en) * 2007-12-07 2012-02-21 The Board Of Regents Of The University Of Texas System Inhibitors of the influenza virus non-structural 1 protein
US8642660B2 (en) * 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2009117484A2 (en) * 2008-03-18 2009-09-24 University Of South Florida Small molecule e2f inhibitor
WO2009137597A1 (en) * 2008-05-06 2009-11-12 The Trustees Of Columbia University In The City Of New York COMPOUNDS THAT INHIBIT PRODUCTION OF sAPPβ AND Aβ AND USES THEREOF
US10301265B2 (en) * 2008-05-28 2019-05-28 Virginia I. Roxas-Duncan Small molecule inhibitors of botulinum neurotoxins
WO2010039538A2 (en) * 2008-09-23 2010-04-08 Georgetown University Flavivirus inhibitors and methods for their use
EP2467361A1 (de) 2009-08-20 2012-06-27 Vifor (International) Ag Neue chinolin-hepcidin-antagonisten
SG182343A1 (en) * 2010-01-06 2012-08-30 Joseph P Errico Methods and compositions of targeted drug development

Similar Documents

Publication Publication Date Title
JP2013516479A5 (enExample)
AU2013339167B2 (en) Novel amine derivative or salt thereof
DK2185515T3 (en) DERIVATIVES OF 1-PHENYL-2-PYRIDINYLALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS
TW519539B (en) Nicotinamide derivatives
EP3889134B1 (en) Compound for inhibiting pge2/ep4 signaling transduction inhibiting, preparation method therefor, and medical uses thereof
JP5461189B2 (ja) キナーゼ活性の阻害剤
EP3081553B1 (en) Sulfonamide derivative or pharmaceutically acceptable acid addition salt thereof
RU2353618C2 (ru) Замещенные амиды бензойной кислоты и их содержащий фармацевтический препарат
CN104940200A (zh) 多取代芳族化合物作为凝血酶的抑制剂
JPWO2005033079A1 (ja) ヘテロ環化合物を含有する新規な抗真菌剤
WO2014096965A2 (en) Novel heterocyclic compounds as bromodomain inhibitors
ZA200504973B (en) Fuse 1,3-dihydro-imidazole ring compounds
CN107709301B (zh) 吡唑衍生物或其药理学上可接受的盐
TW200841879A (en) Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
JPWO2003035639A1 (ja) ピリミジン化合物及びその医薬組成物
TW200920366A (en) 5-membered heterocyclic compound
JP2022519237A (ja) Ｄｎａポリメラーゼシータ阻害剤としてのアセトアミド誘導体
JP2024056742A (ja) キノリン誘導体から調製される新規な阻害剤
WO2006016548A1 (ja) ヘテロ環化合物を含有する新規な抗マラリア剤
WO2011035186A1 (en) Substituted heteroarylamide analogs as mglur5 negative allosteric modulators and methods of making and using the same
US6180650B1 (en) Heterosubstituted pyridine derivatives as PDE 4 inhibitors
BRPI0617880B1 (pt) Composto derivado de piridina substituído por heterociclo, composição farmacêutica,medicamento e agente antifúngico que compreende o dito composto e uso do mesmo para prevenire/ou tratar infecção fúngica
JPWO2006016548A1 (ja) ヘテロ環化合物を含有する新規な抗マラリア剤
AU2006346931A1 (en) 6-1H-imidazo-quinazoline and quinolines derivatives, new potent analgesics and anti-inflammatory agents
KR20150125716A (ko) 새로운 술폰아미드 trpa1 수용체 길항제