JP2013515752A5 - - Google Patents
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- Publication number
- JP2013515752A5 JP2013515752A5 JP2012546361A JP2012546361A JP2013515752A5 JP 2013515752 A5 JP2013515752 A5 JP 2013515752A5 JP 2012546361 A JP2012546361 A JP 2012546361A JP 2012546361 A JP2012546361 A JP 2012546361A JP 2013515752 A5 JP2013515752 A5 JP 2013515752A5
- Authority
- JP
- Japan
- Prior art keywords
- carboline
- cyclo
- pharmaceutical composition
- och
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009060811.7 | 2009-12-28 | ||
| DE102009060811 | 2009-12-28 | ||
| US28239510P | 2010-02-02 | 2010-02-02 | |
| US61/282,395 | 2010-02-02 | ||
| PCT/DE2010/001530 WO2011079841A1 (de) | 2009-12-28 | 2010-12-28 | Beta-carboline zur behandlung von hörschäden und schwindel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515752A JP2013515752A (ja) | 2013-05-09 |
| JP2013515752A5 true JP2013515752A5 (https=) | 2013-10-24 |
| JP5627705B2 JP5627705B2 (ja) | 2014-11-19 |
Family
ID=44246908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012546361A Active JP5627705B2 (ja) | 2009-12-28 | 2010-12-28 | 聴力損傷および目まいの治療用のβ−カルボリン |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9107914B2 (https=) |
| EP (1) | EP2519238B1 (https=) |
| JP (1) | JP5627705B2 (https=) |
| KR (1) | KR20120098855A (https=) |
| CN (1) | CN102844029A (https=) |
| AU (1) | AU2010338669A1 (https=) |
| BR (1) | BR112012015967B1 (https=) |
| CA (1) | CA2785233C (https=) |
| DE (1) | DE112010005017A5 (https=) |
| IL (1) | IL220661A (https=) |
| IN (1) | IN2012DN05066A (https=) |
| MX (1) | MX2012007678A (https=) |
| NZ (1) | NZ600478A (https=) |
| RU (1) | RU2012132429A (https=) |
| SG (1) | SG181599A1 (https=) |
| WO (1) | WO2011079841A1 (https=) |
| ZA (1) | ZA201204476B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105120863B (zh) * | 2013-03-14 | 2021-06-04 | 奥斯特克有限公司 | 促进骨生长的烷基胺骆驼蓬碱衍生物 |
| LT2970890T (lt) | 2013-03-14 | 2020-07-10 | The Brigham And Women`S Hospital, Inc. | Kompozicijos ir būdai, skirti epitelinių kamieninių ląstelių padauginimui ir kultivavimui |
| EP2853533A1 (de) | 2013-09-29 | 2015-04-01 | Audiocure Pharma GmbH | 6-Fluor-9-methyl-ß-carbolin |
| WO2016037016A1 (en) | 2014-09-03 | 2016-03-10 | The Brigham And Women's Hospital, Inc. | Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss |
| CN108779437A (zh) | 2016-01-08 | 2018-11-09 | 麻省理工学院 | 分化的肠内分泌细胞和胰岛素产生细胞的制备 |
| US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| EP3321264A1 (en) * | 2016-11-14 | 2018-05-16 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Selective inhibitors of genotoxic stress-induced ikk/nf-kb pathways |
| US11066419B2 (en) | 2016-12-30 | 2021-07-20 | Frequency Therapeutics, Inc. | 1H-pyrrole-2,5-dione compounds and methods of using same |
| CA3109104A1 (en) | 2018-08-14 | 2020-02-20 | Osteoqc Inc. | Fluoro .beta.-carboline compounds |
| CA3108714A1 (en) | 2018-08-14 | 2020-02-20 | Osteoqc Inc. | Pyrrolo - dipyridine compounds |
| CN113195707A (zh) | 2018-08-17 | 2021-07-30 | 频率治疗公司 | 用于通过上调jag-1来生成毛细胞的组合物和方法 |
| US11617745B2 (en) | 2018-08-17 | 2023-04-04 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating FOXO |
| AU2019339352B2 (en) | 2018-09-12 | 2025-05-22 | Hough Ear Institute | Methods for treating hearing loss incident to cochlear implant surgery |
| EP3772515A1 (en) | 2019-08-09 | 2021-02-10 | Audiocure Pharma GmbH | Stable polymorphic form of 6-fluoro-9-methyl-9h-ss-carboline and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3240514A1 (de) | 1982-10-29 | 1984-05-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Ss-carboline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| CA2140722A1 (en) | 1994-01-24 | 1995-07-25 | Joseph A. Jakubowski | Beta-carboline thromboxane synthase inhibitors |
| HUP0302962A2 (hu) * | 1998-06-12 | 2003-12-29 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Béta-karbolinszármazékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények és a vegyületek alkalmazása |
| US20040038970A1 (en) * | 1998-06-12 | 2004-02-26 | Societe De Conseils De Recherches Etd' Application Scientifiques, S.A.S. A Paris, France Corp. | Beta-carboline compounds |
| US20050137220A1 (en) * | 2003-07-23 | 2005-06-23 | Pharmacia Corporation | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors |
| DE102007009264A1 (de) * | 2007-02-26 | 2008-08-28 | Ellneuroxx Ltd. | 9-Alkyl-ß-Carboline zur Behandlung von neurodegenerativen Erkrankungen |
-
2010
- 2010-12-28 DE DE112010005017T patent/DE112010005017A5/de not_active Withdrawn
- 2010-12-28 JP JP2012546361A patent/JP5627705B2/ja active Active
- 2010-12-28 US US13/514,171 patent/US9107914B2/en active Active
- 2010-12-28 CA CA2785233A patent/CA2785233C/en active Active
- 2010-12-28 AU AU2010338669A patent/AU2010338669A1/en not_active Abandoned
- 2010-12-28 WO PCT/DE2010/001530 patent/WO2011079841A1/de not_active Ceased
- 2010-12-28 SG SG2012042438A patent/SG181599A1/en unknown
- 2010-12-28 BR BR112012015967A patent/BR112012015967B1/pt active IP Right Grant
- 2010-12-28 KR KR1020127017073A patent/KR20120098855A/ko not_active Withdrawn
- 2010-12-28 NZ NZ600478A patent/NZ600478A/xx unknown
- 2010-12-28 EP EP10812791.1A patent/EP2519238B1/de active Active
- 2010-12-28 MX MX2012007678A patent/MX2012007678A/es not_active Application Discontinuation
- 2010-12-28 RU RU2012132429/04A patent/RU2012132429A/ru not_active Application Discontinuation
- 2010-12-28 CN CN2010800630256A patent/CN102844029A/zh active Pending
-
2012
- 2012-06-07 IN IN5066DEN2012 patent/IN2012DN05066A/en unknown
- 2012-06-18 ZA ZA2012/04476A patent/ZA201204476B/en unknown
- 2012-06-26 IL IL220661A patent/IL220661A/en active IP Right Grant
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