JP2013515742A5 - - Google Patents
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- Publication number
- JP2013515742A5 JP2013515742A5 JP2012546222A JP2012546222A JP2013515742A5 JP 2013515742 A5 JP2013515742 A5 JP 2013515742A5 JP 2012546222 A JP2012546222 A JP 2012546222A JP 2012546222 A JP2012546222 A JP 2012546222A JP 2013515742 A5 JP2013515742 A5 JP 2013515742A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- terbinafine
- preparation
- short
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 12
- 238000009472 formulation Methods 0.000 claims 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 5
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 150000001261 hydroxy acids Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229960002722 terbinafine Drugs 0.000 claims 3
- 239000002888 zwitterionic surfactant Substances 0.000 claims 3
- 208000010195 Onychomycosis Diseases 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- JBTWLSYIZRCDFO-UHFFFAOYSA-N ethyl methyl carbonate Chemical compound CCOC(=O)OC JBTWLSYIZRCDFO-UHFFFAOYSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 239000002562 thickening agent Substances 0.000 claims 2
- 201000005882 tinea unguium Diseases 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 229940047648 cocoamphodiacetate Drugs 0.000 claims 1
- 229940047642 disodium cocoamphodiacetate Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 150000004666 short chain fatty acids Chemical class 0.000 claims 1
- 235000021391 short chain fatty acids Nutrition 0.000 claims 1
- 229960000699 terbinafine hydrochloride Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28996709P | 2009-12-23 | 2009-12-23 | |
| US28996209P | 2009-12-23 | 2009-12-23 | |
| US61/289,962 | 2009-12-23 | ||
| US61/289,967 | 2009-12-23 | ||
| PCT/US2010/061940 WO2011079234A2 (en) | 2009-12-23 | 2010-12-22 | Highly permeating terbinafine formulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515742A JP2013515742A (ja) | 2013-05-09 |
| JP2013515742A5 true JP2013515742A5 (enExample) | 2014-02-13 |
| JP5829217B2 JP5829217B2 (ja) | 2015-12-09 |
Family
ID=43770418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012546222A Expired - Fee Related JP5829217B2 (ja) | 2009-12-23 | 2010-12-22 | 高浸透性テルビナフィン製剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9084754B2 (enExample) |
| EP (1) | EP2544659A2 (enExample) |
| JP (1) | JP5829217B2 (enExample) |
| CN (1) | CN102770123A (enExample) |
| AU (1) | AU2010336441B2 (enExample) |
| CA (1) | CA2785643A1 (enExample) |
| WO (1) | WO2011079234A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8952070B2 (en) * | 2011-02-11 | 2015-02-10 | Moberg Pharma Ab | Antifungal composition |
| EP2793833B1 (en) | 2011-12-20 | 2020-06-24 | Vyome Therapeutics Limited | Topical oil composition for the treatment of fungal infections |
| EP2664327A1 (en) * | 2012-05-14 | 2013-11-20 | Almirall S.A. | Topical pharmaceutical compositions comprising terbinafide and urea |
| NL2009669C2 (en) * | 2012-10-19 | 2014-04-23 | Dutch Renewable Energy B V | Enhanced nail penetrating composition. |
| ES2613721T3 (es) | 2012-12-21 | 2017-05-25 | Teikoku Pharma Usa, Inc. | Composiciones y métodos para administración transdérmica de hormonas y otros agentes medicinales |
| US8697753B1 (en) | 2013-02-07 | 2014-04-15 | Polichem Sa | Method of treating onychomycosis |
| EP2952208A1 (en) * | 2014-06-04 | 2015-12-09 | Universidade de Santiago de Compostela | Hydroalcoholic system for nail treatment |
| JP6646662B2 (ja) | 2014-10-21 | 2020-02-14 | ヘキシマ リミテッド | 治療方法 |
| KR101690765B1 (ko) * | 2015-04-17 | 2016-12-28 | 동아제약 주식회사 | 항진균성 활성물질을 포함하는 경피 제제 |
| GB201511799D0 (en) * | 2015-07-06 | 2015-08-19 | Blueberry Therapeutics Ltd | Composition and methods of treatment |
| WO2017031075A1 (en) * | 2015-08-17 | 2017-02-23 | Arno Therapeutics, Inc. | Methods and compositions for enhanced transungual delivery of ar-12 |
| CA2998895A1 (en) * | 2015-10-07 | 2017-04-13 | Exodos Life Sciences Lp | Topical antifungal compositions |
| GB201605127D0 (en) * | 2016-03-25 | 2016-05-11 | Blueberry Therapeutics Ltd | Composition and methods of treatment |
| JP2019521993A (ja) * | 2016-06-13 | 2019-08-08 | ビオーム セラピューティクス リミテッド | 相乗的な抗真菌組成物及びその方法 |
| WO2017216722A2 (en) * | 2016-06-13 | 2017-12-21 | Vyome Biosciences Pvt. Ltd. | Synergistic antifungal compositions and methods thereof |
| RU2019119089A (ru) | 2016-11-28 | 2020-12-21 | Целликс Био Прайвет Лимитед | Композиции и способы лечения грибковых инфекций |
| WO2019214838A1 (en) * | 2018-05-09 | 2019-11-14 | Eviderm Institute Ab | Use of an alcohol-containing composition for improving the skin barrier function |
| US20210154215A1 (en) * | 2018-06-04 | 2021-05-27 | Zenvision Pharma Llp | Antifungal Cuticle Oil Composition |
| EP3829601B1 (fr) | 2018-08-01 | 2024-05-29 | Edix-O Sarl | Compositions injectables à durée d'action prolongée pour leur utilisation dans le traitement de maladies de l'ongle |
| EP3603650A1 (fr) | 2018-08-01 | 2020-02-05 | Edix O Sarl | Compositions injectables et a duree d'action prolongee pour leur utilisation dans le traitement de maladies de l'ongle et/ou pour accelerer la croissance de l'ongle |
| WO2020186447A1 (en) | 2019-03-19 | 2020-09-24 | Dow Global Technologies Llc | Aqueous dispersion comprising multistage polymeric particles |
| CN113208937A (zh) * | 2020-01-21 | 2021-08-06 | 中国医学科学院北京协和医院 | 一种角质软化组合物及其制备方法和应用及治疗灰指甲的外用复方及其制备方法和应用 |
| JP7664026B2 (ja) * | 2020-08-06 | 2025-04-17 | 沢井製薬株式会社 | エフィナコナゾール含有爪外用液 |
| JP2022117408A (ja) * | 2021-01-29 | 2022-08-10 | 花王株式会社 | 外用剤組成物 |
| CN113234028B (zh) * | 2021-04-29 | 2022-08-26 | 上海大学 | 一种5-氟尿嘧啶与肌氨酸的共晶体及其制备方法与用途 |
| CN113786382B (zh) * | 2021-11-04 | 2024-05-28 | 浙江得恩德制药股份有限公司 | 一种盐酸特比萘芬凝胶及制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7713618L (sv) | 1977-12-01 | 1979-06-02 | Astra Laekemedel Ab | Lokalanestetisk blandning |
| IT1180295B (it) | 1984-10-08 | 1987-09-23 | Durst Phototechnik Srl | Ingranditore o riproduttore fotografico a colori |
| FR2673537B1 (fr) | 1991-03-08 | 1993-06-11 | Oreal | Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes. |
| US6841161B1 (en) | 1997-05-14 | 2005-01-11 | Galen (Chemicals) Limited | Topical compositions |
| EP1071413B1 (en) * | 1998-04-17 | 2004-06-16 | Bertek Pharmaceuticals, Inc. | Topical formulations for the treatment of nail fungal diseases |
| US6368618B1 (en) | 1999-07-01 | 2002-04-09 | The University Of Georgia Research Foundation, Inc. | Composition and method for enhanced transdermal absorption of nonsteroidal anti-inflammatory drugs |
| DE10035991A1 (de) * | 2000-07-24 | 2002-02-14 | Polichem Sa | Nagellackzusammensetzung |
| KR100757611B1 (ko) | 2001-09-04 | 2007-09-10 | 트롬스도르프 게엠베하 운트 코. 카게 알츠나이미텔 | 손발톱 성장의 기능장애와 질환을 치료하기 위한 플라스터 |
| US20030091666A1 (en) * | 2001-11-14 | 2003-05-15 | Howard Murad | Methods and compositions for treating dermatological disorders with Morinda citrifolia |
| US7138394B2 (en) | 2002-09-27 | 2006-11-21 | Alpharx Inc. | Vehicle for topical delivery of anti-inflammatory compounds |
| US7462362B2 (en) * | 2003-03-21 | 2008-12-09 | Nexmed Holdings, Inc. | Antifungal nail coat and method of use |
| CN1856294A (zh) | 2003-08-25 | 2006-11-01 | 弗米克斯有限公司 | 渗透性药物泡沫 |
| US20060078580A1 (en) * | 2004-10-08 | 2006-04-13 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
| US20060078599A1 (en) | 2004-10-12 | 2006-04-13 | Mathew Ebmeier | Pharmaceutical composition applicable to body tissue |
| CA2500907A1 (en) | 2005-03-15 | 2006-09-15 | Alpharx Inc. | Vehicle for topical delivery of anti-inflammatory compounds |
| EP1858556A1 (en) | 2005-03-16 | 2007-11-28 | Alpharx Inc. | Vehicle for topical delivery of anti-inflammatory compounds |
| GB0511499D0 (en) * | 2005-06-06 | 2005-07-13 | Medpharm Ltd | Topical ungual formulations |
| US20070224261A1 (en) | 2006-03-22 | 2007-09-27 | Peter Draper | Eutectic liquid drug formulation |
| MX2008015599A (es) * | 2006-06-14 | 2009-03-06 | Reddys Lab Ltd Dr | Composiciones topicas. |
| US20080261986A1 (en) * | 2007-03-30 | 2008-10-23 | Friden Phillip M | Pharmaceutical formulations for iontophoretic delivery of an anti-fungal drug |
| MX2011000932A (es) | 2008-07-23 | 2011-05-19 | Targeted Delivery Technologies Ltd | Metodos para administrar formulaciones antifungicas topicas para el tratamiento de infecciones fungicas. |
| WO2011014850A2 (en) * | 2009-07-31 | 2011-02-03 | Nuvo Research Inc. | Topical eutectic-based formulations |
-
2010
- 2010-12-22 WO PCT/US2010/061940 patent/WO2011079234A2/en not_active Ceased
- 2010-12-22 CA CA2785643A patent/CA2785643A1/en not_active Abandoned
- 2010-12-22 CN CN2010800643152A patent/CN102770123A/zh active Pending
- 2010-12-22 JP JP2012546222A patent/JP5829217B2/ja not_active Expired - Fee Related
- 2010-12-22 EP EP10801340A patent/EP2544659A2/en not_active Withdrawn
- 2010-12-22 AU AU2010336441A patent/AU2010336441B2/en not_active Ceased
-
2012
- 2012-06-15 US US13/525,108 patent/US9084754B2/en not_active Expired - Fee Related
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