JP2013513652A5 - - Google Patents
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- Publication number
- JP2013513652A5 JP2013513652A5 JP2012543903A JP2012543903A JP2013513652A5 JP 2013513652 A5 JP2013513652 A5 JP 2013513652A5 JP 2012543903 A JP2012543903 A JP 2012543903A JP 2012543903 A JP2012543903 A JP 2012543903A JP 2013513652 A5 JP2013513652 A5 JP 2013513652A5
- Authority
- JP
- Japan
- Prior art keywords
- chlorpheniramine
- day
- medicament
- antihistamines
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 12
- 239000000739 antihistaminic agent Substances 0.000 claims 8
- 229960003291 chlorphenamine Drugs 0.000 claims 8
- SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 claims 8
- 229940125715 antihistaminic agent Drugs 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- ZKLPARSLTMPFCP-OAQYLSRUSA-N 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid Chemical compound C1CN(CCOCC(=O)O)CCN1[C@@H](C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-OAQYLSRUSA-N 0.000 claims 4
- ZZHLYYDVIOPZBE-UHFFFAOYSA-N Trimeprazine Chemical compound C1=CC=C2N(CC(CN(C)C)C)C3=CC=CC=C3SC2=C1 ZZHLYYDVIOPZBE-UHFFFAOYSA-N 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 229960001508 levocetirizine Drugs 0.000 claims 4
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 claims 4
- 206010011224 Cough Diseases 0.000 claims 3
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 3
- 230000001387 anti-histamine Effects 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000000839 emulsion Substances 0.000 claims 3
- 239000008187 granular material Substances 0.000 claims 3
- 239000007937 lozenge Substances 0.000 claims 3
- 239000000843 powder Substances 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- 239000006188 syrup Substances 0.000 claims 3
- 235000020357 syrup Nutrition 0.000 claims 3
- 239000003826 tablet Substances 0.000 claims 3
- -1 troche Substances 0.000 claims 3
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 claims 2
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 claims 2
- OCJYIGYOJCODJL-UHFFFAOYSA-N Meclizine Chemical compound CC1=CC=CC(CN2CCN(CC2)C(C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)=C1 OCJYIGYOJCODJL-UHFFFAOYSA-N 0.000 claims 2
- IJHNSHDBIRRJRN-UHFFFAOYSA-N N,N-dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=CC=C1 IJHNSHDBIRRJRN-UHFFFAOYSA-N 0.000 claims 2
- JAUOIFJMECXRGI-UHFFFAOYSA-N Neoclaritin Chemical compound C=1C(Cl)=CC=C2C=1CCC1=CC=CN=C1C2=C1CCNCC1 JAUOIFJMECXRGI-UHFFFAOYSA-N 0.000 claims 2
- 229960003790 alimemazine Drugs 0.000 claims 2
- GXDALQBWZGODGZ-UHFFFAOYSA-N astemizole Chemical compound C1=CC(OC)=CC=C1CCN1CCC(NC=2N(C3=CC=CC=C3N=2)CC=2C=CC(F)=CC=2)CC1 GXDALQBWZGODGZ-UHFFFAOYSA-N 0.000 claims 2
- 229960000725 brompheniramine Drugs 0.000 claims 2
- ZDIGNSYAACHWNL-UHFFFAOYSA-N brompheniramine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Br)C=C1 ZDIGNSYAACHWNL-UHFFFAOYSA-N 0.000 claims 2
- 229960001803 cetirizine Drugs 0.000 claims 2
- 229960002881 clemastine Drugs 0.000 claims 2
- YNNUSGIPVFPVBX-NHCUHLMSSA-N clemastine Chemical compound CN1CCC[C@@H]1CCO[C@@](C)(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 YNNUSGIPVFPVBX-NHCUHLMSSA-N 0.000 claims 2
- 229960001140 cyproheptadine Drugs 0.000 claims 2
- JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 claims 2
- 229960001271 desloratadine Drugs 0.000 claims 2
- 229960004993 dimenhydrinate Drugs 0.000 claims 2
- MZDOIJOUFRQXHC-UHFFFAOYSA-N dimenhydrinate Chemical compound O=C1N(C)C(=O)N(C)C2=NC(Cl)=N[C]21.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 MZDOIJOUFRQXHC-UHFFFAOYSA-N 0.000 claims 2
- 229960000520 diphenhydramine Drugs 0.000 claims 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims 2
- 229960005178 doxylamine Drugs 0.000 claims 2
- HCFDWZZGGLSKEP-UHFFFAOYSA-N doxylamine Chemical compound C=1C=CC=NC=1C(C)(OCCN(C)C)C1=CC=CC=C1 HCFDWZZGGLSKEP-UHFFFAOYSA-N 0.000 claims 2
- 229960003592 fexofenadine Drugs 0.000 claims 2
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims 2
- 229960003088 loratadine Drugs 0.000 claims 2
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960001474 meclozine Drugs 0.000 claims 2
- 229960001190 pheniramine Drugs 0.000 claims 2
- 229960003910 promethazine Drugs 0.000 claims 2
- 229960004431 quetiapine Drugs 0.000 claims 2
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 claims 2
- 229960004559 theobromine Drugs 0.000 claims 2
- 229960001128 triprolidine Drugs 0.000 claims 2
- CBEQULMOCCWAQT-WOJGMQOQSA-N triprolidine Chemical compound C1=CC(C)=CC=C1C(\C=1N=CC=CC=1)=C/CN1CCCC1 CBEQULMOCCWAQT-WOJGMQOQSA-N 0.000 claims 2
- PVLJETXTTWAYEW-UHFFFAOYSA-N Mizolastine Chemical compound N=1C=CC(=O)NC=1N(C)C(CC1)CCN1C1=NC2=CC=CC=C2N1CC1=CC=C(F)C=C1 PVLJETXTTWAYEW-UHFFFAOYSA-N 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 229960001882 dexchlorpheniramine Drugs 0.000 claims 1
- SOYKEARSMXGVTM-HNNXBMFYSA-N dexchlorpheniramine Chemical compound C1([C@H](CCN(C)C)C=2N=CC=CC=2)=CC=C(Cl)C=C1 SOYKEARSMXGVTM-HNNXBMFYSA-N 0.000 claims 1
- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 claims 1
- 229960004193 dextropropoxyphene Drugs 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 229960000930 hydroxyzine Drugs 0.000 claims 1
- ZQDWXGKKHFNSQK-UHFFFAOYSA-N hydroxyzine Chemical compound C1CN(CCOCCO)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZQDWXGKKHFNSQK-UHFFFAOYSA-N 0.000 claims 1
- 229960001144 mizolastine Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0921803.3A GB0921803D0 (en) | 2009-12-14 | 2009-12-14 | Drug composition and its use in therapy |
| GB0921803.3 | 2009-12-14 | ||
| PCT/GB2010/052086 WO2011073647A1 (en) | 2009-12-14 | 2010-12-14 | Therapeutic combinations of theobromine and an antihistamine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015189277A Division JP6078605B2 (ja) | 2009-12-14 | 2015-09-28 | テオブロミンと抗ヒスタミン剤との治療用組み合わせ剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013513652A JP2013513652A (ja) | 2013-04-22 |
| JP2013513652A5 true JP2013513652A5 (enExample) | 2014-02-06 |
Family
ID=41667043
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543903A Pending JP2013513652A (ja) | 2009-12-14 | 2010-12-14 | テオブロミンと抗ヒスタミン剤との治療用組み合わせ剤 |
| JP2015189277A Expired - Fee Related JP6078605B2 (ja) | 2009-12-14 | 2015-09-28 | テオブロミンと抗ヒスタミン剤との治療用組み合わせ剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015189277A Expired - Fee Related JP6078605B2 (ja) | 2009-12-14 | 2015-09-28 | テオブロミンと抗ヒスタミン剤との治療用組み合わせ剤 |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP2512472A1 (enExample) |
| JP (2) | JP2013513652A (enExample) |
| CN (1) | CN102802625A (enExample) |
| AU (1) | AU2010332495C1 (enExample) |
| BR (1) | BR112012014159A8 (enExample) |
| CA (1) | CA2784215A1 (enExample) |
| CO (1) | CO6541638A2 (enExample) |
| GB (1) | GB0921803D0 (enExample) |
| IL (1) | IL220384A0 (enExample) |
| MX (1) | MX2012006624A (enExample) |
| NZ (1) | NZ600267A (enExample) |
| PE (1) | PE20121538A1 (enExample) |
| PH (1) | PH12012501200A1 (enExample) |
| RU (1) | RU2012129675A (enExample) |
| SG (2) | SG181603A1 (enExample) |
| UA (1) | UA105827C2 (enExample) |
| WO (1) | WO2011073647A1 (enExample) |
| ZA (1) | ZA201204294B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10016437B2 (en) | 2009-06-16 | 2018-07-10 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| GB201111485D0 (en) * | 2011-07-05 | 2011-08-17 | Biocopea Ltd | Drug composition and its use in therapy |
| US9308211B2 (en) | 2009-06-16 | 2016-04-12 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| US9314465B2 (en) | 2009-06-16 | 2016-04-19 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| GB0910375D0 (en) | 2009-06-16 | 2009-07-29 | Biocopea Ltd | Drug composition and its use in therapy |
| CN103263533B (zh) * | 2013-05-31 | 2014-11-05 | 杨宏伟 | 一种治疗咳嗽的可可碱组合物及其用途及其制剂 |
| CN104188998A (zh) * | 2014-09-18 | 2014-12-10 | 中山大学 | 一种柚皮苷与盐酸非索非那丁药物组合物及其制剂 |
| CN104224819B (zh) * | 2014-09-18 | 2016-08-17 | 中山大学 | 一种柚皮苷与盐酸左西替利嗪药物组合物及其制剂 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE59550T1 (de) * | 1986-04-17 | 1991-01-15 | Alza Corp | Chlorpheniramine therapie. |
| HUP9700654A2 (hu) | 1997-03-26 | 1999-09-28 | Dezső Korbonits | Teobromin tartalmú köhögéscsillapító készítmények |
| JPH10316568A (ja) * | 1997-05-13 | 1998-12-02 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
| JP2003012514A (ja) * | 2001-07-02 | 2003-01-15 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
| JP2003128549A (ja) * | 2001-08-15 | 2003-05-08 | Rohto Pharmaceut Co Ltd | 粘膜適用組成物 |
| US20080003280A1 (en) * | 2006-06-26 | 2008-01-03 | Levine Brian M | Combination cough treatment compounds and method of treating common coughs |
| US20080254029A1 (en) * | 2007-04-11 | 2008-10-16 | Alcon Research, Ltd. | Use of an Inhibitor of TNFa Plus an Antihistamine to Treat Allergic Rhinitis and Allergic Conjunctivitis |
-
2009
- 2009-12-14 GB GBGB0921803.3A patent/GB0921803D0/en not_active Ceased
-
2010
- 2010-12-14 RU RU2012129675/15A patent/RU2012129675A/ru not_active Application Discontinuation
- 2010-12-14 UA UAA201208623A patent/UA105827C2/uk unknown
- 2010-12-14 JP JP2012543903A patent/JP2013513652A/ja active Pending
- 2010-12-14 PH PH1/2012/501200A patent/PH12012501200A1/en unknown
- 2010-12-14 MX MX2012006624A patent/MX2012006624A/es not_active Application Discontinuation
- 2010-12-14 SG SG2012042495A patent/SG181603A1/en unknown
- 2010-12-14 AU AU2010332495A patent/AU2010332495C1/en not_active Ceased
- 2010-12-14 EP EP10796123A patent/EP2512472A1/en not_active Ceased
- 2010-12-14 WO PCT/GB2010/052086 patent/WO2011073647A1/en not_active Ceased
- 2010-12-14 SG SG10201408374WA patent/SG10201408374WA/en unknown
- 2010-12-14 NZ NZ600267A patent/NZ600267A/xx not_active IP Right Cessation
- 2010-12-14 CN CN2010800570274A patent/CN102802625A/zh active Pending
- 2010-12-14 CA CA2784215A patent/CA2784215A1/en not_active Abandoned
- 2010-12-14 BR BR112012014159A patent/BR112012014159A8/pt not_active IP Right Cessation
- 2010-12-14 PE PE2012000814A patent/PE20121538A1/es not_active Application Discontinuation
-
2012
- 2012-06-12 ZA ZA2012/04294A patent/ZA201204294B/en unknown
- 2012-06-12 CO CO12098529A patent/CO6541638A2/es unknown
- 2012-06-13 IL IL220384A patent/IL220384A0/en unknown
-
2015
- 2015-09-28 JP JP2015189277A patent/JP6078605B2/ja not_active Expired - Fee Related
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