JP2013513652A - テオブロミンと抗ヒスタミン剤との治療用組み合わせ剤 - Google Patents
テオブロミンと抗ヒスタミン剤との治療用組み合わせ剤 Download PDFInfo
- Publication number
- JP2013513652A JP2013513652A JP2012543903A JP2012543903A JP2013513652A JP 2013513652 A JP2013513652 A JP 2013513652A JP 2012543903 A JP2012543903 A JP 2012543903A JP 2012543903 A JP2012543903 A JP 2012543903A JP 2013513652 A JP2013513652 A JP 2013513652A
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- JP
- Japan
- Prior art keywords
- theobromine
- antihistamine
- cough
- chlorpheniramine
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
本明細書で使用されているように、「抗ヒスタミン剤」という用語は、ヒスタミン受容体を介してヒスタミンの作用を阻害する薬剤を意味している。この用語は、当業者によく知られている、十分に定義された種類の薬物を表す。好ましい実施形態において、抗ヒスタミン剤は、H1−受容体抗ヒスタミン剤である。任意の適当な形態の抗ヒスタミン剤を選択することができる。これらは、塩、プロドラッグ、および活性代謝産物を包含する。
咳嗽は、クエン酸の使用によりモルモットにおいて誘発させた。モルモットの1群に、10mg/kgのテオブロミンを投与し、2つの群に、10または30mg/kgのクロルフェニラミンとの組み合わせでテオブロミンを投与した。対照として、第四の群は、ベヒクルのみを受けた。投与は、経口経路を介した。
Claims (6)
- 治療における同時使用、逐次使用、または分離使用のための組み合わせ調製物として、テオブロミンおよび抗ヒスタミン剤を含む薬剤。
- 治療が、咳嗽の治療である、請求項1に記載の薬剤。
- テオブロミンおよび抗ヒスタミン剤を含む医薬組成物。
- 抗ヒスタミン剤が、ジフェンヒドラミン、ロラタジン、デスロラタジン、アリメマジン、ジメンヒドリナート、ドキシラミン、メクリジン、クエチアピン、フェキソフェナジン、フェニラミン、セチリジン、プロメタジン、クレマスチン、クロルフェニラミン、デキスクロルフェニラミン、レボセチリジン、ヒドロキシジン、アリメマジン、アクリバスチン、シプロヘプタジン、アステミゾール、フェキソフェナジン、ロラタジン、セチリジン、レボセチリジン、ブロムフェニラミン、デキストロブロムフェニラミン、プロメタジン、ミゾラスチン、およびトリプロリジンから選択される、請求項1または2に記載の薬剤、または請求項3に記載の組成物。
- 抗ヒスタミン剤が、クロルフェニラミンである、請求項4に記載の薬剤または組成物。
- 抗ヒスタミン剤が、0.1〜30mg/kg/日の投与量で投与される、請求項1、2、4、および5のいずれか1項に記載の薬剤、または請求項3〜5のいずれか1項に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0921803.3A GB0921803D0 (en) | 2009-12-14 | 2009-12-14 | Drug composition and its use in therapy |
GB0921803.3 | 2009-12-14 | ||
PCT/GB2010/052086 WO2011073647A1 (en) | 2009-12-14 | 2010-12-14 | Therapeutic combinations of theobromine and an antihistamine |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015189277A Division JP6078605B2 (ja) | 2009-12-14 | 2015-09-28 | テオブロミンと抗ヒスタミン剤との治療用組み合わせ剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013513652A true JP2013513652A (ja) | 2013-04-22 |
JP2013513652A5 JP2013513652A5 (ja) | 2014-02-06 |
Family
ID=41667043
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012543903A Pending JP2013513652A (ja) | 2009-12-14 | 2010-12-14 | テオブロミンと抗ヒスタミン剤との治療用組み合わせ剤 |
JP2015189277A Expired - Fee Related JP6078605B2 (ja) | 2009-12-14 | 2015-09-28 | テオブロミンと抗ヒスタミン剤との治療用組み合わせ剤 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015189277A Expired - Fee Related JP6078605B2 (ja) | 2009-12-14 | 2015-09-28 | テオブロミンと抗ヒスタミン剤との治療用組み合わせ剤 |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP2512472A1 (ja) |
JP (2) | JP2013513652A (ja) |
CN (1) | CN102802625A (ja) |
AU (1) | AU2010332495C1 (ja) |
BR (1) | BR112012014159A8 (ja) |
CA (1) | CA2784215A1 (ja) |
CO (1) | CO6541638A2 (ja) |
GB (1) | GB0921803D0 (ja) |
IL (1) | IL220384A0 (ja) |
MX (1) | MX2012006624A (ja) |
NZ (1) | NZ600267A (ja) |
PE (1) | PE20121538A1 (ja) |
RU (1) | RU2012129675A (ja) |
SG (2) | SG181603A1 (ja) |
UA (1) | UA105827C2 (ja) |
WO (1) | WO2011073647A1 (ja) |
ZA (1) | ZA201204294B (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10016437B2 (en) | 2009-06-16 | 2018-07-10 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
GB201111485D0 (en) * | 2011-07-05 | 2011-08-17 | Biocopea Ltd | Drug composition and its use in therapy |
GB0910375D0 (en) | 2009-06-16 | 2009-07-29 | Biocopea Ltd | Drug composition and its use in therapy |
US9314465B2 (en) | 2009-06-16 | 2016-04-19 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
US9308211B2 (en) | 2009-06-16 | 2016-04-12 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
CN103263533B (zh) * | 2013-05-31 | 2014-11-05 | 杨宏伟 | 一种治疗咳嗽的可可碱组合物及其用途及其制剂 |
CN104224819B (zh) * | 2014-09-18 | 2016-08-17 | 中山大学 | 一种柚皮苷与盐酸左西替利嗪药物组合物及其制剂 |
CN104188998A (zh) * | 2014-09-18 | 2014-12-10 | 中山大学 | 一种柚皮苷与盐酸非索非那丁药物组合物及其制剂 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62249924A (ja) * | 1986-04-17 | 1987-10-30 | アルザ コ−ポレ−シヨン | 有用な薬剤クロルフエニラミン供給用剤形 |
JPH10316568A (ja) * | 1997-05-13 | 1998-12-02 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
JP2003012514A (ja) * | 2001-07-02 | 2003-01-15 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
WO2008002514A2 (en) * | 2006-06-26 | 2008-01-03 | Levine Brian M | Combination cough treatment compounds and method of treating common coughs |
WO2008127975A2 (en) * | 2007-04-11 | 2008-10-23 | Alcon Research, Ltd. | Use of an inhibitor of tnfa plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP9700654A2 (hu) | 1997-03-26 | 1999-09-28 | Dezső Korbonits | Teobromin tartalmú köhögéscsillapító készítmények |
JP2003128549A (ja) * | 2001-08-15 | 2003-05-08 | Rohto Pharmaceut Co Ltd | 粘膜適用組成物 |
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2009
- 2009-12-14 GB GBGB0921803.3A patent/GB0921803D0/en not_active Ceased
-
2010
- 2010-12-14 BR BR112012014159A patent/BR112012014159A8/pt not_active IP Right Cessation
- 2010-12-14 RU RU2012129675/15A patent/RU2012129675A/ru not_active Application Discontinuation
- 2010-12-14 CA CA2784215A patent/CA2784215A1/en not_active Abandoned
- 2010-12-14 PE PE2012000814A patent/PE20121538A1/es not_active Application Discontinuation
- 2010-12-14 AU AU2010332495A patent/AU2010332495C1/en not_active Ceased
- 2010-12-14 MX MX2012006624A patent/MX2012006624A/es not_active Application Discontinuation
- 2010-12-14 WO PCT/GB2010/052086 patent/WO2011073647A1/en active Application Filing
- 2010-12-14 SG SG2012042495A patent/SG181603A1/en unknown
- 2010-12-14 UA UAA201208623A patent/UA105827C2/uk unknown
- 2010-12-14 EP EP10796123A patent/EP2512472A1/en not_active Ceased
- 2010-12-14 CN CN2010800570274A patent/CN102802625A/zh active Pending
- 2010-12-14 SG SG10201408374WA patent/SG10201408374WA/en unknown
- 2010-12-14 NZ NZ600267A patent/NZ600267A/xx not_active IP Right Cessation
- 2010-12-14 JP JP2012543903A patent/JP2013513652A/ja active Pending
-
2012
- 2012-06-12 ZA ZA2012/04294A patent/ZA201204294B/en unknown
- 2012-06-12 CO CO12098529A patent/CO6541638A2/es unknown
- 2012-06-13 IL IL220384A patent/IL220384A0/en unknown
-
2015
- 2015-09-28 JP JP2015189277A patent/JP6078605B2/ja not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62249924A (ja) * | 1986-04-17 | 1987-10-30 | アルザ コ−ポレ−シヨン | 有用な薬剤クロルフエニラミン供給用剤形 |
JPH10316568A (ja) * | 1997-05-13 | 1998-12-02 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
JP2003012514A (ja) * | 2001-07-02 | 2003-01-15 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
WO2008002514A2 (en) * | 2006-06-26 | 2008-01-03 | Levine Brian M | Combination cough treatment compounds and method of treating common coughs |
WO2008127975A2 (en) * | 2007-04-11 | 2008-10-23 | Alcon Research, Ltd. | Use of an inhibitor of tnfa plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis |
Non-Patent Citations (2)
Title |
---|
JPN5013001810; 'ABSTRACTS: PRESENTED AT POSTER SESSIONS' ANNALS OF ALLERGY, ASTHMA & IMMUNOLOGY V102 N1, 20090101, P A23,A25-A128 * |
JPN6014043655; The FASEB Journal doi: 10.1096/fj.04-1990fje, 2004 * |
Also Published As
Publication number | Publication date |
---|---|
RU2012129675A (ru) | 2014-01-27 |
MX2012006624A (es) | 2012-10-05 |
AU2010332495C1 (en) | 2016-02-11 |
ZA201204294B (en) | 2013-02-27 |
EP2512472A1 (en) | 2012-10-24 |
CN102802625A (zh) | 2012-11-28 |
NZ600267A (en) | 2013-07-26 |
JP6078605B2 (ja) | 2017-02-08 |
BR112012014159A2 (pt) | 2017-08-29 |
GB0921803D0 (en) | 2010-01-27 |
IL220384A0 (en) | 2012-08-30 |
CO6541638A2 (es) | 2012-10-16 |
WO2011073647A1 (en) | 2011-06-23 |
AU2010332495B2 (en) | 2015-01-22 |
PE20121538A1 (es) | 2012-12-21 |
UA105827C2 (uk) | 2014-06-25 |
JP2016040280A (ja) | 2016-03-24 |
BR112012014159A8 (pt) | 2017-12-26 |
AU2010332495A1 (en) | 2012-06-21 |
SG181603A1 (en) | 2012-07-30 |
CA2784215A1 (en) | 2011-06-23 |
SG10201408374WA (en) | 2015-01-29 |
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