JP6118919B2 - テオブロミンとの薬物組み合わせおよび治療におけるその使用 - Google Patents
テオブロミンとの薬物組み合わせおよび治療におけるその使用 Download PDFInfo
- Publication number
- JP6118919B2 JP6118919B2 JP2016001487A JP2016001487A JP6118919B2 JP 6118919 B2 JP6118919 B2 JP 6118919B2 JP 2016001487 A JP2016001487 A JP 2016001487A JP 2016001487 A JP2016001487 A JP 2016001487A JP 6118919 B2 JP6118919 B2 JP 6118919B2
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- Prior art keywords
- theobromine
- cough
- medicament
- dextromethorphan
- day
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
任意の適切な形態のテオブロミンを選択することができる。これらは、塩、プロドラッグ、および活性代謝産物を包含する。テオブロミンはまた、ココアまたはチョコレートの形態であってもよい。テオブロミンについての適切な投与量範囲は、当技術分野において知られているが、組み合わせの相乗効果は、有効投与量が低減されることを意味している。
咳嗽は、クエン酸の使用によりモルモットで誘発させた。モルモットの1群に、10mg/kgのテオブロミンを投与し、第二群に、30mg/kgのデキストロメトルファンとの組み合わせで10mg/kgのテオブロミンを投与した。ベヒクルのみを受けた第三の群は、対照として使用した。投与は、経口経路を介した。
Claims (12)
- 咳嗽の治療における組み合わせ調製物としての、テオブロミンおよびデキストロメトルファンからなる薬剤。
- デキストロメトルファンが、0.1mg/kg/日〜6mg/kg/日の投与量である、請求項1に記載の薬剤。
- 経口投与用に製造される、請求項1または2に記載の薬剤。
- 錠剤、カプセル剤、トローチ剤、ロゼンジ剤、散剤、顆粒剤、懸濁剤、シロップ剤、または乳剤として調製される、請求項1〜3のいずれか1項に記載の薬剤。
- 請求項1または2に記載の薬剤と、1つ以上の賦形剤と、任意で甘味剤、矯味剤、着色剤、および/または保存剤のうちの1つ以上とからなる医薬組成物。
- 経口投与用に製造される、請求項5に記載の医薬組成物。
- 錠剤、カプセル剤、トローチ剤、ロゼンジ剤、散剤、顆粒剤、懸濁剤、シロップ剤、または乳剤として調製される、請求項5または6に記載の医薬組成物。
- 咳嗽の治療のための医薬品の製造における、請求項1〜4のいずれか1項に記載の薬剤または請求項5〜7のいずれか1項に記載の医薬組成物の使用。
- 咳嗽の治療のための医薬品の製造における、デキストロメトルファンと組み合わせたテオブロミンの使用。
- デキストロメトルファンが、0.1mg/kg/日〜6mg/kg/日の投与量である、請求項9に記載の使用。
- 前記医薬品が経口投与用に製造される、請求項9または10に記載の使用。
- 前記医薬品が錠剤、カプセル剤、トローチ剤、ロゼンジ剤、散剤、顆粒剤、懸濁剤、シロップ剤、または乳剤として調製される、請求項9〜11のいずれか1項に記載の使用。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0919889.6A GB0919889D0 (en) | 2009-11-13 | 2009-11-13 | Drug composition and its use in therapy |
GB0919889.6 | 2009-11-13 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012538415A Division JP2013510841A (ja) | 2009-11-13 | 2010-11-12 | テオブロミンとの薬物組み合わせおよび治療におけるその使用 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016128439A JP2016128439A (ja) | 2016-07-14 |
JP6118919B2 true JP6118919B2 (ja) | 2017-04-19 |
Family
ID=41509324
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012538415A Pending JP2013510841A (ja) | 2009-11-13 | 2010-11-12 | テオブロミンとの薬物組み合わせおよび治療におけるその使用 |
JP2016001487A Active JP6118919B2 (ja) | 2009-11-13 | 2016-01-07 | テオブロミンとの薬物組み合わせおよび治療におけるその使用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012538415A Pending JP2013510841A (ja) | 2009-11-13 | 2010-11-12 | テオブロミンとの薬物組み合わせおよび治療におけるその使用 |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP2498777A2 (ja) |
JP (2) | JP2013510841A (ja) |
CN (1) | CN102753174A (ja) |
AU (1) | AU2010317667B2 (ja) |
BR (1) | BR112012011227A2 (ja) |
CA (1) | CA2780703A1 (ja) |
CO (1) | CO6551744A2 (ja) |
GB (1) | GB0919889D0 (ja) |
IL (1) | IL219768A0 (ja) |
MX (1) | MX2012005532A (ja) |
NZ (1) | NZ599949A (ja) |
PE (1) | PE20130147A1 (ja) |
RU (1) | RU2519086C2 (ja) |
UA (1) | UA108993C2 (ja) |
WO (1) | WO2011058373A2 (ja) |
ZA (1) | ZA201204248B (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10016437B2 (en) | 2009-06-16 | 2018-07-10 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
GB0910375D0 (en) | 2009-06-16 | 2009-07-29 | Biocopea Ltd | Drug composition and its use in therapy |
GB201111485D0 (en) * | 2011-07-05 | 2011-08-17 | Biocopea Ltd | Drug composition and its use in therapy |
US9308211B2 (en) | 2009-06-16 | 2016-04-12 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
US9314465B2 (en) | 2009-06-16 | 2016-04-19 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
US20190008850A1 (en) * | 2015-12-30 | 2019-01-10 | Paul J. Markovitz | Method of treating schizophrenia |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5834479A (en) * | 1993-03-05 | 1998-11-10 | Mayer; David J. | Method and composition for alleviating pain |
RU2194700C2 (ru) * | 1996-11-25 | 2002-12-20 | Дзе Проктер Энд Гэмбл Компани | Гуанидинильные гетероциклические соединения, применяемые в качестве агонистов альфа-2 адренорецепторов |
HUP9700654A2 (hu) * | 1997-03-26 | 1999-09-28 | Dezső Korbonits | Teobromin tartalmú köhögéscsillapító készítmények |
US20030206942A1 (en) * | 1998-09-25 | 2003-11-06 | Neema Kulkarni | Fast dissolving orally consumable films containing an antitussive and a mucosa coating agent |
US6207674B1 (en) * | 1999-12-22 | 2001-03-27 | Richard A. Smith | Dextromethorphan and oxidase inhibitor for weaning patients from narcotics and anti-depressants |
MXPA05012742A (es) * | 2003-05-29 | 2006-02-13 | Unilever Nv | Composiciones de tratamiento para el cabello. |
US20060153926A1 (en) * | 2005-01-10 | 2006-07-13 | Bascom Charles C | Compositions, products and methods for controlling weight in a mammal |
US20080003280A1 (en) * | 2006-06-26 | 2008-01-03 | Levine Brian M | Combination cough treatment compounds and method of treating common coughs |
WO2008089260A2 (en) * | 2007-01-16 | 2008-07-24 | Victory Pharma, Inc. | Combined administration of benzonatate and guaifenesin |
-
2009
- 2009-11-13 GB GBGB0919889.6A patent/GB0919889D0/en not_active Ceased
-
2010
- 2010-11-12 CN CN2010800516299A patent/CN102753174A/zh active Pending
- 2010-11-12 AU AU2010317667A patent/AU2010317667B2/en not_active Ceased
- 2010-11-12 WO PCT/GB2010/051895 patent/WO2011058373A2/en active Application Filing
- 2010-11-12 JP JP2012538415A patent/JP2013510841A/ja active Pending
- 2010-11-12 PE PE2012000649A patent/PE20130147A1/es not_active Application Discontinuation
- 2010-11-12 NZ NZ599949A patent/NZ599949A/xx not_active IP Right Cessation
- 2010-11-12 EP EP10825831A patent/EP2498777A2/en not_active Ceased
- 2010-11-12 RU RU2012124038/15A patent/RU2519086C2/ru not_active IP Right Cessation
- 2010-11-12 MX MX2012005532A patent/MX2012005532A/es active IP Right Grant
- 2010-11-12 BR BR112012011227A patent/BR112012011227A2/pt not_active IP Right Cessation
- 2010-11-12 CA CA2780703A patent/CA2780703A1/en not_active Abandoned
- 2010-12-11 UA UAA201207164A patent/UA108993C2/en unknown
-
2012
- 2012-05-11 CO CO12078027A patent/CO6551744A2/es not_active Application Discontinuation
- 2012-05-13 IL IL219768A patent/IL219768A0/en unknown
- 2012-06-11 ZA ZA2012/04248A patent/ZA201204248B/en unknown
-
2016
- 2016-01-07 JP JP2016001487A patent/JP6118919B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
RU2012124038A (ru) | 2013-12-20 |
ZA201204248B (en) | 2013-02-27 |
BR112012011227A2 (pt) | 2017-06-13 |
EP2498777A2 (en) | 2012-09-19 |
NZ599949A (en) | 2013-08-30 |
PE20130147A1 (es) | 2013-03-13 |
IL219768A0 (en) | 2012-07-31 |
RU2519086C2 (ru) | 2014-06-10 |
CO6551744A2 (es) | 2012-10-31 |
JP2013510841A (ja) | 2013-03-28 |
GB0919889D0 (en) | 2009-12-30 |
WO2011058373A3 (en) | 2011-07-07 |
JP2016128439A (ja) | 2016-07-14 |
AU2010317667B2 (en) | 2014-05-29 |
CN102753174A (zh) | 2012-10-24 |
UA108993C2 (en) | 2015-07-10 |
WO2011058373A2 (en) | 2011-05-19 |
CA2780703A1 (en) | 2011-05-19 |
MX2012005532A (es) | 2012-09-28 |
AU2010317667A1 (en) | 2012-06-07 |
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