RU2012129675A - Терапевтические комбинации теобромина и антигистамина - Google Patents
Терапевтические комбинации теобромина и антигистамина Download PDFInfo
- Publication number
- RU2012129675A RU2012129675A RU2012129675/15A RU2012129675A RU2012129675A RU 2012129675 A RU2012129675 A RU 2012129675A RU 2012129675/15 A RU2012129675/15 A RU 2012129675/15A RU 2012129675 A RU2012129675 A RU 2012129675A RU 2012129675 A RU2012129675 A RU 2012129675A
- Authority
- RU
- Russia
- Prior art keywords
- antihistamine
- fexofenadine
- loratadine
- cetirizine
- promethazine
- Prior art date
Links
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 title claims abstract 17
- 230000001387 anti-histamine Effects 0.000 title claims abstract 17
- 239000000739 antihistaminic agent Substances 0.000 title claims abstract 17
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 title claims abstract 10
- 230000001225 therapeutic effect Effects 0.000 title 1
- ZZHLYYDVIOPZBE-UHFFFAOYSA-N Trimeprazine Chemical compound C1=CC=C2N(CC(CN(C)C)C)C3=CC=CC=C3SC2=C1 ZZHLYYDVIOPZBE-UHFFFAOYSA-N 0.000 claims abstract 10
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 claims abstract 8
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 claims abstract 8
- 229960001803 cetirizine Drugs 0.000 claims abstract 8
- 229960003592 fexofenadine Drugs 0.000 claims abstract 8
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims abstract 8
- 229960003088 loratadine Drugs 0.000 claims abstract 8
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 claims abstract 8
- 229960003910 promethazine Drugs 0.000 claims abstract 8
- 229960003291 chlorphenamine Drugs 0.000 claims abstract 7
- SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 claims abstract 7
- 239000003814 drug Substances 0.000 claims abstract 6
- 239000000203 mixture Substances 0.000 claims abstract 6
- ZKLPARSLTMPFCP-OAQYLSRUSA-N 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid Chemical compound C1CN(CCOCC(=O)O)CCN1[C@@H](C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-OAQYLSRUSA-N 0.000 claims abstract 5
- 229960003790 alimemazine Drugs 0.000 claims abstract 5
- 229940079593 drug Drugs 0.000 claims abstract 5
- 229960001508 levocetirizine Drugs 0.000 claims abstract 5
- 206010011224 Cough Diseases 0.000 claims abstract 4
- IJHNSHDBIRRJRN-UHFFFAOYSA-N N,N-dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=CC=C1 IJHNSHDBIRRJRN-UHFFFAOYSA-N 0.000 claims abstract 4
- JAUOIFJMECXRGI-UHFFFAOYSA-N Neoclaritin Chemical compound C=1C(Cl)=CC=C2C=1CCC1=CC=CN=C1C2=C1CCNCC1 JAUOIFJMECXRGI-UHFFFAOYSA-N 0.000 claims abstract 4
- GXDALQBWZGODGZ-UHFFFAOYSA-N astemizole Chemical compound C1=CC(OC)=CC=C1CCN1CCC(NC=2N(C3=CC=CC=C3N=2)CC=2C=CC(F)=CC=2)CC1 GXDALQBWZGODGZ-UHFFFAOYSA-N 0.000 claims abstract 4
- 229960000725 brompheniramine Drugs 0.000 claims abstract 4
- ZDIGNSYAACHWNL-UHFFFAOYSA-N brompheniramine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Br)C=C1 ZDIGNSYAACHWNL-UHFFFAOYSA-N 0.000 claims abstract 4
- 229960002881 clemastine Drugs 0.000 claims abstract 4
- YNNUSGIPVFPVBX-NHCUHLMSSA-N clemastine Chemical compound CN1CCC[C@@H]1CCO[C@@](C)(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 YNNUSGIPVFPVBX-NHCUHLMSSA-N 0.000 claims abstract 4
- 229960001271 desloratadine Drugs 0.000 claims abstract 4
- 229960004993 dimenhydrinate Drugs 0.000 claims abstract 4
- MZDOIJOUFRQXHC-UHFFFAOYSA-N dimenhydrinate Chemical compound O=C1N(C)C(=O)N(C)C2=NC(Cl)=N[C]21.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 MZDOIJOUFRQXHC-UHFFFAOYSA-N 0.000 claims abstract 4
- 229960000520 diphenhydramine Drugs 0.000 claims abstract 4
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical group C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims abstract 4
- 229960005178 doxylamine Drugs 0.000 claims abstract 4
- HCFDWZZGGLSKEP-UHFFFAOYSA-N doxylamine Chemical compound C=1C=CC=NC=1C(C)(OCCN(C)C)C1=CC=CC=C1 HCFDWZZGGLSKEP-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 4
- 229960001190 pheniramine Drugs 0.000 claims abstract 4
- 229960004431 quetiapine Drugs 0.000 claims abstract 4
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 claims abstract 4
- 229960004559 theobromine Drugs 0.000 claims abstract 4
- 238000002560 therapeutic procedure Methods 0.000 claims abstract 4
- 229960001128 triprolidine Drugs 0.000 claims abstract 4
- CBEQULMOCCWAQT-WOJGMQOQSA-N triprolidine Chemical compound C1=CC(C)=CC=C1C(\C=1N=CC=CC=1)=C/CN1CCCC1 CBEQULMOCCWAQT-WOJGMQOQSA-N 0.000 claims abstract 4
- 229960001140 cyproheptadine Drugs 0.000 claims abstract 3
- JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 claims abstract 3
- SURLGNKAQXKNSP-DBLYXWCISA-N chlorin Chemical compound C\1=C/2\N/C(=C\C3=N/C(=C\C=4NC(/C=C\5/C=CC/1=N/5)=CC=4)/C=C3)/CC\2 SURLGNKAQXKNSP-DBLYXWCISA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- OCJYIGYOJCODJL-UHFFFAOYSA-N Meclizine Chemical compound CC1=CC=CC(CN2CCN(CC2)C(C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)=C1 OCJYIGYOJCODJL-UHFFFAOYSA-N 0.000 abstract 2
- 229960001474 meclozine Drugs 0.000 abstract 2
- 229960003792 acrivastine Drugs 0.000 abstract 1
- PWACSDKDOHSSQD-IUTFFREVSA-N acrivastine Chemical compound C1=CC(C)=CC=C1C(\C=1N=C(\C=C\C(O)=O)C=CC=1)=C/CN1CCCC1 PWACSDKDOHSSQD-IUTFFREVSA-N 0.000 abstract 1
- 229960001882 dexchlorpheniramine Drugs 0.000 abstract 1
- SOYKEARSMXGVTM-HNNXBMFYSA-N dexchlorpheniramine Chemical compound C1([C@H](CCN(C)C)C=2N=CC=CC=2)=CC=C(Cl)C=C1 SOYKEARSMXGVTM-HNNXBMFYSA-N 0.000 abstract 1
- 229960000930 hydroxyzine Drugs 0.000 abstract 1
- ZQDWXGKKHFNSQK-UHFFFAOYSA-N hydroxyzine Chemical compound C1CN(CCOCCO)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZQDWXGKKHFNSQK-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0921803.3A GB0921803D0 (en) | 2009-12-14 | 2009-12-14 | Drug composition and its use in therapy |
| GB0921803.3 | 2009-12-14 | ||
| PCT/GB2010/052086 WO2011073647A1 (en) | 2009-12-14 | 2010-12-14 | Therapeutic combinations of theobromine and an antihistamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012129675A true RU2012129675A (ru) | 2014-01-27 |
Family
ID=41667043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012129675/15A RU2012129675A (ru) | 2009-12-14 | 2010-12-14 | Терапевтические комбинации теобромина и антигистамина |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP2512472A1 (enExample) |
| JP (2) | JP2013513652A (enExample) |
| CN (1) | CN102802625A (enExample) |
| AU (1) | AU2010332495C1 (enExample) |
| BR (1) | BR112012014159A8 (enExample) |
| CA (1) | CA2784215A1 (enExample) |
| CO (1) | CO6541638A2 (enExample) |
| GB (1) | GB0921803D0 (enExample) |
| IL (1) | IL220384A0 (enExample) |
| MX (1) | MX2012006624A (enExample) |
| NZ (1) | NZ600267A (enExample) |
| PE (1) | PE20121538A1 (enExample) |
| PH (1) | PH12012501200A1 (enExample) |
| RU (1) | RU2012129675A (enExample) |
| SG (2) | SG181603A1 (enExample) |
| UA (1) | UA105827C2 (enExample) |
| WO (1) | WO2011073647A1 (enExample) |
| ZA (1) | ZA201204294B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10016437B2 (en) | 2009-06-16 | 2018-07-10 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| GB201111485D0 (en) * | 2011-07-05 | 2011-08-17 | Biocopea Ltd | Drug composition and its use in therapy |
| US9308211B2 (en) | 2009-06-16 | 2016-04-12 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| US9314465B2 (en) | 2009-06-16 | 2016-04-19 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| GB0910375D0 (en) | 2009-06-16 | 2009-07-29 | Biocopea Ltd | Drug composition and its use in therapy |
| CN103263533B (zh) * | 2013-05-31 | 2014-11-05 | 杨宏伟 | 一种治疗咳嗽的可可碱组合物及其用途及其制剂 |
| CN104188998A (zh) * | 2014-09-18 | 2014-12-10 | 中山大学 | 一种柚皮苷与盐酸非索非那丁药物组合物及其制剂 |
| CN104224819B (zh) * | 2014-09-18 | 2016-08-17 | 中山大学 | 一种柚皮苷与盐酸左西替利嗪药物组合物及其制剂 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE59550T1 (de) * | 1986-04-17 | 1991-01-15 | Alza Corp | Chlorpheniramine therapie. |
| HUP9700654A2 (hu) | 1997-03-26 | 1999-09-28 | Dezső Korbonits | Teobromin tartalmú köhögéscsillapító készítmények |
| JPH10316568A (ja) * | 1997-05-13 | 1998-12-02 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
| JP2003012514A (ja) * | 2001-07-02 | 2003-01-15 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
| JP2003128549A (ja) * | 2001-08-15 | 2003-05-08 | Rohto Pharmaceut Co Ltd | 粘膜適用組成物 |
| US20080003280A1 (en) * | 2006-06-26 | 2008-01-03 | Levine Brian M | Combination cough treatment compounds and method of treating common coughs |
| US20080254029A1 (en) * | 2007-04-11 | 2008-10-16 | Alcon Research, Ltd. | Use of an Inhibitor of TNFa Plus an Antihistamine to Treat Allergic Rhinitis and Allergic Conjunctivitis |
-
2009
- 2009-12-14 GB GBGB0921803.3A patent/GB0921803D0/en not_active Ceased
-
2010
- 2010-12-14 RU RU2012129675/15A patent/RU2012129675A/ru not_active Application Discontinuation
- 2010-12-14 UA UAA201208623A patent/UA105827C2/uk unknown
- 2010-12-14 JP JP2012543903A patent/JP2013513652A/ja active Pending
- 2010-12-14 PH PH1/2012/501200A patent/PH12012501200A1/en unknown
- 2010-12-14 MX MX2012006624A patent/MX2012006624A/es not_active Application Discontinuation
- 2010-12-14 SG SG2012042495A patent/SG181603A1/en unknown
- 2010-12-14 AU AU2010332495A patent/AU2010332495C1/en not_active Ceased
- 2010-12-14 EP EP10796123A patent/EP2512472A1/en not_active Ceased
- 2010-12-14 WO PCT/GB2010/052086 patent/WO2011073647A1/en not_active Ceased
- 2010-12-14 SG SG10201408374WA patent/SG10201408374WA/en unknown
- 2010-12-14 NZ NZ600267A patent/NZ600267A/xx not_active IP Right Cessation
- 2010-12-14 CN CN2010800570274A patent/CN102802625A/zh active Pending
- 2010-12-14 CA CA2784215A patent/CA2784215A1/en not_active Abandoned
- 2010-12-14 BR BR112012014159A patent/BR112012014159A8/pt not_active IP Right Cessation
- 2010-12-14 PE PE2012000814A patent/PE20121538A1/es not_active Application Discontinuation
-
2012
- 2012-06-12 ZA ZA2012/04294A patent/ZA201204294B/en unknown
- 2012-06-12 CO CO12098529A patent/CO6541638A2/es unknown
- 2012-06-13 IL IL220384A patent/IL220384A0/en unknown
-
2015
- 2015-09-28 JP JP2015189277A patent/JP6078605B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PE20121538A1 (es) | 2012-12-21 |
| CA2784215A1 (en) | 2011-06-23 |
| NZ600267A (en) | 2013-07-26 |
| IL220384A0 (en) | 2012-08-30 |
| WO2011073647A1 (en) | 2011-06-23 |
| SG10201408374WA (en) | 2015-01-29 |
| JP6078605B2 (ja) | 2017-02-08 |
| AU2010332495B2 (en) | 2015-01-22 |
| UA105827C2 (uk) | 2014-06-25 |
| JP2013513652A (ja) | 2013-04-22 |
| AU2010332495A1 (en) | 2012-06-21 |
| CO6541638A2 (es) | 2012-10-16 |
| JP2016040280A (ja) | 2016-03-24 |
| BR112012014159A2 (pt) | 2017-08-29 |
| EP2512472A1 (en) | 2012-10-24 |
| PH12012501200A1 (en) | 2012-11-26 |
| AU2010332495C1 (en) | 2016-02-11 |
| GB0921803D0 (en) | 2010-01-27 |
| MX2012006624A (es) | 2012-10-05 |
| BR112012014159A8 (pt) | 2017-12-26 |
| CN102802625A (zh) | 2012-11-28 |
| SG181603A1 (en) | 2012-07-30 |
| ZA201204294B (en) | 2013-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HZ9A | Changing address for correspondence with an applicant | ||
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20150915 |
|
| FZ9A | Application not withdrawn (correction of the notice of withdrawal) |
Effective date: 20160906 |