JP2013513651A - テオブロミンのうっ血除去剤との組み合わせおよび咳嗽を治療するためのその使用 - Google Patents
テオブロミンのうっ血除去剤との組み合わせおよび咳嗽を治療するためのその使用 Download PDFInfo
- Publication number
- JP2013513651A JP2013513651A JP2012543902A JP2012543902A JP2013513651A JP 2013513651 A JP2013513651 A JP 2013513651A JP 2012543902 A JP2012543902 A JP 2012543902A JP 2012543902 A JP2012543902 A JP 2012543902A JP 2013513651 A JP2013513651 A JP 2013513651A
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- JP
- Japan
- Prior art keywords
- decongestant
- theobromine
- cough
- pseudoephedrine
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
本明細書で使用されているように、「うっ血除去剤」という用語は、当業者によく知られている、定義された種類の薬物である。うっ血除去剤は、α−アドレナリン作動性受容体作動薬であることが好ましい。任意の適当な形態のうっ血除去剤を選択することができる。これらは、塩、プロドラッグ、および活性代謝産物を包含する。
覚醒モルモットにおけるクエン酸誘発咳嗽に対して、2つの異なる投与量のプソイドエフェドリンとの組み合わせにおけるテオブロミンの鎮咳活性を検討する試験を設計した。
1−ベヒクル対照
2−テオブロミン(10mg/kg.p.o.)
3−テオブロミン(10mg/kg、p.o.)+プソイドエフェドリン(10mg/kg.p.o.)
4−テオブロミン(10mg/kg、p.o.)+プソイドエフェドリン(30mg/kg.p.o.)
雄性Dunkin Hartleyモルモット(400〜500g、Harlan UK Ltdにより供給された)を、試験を通して使用した。
結果は、テオブロミン(10mg/kg、p.o.)による前治療が、クエン酸誘発咳嗽の数(13±3)(図1を参照)、ならびに最初の咳嗽までの発症時間(156±15s)(データ省略)について有意な低下を引き起こしたことを示している。プソイドエフェドリン(10mg/kgおよび30mg/kg)との組み合わせにおいて、クエン酸誘発咳嗽活性に対するテオブロミンの阻害性応答は、咳嗽の総数(9±2 c.f. 13±3)(図1)と最初の咳嗽までの発症時間(170±15s c.f.156±15s)(データ省略)の両方に関して、最高投与量で増強された。
Claims (6)
- 治療における同時使用、逐次使用、または分離使用のための組み合わせ調製物として、テオブロミンおよびうっ血除去剤を含む薬剤。
- 治療が、咳嗽の治療である、請求項1に記載の薬剤。
- テオブロミンおよびうっ血除去剤を含む医薬組成物。
- うっ血除去剤が、エフェドリン、レブメタンフェタミン、ナファゾリン、オキシメタゾリン、フェニレフリン、フェニルプロパノールアミン、プロピルヘキセドリン、プソイドエフェドリン、シネフリン、およびテトラヒドロゾリンから選択される、請求項1または2に記載の薬剤、または請求項3に記載の組成物。
- うっ血除去剤が、プソイドエフェドリンである、請求項4記載の薬剤または組成物。
- うっ血除去剤が、0.1〜30mg/kg/日の投与量で投与される、請求項1、2、4、および5のいずれか1項に記載の薬剤、または請求項3〜5のいずれか1項に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0921805.8 | 2009-12-14 | ||
GBGB0921805.8A GB0921805D0 (en) | 2009-12-14 | 2009-12-14 | Drug composition and its use in therapy |
PCT/GB2010/052085 WO2011073646A1 (en) | 2009-12-14 | 2010-12-14 | Combination of theobromine with a decongestant and its use for the treatment of cough |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015189231A Division JP2016040279A (ja) | 2009-12-14 | 2015-09-28 | テオブロミンのうっ血除去剤との組み合わせおよび咳嗽を治療するためのその使用 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013513651A true JP2013513651A (ja) | 2013-04-22 |
JP2013513651A5 JP2013513651A5 (ja) | 2014-02-06 |
Family
ID=41667045
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012543902A Pending JP2013513651A (ja) | 2009-12-14 | 2010-12-14 | テオブロミンのうっ血除去剤との組み合わせおよび咳嗽を治療するためのその使用 |
JP2015189231A Pending JP2016040279A (ja) | 2009-12-14 | 2015-09-28 | テオブロミンのうっ血除去剤との組み合わせおよび咳嗽を治療するためのその使用 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015189231A Pending JP2016040279A (ja) | 2009-12-14 | 2015-09-28 | テオブロミンのうっ血除去剤との組み合わせおよび咳嗽を治療するためのその使用 |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP2512464A1 (ja) |
JP (2) | JP2013513651A (ja) |
CN (2) | CN102740843A (ja) |
AU (1) | AU2010332494B2 (ja) |
BR (1) | BR112012014161A2 (ja) |
CA (1) | CA2784214C (ja) |
CO (1) | CO6541630A2 (ja) |
EC (1) | ECSP12012132A (ja) |
GB (1) | GB0921805D0 (ja) |
IL (1) | IL220383A (ja) |
MX (1) | MX343222B (ja) |
NZ (1) | NZ600243A (ja) |
PE (1) | PE20121537A1 (ja) |
RU (1) | RU2564904C2 (ja) |
SG (2) | SG181686A1 (ja) |
UA (1) | UA105944C2 (ja) |
WO (1) | WO2011073646A1 (ja) |
ZA (1) | ZA201204293B (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201111485D0 (en) * | 2011-07-05 | 2011-08-17 | Biocopea Ltd | Drug composition and its use in therapy |
US9314465B2 (en) | 2009-06-16 | 2016-04-19 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
GB0910375D0 (en) | 2009-06-16 | 2009-07-29 | Biocopea Ltd | Drug composition and its use in therapy |
US9308211B2 (en) | 2009-06-16 | 2016-04-12 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
US10016437B2 (en) | 2009-06-16 | 2018-07-10 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003321357A (ja) * | 2002-05-02 | 2003-11-11 | Rohto Pharmaceut Co Ltd | 内服用組成物 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09502201A (ja) * | 1993-09-07 | 1997-03-04 | ザ、プロクター、エンド、ギャンブル、カンパニー | プロピオン酸非ステロイド系抗炎症剤のアミノ酸塩とうっ血除去剤、去痰剤、抗ヒスタミン剤及び鎮咳剤のうち少くとも1種を含有した組成物 |
HUP9700654A2 (hu) * | 1997-03-26 | 1999-09-28 | Dezső Korbonits | Teobromin tartalmú köhögéscsillapító készítmények |
US6417206B1 (en) * | 2001-01-26 | 2002-07-09 | Medpointe Healthcare Inc. | Antitussive/antihist aminic/decongestant compositions |
JP2002308761A (ja) * | 2001-04-09 | 2002-10-23 | Taisho Pharmaceut Co Ltd | 風邪用咳止め薬 |
JP2003128549A (ja) * | 2001-08-15 | 2003-05-08 | Rohto Pharmaceut Co Ltd | 粘膜適用組成物 |
RU2311919C2 (ru) * | 2002-12-30 | 2007-12-10 | Каунсел Оф Сайнтифик Энд Индастриал Рисерч | Разработка противокашлевой и смягчающей горло травяной композиции |
US20040202677A1 (en) * | 2003-04-10 | 2004-10-14 | Hopkins Kevin J. | Method of enhanced regional body fat reduction |
US20060153926A1 (en) * | 2005-01-10 | 2006-07-13 | Bascom Charles C | Compositions, products and methods for controlling weight in a mammal |
US20080003280A1 (en) * | 2006-06-26 | 2008-01-03 | Levine Brian M | Combination cough treatment compounds and method of treating common coughs |
KR20080009994A (ko) * | 2006-07-25 | 2008-01-30 | 안국약품 주식회사 | 기침 치료용 조성물 |
CN100518775C (zh) * | 2007-03-16 | 2009-07-29 | 邓丽菊 | 一种治疗咳喘的药物组合物及其制剂 |
-
2009
- 2009-12-14 GB GBGB0921805.8A patent/GB0921805D0/en not_active Ceased
-
2010
- 2010-12-14 SG SG2012043642A patent/SG181686A1/en unknown
- 2010-12-14 SG SG10201408377QA patent/SG10201408377QA/en unknown
- 2010-12-14 BR BR112012014161A patent/BR112012014161A2/pt not_active IP Right Cessation
- 2010-12-14 NZ NZ600243A patent/NZ600243A/xx not_active IP Right Cessation
- 2010-12-14 CA CA2784214A patent/CA2784214C/en not_active Expired - Fee Related
- 2010-12-14 AU AU2010332494A patent/AU2010332494B2/en not_active Ceased
- 2010-12-14 EP EP10795446A patent/EP2512464A1/en not_active Ceased
- 2010-12-14 WO PCT/GB2010/052085 patent/WO2011073646A1/en active Application Filing
- 2010-12-14 RU RU2012129839/15A patent/RU2564904C2/ru not_active IP Right Cessation
- 2010-12-14 JP JP2012543902A patent/JP2013513651A/ja active Pending
- 2010-12-14 CN CN2010800570306A patent/CN102740843A/zh active Pending
- 2010-12-14 PE PE2012000813A patent/PE20121537A1/es not_active Application Discontinuation
- 2010-12-14 CN CN201610214436.XA patent/CN105816462A/zh active Pending
- 2010-12-14 MX MX2012006625A patent/MX343222B/es active IP Right Grant
- 2010-12-14 UA UAA201208706A patent/UA105944C2/uk unknown
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2012
- 2012-06-12 EC ECSP12012132 patent/ECSP12012132A/es unknown
- 2012-06-12 CO CO12098537A patent/CO6541630A2/es unknown
- 2012-06-12 ZA ZA2012/04293A patent/ZA201204293B/en unknown
- 2012-06-13 IL IL220383A patent/IL220383A/en not_active IP Right Cessation
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2015
- 2015-09-28 JP JP2015189231A patent/JP2016040279A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003321357A (ja) * | 2002-05-02 | 2003-11-11 | Rohto Pharmaceut Co Ltd | 内服用組成物 |
Non-Patent Citations (3)
Title |
---|
JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. Vol.102,pp.136−142, JPN6014045423, 2006, ISSN: 0002927568 * |
THE FASEB JOURNAL, vol. doi: 10.1096/fj.04-1990fje, JPN6014045421, 2004, ISSN: 0002927567 * |
WANGEMANN G.: "CLINICAL EXPERIENCE WITH DYSPNOCEDY AN ANTI-ASTHMA DRUG", ARZTLICHE WOCHENSCHRIFT 1950, vol. V5 N17, JPN5013001469, 1950, pages 272 - 273, ISSN: 0002927566 * |
Also Published As
Publication number | Publication date |
---|---|
PE20121537A1 (es) | 2012-12-21 |
ECSP12012132A (es) | 2012-09-28 |
AU2010332494A1 (en) | 2012-06-14 |
UA105944C2 (uk) | 2014-07-10 |
GB0921805D0 (en) | 2010-01-27 |
CO6541630A2 (es) | 2012-10-16 |
CA2784214C (en) | 2018-01-09 |
WO2011073646A1 (en) | 2011-06-23 |
IL220383A0 (en) | 2012-08-30 |
CN105816462A (zh) | 2016-08-03 |
MX2012006625A (es) | 2012-10-05 |
MX343222B (es) | 2016-10-28 |
BR112012014161A2 (pt) | 2016-05-17 |
EP2512464A1 (en) | 2012-10-24 |
RU2012129839A (ru) | 2014-01-27 |
ZA201204293B (en) | 2013-02-27 |
AU2010332494B2 (en) | 2015-01-15 |
NZ600243A (en) | 2013-07-26 |
IL220383A (en) | 2017-01-31 |
CN102740843A (zh) | 2012-10-17 |
JP2016040279A (ja) | 2016-03-24 |
CA2784214A1 (en) | 2011-06-23 |
SG181686A1 (en) | 2012-07-30 |
SG10201408377QA (en) | 2015-02-27 |
RU2564904C2 (ru) | 2015-10-10 |
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