JP2013513619A5 - - Google Patents
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- Publication number
- JP2013513619A5 JP2013513619A5 JP2012543317A JP2012543317A JP2013513619A5 JP 2013513619 A5 JP2013513619 A5 JP 2013513619A5 JP 2012543317 A JP2012543317 A JP 2012543317A JP 2012543317 A JP2012543317 A JP 2012543317A JP 2013513619 A5 JP2013513619 A5 JP 2013513619A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- heterocycloalkyl
- alkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 125000001072 heteroaryl group Chemical group 0.000 claims 24
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 20
- 125000000753 cycloalkyl group Chemical group 0.000 claims 20
- 125000004404 heteroalkyl group Chemical group 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000007082 Aβ accumulation Effects 0.000 claims 2
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 102000029797 Prion Human genes 0.000 claims 1
- 108091000054 Prion Proteins 0.000 claims 1
- 102000019197 Superoxide Dismutase Human genes 0.000 claims 1
- 108010012715 Superoxide dismutase Proteins 0.000 claims 1
- 206010044688 Trisomy 21 Diseases 0.000 claims 1
- 102000003802 alpha-Synuclein Human genes 0.000 claims 1
- 108090000185 alpha-Synuclein Proteins 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000004957 naphthylene group Chemical group 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 125000005936 piperidyl group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- NRZNTGUFHSJBTD-HKOYGPOVSA-N COCCOCCOCCOC(/C(/C#N)=C/c1ccc(cc(cc2)N3CCCCC3)c2c1)=O Chemical compound COCCOCCOCCOC(/C(/C#N)=C/c1ccc(cc(cc2)N3CCCCC3)c2c1)=O NRZNTGUFHSJBTD-HKOYGPOVSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28547009P | 2009-12-10 | 2009-12-10 | |
| US61/285,470 | 2009-12-10 | ||
| PCT/US2010/059952 WO2011072257A2 (en) | 2009-12-10 | 2010-12-10 | Amyloid binding agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013513619A JP2013513619A (ja) | 2013-04-22 |
| JP2013513619A5 true JP2013513619A5 (enExample) | 2013-08-29 |
| JP5591946B2 JP5591946B2 (ja) | 2014-09-17 |
Family
ID=44146211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543317A Active JP5591946B2 (ja) | 2009-12-10 | 2010-12-10 | アミロイド結合剤 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US8940918B2 (enExample) |
| EP (1) | EP2509940B1 (enExample) |
| JP (1) | JP5591946B2 (enExample) |
| KR (3) | KR102079160B1 (enExample) |
| CN (2) | CN103201258B (enExample) |
| AU (1) | AU2010327918B2 (enExample) |
| BR (1) | BR112012013810B1 (enExample) |
| CA (1) | CA2783466C (enExample) |
| CY (1) | CY1116487T1 (enExample) |
| DK (1) | DK2509940T3 (enExample) |
| ES (1) | ES2546063T3 (enExample) |
| HR (1) | HRP20150854T1 (enExample) |
| HU (1) | HUE027199T2 (enExample) |
| IN (1) | IN2012DN05186A (enExample) |
| ME (1) | ME02194B (enExample) |
| MX (1) | MX347591B (enExample) |
| NZ (1) | NZ600459A (enExample) |
| PL (1) | PL2509940T3 (enExample) |
| PT (1) | PT2509940E (enExample) |
| RS (1) | RS54158B1 (enExample) |
| RU (1) | RU2517174C2 (enExample) |
| SG (1) | SG181561A1 (enExample) |
| SI (1) | SI2509940T1 (enExample) |
| SM (1) | SMT201500216B (enExample) |
| WO (1) | WO2011072257A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013180815A1 (en) * | 2012-05-30 | 2013-12-05 | University Of Tennessee Research Foundation | Compounds for amide-forming reactions |
| US9588129B2 (en) | 2013-03-15 | 2017-03-07 | Amira Medical Technologies Inc. | Methods for analyzing blood to detect diseases associated with abnormal protein aggregation |
| AR098232A1 (es) | 2013-10-31 | 2016-05-18 | Cognoptix Inc | Métodos de preparación de una formulación oftálmica y usos de la misma |
| EP3068283A1 (en) * | 2013-11-12 | 2016-09-21 | Cognoptix, Inc. | Method for measuring fluorescence in ocular tissue |
| WO2015143185A1 (en) * | 2014-03-19 | 2015-09-24 | Amydis Diagnostics | Amyloid targeting agents and methods of using the same |
| CA2960723A1 (en) * | 2014-09-12 | 2016-03-17 | Amydis Diagnostics, Inc. | In vitro compositions comprising human sample and amyloid targeting agent |
| WO2018208709A1 (en) | 2017-05-09 | 2018-11-15 | Warner Babcock Institute For Green Chemistry, Llc | Stilbene derivatives for the treatment of cns and other disorders |
| WO2019232422A1 (en) * | 2018-05-31 | 2019-12-05 | Amydis, Inc. | Compositions and methods for detection of traumatic brain injury |
| JP7465264B2 (ja) * | 2018-11-02 | 2024-04-10 | アミディス， インコーポレイテッド | 神経障害を検出するためのリン酸化合物 |
| KR102240400B1 (ko) | 2020-11-19 | 2021-04-15 | 한국원자력연구원 | 베타-아밀로이드 검출용 수용성 화합물 |
| MX2023010666A (es) * | 2021-03-12 | 2023-10-30 | Amydis Inc | Métodos para detectar la amiloidosis sistémica por medio de unión a proteína mal plegada o agregada. |
| CN115322165A (zh) * | 2022-09-30 | 2022-11-11 | 镇江百单医疗生物科技有限公司 | 近红外荧光探针成像肝纤维化中亚铁离子的动态波动 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2583614A (en) * | 1950-05-13 | 1952-01-29 | Eastman Kodak Co | Acylated methine dye compounds |
| US2798090A (en) * | 1953-03-02 | 1957-07-02 | Eastman Kodak Co | Process for preparing benzalaniline-3-sulfonic acid compounds |
| US3074971A (en) * | 1959-01-23 | 1963-01-22 | Gen Aniline & Film Corp | alpha-cyanocinnamic acid esters |
| US3149146A (en) * | 1960-03-09 | 1964-09-15 | Gen Aniline & Film Corp | Alpha-cyano-2-alkenoxy-1-naphthaleneacrylic acid esters |
| FR1321641A (fr) | 1962-03-08 | 1963-03-22 | Gen Aniline & Film Corp | Nouvelles compositions absorbantes de rayons ultraviolets |
| BE794010A (fr) * | 1972-01-13 | 1973-05-02 | Du Pont | Colorants cationiques de couleur jaune-vert |
| DE2714653C3 (de) | 1977-04-01 | 1980-10-30 | Bayer Ag, 5090 Leverkusen | Kationische Styrylfarbstoffe und Verfahren zum Färben mit diesen Farbstoffen |
| DE2942185A1 (de) * | 1979-10-18 | 1981-04-30 | Basf Ag, 6700 Ludwigshafen | Basische farbstoffe |
| JPS5815912A (ja) * | 1981-07-22 | 1983-01-29 | Ss Pharmaceut Co Ltd | 消炎鎮痛剤 |
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| JPS63163826A (ja) * | 1986-12-26 | 1988-07-07 | Idemitsu Kosan Co Ltd | 有機非線型光学材料 |
| DE3905916A1 (de) * | 1989-02-25 | 1990-08-30 | Basf Ag | Verwendung von derivaten des n-phenyl-3,4,5,6-tetrahydrophthalimids zur desikkation und abszission von pflanzenorganen |
| DK0495421T3 (da) | 1991-01-15 | 1996-12-09 | Alcon Lab Inc | Anvendelse af carragenaner i topiske ophthalmiske sammensætninger |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| DE4430691A1 (de) * | 1994-08-30 | 1996-03-07 | Bayer Ag | Elektrolumineszierende Anordnungen und deren Verwendung |
| ATE507203T1 (de) * | 2002-01-18 | 2011-05-15 | Hospital For Sick Children | Verbindungen für die modulation der proliferation von zellen |
| GB0228410D0 (en) * | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
| MXPA05009434A (es) * | 2003-03-05 | 2005-11-23 | Celgene Corp | Compuestos de difeniletileno y usos de los mismos. |
| US7517695B2 (en) * | 2004-01-20 | 2009-04-14 | The Curators Of The University Of Missouri | Local flow and shear stress sensor based on molecular rotors |
| WO2005092904A1 (en) * | 2004-03-26 | 2005-10-06 | Hsc Research And Development Limited Partnership | Novel compounds for modulating cell proliferation |
| AU2005310979A1 (en) * | 2004-11-16 | 2006-06-08 | Bellus Health (International) Limited | Compounds for the treatment of CNS and amyloid associated diseases |
| WO2007011834A2 (en) | 2005-07-15 | 2007-01-25 | The Regents Of The University Of California | Compounds and method for the diagnosis and treatment of amyloid associated diseases |
| ES2759627T3 (es) | 2006-07-31 | 2020-05-11 | Basf Se | Procedimiento integrado consistente en la hidrogenación con catalizadores de rutenio y regeneración de los mismos |
| FR2905009A1 (fr) * | 2006-08-18 | 2008-02-22 | Servier Lab | Methode de criblage de composes aux proprietes anti-amyloide |
| CN101209976B (zh) * | 2006-12-29 | 2012-01-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 取代的酒石酸衍生物及其用于制备β-分泌酶抑制剂的用途 |
| WO2009052837A2 (en) * | 2007-10-24 | 2009-04-30 | Tallinn University Of Technology | Maldi ms-based high-throughput screening method for substances inhibiting aggregation of alzheimer's amyloid beta peptides |
-
2010
- 2010-12-10 AU AU2010327918A patent/AU2010327918B2/en active Active
- 2010-12-10 ME MEP-2015-118A patent/ME02194B/me unknown
- 2010-12-10 KR KR1020197027350A patent/KR102079160B1/ko active Active
- 2010-12-10 IN IN5186DEN2012 patent/IN2012DN05186A/en unknown
- 2010-12-10 KR KR1020127017823A patent/KR101849680B1/ko active Active
- 2010-12-10 EP EP10836776.4A patent/EP2509940B1/en active Active
- 2010-12-10 CN CN201080062250.8A patent/CN103201258B/zh active Active
- 2010-12-10 PT PT108367764T patent/PT2509940E/pt unknown
- 2010-12-10 SI SI201030996T patent/SI2509940T1/sl unknown
- 2010-12-10 SG SG2012041919A patent/SG181561A1/en unknown
- 2010-12-10 PL PL10836776T patent/PL2509940T3/pl unknown
- 2010-12-10 HR HRP20150854TT patent/HRP20150854T1/hr unknown
- 2010-12-10 DK DK10836776.4T patent/DK2509940T3/en active
- 2010-12-10 CN CN201511023642.4A patent/CN105669597B/zh active Active
- 2010-12-10 US US13/515,239 patent/US8940918B2/en active Active
- 2010-12-10 WO PCT/US2010/059952 patent/WO2011072257A2/en not_active Ceased
- 2010-12-10 CA CA2783466A patent/CA2783466C/en active Active
- 2010-12-10 JP JP2012543317A patent/JP5591946B2/ja active Active
- 2010-12-10 BR BR112012013810-3A patent/BR112012013810B1/pt active IP Right Grant
- 2010-12-10 KR KR1020187010217A patent/KR20180041767A/ko not_active Ceased
- 2010-12-10 ES ES10836776.4T patent/ES2546063T3/es active Active
- 2010-12-10 RS RS20150537A patent/RS54158B1/sr unknown
- 2010-12-10 MX MX2012006552A patent/MX347591B/es active IP Right Grant
- 2010-12-10 NZ NZ600459A patent/NZ600459A/en unknown
- 2010-12-10 RU RU2012128798/04A patent/RU2517174C2/ru active
- 2010-12-10 HU HUE10836776A patent/HUE027199T2/en unknown
-
2014
- 2014-12-16 US US14/572,465 patent/US9551722B2/en active Active
-
2015
- 2015-07-13 CY CY20151100606T patent/CY1116487T1/el unknown
- 2015-09-14 SM SM201500216T patent/SMT201500216B/xx unknown
-
2016
- 2016-12-09 US US15/375,006 patent/US20170315137A1/en not_active Abandoned
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