JP2013513135A5 - - Google Patents
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- Publication number
- JP2013513135A5 JP2013513135A5 JP2012543176A JP2012543176A JP2013513135A5 JP 2013513135 A5 JP2013513135 A5 JP 2013513135A5 JP 2012543176 A JP2012543176 A JP 2012543176A JP 2012543176 A JP2012543176 A JP 2012543176A JP 2013513135 A5 JP2013513135 A5 JP 2013513135A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrophilic polymer
- oxazolin
- contact lens
- layer
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 claims description 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 2
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 125000002947 alkylene group Chemical group 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 229920001477 hydrophilic polymer Polymers 0.000 claims 21
- 238000000034 method Methods 0.000 claims 16
- 239000011248 coating agent Substances 0.000 claims 15
- 238000000576 coating method Methods 0.000 claims 15
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 11
- 239000000178 monomer Substances 0.000 claims 9
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 9
- 229920002554 vinyl polymer Polymers 0.000 claims 9
- HONIICLYMWZJFZ-UHFFFAOYSA-O azetidin-1-ium Chemical compound C1C[NH2+]C1 HONIICLYMWZJFZ-UHFFFAOYSA-O 0.000 claims 7
- IEJPPSMHUUQABK-UHFFFAOYSA-N 2,4-diphenyl-4h-1,3-oxazol-5-one Chemical compound O=C1OC(C=2C=CC=CC=2)=NC1C1=CC=CC=C1 IEJPPSMHUUQABK-UHFFFAOYSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 229920001296 polysiloxane Polymers 0.000 claims 6
- 239000000017 hydrogel Substances 0.000 claims 5
- 229920002518 Polyallylamine hydrochloride Polymers 0.000 claims 4
- 229920001519 homopolymer Polymers 0.000 claims 4
- 229920001577 copolymer Polymers 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- DQRFCVHLNUNVPL-UHFFFAOYSA-N 2h-1,3-oxazol-5-one Chemical compound O=C1OCN=C1 DQRFCVHLNUNVPL-UHFFFAOYSA-N 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
- 229920002873 Polyethylenimine Polymers 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- -1 hyaluronic acid aldehyde Chemical class 0.000 claims 2
- 239000004584 polyacrylic acid Substances 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- FPPNONHSLAHRLW-UHFFFAOYSA-N 2-ethenyl-4,4-diethyl-1,3-oxazol-5-one Chemical compound CCC1(CC)N=C(C=C)OC1=O FPPNONHSLAHRLW-UHFFFAOYSA-N 0.000 claims 1
- QKPKBBFSFQAMIY-UHFFFAOYSA-N 2-ethenyl-4,4-dimethyl-1,3-oxazol-5-one Chemical group CC1(C)N=C(C=C)OC1=O QKPKBBFSFQAMIY-UHFFFAOYSA-N 0.000 claims 1
- DMDNNZDDQOLFPX-UHFFFAOYSA-N 2-ethenyl-4-ethyl-4-methyl-1,3-oxazol-5-one Chemical compound CCC1(C)N=C(C=C)OC1=O DMDNNZDDQOLFPX-UHFFFAOYSA-N 0.000 claims 1
- SQZSACNFCGPRRH-UHFFFAOYSA-N 2-ethenyl-4-methyl-4-nonyl-1,3-oxazol-5-one Chemical compound CCCCCCCCCC1(C)N=C(C=C)OC1=O SQZSACNFCGPRRH-UHFFFAOYSA-N 0.000 claims 1
- HQGFOVSJARUBLL-UHFFFAOYSA-N 4,4-dibutyl-2-ethenyl-1,3-oxazol-5-one Chemical compound CCCCC1(CCCC)N=C(C=C)OC1=O HQGFOVSJARUBLL-UHFFFAOYSA-N 0.000 claims 1
- MUWZQYSJSCDUDT-UHFFFAOYSA-N 4,4-dimethyl-2-prop-1-en-2-yl-1,3-oxazol-5-one Chemical compound CC(=C)C1=NC(C)(C)C(=O)O1 MUWZQYSJSCDUDT-UHFFFAOYSA-N 0.000 claims 1
- HIPFXTMAGCIYHP-UHFFFAOYSA-N 4,4-diphenyl-2-prop-1-en-2-yl-1,3-oxazol-5-one Chemical compound O=C1OC(C(=C)C)=NC1(C=1C=CC=CC=1)C1=CC=CC=C1 HIPFXTMAGCIYHP-UHFFFAOYSA-N 0.000 claims 1
- PAWWCZYDPHQUEE-UHFFFAOYSA-N 4-benzyl-4-methyl-2-prop-1-en-2-yl-1,3-oxazol-5-one Chemical compound O=C1OC(C(=C)C)=NC1(C)CC1=CC=CC=C1 PAWWCZYDPHQUEE-UHFFFAOYSA-N 0.000 claims 1
- LEPHQAPDYFHROC-UHFFFAOYSA-N 4-butyl-4-methyl-2-prop-1-en-2-yl-1,3-oxazol-5-one Chemical compound CCCCC1(C)N=C(C(C)=C)OC1=O LEPHQAPDYFHROC-UHFFFAOYSA-N 0.000 claims 1
- BIJRDVLWMJIKTR-UHFFFAOYSA-N 4-dodecyl-4-methyl-2-prop-1-en-2-yl-1,3-oxazol-5-one Chemical compound CCCCCCCCCCCCC1(C)N=C(C(C)=C)OC1=O BIJRDVLWMJIKTR-UHFFFAOYSA-N 0.000 claims 1
- URDUKROSCCHPQL-UHFFFAOYSA-N 4-methyl-4-phenyl-2-prop-1-en-2-yl-1,3-oxazol-5-one Chemical compound O=C1OC(C(=C)C)=NC1(C)C1=CC=CC=C1 URDUKROSCCHPQL-UHFFFAOYSA-N 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Natural products OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000003926 acrylamides Chemical class 0.000 claims 1
- 125000003172 aldehyde group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26746909P | 2009-12-08 | 2009-12-08 | |
| US61/267,469 | 2009-12-08 | ||
| PCT/US2010/059022 WO2011071791A1 (en) | 2009-12-08 | 2010-12-06 | A silicone hydrogel lens with a covalently attached coating |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013513135A JP2013513135A (ja) | 2013-04-18 |
| JP2013513135A5 true JP2013513135A5 (https=) | 2015-03-05 |
| JP5877793B2 JP5877793B2 (ja) | 2016-03-08 |
Family
ID=44081708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543176A Active JP5877793B2 (ja) | 2009-12-08 | 2010-12-06 | 共有結合コーティングを有するシリコーンハイドロゲルレンズ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8557334B2 (https=) |
| EP (1) | EP2510052B1 (https=) |
| JP (1) | JP5877793B2 (https=) |
| CA (1) | CA2777961C (https=) |
| TW (1) | TWI483996B (https=) |
| WO (1) | WO2011071791A1 (https=) |
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| US9170349B2 (en) | 2011-05-04 | 2015-10-27 | Johnson & Johnson Vision Care, Inc. | Medical devices having homogeneous charge density and methods for making same |
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-
2010
- 2010-11-15 TW TW099139240A patent/TWI483996B/zh active
- 2010-12-06 JP JP2012543176A patent/JP5877793B2/ja active Active
- 2010-12-06 EP EP10836462.1A patent/EP2510052B1/en active Active
- 2010-12-06 US US12/960,617 patent/US8557334B2/en active Active
- 2010-12-06 CA CA2777961A patent/CA2777961C/en active Active
- 2010-12-06 WO PCT/US2010/059022 patent/WO2011071791A1/en not_active Ceased
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