JP2013512877A5 - - Google Patents
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- JP2013512877A5 JP2013512877A5 JP2012541498A JP2012541498A JP2013512877A5 JP 2013512877 A5 JP2013512877 A5 JP 2013512877A5 JP 2012541498 A JP2012541498 A JP 2012541498A JP 2012541498 A JP2012541498 A JP 2012541498A JP 2013512877 A5 JP2013512877 A5 JP 2013512877A5
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- pharmaceutical composition
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- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 210000000130 stem cell Anatomy 0.000 claims 13
- 238000004519 manufacturing process Methods 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 11
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 8
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 8
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 7
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- 102000019034 Chemokines Human genes 0.000 claims 6
- 108010012236 Chemokines Proteins 0.000 claims 6
- 229920000728 polyester Polymers 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000000021 stimulant Substances 0.000 claims 5
- 239000011164 primary particle Substances 0.000 claims 4
- LKBSMPFEKIBRGC-UHFFFAOYSA-N 2-[[2-(4-methoxyanilino)-4-pyrimidinyl]amino]ethanol Chemical compound C1=CC(OC)=CC=C1NC1=NC=CC(NCCO)=N1 LKBSMPFEKIBRGC-UHFFFAOYSA-N 0.000 claims 3
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 3
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- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
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- 239000004632 polycaprolactone Substances 0.000 claims 2
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 claims 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
- BWRRWBIBNBVHQF-UHFFFAOYSA-N 4-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)butanoic acid Chemical compound O1C(CCCC(=O)O)=NC(C=2N=CC=CC=2)=N1 BWRRWBIBNBVHQF-UHFFFAOYSA-N 0.000 claims 1
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- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 1
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- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 1
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- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2009066251 | 2009-12-02 | ||
| EPPCT/EP2009/066251 | 2009-12-02 | ||
| PCT/EP2010/068700 WO2011067317A1 (en) | 2009-12-02 | 2010-12-02 | Pharmaceutical compositions for the stimulation of stem cells. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013512877A JP2013512877A (ja) | 2013-04-18 |
| JP2013512877A5 true JP2013512877A5 (https=) | 2014-02-13 |
Family
ID=42316097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012541498A Withdrawn JP2013512877A (ja) | 2009-12-02 | 2010-12-02 | 幹細胞の刺激のための医薬組成物 |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JP2013512877A (https=) |
| KR (1) | KR20120099751A (https=) |
| CN (1) | CN102711798A (https=) |
| AU (1) | AU2010326633A1 (https=) |
| BR (1) | BR112012013164A2 (https=) |
| CA (1) | CA2781493A1 (https=) |
| IL (1) | IL219901A0 (https=) |
| MX (1) | MX2012005976A (https=) |
| NZ (1) | NZ599930A (https=) |
| RU (1) | RU2012120834A (https=) |
| TW (1) | TW201141510A (https=) |
| WO (1) | WO2011067317A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6538081B2 (ja) * | 2014-07-07 | 2019-07-03 | メディポスト カンパニー リミテッド | 刺激を受けた幹細胞の馴化培地の発毛促進能およびそれらの使用 |
| CN105079791A (zh) * | 2015-09-18 | 2015-11-25 | 郑榆坤 | 一种刺激体内内源干细胞的组合物及其应用 |
| RU2634576C1 (ru) * | 2016-10-24 | 2017-10-31 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) | Способ стимуляции регенерации тканей |
| CN107050428B (zh) * | 2017-03-23 | 2020-05-05 | 温州医科大学 | Fgf20药物及其对脑创伤的治疗应用 |
| CN107648592B (zh) * | 2017-11-13 | 2021-05-14 | 深圳市喆邦生物工程有限公司 | 趋化因子ccl4作为制备治疗骨折药物的应用 |
| RU2686718C1 (ru) * | 2018-03-12 | 2019-04-30 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) | Средство, стимулирующее функции мезенхимальных клеток-предшественников in vitro |
| KR102106710B1 (ko) | 2018-10-11 | 2020-05-04 | 강원대학교산학협력단 | 인간 전분화능 줄기세포로부터 조혈모세포 및 대식세포 분화 증진 방법 |
| CN111195350A (zh) * | 2020-01-15 | 2020-05-26 | 重庆大学 | IGF1和IGF1Ec24联合在制备促进组织修复与再生的药物中的应用 |
| WO2021187895A1 (ko) * | 2020-03-17 | 2021-09-23 | 주식회사 히에라바이오 | 심장줄기세포를 포함하는 허혈성 질환의 예방 또는 치료용 조성물 |
| CN111621525B (zh) * | 2020-06-18 | 2021-04-23 | 中赛干细胞基因工程有限公司 | Stx1b基因在促进人脂肪间充质干细胞生长和分化中的用途 |
| KR20240131080A (ko) * | 2023-02-23 | 2024-08-30 | 서울대학교산학협력단 | 배외내배엽 줄기세포의 배양용 배지 조성물 |
| CN116836920B (zh) * | 2023-08-21 | 2024-05-24 | 广东横琴粤澳深度合作区齐美国际干细胞医院有限公司 | 一种无血清培养基及其制备间充质干细胞的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1786471B1 (en) * | 2004-07-30 | 2015-02-11 | Mayo Foundation For Medical Education And Research | Treating cardiovascular tissue |
| WO2006081190A2 (en) * | 2005-01-25 | 2006-08-03 | Five Prime Therapeutics, Inc. | Compositions and methods for treating cardiac conditions |
| US9765298B2 (en) * | 2006-07-24 | 2017-09-19 | Mayo Foundation For Medical Education And Research | Methods and materials for providing cardiac cells |
| US8481075B2 (en) * | 2007-12-13 | 2013-07-09 | Beijing Shengyiyao Science & Technology Development Co. Ltd. | Preparation and application of biodegradable-material-made microsphere vascular embolus containing liposome-encapsulated cytokines |
-
2010
- 2010-12-02 NZ NZ599930A patent/NZ599930A/en not_active IP Right Cessation
- 2010-12-02 RU RU2012120834/15A patent/RU2012120834A/ru not_active Application Discontinuation
- 2010-12-02 WO PCT/EP2010/068700 patent/WO2011067317A1/en not_active Ceased
- 2010-12-02 AU AU2010326633A patent/AU2010326633A1/en not_active Abandoned
- 2010-12-02 KR KR1020127017238A patent/KR20120099751A/ko not_active Withdrawn
- 2010-12-02 TW TW099141986A patent/TW201141510A/zh unknown
- 2010-12-02 JP JP2012541498A patent/JP2013512877A/ja not_active Withdrawn
- 2010-12-02 BR BR112012013164A patent/BR112012013164A2/pt not_active IP Right Cessation
- 2010-12-02 CN CN201080053800XA patent/CN102711798A/zh active Pending
- 2010-12-02 CA CA2781493A patent/CA2781493A1/en not_active Abandoned
- 2010-12-02 MX MX2012005976A patent/MX2012005976A/es unknown
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2012
- 2012-05-20 IL IL219901A patent/IL219901A0/en unknown
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