JP2011529946A5 - - Google Patents
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- JP2011529946A5 JP2011529946A5 JP2011521575A JP2011521575A JP2011529946A5 JP 2011529946 A5 JP2011529946 A5 JP 2011529946A5 JP 2011521575 A JP2011521575 A JP 2011521575A JP 2011521575 A JP2011521575 A JP 2011521575A JP 2011529946 A5 JP2011529946 A5 JP 2011529946A5
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- Prior art keywords
- particles
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- growth factor
- pharmaceutical preparation
- Prior art date
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- 239000002245 particle Substances 0.000 claims 19
- 239000004480 active ingredient Substances 0.000 claims 11
- 239000000825 pharmaceutical preparation Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 7
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 6
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 5
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 4
- 210000005003 heart tissue Anatomy 0.000 claims 4
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 3
- 102000014429 Insulin-like growth factor Human genes 0.000 claims 3
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 208000010125 myocardial infarction Diseases 0.000 claims 3
- 230000008929 regeneration Effects 0.000 claims 3
- 238000011069 regeneration method Methods 0.000 claims 3
- 102100037597 Brain-derived neurotrophic factor Human genes 0.000 claims 2
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims 2
- 108010008951 Chemokine CXCL12 Proteins 0.000 claims 2
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 2
- 101800003838 Epidermal growth factor Proteins 0.000 claims 2
- 102000003951 Erythropoietin Human genes 0.000 claims 2
- 108090000394 Erythropoietin Proteins 0.000 claims 2
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 2
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 2
- 102000004858 Growth differentiation factor-9 Human genes 0.000 claims 2
- 108090001086 Growth differentiation factor-9 Proteins 0.000 claims 2
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims 2
- 108010056852 Myostatin Proteins 0.000 claims 2
- 102000015336 Nerve Growth Factor Human genes 0.000 claims 2
- 108090000742 Neurotrophin 3 Proteins 0.000 claims 2
- 102100029268 Neurotrophin-3 Human genes 0.000 claims 2
- 102000003683 Neurotrophin-4 Human genes 0.000 claims 2
- 108090000099 Neurotrophin-4 Proteins 0.000 claims 2
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims 2
- 102000036693 Thrombopoietin Human genes 0.000 claims 2
- 108010041111 Thrombopoietin Proteins 0.000 claims 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 claims 2
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 229940116977 epidermal growth factor Drugs 0.000 claims 2
- 229940105423 erythropoietin Drugs 0.000 claims 2
- 229940126864 fibroblast growth factor Drugs 0.000 claims 2
- 210000003714 granulocyte Anatomy 0.000 claims 2
- 229940053128 nerve growth factor Drugs 0.000 claims 2
- 229940032018 neurotrophin 3 Drugs 0.000 claims 2
- 229940097998 neurotrophin 4 Drugs 0.000 claims 2
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 1
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 1
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 1
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 1
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 claims 1
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102000007072 Nerve Growth Factors Human genes 0.000 claims 1
- 101710111489 Neurotrophin 1 Proteins 0.000 claims 1
- 102100037765 Periostin Human genes 0.000 claims 1
- 101710199268 Periostin Proteins 0.000 claims 1
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 1
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 108010023082 activin A Proteins 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 229940112869 bone morphogenetic protein Drugs 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 238000001361 intraarterial administration Methods 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 239000004632 polycaprolactone Substances 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000012798 spherical particle Substances 0.000 claims 1
- 230000001839 systemic circulation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0814302.6 | 2008-08-05 | ||
| GBGB0814302.6A GB0814302D0 (en) | 2008-08-05 | 2008-08-05 | Compounds and methods |
| PCT/EP2009/060171 WO2010015665A2 (en) | 2008-08-05 | 2009-08-05 | Compounds and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011529946A JP2011529946A (ja) | 2011-12-15 |
| JP2011529946A5 true JP2011529946A5 (https=) | 2012-08-30 |
| JP5623400B2 JP5623400B2 (ja) | 2014-11-12 |
Family
ID=39846672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011521575A Expired - Fee Related JP5623400B2 (ja) | 2008-08-05 | 2009-08-05 | 直径１０〜２０μｍのマイクロスフェアを含む非経口組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20120195939A1 (https=) |
| EP (1) | EP2323626B1 (https=) |
| JP (1) | JP5623400B2 (https=) |
| KR (1) | KR101639827B1 (https=) |
| CN (1) | CN102170868A (https=) |
| AU (1) | AU2009279086B2 (https=) |
| BR (1) | BRPI0917571B1 (https=) |
| CA (1) | CA2732785C (https=) |
| CL (1) | CL2011000244A1 (https=) |
| ES (1) | ES2677005T3 (https=) |
| GB (1) | GB0814302D0 (https=) |
| MX (1) | MX2011001261A (https=) |
| WO (1) | WO2010015665A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| GB0814302D0 (en) | 2008-08-05 | 2008-10-01 | Coretherapix Slu | Compounds and methods |
| WO2014022685A1 (en) | 2012-08-03 | 2014-02-06 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Recruitment of mesenchymal cells using controlled release systems |
| AU2013302799B2 (en) | 2012-08-13 | 2018-03-01 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| WO2014066545A1 (en) * | 2012-10-26 | 2014-05-01 | Cedars-Sinai Medical Center | Therapeutic cells depleted of specific subpopulations of cells for use in tissue repair of regeneration |
| ES2606636T3 (es) * | 2013-01-24 | 2017-03-24 | Pierre Fabre Médicament S.A.S. | Composición que comprende un antagomir encapsulado |
| WO2014114465A1 (en) * | 2013-01-24 | 2014-07-31 | Bernardo Nadal-Ginard | Modulation of cardiac stem-progenitor cell differentiation, assays and uses thereof |
| CA2962444C (en) | 2014-10-03 | 2023-09-05 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| CN104650333B (zh) * | 2015-02-05 | 2016-08-24 | 浙江大学 | 聚乳酸/氢化聚丁二烯热塑性超分子弹性体及其制备方法 |
| WO2016139590A1 (en) * | 2015-03-02 | 2016-09-09 | Accurate Medical Therapeutics Ltd. | Embolization particulates for occluding a blood vessel |
| EP3277363B1 (en) | 2015-03-30 | 2019-06-19 | TARIS Biomedical LLC | Devices for local delivery of drug to upper urinary tract |
| EP3402543B1 (en) | 2016-01-11 | 2021-09-08 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| ES2865433T3 (es) | 2016-05-04 | 2021-10-15 | Accurate Medical Therapeutics Ltd | Cabezal de microcatéter de embolización que tiene un patrón ranurado |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| EP3471705A1 (en) | 2016-06-20 | 2019-04-24 | Virbac | Method and apparatus for preparing a micro-particles composition |
| US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| EP4699658A2 (en) | 2017-04-19 | 2026-02-25 | Cedars-Sinai Medical Center | Methods and compositions for treating skeletal muscular dystrophy |
| WO2019087191A1 (en) | 2017-11-02 | 2019-05-09 | Accurate Medical Therapeutics Ltd. | Embolization catheter with integral filter |
| US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| US12414999B2 (en) * | 2018-01-12 | 2025-09-16 | President And Fellows Of Harvard College | Compositions and methods relating to macrophages and/or monocytes with adhered particles |
| US12146137B2 (en) | 2018-02-05 | 2024-11-19 | Cedars-Sinai Medical Center | Methods for therapeutic use of exosomes and Y-RNAS |
| EP3972500B1 (en) | 2019-05-23 | 2025-04-30 | Accurate Medical Therapeutics Ltd. | Embolization catheter for reflux free delivery of microspheres |
| US20240082167A1 (en) * | 2021-01-22 | 2024-03-14 | University Of Connecticut | Synthetic artificial stem cells (sasc) |
| EP4658295A2 (en) * | 2023-02-02 | 2025-12-10 | Silver Creek Pharmaceuticals, Inc. | Methods of treatment using igf-1 chimeric proteins |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6007845A (en) | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
| PT796090E (pt) | 1994-12-16 | 2003-07-31 | Elan Drug Delivery Ltd | Microparticulas reticuladas e sua utilizacao como veiculos terapeuticos |
| US5942253A (en) | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
| CA2161863A1 (en) | 1995-10-31 | 1997-05-01 | Michael Vivian Sefton | Angiogenic material and uses thereof |
| US6511477B2 (en) | 1997-03-13 | 2003-01-28 | Biocardia, Inc. | Method of drug delivery to interstitial regions of the myocardium |
| EP0977593A1 (en) | 1997-04-24 | 2000-02-09 | Nycomed Imaging A/S | Embolus therapy using insoluble microparticles or vesicles containing contrast agents |
| EP0896825B1 (en) | 1997-08-14 | 2002-07-17 | Sulzer Innotec Ag | Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors |
| AU1384199A (en) * | 1997-11-07 | 1999-05-31 | Chiron Corporation | Method for producing igf-1 sustained-release formulations |
| JP2002527401A (ja) | 1998-10-13 | 2002-08-27 | カイロン コーポレイション | Ｆｇｆの脈管形成的に有効な単位用量および投与方法 |
| WO2000028969A2 (en) | 1998-11-18 | 2000-05-25 | University Of Florida | Methods for preparing coated drug particles and pharmaceutical formulations thereof |
| US7651703B2 (en) | 1999-10-15 | 2010-01-26 | Genentech, Inc. | Injection vehicle for polymer-based formulations |
| US7547674B2 (en) | 2001-06-06 | 2009-06-16 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| JPWO2003059375A1 (ja) * | 2002-01-17 | 2005-05-19 | 株式会社カルディオ | 組織再生複合療法 |
| US20030199464A1 (en) | 2002-04-23 | 2003-10-23 | Silviu Itescu | Regeneration of endogenous myocardial tissue by induction of neovascularization |
| WO2004022000A2 (en) | 2002-09-05 | 2004-03-18 | Ambrose Catherine G | Antibiotic microspheres for treatment of infections and osteomyelitis |
| WO2004084819A2 (en) * | 2003-03-19 | 2004-10-07 | University Of Kentucky Research Foundation | Poly(acryloyl-hydroxyethyl starch)-plga composite microspheres |
| US20050142205A1 (en) * | 2003-07-18 | 2005-06-30 | Julia Rashba-Step | Methods for encapsulating small spherical particles prepared by controlled phase separation |
| WO2005007122A2 (en) * | 2003-07-18 | 2005-01-27 | Oakwood Laboratories, L.L.C. | Polymer stabilization |
| JP4532092B2 (ja) * | 2003-09-30 | 2010-08-25 | 泰彦 田畑 | 血管新生剤 |
| WO2005055949A2 (en) | 2003-12-09 | 2005-06-23 | The Children's Hospital Of Philadelphia | Sustained release preparations composed of biocompatible complex microparticles |
| JP5048323B2 (ja) * | 2004-03-31 | 2012-10-17 | 株式会社ツーセル | 損傷組織の治療剤と治療方法 |
| US7854944B2 (en) | 2004-12-17 | 2010-12-21 | Advanced Cardiovascular Systems, Inc. | Tissue regeneration |
| ES2273572B1 (es) * | 2005-05-04 | 2008-04-01 | Universidad De Sevilla | Procedimiento de preparacion de particulas de tamaño micro y nanometrico con productos labiles y particulas obtenidas. |
| WO2007028053A2 (en) | 2005-09-02 | 2007-03-08 | X-Cell Medical Incorporated | Methods of treating and preventing cardiac disorders |
| KR100718329B1 (ko) | 2005-09-08 | 2007-05-14 | 광주과학기술원 | 다당류로 기능화된 수화젤막을 가지는 나노입자와 이를포함하는 서방형 약물전달시스템 및 그 제조방법 |
| EP1976547A1 (en) * | 2005-11-11 | 2008-10-08 | Vascular Biosciences | R-ras activity in vascular regulation |
| AU2006315601A1 (en) * | 2005-11-14 | 2007-05-24 | Enterprise Partners Venture Capital | Stem cell factor therapy for tissue injury |
| CU23388B6 (es) | 2006-01-31 | 2009-07-16 | Ct Ingenieria Genetica Biotech | Composición farmacéutica de microesferas para prevenir la amputación del pie diabético |
| ES2459743T3 (es) | 2006-10-19 | 2014-05-12 | Ono Pharmaceutical Co., Ltd. | Preparación de liberación sostenida para terapia de regeneración tisular |
| WO2008108736A1 (en) | 2007-03-06 | 2008-09-12 | Agency For Science, Technology And Research | Particles for delivery of bioactive factors |
| EP2244697A1 (en) | 2008-01-29 | 2010-11-03 | Shire Human Genetic Therapies, Inc. | Therapeutic compositions |
| US8642333B2 (en) | 2008-02-04 | 2014-02-04 | Massachusetts Institute Of Technology | Particulate delivery vehicles for embryoid bodies |
| US20090297621A1 (en) * | 2008-06-03 | 2009-12-03 | Abbott Cardiovascular Systems Inc. | Microparticles For The Treatment Of Disease |
| GB0814302D0 (en) | 2008-08-05 | 2008-10-01 | Coretherapix Slu | Compounds and methods |
-
2008
- 2008-08-05 GB GBGB0814302.6A patent/GB0814302D0/en not_active Ceased
-
2009
- 2009-08-05 WO PCT/EP2009/060171 patent/WO2010015665A2/en not_active Ceased
- 2009-08-05 CN CN2009801391387A patent/CN102170868A/zh active Pending
- 2009-08-05 ES ES09781530.2T patent/ES2677005T3/es active Active
- 2009-08-05 JP JP2011521575A patent/JP5623400B2/ja not_active Expired - Fee Related
- 2009-08-05 AU AU2009279086A patent/AU2009279086B2/en not_active Ceased
- 2009-08-05 CA CA2732785A patent/CA2732785C/en active Active
- 2009-08-05 BR BRPI0917571-7A patent/BRPI0917571B1/pt not_active IP Right Cessation
- 2009-08-05 MX MX2011001261A patent/MX2011001261A/es active IP Right Grant
- 2009-08-05 EP EP09781530.2A patent/EP2323626B1/en active Active
- 2009-08-05 KR KR1020117004837A patent/KR101639827B1/ko not_active Expired - Fee Related
-
2011
- 2011-02-04 CL CL2011000244A patent/CL2011000244A1/es unknown
-
2012
- 2012-03-20 US US13/425,041 patent/US20120195939A1/en not_active Abandoned
-
2013
- 2013-01-08 US US13/736,267 patent/US20130189321A1/en not_active Abandoned
- 2013-04-30 US US13/873,812 patent/US8846099B2/en active Active
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