JP2013512078A5 - - Google Patents

Info

Publication number

JP2013512078A5

JP2013512078A5 JP2012542164A JP2012542164A JP2013512078A5 JP 2013512078 A5 JP2013512078 A5 JP 2013512078A5 JP 2012542164 A JP2012542164 A JP 2012542164A JP 2012542164 A JP2012542164 A JP 2012542164A JP 2013512078 A5 JP2013512078 A5 JP 2013512078A5

Authority

JP

Japan

Prior art keywords

substrate

blood

beads

cytokine

pathogen

Prior art date

2010-12-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000758 substrate Substances 0.000 claims description 17
• 239000011324 bead Substances 0.000 claims description 15
• 239000008280 blood Substances 0.000 claims description 13
• 210000004369 blood Anatomy 0.000 claims description 13
• 244000052769 pathogen Species 0.000 claims description 10
• 102000004127 Cytokines Human genes 0.000 claims description 8
• 108090000695 Cytokines Proteins 0.000 claims description 8
• 239000011148 porous material Substances 0.000 claims description 8
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 6
• 229920000669 heparin Polymers 0.000 claims description 6
• 229960002897 heparin Drugs 0.000 claims description 6
• 239000007787 solid Substances 0.000 claims description 5
• 238000009792 diffusion process Methods 0.000 claims description 3
• 238000000034 method Methods 0.000 claims description 3
• 230000001717 pathogenic effect Effects 0.000 claims 6
• 150000004676 glycans Chemical class 0.000 claims 5
• 229920001282 polysaccharide Polymers 0.000 claims 5
• 239000005017 polysaccharide Substances 0.000 claims 5
• 239000003463 adsorbent Substances 0.000 claims 4
• 239000012530 fluid Substances 0.000 claims 3
• YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• 229920001661 Chitosan Polymers 0.000 claims 1
• 229920002971 Heparan sulfate Polymers 0.000 claims 1
• 239000004698 Polyethylene Substances 0.000 claims 1
• 230000017531 blood circulation Effects 0.000 claims 1
• 229940077731 carbohydrate nutrients Drugs 0.000 claims 1
• 150000001720 carbohydrates Chemical class 0.000 claims 1
• 235000014633 carbohydrates Nutrition 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
• FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
• -1 polyethylene Polymers 0.000 claims 1
• 229920000573 polyethylene Polymers 0.000 claims 1
• 229960004889 salicylic acid Drugs 0.000 claims 1
• 239000002156 adsorbate Substances 0.000 description 3
• 238000001179 sorption measurement Methods 0.000 description 3
• 239000002245 particle Substances 0.000 description 2
• 241000004176 Alphacoronavirus Species 0.000 description 1
• 241000606161 Chlamydia Species 0.000 description 1
• 241000701022 Cytomegalovirus Species 0.000 description 1
• 241000725619 Dengue virus Species 0.000 description 1
• 208000005176 Hepatitis C Diseases 0.000 description 1
• 241000186779 Listeria monocytogenes Species 0.000 description 1
• 241000224016 Plasmodium Species 0.000 description 1
• 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
• 229920001247 Reticulated foam Polymers 0.000 description 1
• 206010041925 Staphylococcal infections Diseases 0.000 description 1
• 241000191967 Staphylococcus aureus Species 0.000 description 1
• 241000193996 Streptococcus pyogenes Species 0.000 description 1
• 241000607447 Yersinia enterocolitica Species 0.000 description 1
• 229940065181 bacillus anthracis Drugs 0.000 description 1
• 230000006835 compression Effects 0.000 description 1
• 238000007906 compression Methods 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
• 239000000835 fiber Substances 0.000 description 1
• 208000002672 hepatitis B Diseases 0.000 description 1
• 239000000463 material Substances 0.000 description 1
• 239000012528 membrane Substances 0.000 description 1
• 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 1
• 229940098232 yersinia enterocolitica Drugs 0.000 description 1