JP2013511974A5 - - Google Patents
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- Publication number
- JP2013511974A5 JP2013511974A5 JP2012540491A JP2012540491A JP2013511974A5 JP 2013511974 A5 JP2013511974 A5 JP 2013511974A5 JP 2012540491 A JP2012540491 A JP 2012540491A JP 2012540491 A JP2012540491 A JP 2012540491A JP 2013511974 A5 JP2013511974 A5 JP 2013511974A5
- Authority
- JP
- Japan
- Prior art keywords
- gsk
- inhibitor
- alkyl
- cells
- embryonic stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 24
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 claims 23
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 claims 23
- 239000003112 inhibitor Substances 0.000 claims 23
- 210000001671 embryonic stem cell Anatomy 0.000 claims 13
- 210000001900 endoderm Anatomy 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 230000004069 differentiation Effects 0.000 claims 6
- 238000000338 in vitro Methods 0.000 claims 6
- 230000001939 inductive effect Effects 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 210000004039 endoderm cell Anatomy 0.000 claims 4
- 230000001747 exhibiting effect Effects 0.000 claims 4
- 208000019423 liver disease Diseases 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 206010067125 Liver injury Diseases 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 1
- 0 OC(CCCC*1c(cccc2)c2C(C(C(N2)=O)=C3C2=O)=C1)CCCC[n]1c(cccc2)c2c3c1 Chemical compound OC(CCCC*1c(cccc2)c2C(C(C(N2)=O)=C3C2=O)=C1)CCCC[n]1c(cccc2)c2c3c1 0.000 description 5
- CIHOBERXWCVXQB-DAXSKMNVSA-N C/C=C\c1c(C)[n](CCOCCOCCOCC[n]2c3ccccc3c3c2)c(C)c1C(C(N1)=O)=C3C1=O Chemical compound C/C=C\c1c(C)[n](CCOCCOCCOCC[n]2c3ccccc3c3c2)c(C)c1C(C(N1)=O)=C3C1=O CIHOBERXWCVXQB-DAXSKMNVSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0920865A GB0920865D0 (en) | 2009-11-27 | 2009-11-27 | Composition and method for differentiation of human embryonic stem cells |
| GB0920865.3 | 2009-11-27 | ||
| GBGB1002329.9A GB201002329D0 (en) | 2010-02-11 | 2010-02-11 | Composition and method for differentiation of human embryonic stem cells |
| GB1002329.9 | 2010-02-11 | ||
| PCT/GB2010/002184 WO2011064549A2 (en) | 2009-11-27 | 2010-11-26 | Composition and method for differentiation of human embryonic stem cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013511974A JP2013511974A (ja) | 2013-04-11 |
| JP2013511974A5 true JP2013511974A5 (enExample) | 2013-11-28 |
Family
ID=43827702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012540491A Pending JP2013511974A (ja) | 2009-11-27 | 2010-11-26 | ヒト胚性幹細胞の分化のための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8815590B2 (enExample) |
| EP (1) | EP2470643A2 (enExample) |
| JP (1) | JP2013511974A (enExample) |
| CN (1) | CN102834505A (enExample) |
| WO (1) | WO2011064549A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2502704B (en) | 2010-11-15 | 2019-12-04 | Accelerated Biosciences Corp | Generation of neural stem cells from human trophoblast stem cells |
| CA3137404A1 (en) | 2012-11-30 | 2014-06-05 | Accelerated Biosciences Corp. | Pancreatic progenitor cells expressing betatrophin and insulin |
| EP2961829A4 (en) | 2013-02-27 | 2016-08-17 | Univ California | GENERATION OF THYME PEPPER THERAPEUTIC CELLS IN VITRO |
| JP6836990B2 (ja) | 2014-11-26 | 2021-03-03 | アクセラレイテッド・バイオサイエンシズ・コーポレーション | 誘導肝細胞およびそれらの使用 |
| CN105115951B (zh) * | 2015-08-10 | 2018-01-26 | 山东省科学院生物研究所 | 一种快速评价化合物对斑马鱼肝脏功能损伤作用的方法 |
| CN111876380B (zh) * | 2020-08-04 | 2022-06-28 | 浙江大学 | 使人胚胎干细胞分化成间充质干细胞的诱导培养基 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7282366B2 (en) * | 2000-04-27 | 2007-10-16 | Geron Corporation | Hepatocytes for therapy and drug screening made from embryonic stem cells |
| CA2695225C (en) * | 2007-07-31 | 2021-06-01 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| DK2297319T3 (en) * | 2008-06-03 | 2015-10-19 | Viacyte Inc | GROWTH FACTORS FOR PREPARING DEFINITIVE ENDODERM |
-
2010
- 2010-11-26 US US13/512,240 patent/US8815590B2/en not_active Expired - Fee Related
- 2010-11-26 JP JP2012540491A patent/JP2013511974A/ja active Pending
- 2010-11-26 WO PCT/GB2010/002184 patent/WO2011064549A2/en not_active Ceased
- 2010-11-26 EP EP10801193A patent/EP2470643A2/en not_active Withdrawn
- 2010-11-26 CN CN2010800620023A patent/CN102834505A/zh active Pending
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