JP2010524894A5 - - Google Patents

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Publication number
JP2010524894A5
JP2010524894A5 JP2010503511A JP2010503511A JP2010524894A5 JP 2010524894 A5 JP2010524894 A5 JP 2010524894A5 JP 2010503511 A JP2010503511 A JP 2010503511A JP 2010503511 A JP2010503511 A JP 2010503511A JP 2010524894 A5 JP2010524894 A5 JP 2010524894A5
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JP
Japan
Prior art keywords
alkyl
phenyl
optionally substituted
carbocyclyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010503511A
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English (en)
Japanese (ja)
Other versions
JP5675341B2 (ja
JP2010524894A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2008/054711 external-priority patent/WO2008128982A1/en
Publication of JP2010524894A publication Critical patent/JP2010524894A/ja
Publication of JP2010524894A5 publication Critical patent/JP2010524894A5/ja
Application granted granted Critical
Publication of JP5675341B2 publication Critical patent/JP5675341B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010503511A 2007-04-18 2008-04-18 グルタミニルシクラーゼ阻害剤としてのチオキソキナゾリノン誘導体 Expired - Fee Related JP5675341B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91254007P 2007-04-18 2007-04-18
US60/912,540 2007-04-18
PCT/EP2008/054711 WO2008128982A1 (en) 2007-04-18 2008-04-18 Thioxoquinazolinone derivatives as glutaminyl cyclase inhibitors

Publications (3)

Publication Number Publication Date
JP2010524894A JP2010524894A (ja) 2010-07-22
JP2010524894A5 true JP2010524894A5 (enExample) 2011-09-08
JP5675341B2 JP5675341B2 (ja) 2015-02-25

Family

ID=39684456

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010503511A Expired - Fee Related JP5675341B2 (ja) 2007-04-18 2008-04-18 グルタミニルシクラーゼ阻害剤としてのチオキソキナゾリノン誘導体

Country Status (6)

Country Link
US (1) US9034907B2 (enExample)
EP (1) EP2160389B1 (enExample)
JP (1) JP5675341B2 (enExample)
DK (1) DK2160389T3 (enExample)
ES (1) ES2478673T3 (enExample)
WO (1) WO2008128982A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732162B2 (en) * 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
JP5676249B2 (ja) * 2007-04-20 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体
AU2008297070A1 (en) * 2007-09-12 2009-03-19 Probiodrug Ag Transgenic mice
WO2009090190A1 (en) * 2008-01-14 2009-07-23 Probiodrug Ag Mouse models carrying a knock-out mutation of the glutaminyl cyclase gene
KR101706789B1 (ko) 2008-07-21 2017-02-14 프로비오드룩 아게 진단용 항체 검사법
CA2759187A1 (en) * 2009-04-03 2010-10-07 Medisyn Technologies, Inc. Compositions for treatment of alzheimer's disease
PL2475428T3 (pl) 2009-09-11 2015-12-31 Probiodrug Ag Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
WO2011076854A1 (en) 2009-12-22 2011-06-30 Probiodrug Ag CLEAVAGE OF β-AMYLOID PRECURSOR PROTEIN
EP2537029A1 (en) 2010-02-18 2012-12-26 Probiodrug AG Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase
WO2012058211A2 (en) * 2010-10-29 2012-05-03 Emory University Quinazoline derivatives, compositions, and uses related thereto
CN103459421B (zh) 2011-03-16 2017-07-14 前体生物药物股份公司 诊断性抗体测定
WO2013181135A1 (en) * 2012-05-31 2013-12-05 Emory University Quinazoline derivatives, compositions, and uses related thereto
US20170363645A1 (en) 2014-12-19 2017-12-21 Probiodrug Ag Novel Method for the Detection of pGlu-Abeta Peptides
WO2017100599A1 (en) 2015-12-09 2017-06-15 Luc Therapeutics Thienopyrimidinone nmda receptor modulators and uses thereof
ES2821010T3 (es) 2015-12-09 2021-04-23 Cadent Therapeutics Inc Moduladores heteroaromáticos del receptor NMDA y usos de los mismos
AU2017382339B2 (en) 2016-12-22 2024-02-15 Novartis Ag NMDA receptor modulators and uses thereof
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
EP3521308B1 (en) 2018-01-31 2024-03-13 Vivoryon Therapeutics N.V. Humanized and de-immunized antibodies
PT3830092T (pt) 2018-08-03 2023-07-25 Novartis Ag Moduladores do recetor nmda heteroaromáticos e suas utilizações

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684654A (en) 1985-08-14 1987-08-04 American Cyanamid Company 3-heteroalkyl-2,4-quinzaolinediones
EP0293500A1 (en) 1987-06-01 1988-12-07 American Cyanamid Company 3-heteroalkyl-2,4.quinzaoline-diones
US6948038B2 (en) * 2001-07-24 2005-09-20 Microsoft Corporation System and method for backing up and restoring data
WO2003053958A1 (en) 2001-12-20 2003-07-03 Celltech R & D Limited Quinazolinedione derivatives
US8338120B2 (en) 2003-05-05 2012-12-25 Probiodrug Ag Method of treating inflammation with glutaminyl cyclase inhibitors
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
EP1620091B1 (en) * 2003-05-05 2010-03-31 Probiodrug AG Inhibitors of glutaminyl cyclase
KR20060009902A (ko) 2003-05-05 2006-02-01 프로비오드룩 아게 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도
AU2004283461B2 (en) 2003-10-15 2010-02-11 Probiodrug Ag Use of effectors of glutaminyl and glutamate cyclases
US7667044B2 (en) 2003-11-03 2010-02-23 Probiodrug Ag Compounds for the treatment of neurological disorders
US20050171112A1 (en) 2003-11-03 2005-08-04 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
AU2004290499C1 (en) 2003-11-03 2011-02-24 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
WO2005075436A2 (en) * 2004-02-05 2005-08-18 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
WO2008034891A2 (en) 2006-09-21 2008-03-27 Probiodrug Ag Novel genes related to glutaminyl cyclase
US8420684B2 (en) 2006-11-09 2013-04-16 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5599614B2 (ja) 2006-11-09 2014-10-01 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
EP2395095A1 (en) 2007-01-19 2011-12-14 Probiodrug AG In vivo screening models for treatment of Alzheimer's disease and other QPCT-related disorders
WO2008110523A1 (en) 2007-03-09 2008-09-18 Probiodrug Ag Imidazo [1,5-a] pyridine derivatives as inhibitors of glutaminyl cyclase

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