JP2010524894A5 - - Google Patents
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- Publication number
- JP2010524894A5 JP2010524894A5 JP2010503511A JP2010503511A JP2010524894A5 JP 2010524894 A5 JP2010524894 A5 JP 2010524894A5 JP 2010503511 A JP2010503511 A JP 2010503511A JP 2010503511 A JP2010503511 A JP 2010503511A JP 2010524894 A5 JP2010524894 A5 JP 2010524894A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- optionally substituted
- carbocyclyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004452 carbocyclyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 0 C*(C)*c(cc1)cc2c1[n]c(*)n2 Chemical compound C*(C)*c(cc1)cc2c1[n]c(*)n2 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91254007P | 2007-04-18 | 2007-04-18 | |
| US60/912,540 | 2007-04-18 | ||
| PCT/EP2008/054711 WO2008128982A1 (en) | 2007-04-18 | 2008-04-18 | Thioxoquinazolinone derivatives as glutaminyl cyclase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010524894A JP2010524894A (ja) | 2010-07-22 |
| JP2010524894A5 true JP2010524894A5 (enExample) | 2011-09-08 |
| JP5675341B2 JP5675341B2 (ja) | 2015-02-25 |
Family
ID=39684456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503511A Expired - Fee Related JP5675341B2 (ja) | 2007-04-18 | 2008-04-18 | グルタミニルシクラーゼ阻害剤としてのチオキソキナゾリノン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9034907B2 (enExample) |
| EP (1) | EP2160389B1 (enExample) |
| JP (1) | JP5675341B2 (enExample) |
| DK (1) | DK2160389T3 (enExample) |
| ES (1) | ES2478673T3 (enExample) |
| WO (1) | WO2008128982A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| EP2142536B1 (en) * | 2007-04-20 | 2015-10-21 | Probiodrug AG | Aminopyrimidine derivatives as glutaminyl cyclase inhibitors |
| EP2195336B1 (en) * | 2007-09-12 | 2015-01-21 | Probiodrug AG | Transgenic mice |
| WO2009090190A1 (en) * | 2008-01-14 | 2009-07-23 | Probiodrug Ag | Mouse models carrying a knock-out mutation of the glutaminyl cyclase gene |
| EP3338796A1 (en) | 2008-07-21 | 2018-06-27 | Probiodrug AG | Diagnostic antibody assay |
| CA2759187A1 (en) * | 2009-04-03 | 2010-10-07 | Medisyn Technologies, Inc. | Compositions for treatment of alzheimer's disease |
| WO2011029920A1 (en) | 2009-09-11 | 2011-03-17 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| US20110152341A1 (en) | 2009-12-22 | 2011-06-23 | Probiodrug Ag | Cleavage of b-amyloid precursor protein |
| JP2013519891A (ja) | 2010-02-18 | 2013-05-30 | プロビオドルグ エージー | ピログルタミン酸修飾ｍｃｐ−１を決定することにより炎症性疾患を診断する方法及びグルタミニルシクラーゼの阻害剤のスクリーニング方法 |
| EP2632466A4 (en) * | 2010-10-29 | 2014-03-19 | Univ Emory | CHINAZOLINE DERIVATIVES, COMPOSITIONS THEREOF AND USES THEREOF |
| SG192805A1 (en) | 2011-03-16 | 2013-09-30 | Probiodrug Ag | Diagnostic antibody assay |
| WO2013181135A1 (en) * | 2012-05-31 | 2013-12-05 | Emory University | Quinazoline derivatives, compositions, and uses related thereto |
| JP2018501482A (ja) | 2014-12-19 | 2018-01-18 | プロビオドルグ エージー | ｐＧｌｕ−Ａｂｅｔａペプチドの検出のための新規の方法 |
| US10500205B2 (en) | 2015-12-09 | 2019-12-10 | Cadent Therapeutics, Inc. | Thienopyrimidinone NMDA receptor modulators and uses thereof |
| RS60834B1 (sr) | 2015-12-09 | 2020-10-30 | Cadent Therapeutics Inc | Modulatori heteroaromatskog nmda receptora i njihove upotrebe |
| AU2017382339B2 (en) | 2016-12-22 | 2024-02-15 | Novartis Ag | NMDA receptor modulators and uses thereof |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| EP3521308B1 (en) | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
| CR20210125A (es) | 2018-08-03 | 2021-06-30 | Cadent Therapeutics Inc | Moduladores del receptor nmda heteroaromático y usos de los mismos |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0293500A1 (en) | 1987-06-01 | 1988-12-07 | American Cyanamid Company | 3-heteroalkyl-2,4.quinzaoline-diones |
| US4684654A (en) * | 1985-08-14 | 1987-08-04 | American Cyanamid Company | 3-heteroalkyl-2,4-quinzaolinediones |
| US6948038B2 (en) * | 2001-07-24 | 2005-09-20 | Microsoft Corporation | System and method for backing up and restoring data |
| WO2003053958A1 (en) | 2001-12-20 | 2003-07-03 | Celltech R & D Limited | Quinazolinedione derivatives |
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| KR20110059664A (ko) * | 2003-05-05 | 2011-06-02 | 프로비오드룩 아게 | 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도 |
| US8338120B2 (en) * | 2003-05-05 | 2012-12-25 | Probiodrug Ag | Method of treating inflammation with glutaminyl cyclase inhibitors |
| WO2004098591A2 (en) * | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
| EP2289498A1 (en) * | 2003-10-15 | 2011-03-02 | Probiodrug AG | Use of inhibitors of glutaminyl clyclase |
| US7667044B2 (en) * | 2003-11-03 | 2010-02-23 | Probiodrug Ag | Compounds for the treatment of neurological disorders |
| EP1680120A2 (en) * | 2003-11-03 | 2006-07-19 | Probiodrug AG | Combinations useful for the treatment of neuronal disorders |
| US20050171112A1 (en) * | 2003-11-03 | 2005-08-04 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| EP1713780B1 (en) * | 2004-02-05 | 2012-01-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| EP2581449B1 (en) * | 2006-09-21 | 2016-09-14 | Probiodrug AG | Novel genes related to glutaminyl cyclase |
| WO2008055950A1 (en) * | 2006-11-09 | 2008-05-15 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| US8420684B2 (en) * | 2006-11-09 | 2013-04-16 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| EP2091948B1 (en) * | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| JP2010516235A (ja) * | 2007-01-19 | 2010-05-20 | プロビオドルグ エージー | アルツハイマー病及び他のｑｐｃｔ関連障害の治療のためのインビボスクリーニングモデル |
| DK2118101T3 (da) * | 2007-03-09 | 2013-01-02 | Probiodrug Ag | IMIDAZO (1,5-A)-PYRIDinderivater som glutaminylcyclaseinhibitorer |
-
2008
- 2008-04-18 WO PCT/EP2008/054711 patent/WO2008128982A1/en not_active Ceased
- 2008-04-18 EP EP08749601.4A patent/EP2160389B1/en active Active
- 2008-04-18 US US12/105,849 patent/US9034907B2/en active Active
- 2008-04-18 JP JP2010503511A patent/JP5675341B2/ja not_active Expired - Fee Related
- 2008-04-18 DK DK08749601.4T patent/DK2160389T3/da active
- 2008-04-18 ES ES08749601.4T patent/ES2478673T3/es active Active
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