RU2015148585A - Улучшение органов для трансплантации - Google Patents
Улучшение органов для трансплантации Download PDFInfo
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- RU2015148585A RU2015148585A RU2015148585A RU2015148585A RU2015148585A RU 2015148585 A RU2015148585 A RU 2015148585A RU 2015148585 A RU2015148585 A RU 2015148585A RU 2015148585 A RU2015148585 A RU 2015148585A RU 2015148585 A RU2015148585 A RU 2015148585A
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- Prior art keywords
- stem cells
- cells
- organ
- exposed
- transplantation
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- 238000002054 transplantation Methods 0.000 title claims 5
- 210000000130 stem cell Anatomy 0.000 claims 25
- 238000000034 method Methods 0.000 claims 19
- 210000000056 organ Anatomy 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 8
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims 2
- 101710150336 Protein Rex Proteins 0.000 claims 2
- 108010017842 Telomerase Proteins 0.000 claims 2
- 230000032823 cell division Effects 0.000 claims 2
- 210000001654 germ layer Anatomy 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 210000004602 germ cell Anatomy 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 210000004969 inflammatory cell Anatomy 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 210000004991 placental stem cell Anatomy 0.000 claims 1
- 210000001541 thymus gland Anatomy 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/80—Undefined extracts from animals
- C12N2500/84—Undefined extracts from animals from mammals
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/03—Coculture with; Conditioned medium produced by non-embryonic pluripotent stem cells
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (19)
1. Способ, включающий трансплантацию органа, подвергнутого воздействию экзогенных стволовых клеток.
2. Способ по п. 1, где орган подвергают воздействию стволовых клеток до трансплантации реципиенту.
3. Способ по п. 1, где орган подвергают воздействию стволовых клеток в течение трансплантации реципиенту.
4. Способ по п. 1, где орган подвергают воздействию стволовых клеток после трансплантации реципиенту.
5. Способ по п. 1, где стволовые клетки являются неэмбриональными, неполовыми клетками, экспрессирующими один или несколько из oct4, теломеразы, rex-1 или rox-1, и/или могут дифференцироваться в типы клеток по меньшей мере двух из эндодермального, эктодермального и мезодермального зародышевых листков.
6. Способ по п. 1, где стволовые клетки являются неэмбриональными, неполовыми клетками, экспрессирующими один или несколько из oct4, теломеразы, rex-1 или rox-1, и/или могут дифференцироваться в типы клеток эндодермального, эктодермального и мезодермального зародышевых листков.
7. Способ по п. 5 или 6, где стволовые клетки являются несовпадающими по HLA, аллогенными клетками.
8. Способ по п. 1, где стволовые клетки выбраны из группы, состоящей из мезенхимальных стромальных (стволовых) клеток, эмбриональных стволовых клеток, индуцированных плюрипотентных стволовых клеток, примордиальных эмбриональных половых клеток, определенных клеток-предшественников, гематопоэтических стволовых клеток, зрелых стволовых клеток жировой ткани, овальных клеток, стволовых клеток пуповинной крови, плацентарных стволовых клеток, небольших эмбрионально-подобных стволовых клеток, стволовых клеток амниотической жидкости, стволовых клеток-предшественников кожи и стволовых клеток костного мозга.
9. Способ по п. 1, где стволовые клетки подвергают по меньшей мере 10-40 делениям клеток.
10. Способ по п. 9, где стволовые клетки подвергают по меньшей мере 30-35 делениям клеток.
11. Способ по п. 1, где концентрация стволовых клеток, воздействию которых подвергают орган, составляет от приблизительно 1×106 клеток/мл до приблизительно 10×106 клеток/мл.
12. Способ по п. 1, где органа подвергают воздействию стволовых клеток в течение приблизительно 2-4 ч.
13. Способ по п. 1, где стволовые клетки содержатся в жидкости для перфузии в орган или в носителе для внутриорганного введения.
14. Способ по п. 1, где стволовые клетки содержатся в среде, в которую орган погружают до трансплантации.
15. Способ по п. 1, где орган выбран из группы, состоящей из легкого, почки, сердца, печени, поджелудочной железы, тимуса, желудочно-кишечного тракта и композитных аллотрансплантатов.
16. Способ по п. 1, где подвергание воздействию стволовых клеток снижает воспаление в органе.
17. Способ по п. 1, где подвергание воздействию стволовых клеток снижает наличие воспалительных клеток в органе.
18. Способ по п. 1, где подвергание воздействию стволовых клеток снижает воспалительные цитокины в органе.
19. Способ по п. 1, где подвергание воздействию стволовых клеток снижает повреждение при ишемии-реперфузии.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361811525P | 2013-04-12 | 2013-04-12 | |
| US61/811,525 | 2013-04-12 | ||
| PCT/US2014/034015 WO2014169277A1 (en) | 2013-04-12 | 2014-04-14 | Improving organs for transplantation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018130072A Division RU2778304C2 (ru) | 2013-04-12 | 2014-04-14 | Улучшение органов для трансплантации |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015148585A true RU2015148585A (ru) | 2017-05-15 |
| RU2665364C2 RU2665364C2 (ru) | 2018-08-29 |
Family
ID=51686949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015148585A RU2665364C2 (ru) | 2013-04-12 | 2014-04-14 | Улучшение органов для трансплантации |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9861660B2 (ru) |
| EP (2) | EP2983680B1 (ru) |
| JP (5) | JP6666240B2 (ru) |
| KR (3) | KR102207592B1 (ru) |
| CN (3) | CN115177637A (ru) |
| AU (1) | AU2014250761B2 (ru) |
| CA (1) | CA2909267C (ru) |
| DK (1) | DK2983680T3 (ru) |
| ES (1) | ES2827250T3 (ru) |
| HK (1) | HK1214130A1 (ru) |
| HU (1) | HUE052516T2 (ru) |
| IL (4) | IL289870B2 (ru) |
| MX (3) | MX2015014386A (ru) |
| PL (1) | PL2983680T3 (ru) |
| PT (1) | PT2983680T (ru) |
| RU (1) | RU2665364C2 (ru) |
| SG (3) | SG10201914136UA (ru) |
| WO (1) | WO2014169277A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2568991T6 (en) | 2010-05-12 | 2019-03-18 | Abt Holding Co | MODULATION OF SPLENOCYTES IN CELL THERAPY |
| HUE052516T2 (hu) * | 2013-04-12 | 2021-05-28 | Houston Methodist Hospital | Szervek javítása transzplantációhoz |
| US20170112879A1 (en) * | 2014-06-09 | 2017-04-27 | University Of Washington | Methods of protection against ischemia reperfusion injury |
| WO2016100375A2 (en) | 2014-12-15 | 2016-06-23 | Washington University | Compositions and methods for targeted cytokine delivery |
| AU2016387339B2 (en) | 2016-01-21 | 2022-11-17 | Abt Holding Company | Stem cells for wound healing |
| AU2017213659B2 (en) | 2016-02-05 | 2024-04-18 | Washington University | Compositions and methods for targeted cytokine delivery |
| US11351227B2 (en) | 2017-04-27 | 2022-06-07 | Washington University | Chemokine decoy receptors of rodent gammaherpesviruses and uses thereof |
| JP7440987B2 (ja) | 2021-12-28 | 2024-02-29 | 株式会社ポル・メド・テック | 移植材料の製造方法、及び移植材料 |
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