JP2013511556A5 - - Google Patents
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- Publication number
- JP2013511556A5 JP2013511556A5 JP2012540154A JP2012540154A JP2013511556A5 JP 2013511556 A5 JP2013511556 A5 JP 2013511556A5 JP 2012540154 A JP2012540154 A JP 2012540154A JP 2012540154 A JP2012540154 A JP 2012540154A JP 2013511556 A5 JP2013511556 A5 JP 2013511556A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- hydroxybenzenesulfonamide
- halo
- nitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 28
- 125000001475 halogen functional group Chemical group 0.000 claims 13
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- -1 N-hydroxylsulfonamidyl Chemical group 0.000 claims 6
- 208000002815 pulmonary hypertension Diseases 0.000 claims 6
- 206010024119 Left ventricular failure Diseases 0.000 claims 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 4
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- JTMRAKAVHPQVLR-UHFFFAOYSA-N 2-bromo-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=CC=C1Br JTMRAKAVHPQVLR-UHFFFAOYSA-N 0.000 claims 2
- QVWABNGSRMHSSC-UHFFFAOYSA-N 2-fluoro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=CC=C1F QVWABNGSRMHSSC-UHFFFAOYSA-N 0.000 claims 2
- 208000019622 heart disease Diseases 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- UHLUYTLUWPLQIV-UHFFFAOYSA-N n-hydroxy-2-(trifluoromethyl)benzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=CC=C1C(F)(F)F UHLUYTLUWPLQIV-UHFFFAOYSA-N 0.000 claims 2
- RPCWSYAQEVLTEE-UHFFFAOYSA-N n-hydroxy-2-iodobenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=CC=C1I RPCWSYAQEVLTEE-UHFFFAOYSA-N 0.000 claims 2
- RZRWBKKAFHXNEQ-UHFFFAOYSA-N n-hydroxy-2-methylsulfonylbenzenesulfonamide Chemical compound CS(=O)(=O)C1=CC=CC=C1S(=O)(=O)NO RZRWBKKAFHXNEQ-UHFFFAOYSA-N 0.000 claims 2
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- ZRWVFIVDXWDXDB-UHFFFAOYSA-N 2,3-dichloro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=CC(Cl)=C1Cl ZRWVFIVDXWDXDB-UHFFFAOYSA-N 0.000 claims 1
- PMCCDTRQTMOMDO-UHFFFAOYSA-N 2,4-dibromo-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=C(Br)C=C1Br PMCCDTRQTMOMDO-UHFFFAOYSA-N 0.000 claims 1
- XZXRZAJTPROFFJ-UHFFFAOYSA-N 2,4-difluoro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=C(F)C=C1F XZXRZAJTPROFFJ-UHFFFAOYSA-N 0.000 claims 1
- NQRQXMMHKBZSFH-UHFFFAOYSA-N 2,6-dichloro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=C(Cl)C=CC=C1Cl NQRQXMMHKBZSFH-UHFFFAOYSA-N 0.000 claims 1
- KYAYUXVCXCRWGE-UHFFFAOYSA-N 2-bromo-4-fluoro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=C(F)C=C1Br KYAYUXVCXCRWGE-UHFFFAOYSA-N 0.000 claims 1
- KDAUHUPSWREKDU-UHFFFAOYSA-N 2-chloro-4-fluoro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=C(F)C=C1Cl KDAUHUPSWREKDU-UHFFFAOYSA-N 0.000 claims 1
- CRGRKPVYYZZUHX-UHFFFAOYSA-N 2-chloro-n-hydroxy-4-(trifluoromethyl)benzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=C(C(F)(F)F)C=C1Cl CRGRKPVYYZZUHX-UHFFFAOYSA-N 0.000 claims 1
- BASKBTQCHRZHSH-UHFFFAOYSA-N 2-chloro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=CC=C1Cl BASKBTQCHRZHSH-UHFFFAOYSA-N 0.000 claims 1
- SNDSZUKNUDOLGZ-UHFFFAOYSA-N 4-bromo-2-chloro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=C(Br)C=C1Cl SNDSZUKNUDOLGZ-UHFFFAOYSA-N 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000026151 Chronic thromboembolic pulmonary hypertension Diseases 0.000 claims 1
- 208000003037 Diastolic Heart Failure Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 1
- 208000008253 Systolic Heart Failure Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000005163 aryl sulfanyl group Chemical group 0.000 claims 1
- 125000005135 aryl sulfinyl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000005171 cycloalkylsulfanyl group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- YWZWWGLSOOIVSN-UHFFFAOYSA-N n-hydroxy-2,4,6-tri(propan-2-yl)benzenesulfonamide Chemical compound CC(C)C1=CC(C(C)C)=C(S(=O)(=O)NO)C(C(C)C)=C1 YWZWWGLSOOIVSN-UHFFFAOYSA-N 0.000 claims 1
- NBJISJHKYNUFIN-UHFFFAOYSA-N n-hydroxy-2,5-bis(trifluoromethyl)benzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC(C(F)(F)F)=CC=C1C(F)(F)F NBJISJHKYNUFIN-UHFFFAOYSA-N 0.000 claims 1
- SEBLDBIKKKKJMQ-UHFFFAOYSA-N n-hydroxy-2-nitro-4-(trifluoromethyl)benzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=C(C(F)(F)F)C=C1[N+]([O-])=O SEBLDBIKKKKJMQ-UHFFFAOYSA-N 0.000 claims 1
- MGMDZPKSAJJKCS-UHFFFAOYSA-N n-hydroxy-2-phenylbenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=CC=C1C1=CC=CC=C1 MGMDZPKSAJJKCS-UHFFFAOYSA-N 0.000 claims 1
- 210000003462 vein Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26369809P | 2009-11-23 | 2009-11-23 | |
| US61/263,698 | 2009-11-23 | ||
| US26412909P | 2009-11-24 | 2009-11-24 | |
| US61/264,129 | 2009-11-24 | ||
| PCT/US2010/057844 WO2011063400A1 (en) | 2009-11-23 | 2010-11-23 | Nitroxyl donors for the treatment of pulmonary hypertension |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016015102A Division JP2016128481A (ja) | 2009-11-23 | 2016-01-29 | 肺高血圧症の処置のためのニトロキシル供与体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013511556A JP2013511556A (ja) | 2013-04-04 |
| JP2013511556A5 true JP2013511556A5 (OSRAM) | 2014-01-16 |
Family
ID=43513876
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012540154A Pending JP2013511556A (ja) | 2009-11-23 | 2010-11-23 | 肺高血圧症の処置のためのニトロキシル供与体 |
| JP2016015102A Pending JP2016128481A (ja) | 2009-11-23 | 2016-01-29 | 肺高血圧症の処置のためのニトロキシル供与体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016015102A Pending JP2016128481A (ja) | 2009-11-23 | 2016-01-29 | 肺高血圧症の処置のためのニトロキシル供与体 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20110160200A1 (OSRAM) |
| EP (1) | EP2504003B1 (OSRAM) |
| JP (2) | JP2013511556A (OSRAM) |
| CY (1) | CY1118603T1 (OSRAM) |
| DK (1) | DK2504003T3 (OSRAM) |
| ES (1) | ES2611852T3 (OSRAM) |
| HR (1) | HRP20170183T1 (OSRAM) |
| HU (1) | HUE032253T2 (OSRAM) |
| LT (1) | LT2504003T (OSRAM) |
| PL (1) | PL2504003T3 (OSRAM) |
| PT (1) | PT2504003T (OSRAM) |
| RS (1) | RS55697B1 (OSRAM) |
| SI (1) | SI2504003T1 (OSRAM) |
| SM (2) | SMT201700090T1 (OSRAM) |
| WO (2) | WO2011063339A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102753520B (zh) * | 2009-12-07 | 2016-06-08 | 约翰斯霍普金斯大学 | N-酰氧基磺酰胺和n-羟基-n-酰基磺酰胺衍生物 |
| WO2011071947A2 (en) | 2009-12-07 | 2011-06-16 | Johns Hopkins University | Bis-acylated hydroxylamine derivatives |
| US9181213B2 (en) | 2011-10-17 | 2015-11-10 | The Johns Hopkins University | Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as HNO donors |
| BR112015017251B1 (pt) | 2013-01-18 | 2021-10-26 | Cardioxyl Pharmaceuticals, Inc. | Composições farmacêuticas compreendendo doadores de nitroxil, misturas e usos das referidas composições farmacêuticas |
| WO2014184234A1 (en) * | 2013-05-14 | 2014-11-20 | Active Biotech Ab | N-(heteroaryl)-sulfonamide derivatives useful as s100-inhibitors |
| EP3126329B1 (en) | 2014-01-17 | 2019-05-29 | Cardioxyl Pharmaceuticals Inc. | N-hydroxymethanesulfonamide nitroxyl donors |
| ES2749682T3 (es) | 2014-05-27 | 2020-03-23 | Cardioxyl Pharmaceuticals Inc | Derivados de pirazolona como donadores de nitroxilo |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
| WO2017070084A1 (en) | 2015-10-19 | 2017-04-27 | Cardioxyl Pharmaceuticals, Inc. | N-hydroxylsulfonamide derivatives as nitroxyl donors |
| EP3365328A1 (en) | 2015-10-19 | 2018-08-29 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| EP3490975B1 (en) | 2016-07-28 | 2021-05-05 | The Johns Hopkins University | O-substituted hydroxamic acids |
| EP3565544A1 (en) | 2017-01-03 | 2019-11-13 | Cardioxyl Pharmaceuticals Inc. | Method of administering nitroxyl donating compounds |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3219428A (en) * | 1961-04-17 | 1965-11-23 | Hooker Chemical Corp | O,n-diacylated-3,4-dihalophenylhydroxylamines as herbicides |
| US3382243A (en) * | 1965-05-17 | 1968-05-07 | American Home Prod | Acetamides and their preparation |
| US3948967A (en) * | 1968-01-03 | 1976-04-06 | Velsicol Chemical Corporation | Aryl urea carbonates |
| US3661944A (en) * | 1970-07-01 | 1972-05-09 | Smith Kline French Lab | 4-(n-lower alkanoyl)hydroxylamino-4'-aminodiphenylsulfone compounds |
| US3746727A (en) * | 1971-06-07 | 1973-07-17 | Shell Oil Co | Benzenesulfhydroxamic acids and their derivatives |
| US3751255A (en) * | 1972-03-24 | 1973-08-07 | Eastman Kodak Co | Photosensitive and thermosensitive element, composition and process |
| JPS567710A (en) * | 1979-06-28 | 1981-01-27 | Sansho Seiyaku Kk | Whitening cosmetic |
| US4405357A (en) * | 1980-06-02 | 1983-09-20 | Fmc Corporation | Herbicidal 3-isoxazolidinones and hydroxamic acids |
| US4539321A (en) * | 1981-10-26 | 1985-09-03 | William H. Rorer, Inc. | 5-Diaza-aryl-3-substituted pyridone compounds |
| DE3583799D1 (de) * | 1985-01-11 | 1991-09-19 | Abbott Lab Ltd | Feste zubereitung mit langsamer freisetzung. |
| US4663351A (en) * | 1985-08-23 | 1987-05-05 | Berlex Laboratories, Inc. | Dobutamine tri-isobutyric acid ester and the use thereof as a cardiotonic agent |
| US4798824A (en) * | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US4954526A (en) * | 1989-02-28 | 1990-09-04 | The United States Of America As Represented By The Department Of Health And Human Services | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents |
| US5721365A (en) * | 1989-09-15 | 1998-02-24 | Us Health | N-substituted piperazine NONOates |
| US5039705A (en) * | 1989-09-15 | 1991-08-13 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
| US5366997A (en) * | 1991-09-24 | 1994-11-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs |
| US5212204A (en) * | 1989-10-18 | 1993-05-18 | The United States Of America As Represented By The Department Of Health And Human Services | Antihypertensive compositions and use thereof |
| JP2773959B2 (ja) * | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
| WO1993006236A1 (en) * | 1991-09-20 | 1993-04-01 | Zeneca Limited | Enzymatic production of optical isomers of tetrahydropyran-2-ones |
| US5814666A (en) * | 1992-04-13 | 1998-09-29 | The United States As Represented By The Department Of Health And Human Services | Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents |
| US5278192A (en) * | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
| US6200558B1 (en) * | 1993-09-14 | 2001-03-13 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| DK1026147T3 (da) * | 1993-06-24 | 2004-03-22 | Albany Molecular Res Inc | Forbindelser, der er anvendelige som mellemprodukter i fremstillingen af piperidinderivater |
| EP0726768B1 (en) * | 1993-11-02 | 2000-05-17 | THE UNITED STATES OF AMERICA, represented by THE SECRETARY, Department of Health and Human Services | Use of nitric oxide releasing compounds for the manufacture of a medicament for protection in ischemia reperfusion injury |
| US5700830A (en) * | 1994-11-22 | 1997-12-23 | The United States Of America As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents for reducing metastasis risk |
| US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
| US6043232A (en) * | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
| US5674894A (en) * | 1995-05-15 | 1997-10-07 | G.D. Searle & Co. | Amidine derivatives useful as platelet aggregation inhibitors and vasodilators |
| US5714511A (en) * | 1995-07-31 | 1998-02-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs |
| DE19545878A1 (de) * | 1995-12-08 | 1997-06-12 | Basf Ag | Pyridylcarbamate, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung |
| US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| US5958427A (en) * | 1996-11-08 | 1999-09-28 | Salzman; Andrew L. | Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications |
| TW453999B (en) * | 1997-06-27 | 2001-09-11 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| US6525081B1 (en) * | 1997-10-24 | 2003-02-25 | Shionogi & Co., Ltd. | Antirheumatic |
| US6596705B1 (en) * | 1998-02-09 | 2003-07-22 | The Regents Of The University Of California | Inhibition of L-selectin and P-selection mediated binding using heparin |
| UA73092C2 (uk) * | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| WO2000006128A1 (fr) * | 1998-07-28 | 2000-02-10 | Tanabe Seiyaku Co., Ltd. | Preparation capable de liberer un medicament au niveau d'un site cible dans l'intestin |
| WO2000025776A1 (en) * | 1998-10-30 | 2000-05-11 | Nitromed, Inc. | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| MXPA02001694A (es) * | 1999-08-30 | 2002-08-06 | Aventis Pharma Gmbh | Uso de inhibidores del sistema renina-angiotensina en la prevencion de eventos cardiovasculares. |
| US7045152B2 (en) * | 1999-09-08 | 2006-05-16 | Duke University | Treating pulmonary disorders with gaseous agent causing repletion of GSNO |
| US20010053795A1 (en) * | 2000-06-20 | 2001-12-20 | Bond Richard A. | Paradoxical pharmacology |
| EP1301500B1 (en) * | 2000-06-22 | 2007-11-21 | Nitromed, Inc. | Nitrosated and nitrosylated taxanes, compositions and methods of use |
| EP1406609B1 (en) * | 2000-12-21 | 2006-09-06 | Nitromed, Inc. | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| US7122529B2 (en) * | 2001-07-12 | 2006-10-17 | The Johns Hopkins University | Compounds that release nitric oxide at controlled rates upon photolysis |
| FR2832634A1 (fr) * | 2001-11-29 | 2003-05-30 | Univ Pasteur | Utilisation des isomeres l de derives aminoacides de l'hydroxyguanidine pour la production de no, compositions pharmaceutiques les contenant et utilisations pharmaceutiques |
| US20040038947A1 (en) * | 2002-06-14 | 2004-02-26 | The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services | Method of treating ischemia/reperfusion injury with nitroxyl donors |
| US20040077691A1 (en) * | 2002-06-21 | 2004-04-22 | Medinox, Inc. | Hydroxamate derivatives of non-steroidal anti-inflammatory drugs |
| US6936639B2 (en) | 2002-08-21 | 2005-08-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxyl progenitors in the treatment of heart failure |
| US20050009789A1 (en) * | 2003-05-13 | 2005-01-13 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Service | Cyclooxygenase inhibition with nitroxyl |
| JP2007514759A (ja) * | 2003-12-19 | 2007-06-07 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| EP1718621A4 (en) | 2004-01-30 | 2009-08-19 | Univ Johns Hopkins | NITROXYL PREPARATION COMPOUNDS APPLICATION METHOD |
| US8168771B2 (en) * | 2005-01-31 | 2012-05-01 | The Johns Hopkins University | Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants |
| CA2613477C (en) * | 2005-06-23 | 2013-12-03 | Johns Hopkins University | Thiol-sensitive positive inotropes |
| WO2007045962A2 (en) * | 2005-10-18 | 2007-04-26 | Orchid Research Laboratories Limited | Novel hdac inhibitors |
| PT2489350E (pt) * | 2006-03-17 | 2014-03-10 | Univ Johns Hopkins Med | Derivados de n-hidroxilsulfonamida como novos dadores de nitroxilo fisiologicamente úteis |
| JP2011502105A (ja) * | 2007-09-26 | 2011-01-20 | ジョンズ ホプキンス ユニバーシティ | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
| EP3067352A3 (en) | 2008-05-07 | 2016-10-19 | Cardioxyl Pharmaceuticals Inc. | Novel nitroso compounds as nitroxyl donors and methods of use thereof |
| WO2011071947A2 (en) * | 2009-12-07 | 2011-06-16 | Johns Hopkins University | Bis-acylated hydroxylamine derivatives |
| CN102753520B (zh) * | 2009-12-07 | 2016-06-08 | 约翰斯霍普金斯大学 | N-酰氧基磺酰胺和n-羟基-n-酰基磺酰胺衍生物 |
-
2010
- 2010-11-22 WO PCT/US2010/057640 patent/WO2011063339A1/en not_active Ceased
- 2010-11-22 US US12/951,900 patent/US20110160200A1/en not_active Abandoned
- 2010-11-23 JP JP2012540154A patent/JP2013511556A/ja active Pending
- 2010-11-23 HR HRP20170183TT patent/HRP20170183T1/hr unknown
- 2010-11-23 PL PL10784416T patent/PL2504003T3/pl unknown
- 2010-11-23 SM SM20170090T patent/SMT201700090T1/it unknown
- 2010-11-23 LT LTEP10784416.9T patent/LT2504003T/lt unknown
- 2010-11-23 DK DK10784416.9T patent/DK2504003T3/en active
- 2010-11-23 RS RS20170138A patent/RS55697B1/sr unknown
- 2010-11-23 WO PCT/US2010/057844 patent/WO2011063400A1/en not_active Ceased
- 2010-11-23 HU HUE10784416A patent/HUE032253T2/en unknown
- 2010-11-23 EP EP10784416.9A patent/EP2504003B1/en active Active
- 2010-11-23 PT PT107844169T patent/PT2504003T/pt unknown
- 2010-11-23 ES ES10784416.9T patent/ES2611852T3/es active Active
- 2010-11-23 SI SI201031332A patent/SI2504003T1/sl unknown
-
2015
- 2015-04-24 US US14/696,319 patent/US20160081951A1/en not_active Abandoned
-
2016
- 2016-01-29 JP JP2016015102A patent/JP2016128481A/ja active Pending
-
2017
- 2017-02-07 CY CY20171100169T patent/CY1118603T1/el unknown
- 2017-02-09 SM SM201700090T patent/SMT201700090B/it unknown
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