JP2013509194A - Ａｘ２１３およびａｘ１３２ｐｃｓｋ９アンタゴニストおよびバリアント - Google Patents

Ａｘ２１３およびａｘ１３２ｐｃｓｋ９アンタゴニストおよびバリアント Download PDF

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Publication number
JP2013509194A
JP2013509194A JP2012537115A JP2012537115A JP2013509194A JP 2013509194 A JP2013509194 A JP 2013509194A JP 2012537115 A JP2012537115 A JP 2012537115A JP 2012537115 A JP2012537115 A JP 2012537115A JP 2013509194 A JP2013509194 A JP 2013509194A
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Prior art keywords
pcsk9
seq
sequence
specific
specific antagonist
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Withdrawn
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JP2012537115A
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English (en)
Japanese (ja)
Inventor
ルオ，ピーター・ペイチ
ニー，ヤン
ワン，ケビン・カイリ
シエ，マーク
ワン，シンウエイ
ドン，フエン
ゴロソフ，アンドレイ
ワン，ウエイロン
リー，ヤン
シヤン，ピング
ピーターソン，ローレンス・ビー
クボン，ローズ
シヤーマ，スジヤータ
コンドラ，ジヨン
ルー，ジユン
パルタサラテイー，ゴパラクリシユナン
ソワソン，ステフアン
バーン，ノエル
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Merck and Co Inc
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Merck and Co Inc
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Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JP2013509194A publication Critical patent/JP2013509194A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2012537115A 2009-10-30 2010-10-29 Ａｘ２１３およびａｘ１３２ｐｃｓｋ９アンタゴニストおよびバリアント Withdrawn JP2013509194A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25673209P 2009-10-30 2009-10-30
US61/256,732 2009-10-30
US32314810P 2010-04-12 2010-04-12
US61/323,148 2010-04-12
PCT/US2010/054714 WO2011053783A2 (en) 2009-10-30 2010-10-29 Ax213 and ax132 pcsk9 antagonists and variants

Publications (1)

Publication Number Publication Date
JP2013509194A true JP2013509194A (ja) 2013-03-14

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Family Applications (1)

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JP2012537115A Withdrawn JP2013509194A (ja) 2009-10-30 2010-10-29 Ａｘ２１３およびａｘ１３２ｐｃｓｋ９アンタゴニストおよびバリアント

Country Status (8)

Country Link
US (1) US8877900B2 (enExample)
EP (1) EP2493507A4 (enExample)
JP (1) JP2013509194A (enExample)
CN (1) CN102639150A (enExample)
AU (1) AU2010313324A1 (enExample)
CA (1) CA2777542A1 (enExample)
IN (1) IN2012DN03824A (enExample)
WO (1) WO2011053783A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022548950A (ja) * 2019-09-19 2022-11-22 イノベント バイオロジクス（スーチョウ）カンパニー，リミティド 抗ｐｃｓｋ９抗体を利用したコレステロール関連疾患の予防または治療方法

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