JP2013508413A - ｍＧｌｕＲ４アロステリック増強剤、組成物、および神経機能不全を治療する方法 - Google Patents

ｍＧｌｕＲ４アロステリック増強剤、組成物、および神経機能不全を治療する方法 Download PDF

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JP2013508413A
JP2013508413A JP2012535430A JP2012535430A JP2013508413A JP 2013508413 A JP2013508413 A JP 2013508413A JP 2012535430 A JP2012535430 A JP 2012535430A JP 2012535430 A JP2012535430 A JP 2012535430A JP 2013508413 A JP2013508413 A JP 2013508413A
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optionally substituted
cycloalkyl
alkyl
thiocarbonyl
carbonyl
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JP2013508413A5 (enExample
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ジェフリー コン，ピー．
ダブリュ． リンズリー，クレイグ
アール． ホプキンス，コーリー
エム． ニスウェンダー，コリーン
ディー． ゴグリオッティ，ロッコ
エム． サロヴィッチ，ジェームス
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Vanderbilt University
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JP2012535430A 2009-10-22 2010-10-22 ｍＧｌｕＲ４アロステリック増強剤、組成物、および神経機能不全を治療する方法 Withdrawn JP2013508413A (ja)

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US25406209P 2009-10-22 2009-10-22
US61/254,062 2009-10-22
US29272510P 2010-01-06 2010-01-06
US61/292,725 2010-01-06
PCT/US2010/053837 WO2011050316A1 (en) 2009-10-22 2010-10-22 Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

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JP2013508413A5 JP2013508413A5 (enExample) 2013-12-05

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JP2012535430A Withdrawn JP2013508413A (ja) 2009-10-22 2010-10-22 ｍＧｌｕＲ４アロステリック増強剤、組成物、および神経機能不全を治療する方法

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SG173465A1 (en) 2009-01-28 2011-09-29 Univ Vanderbilt Substituted 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazoles as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US8759377B2 (en) 2009-11-23 2014-06-24 Vanderbilt University Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
CA2794801C (en) 2010-04-07 2019-01-15 F. Hoffmann-La Roche Ag Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
KR20140074964A (ko) 2011-09-27 2014-06-18 에프. 호프만-라 로슈 아게 피라졸-4-일-헤테로사이클릴-카복사마이드 화합물 및 사용 방법
EP2853532B1 (en) 2013-09-28 2020-12-09 Instytut Farmakologii Polskiej Akademii Nauk 1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III
US10221172B2 (en) 2015-01-13 2019-03-05 Vanderbilt University Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US10526323B2 (en) 2015-01-30 2020-01-07 Vanderbilt University Indazole and azaindazole substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
WO2016123627A1 (en) 2015-01-30 2016-08-04 Vanderbilt University Isoquiniline and napthalene-substituted compounds as mglur4 allosteric potentiators, compounds, and methods of treating neurological dysfunction
WO2016179351A1 (en) 2015-05-05 2016-11-10 Northwestern University Treatment of levodopa-induced dyskinesias
WO2016202935A1 (en) 2015-06-19 2016-12-22 Bayer Pharma Aktiengesellschaft Glucose transport inhibitors
US10710997B2 (en) 2016-09-01 2020-07-14 Vanderbilt University Isoquinoline amide and isoquinoline amide-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US10294222B2 (en) 2016-09-01 2019-05-21 Vanderbilt University Benzomorpholine and benzomorpholine-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
WO2018089544A1 (en) * 2016-11-08 2018-05-17 Vanderbilt University Isoquinoline amine compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US10968227B2 (en) 2016-11-08 2021-04-06 Vanderbilt University Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US11319304B2 (en) 2017-06-28 2022-05-03 Vanderbilt University Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
BR112020003292A2 (pt) 2017-08-16 2020-08-18 Vanderbilt University compostos indazol como potencializadores alostéricos de mglur4 e seus usos terapêuticos, bem como composição farmacêutica e método para fabricação de medicamento para potenciar a atividade do receptor mglur4
IL280213B2 (en) 2018-07-26 2024-06-01 Domain Therapeutics Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
WO2020150417A2 (en) * 2019-01-17 2020-07-23 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
KR20220004996A (ko) 2019-04-03 2022-01-12 알리고스 테라퓨틱스 인코포레이티드 피롤 화합물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660753B2 (en) * 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
EP1646377A4 (en) 2003-07-11 2009-09-09 Merck & Co Inc TREATMENT OF MOVEMENT DISORDERS WITH METABOTROPIC GLUTAMATE 4 RECEPTOR POSITIVE ALLOSTERIC MODULATOR
US20060281803A1 (en) 2003-09-23 2006-12-14 Lindsley Craig W Pyrazole modulators of metabotropic glutamate receptors
CN101133027B (zh) 2005-03-04 2011-03-30 弗·哈夫曼-拉罗切有限公司 作为mglur5拮抗剂的吡啶-2-甲酰胺衍生物
CN101312951A (zh) * 2005-11-21 2008-11-26 盐野义制药株式会社 具有Ⅰ型11β羟基类固醇脱氢酶抑制活性的杂环化合物
US8110530B2 (en) * 2006-12-21 2012-02-07 Kumiai Chemical Industry Co., Ltd. Herbicidal composition
CA2681572C (en) 2007-03-23 2014-02-11 Icagen, Inc. Inhibitors of ion channels
WO2008145616A1 (en) * 2007-05-25 2008-12-04 Abbott Gmbh & Co. Kg Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (mglu2 receptor)
GB0713686D0 (en) * 2007-07-13 2007-08-22 Addex Pharmaceuticals Sa New compounds 2

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