CN102665411A - 用于治疗神经学上的功能失调的mglur4变构增效剂、组合物和方法 - Google Patents

用于治疗神经学上的功能失调的mglur4变构增效剂、组合物和方法 Download PDF

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CN102665411A
CN102665411A CN2010800589726A CN201080058972A CN102665411A CN 102665411 A CN102665411 A CN 102665411A CN 2010800589726 A CN2010800589726 A CN 2010800589726A CN 201080058972 A CN201080058972 A CN 201080058972A CN 102665411 A CN102665411 A CN 102665411A
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substituted
optionally substituted
cycloalkyl
optionally
membered ring
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P·J·康那
C·W·林斯利
C·R·霍普金斯
C·M·尼斯温德
R·D·高格廖蒂
J·M·萨洛维奇
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Vanderbilt University
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Vanderbilt University
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CN2010800589726A 2009-10-22 2010-10-22 用于治疗神经学上的功能失调的mglur4变构增效剂、组合物和方法 Pending CN102665411A (zh)

Applications Claiming Priority (5)

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US25406209P 2009-10-22 2009-10-22
US61/254,062 2009-10-22
US29272510P 2010-01-06 2010-01-06
US61/292,725 2010-01-06
PCT/US2010/053837 WO2011050316A1 (en) 2009-10-22 2010-10-22 Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

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CN2010800589745A Pending CN102665417A (zh) 2009-10-22 2010-10-22 用于治疗神经学上的功能失调的mglur4变构增效剂、组合物和方法

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JP2012516355A (ja) 2009-01-28 2012-07-19 ヴァンダービルト ユニバーシティー ｍＧＬｕＲ４アロステリック増強剤としての置換された１，１，３，３−テトラオキシドベンゾ［ｄ］［１，３，２］ジチアゾール、組成物、および神経機能不全を治療する方法
US8759377B2 (en) 2009-11-23 2014-06-24 Vanderbilt University Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
CN102933572B (zh) 2010-04-07 2015-01-07 霍夫曼-拉罗奇有限公司 吡唑-4-基-杂环基-甲酰胺化合物及其使用方法
BR112014007203A2 (pt) 2011-09-27 2017-06-13 F.Hoffmann-La Roche Ag composto, composição farmacêutica, método de tratamento, utilização de um composto, conjunto e invenção
EP2853532B1 (en) 2013-09-28 2020-12-09 Instytut Farmakologii Polskiej Akademii Nauk 1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III
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