JP2013508413A5 - - Google Patents
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- JP2013508413A5 JP2013508413A5 JP2012535430A JP2012535430A JP2013508413A5 JP 2013508413 A5 JP2013508413 A5 JP 2013508413A5 JP 2012535430 A JP2012535430 A JP 2012535430A JP 2012535430 A JP2012535430 A JP 2012535430A JP 2013508413 A5 JP2013508413 A5 JP 2013508413A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- cycloalkyl
- alkyl
- heteroaryl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 claims 33
- 125000001072 heteroaryl group Chemical group 0.000 claims 24
- 125000000217 alkyl group Chemical group 0.000 claims 23
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 20
- 229910052799 carbon Inorganic materials 0.000 claims 18
- 229910052760 oxygen Inorganic materials 0.000 claims 18
- 229910052717 sulfur Inorganic materials 0.000 claims 18
- 229910052757 nitrogen Inorganic materials 0.000 claims 17
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 15
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 14
- 229910052736 halogen Inorganic materials 0.000 claims 14
- 150000002367 halogens Chemical class 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- KXKVLQRXCPHEJC-UHFFFAOYSA-N methyl acetate Chemical compound COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 12
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 10
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 7
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 6
- 150000001242 acetic acid derivatives Chemical class 0.000 claims 6
- WMOVHXAZOJBABW-UHFFFAOYSA-N tert-butyl acetate Chemical compound CC(=O)OC(C)(C)C WMOVHXAZOJBABW-UHFFFAOYSA-N 0.000 claims 6
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 claims 4
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 4
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 4
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 4
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 claims 2
- HPARLNRMYDSBNO-UHFFFAOYSA-N 1,4-benzodioxine Chemical compound C1=CC=C2OC=COC2=C1 HPARLNRMYDSBNO-UHFFFAOYSA-N 0.000 claims 2
- CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical compound C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 claims 2
- WITJHZRCLVXYCA-UHFFFAOYSA-N 3h-1,2-benzodioxepine Chemical compound C1=CCOOC2=CC=CC=C21 WITJHZRCLVXYCA-UHFFFAOYSA-N 0.000 claims 2
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 2
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 2
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 claims 2
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229930192474 thiophene Natural products 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002240 furans Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- QFYXSLAAXZTRLG-UHFFFAOYSA-N pyrrolidine-2,3-dione Chemical compound O=C1CCNC1=O QFYXSLAAXZTRLG-UHFFFAOYSA-N 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 claims 1
- -1 thiadiazole compound Chemical class 0.000 claims 1
- MJJUUVLFRCEUPH-UHFFFAOYSA-N COc(c(Cl)c1)ccc1S([n](cc1)cc1NC(c1ccccn1)=O)(=O)=O Chemical compound COc(c(Cl)c1)ccc1S([n](cc1)cc1NC(c1ccccn1)=O)(=O)=O MJJUUVLFRCEUPH-UHFFFAOYSA-N 0.000 description 1
- WMEJMNLBIVBBNN-UHFFFAOYSA-N Cc(cc1-c2ccc(C(Nc(cc3)c[n]3S(c3ccc4OCOc4c3)(=O)=O)=O)[o]2)ccc1S([n](cc1)cc1NC(c1ccc[o]1)=O)(=O)=O Chemical compound Cc(cc1-c2ccc(C(Nc(cc3)c[n]3S(c3ccc4OCOc4c3)(=O)=O)=O)[o]2)ccc1S([n](cc1)cc1NC(c1ccc[o]1)=O)(=O)=O WMEJMNLBIVBBNN-UHFFFAOYSA-N 0.000 description 1
- CTRBCPANRFNGLH-UHFFFAOYSA-N O=C(c1ccc[o]1)Nc(cc1)c[n]1S(c(cc1)ccc1OC(F)F)(=O)=O Chemical compound O=C(c1ccc[o]1)Nc(cc1)c[n]1S(c(cc1)ccc1OC(F)F)(=O)=O CTRBCPANRFNGLH-UHFFFAOYSA-N 0.000 description 1
- RSVCJRQQLSSFEY-UHFFFAOYSA-N O=C(c1ccc[o]1)Nc(cc1)c[n]1S(c(cc1)ccc1OI)(=O)=O Chemical compound O=C(c1ccc[o]1)Nc(cc1)c[n]1S(c(cc1)ccc1OI)(=O)=O RSVCJRQQLSSFEY-UHFFFAOYSA-N 0.000 description 1
- XSNZVJUKGSRHNH-UHFFFAOYSA-N O=C(c1ccc[o]1)Nc(cc1)c[n]1S(c(cc1)ncc1Cl)(=O)=O Chemical compound O=C(c1ccc[o]1)Nc(cc1)c[n]1S(c(cc1)ncc1Cl)(=O)=O XSNZVJUKGSRHNH-UHFFFAOYSA-N 0.000 description 1
- KOMPAKWFRJCLCX-UHFFFAOYSA-N OCc(cc1)ccc1S([n](cc1)cc1NC(c1ncccc1)=O)(=O)=O Chemical compound OCc(cc1)ccc1S([n](cc1)cc1NC(c1ncccc1)=O)(=O)=O KOMPAKWFRJCLCX-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25406209P | 2009-10-22 | 2009-10-22 | |
| US61/254,062 | 2009-10-22 | ||
| US29272510P | 2010-01-06 | 2010-01-06 | |
| US61/292,725 | 2010-01-06 | ||
| PCT/US2010/053837 WO2011050316A1 (en) | 2009-10-22 | 2010-10-22 | Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013508413A JP2013508413A (ja) | 2013-03-07 |
| JP2013508413A5 true JP2013508413A5 (enExample) | 2013-12-05 |
Family
ID=43900711
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012535430A Withdrawn JP2013508413A (ja) | 2009-10-22 | 2010-10-22 | ｍＧｌｕＲ４アロステリック増強剤、組成物、および神経機能不全を治療する方法 |
| JP2012535428A Pending JP2013508412A (ja) | 2009-10-22 | 2010-10-22 | ｍＧｌｕＲ４アロステリック増強剤、組成物、および神経機能不全を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012535428A Pending JP2013508412A (ja) | 2009-10-22 | 2010-10-22 | ｍＧｌｕＲ４アロステリック増強剤、組成物、および神経機能不全を治療する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9180192B2 (enExample) |
| EP (2) | EP2490529A4 (enExample) |
| JP (2) | JP2013508413A (enExample) |
| KR (2) | KR20120129869A (enExample) |
| CN (2) | CN102665411A (enExample) |
| AU (2) | AU2010310440A1 (enExample) |
| BR (2) | BR112012009576A2 (enExample) |
| CA (2) | CA2779298A1 (enExample) |
| IL (2) | IL219296A0 (enExample) |
| MX (2) | MX2012004774A (enExample) |
| RU (2) | RU2012121630A (enExample) |
| WO (2) | WO2011050305A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010208176A1 (en) | 2009-01-28 | 2011-09-15 | Vanderbilt University | Substituted 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazoles as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US8759377B2 (en) | 2009-11-23 | 2014-06-24 | Vanderbilt University | Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| SG184475A1 (en) | 2010-04-07 | 2012-11-29 | Hoffmann La Roche | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| US8614206B2 (en) | 2011-09-27 | 2013-12-24 | F. Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| EP2853532B1 (en) | 2013-09-28 | 2020-12-09 | Instytut Farmakologii Polskiej Akademii Nauk | 1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III |
| US10221172B2 (en) | 2015-01-13 | 2019-03-05 | Vanderbilt University | Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US10227343B2 (en) | 2015-01-30 | 2019-03-12 | Vanderbilt University | Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2016123629A1 (en) | 2015-01-30 | 2016-08-04 | Vanderbilt University | Indazole and azaindazole substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US9987242B2 (en) | 2015-05-05 | 2018-06-05 | Northwestern University | Treatment of Levodopa-induced Dyskinesias |
| WO2016202935A1 (en) | 2015-06-19 | 2016-12-22 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
| US10710997B2 (en) | 2016-09-01 | 2020-07-14 | Vanderbilt University | Isoquinoline amide and isoquinoline amide-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US10294222B2 (en) | 2016-09-01 | 2019-05-21 | Vanderbilt University | Benzomorpholine and benzomorpholine-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US10968227B2 (en) | 2016-11-08 | 2021-04-06 | Vanderbilt University | Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2018089544A1 (en) * | 2016-11-08 | 2018-05-17 | Vanderbilt University | Isoquinoline amine compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US11319304B2 (en) | 2017-06-28 | 2022-05-03 | Vanderbilt University | Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| BR112020003292A2 (pt) * | 2017-08-16 | 2020-08-18 | Vanderbilt University | compostos indazol como potencializadores alostéricos de mglur4 e seus usos terapêuticos, bem como composição farmacêutica e método para fabricação de medicamento para potenciar a atividade do receptor mglur4 |
| US20220089609A1 (en) | 2018-07-26 | 2022-03-24 | Domain Therapeutics | Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4 |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| WO2020150417A2 (en) * | 2019-01-17 | 2020-07-23 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| CN114258391A (zh) | 2019-04-03 | 2022-03-29 | 阿里戈斯治疗公司 | 吡咯化合物 |
| TW202317087A (zh) | 2021-08-10 | 2023-05-01 | 美商Ｉｆｍ Ｄｕｅ有限公司 | 用於治療與sting活性相關病況之化合物及組合物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6660753B2 (en) * | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| US20060166972A1 (en) * | 2003-07-11 | 2006-07-27 | Conn P J | Treatment of movement disorders with a metabotropic glutamate 4 receptor positive allosteric modulator |
| JP2007506741A (ja) * | 2003-09-23 | 2007-03-22 | メルク エンド カムパニー インコーポレーテッド | 向代謝性グルタミン酸受容体のピラゾール系調節剤 |
| CN101133027B (zh) * | 2005-03-04 | 2011-03-30 | 弗·哈夫曼-拉罗切有限公司 | 作为mglur5拮抗剂的吡啶-2-甲酰胺衍生物 |
| CA2630665C (en) | 2005-11-21 | 2011-03-15 | Shionogi & Co., Ltd. | Heterocyclic compound having inhibitory activity on 11-.beta.-hydroxysteroid dehydrogenase type i |
| US8110530B2 (en) | 2006-12-21 | 2012-02-07 | Kumiai Chemical Industry Co., Ltd. | Herbicidal composition |
| JP5361857B2 (ja) * | 2007-03-23 | 2013-12-04 | ファイザー・リミテッド | イオンチャネルの阻害剤 |
| NZ581127A (en) * | 2007-05-25 | 2012-06-29 | Abbott Gmbh & Co Kg | Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (mglu2 receptor) |
| GB0713686D0 (en) | 2007-07-13 | 2007-08-22 | Addex Pharmaceuticals Sa | New compounds 2 |
-
2010
- 2010-10-22 CN CN2010800589726A patent/CN102665411A/zh active Pending
- 2010-10-22 CA CA2779298A patent/CA2779298A1/en not_active Abandoned
- 2010-10-22 US US13/503,644 patent/US9180192B2/en active Active
- 2010-10-22 BR BR112012009576A patent/BR112012009576A2/pt not_active IP Right Cessation
- 2010-10-22 RU RU2012121630/04A patent/RU2012121630A/ru not_active Application Discontinuation
- 2010-10-22 BR BR112012009574A patent/BR112012009574A2/pt not_active IP Right Cessation
- 2010-10-22 US US13/503,645 patent/US20130338154A1/en not_active Abandoned
- 2010-10-22 WO PCT/US2010/053825 patent/WO2011050305A1/en not_active Ceased
- 2010-10-22 RU RU2012121633/04A patent/RU2012121633A/ru not_active Application Discontinuation
- 2010-10-22 MX MX2012004774A patent/MX2012004774A/es unknown
- 2010-10-22 MX MX2012004771A patent/MX2012004771A/es not_active Application Discontinuation
- 2010-10-22 EP EP10825779.1A patent/EP2490529A4/en not_active Withdrawn
- 2010-10-22 EP EP10825772.6A patent/EP2490537A4/en not_active Withdrawn
- 2010-10-22 AU AU2010310440A patent/AU2010310440A1/en not_active Abandoned
- 2010-10-22 AU AU2010310518A patent/AU2010310518A1/en not_active Abandoned
- 2010-10-22 KR KR1020127013201A patent/KR20120129869A/ko not_active Withdrawn
- 2010-10-22 WO PCT/US2010/053837 patent/WO2011050316A1/en not_active Ceased
- 2010-10-22 JP JP2012535430A patent/JP2013508413A/ja not_active Withdrawn
- 2010-10-22 CA CA2779292A patent/CA2779292A1/en not_active Abandoned
- 2010-10-22 KR KR1020127013191A patent/KR20120088755A/ko not_active Withdrawn
- 2010-10-22 CN CN2010800589745A patent/CN102665417A/zh active Pending
- 2010-10-22 JP JP2012535428A patent/JP2013508412A/ja active Pending
-
2012
- 2012-04-19 IL IL219296A patent/IL219296A0/en unknown
- 2012-04-19 IL IL219297A patent/IL219297A0/en unknown