JP2013507970A5 - - Google Patents
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- JP2013507970A5 JP2013507970A5 JP2012535411A JP2012535411A JP2013507970A5 JP 2013507970 A5 JP2013507970 A5 JP 2013507970A5 JP 2012535411 A JP2012535411 A JP 2012535411A JP 2012535411 A JP2012535411 A JP 2012535411A JP 2013507970 A5 JP2013507970 A5 JP 2013507970A5
- Authority
- JP
- Japan
- Prior art keywords
- mucosal
- cells
- nucleic acid
- antigen
- epitope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 25
- 102000036639 antigens Human genes 0.000 claims 25
- 108091007433 antigens Proteins 0.000 claims 25
- 210000001744 T-lymphocyte Anatomy 0.000 claims 16
- 150000007523 nucleic acids Chemical class 0.000 claims 12
- 210000004379 membrane Anatomy 0.000 claims 11
- 239000012528 membrane Substances 0.000 claims 11
- 102000037865 fusion proteins Human genes 0.000 claims 10
- 108020001507 fusion proteins Proteins 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 101001030625 Homo sapiens Mucin-like protein 1 Proteins 0.000 claims 3
- 102100038565 Mucin-like protein 1 Human genes 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 108010026867 Oligo-1,6-Glucosidase Proteins 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 210000004400 mucous membrane Anatomy 0.000 claims 3
- 102100034605 Atrial natriuretic peptide receptor 3 Human genes 0.000 claims 2
- 108010083123 CDX2 Transcription Factor Proteins 0.000 claims 2
- 102100031672 Homeobox protein CDX-1 Human genes 0.000 claims 2
- 102100031671 Homeobox protein CDX-2 Human genes 0.000 claims 2
- 101000924488 Homo sapiens Atrial natriuretic peptide receptor 3 Proteins 0.000 claims 2
- 101000777808 Homo sapiens Homeobox protein CDX-1 Proteins 0.000 claims 2
- 102100027918 Sucrase-isomaltase, intestinal Human genes 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 1
- 101710095468 Cyclase Proteins 0.000 claims 1
- 102000018315 Parkinson Disease Associated Proteins Human genes 0.000 claims 1
- 108010066305 Parkinson Disease Associated Proteins Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- RQFCJASXJCIDSX-UUOKFMHZSA-N guanosine 5'-monophosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O RQFCJASXJCIDSX-UUOKFMHZSA-N 0.000 claims 1
- 210000004754 hybrid cell Anatomy 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25411909P | 2009-10-22 | 2009-10-22 | |
| US61/254,119 | 2009-10-22 | ||
| PCT/US2010/053733 WO2011066048A1 (en) | 2009-10-22 | 2010-10-22 | Cell-based anti-cancer compositions and methods of making and using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013507970A JP2013507970A (ja) | 2013-03-07 |
| JP2013507970A5 true JP2013507970A5 (https=) | 2013-12-12 |
| JP5955771B2 JP5955771B2 (ja) | 2016-07-20 |
Family
ID=44066847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012535411A Active JP5955771B2 (ja) | 2009-10-22 | 2010-10-22 | 細胞ベースの抗癌組成物ならびに当該物の製造方法および使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20120251509A1 (https=) |
| EP (2) | EP3444333A1 (https=) |
| JP (1) | JP5955771B2 (https=) |
| WO (1) | WO2011066048A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2545942C (en) | 2003-11-14 | 2012-07-10 | Lorus Therapeutics Inc. | Aryl imidazoles and their use as anti-cancer agents |
| SG10201407757XA (en) | 2009-10-23 | 2015-01-29 | Millennium Pharm Inc | Anti-gcc antibody molecules and related compositions and methods |
| US9156915B2 (en) | 2012-04-26 | 2015-10-13 | Thomas Jefferson University | Anti-GCC antibody molecules |
| AU2013251312B2 (en) | 2012-04-27 | 2018-03-22 | Takeda Pharmaceutical Company Limited | Anti-GCC antibody molecules and use of same to test for susceptibility to GCC-targeted therapy |
| US9393268B2 (en) * | 2013-03-15 | 2016-07-19 | Thomas Jefferson University | Cell-based anti-cancer compositions with reduced toxicity and methods of making and using the same |
| WO2015051304A1 (en) | 2013-10-04 | 2015-04-09 | Aptose Biosciences Inc. | Compositions, biomarkers and their use in treatment of cancer |
| IL302560B2 (en) * | 2015-10-13 | 2025-08-01 | Hope City | Chimeric antigen receptors containing a chlorotoxin domain |
| JP2018042481A (ja) * | 2016-09-13 | 2018-03-22 | テラ株式会社 | 抗原特異的ｔ細胞含有組成物及びその製造方法 |
| BR112019011065A2 (pt) | 2016-12-03 | 2019-10-01 | Juno Therapeutics Inc | métodos para determinação da dosagem de células t car |
| KR20190098747A (ko) | 2016-12-05 | 2019-08-22 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 치료법을 위한 조작된 세포의 제조방법 |
| WO2019089511A1 (en) | 2017-10-30 | 2019-05-09 | Aptose Biosciences Inc. | Aryl imidazoles for the treatment of cancer |
| MA51210A (fr) | 2017-12-01 | 2020-10-07 | Juno Therapeutics Inc | Procédés de dosage et de modulation de cellules génétiquement modifiées |
| CA3093705A1 (en) * | 2018-03-16 | 2019-09-19 | Thomas Jefferson University | Anti-gucy2c chimeric antigen receptor compositions and methods |
| US20250243272A1 (en) * | 2019-11-08 | 2025-07-31 | Good T Cells, Inc. | Epitope of regulatory t cell surface antigen, and antibody specifically binding thereto |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4375414A (en) | 1971-05-20 | 1983-03-01 | Meir Strahilevitz | Immunological methods for removing species from the blood circulatory system and devices therefor |
| US4022878A (en) | 1972-05-15 | 1977-05-10 | Biological Developments, Inc. | Methods and compounds for producing specific antibodies |
| US4526716A (en) | 1981-11-20 | 1985-07-02 | The Ohio State University | Antigenic modification of polypeptides |
| US4329281A (en) | 1978-06-05 | 1982-05-11 | Hoffmann-La Roche Inc. | Hapten compositions |
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US5364773A (en) | 1991-03-07 | 1994-11-15 | Virogenetics Corporation | Genetically engineered vaccine strain |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| JPS62162963A (ja) | 1986-01-10 | 1987-07-18 | Sadao Shiosaka | 金属コロイド粒子を担体とする低分子物質に対する特異抗体の作成法 |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5693622A (en) | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5204243A (en) | 1990-02-14 | 1993-04-20 | Health Research Incorporated | Recombinant poxvirus internal cores |
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| WO1991018088A1 (en) | 1990-05-23 | 1991-11-28 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Adeno-associated virus (aav)-based eucaryotic vectors |
| MY109299A (en) | 1990-08-15 | 1996-12-31 | Virogenetics Corp | Recombinant pox virus encoding flaviviral structural proteins |
| US5514375A (en) | 1990-08-15 | 1996-05-07 | Virogenetics Corporation | Flavivirus recombinant poxvirus vaccine |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| DE69233158T2 (de) | 1991-03-07 | 2004-05-13 | Connaught Technology Corp., Greenville | Gentechnologisch hergestellter stamm für impfstoffe |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US6413935B1 (en) | 1993-09-14 | 2002-07-02 | Epimmune Inc. | Induction of immune response against desired determinants |
| DE69435171D1 (de) | 1993-09-14 | 2009-01-08 | Pharmexa Inc | Pan dr-bindeproteinen zur erhöhung der immunantwort |
| US5658785A (en) | 1994-06-06 | 1997-08-19 | Children's Hospital, Inc. | Adeno-associated virus materials and methods |
| US5707618A (en) | 1995-03-24 | 1998-01-13 | Genzyme Corporation | Adenovirus vectors for gene therapy |
| US5668267A (en) * | 1995-05-31 | 1997-09-16 | Washington University | Polynucleotides encoding mammaglobin, a mammary-specific breast cancer protein |
| DE69723580T2 (de) | 1996-05-03 | 2004-06-03 | Thomas Jefferson University | Impfstoff gegen metastasierenden kolorektalkrebs. |
| US5780447A (en) | 1996-06-14 | 1998-07-14 | St. Jude Children's Research Hospital | Recombinant adeno-associated viral vectors |
| US6413517B1 (en) | 1997-01-23 | 2002-07-02 | Epimmune, Inc. | Identification of broadly reactive DR restricted epitopes |
| US20020018783A1 (en) * | 1997-03-20 | 2002-02-14 | Michel Sadelain | Fusion proteins of a single chain antibody and cd28 and uses thereof |
| CA2404431C (en) | 2000-03-27 | 2011-06-07 | Thomas Jefferson University | Guanylyl cyclase c in the detection of stomach and esophageal cancers |
| CA2417866A1 (en) * | 2000-08-03 | 2002-02-14 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of colon cancer |
| WO2005049073A2 (en) * | 2003-11-19 | 2005-06-02 | Survac Aps | Proteins belonging to the bcl-2 family and fragments thereof, and their use in cancer patients |
| EP1994406A1 (en) * | 2006-03-16 | 2008-11-26 | Leiden University Medical Center | Methods for identifying t-cell epitopes associated with impaired peptide processing and applications of the identified epitopes |
| US20110206736A1 (en) * | 2008-09-23 | 2011-08-25 | Thomas Jefferson University | Cancer Vaccines Against Mucosal Antigens and Methods of Making and Using the Same |
| US9001515B2 (en) | 2012-04-20 | 2015-04-07 | Cisco Technology, Inc. | Universal pull tab release for modules including fiber optic and cable accessibilities |
| US9939808B2 (en) | 2014-03-06 | 2018-04-10 | Texas Instruments Incorporated | Monitor data attachment to product lots for batch processes |
-
2010
- 2010-10-22 WO PCT/US2010/053733 patent/WO2011066048A1/en not_active Ceased
- 2010-10-22 EP EP18174732.0A patent/EP3444333A1/en not_active Withdrawn
- 2010-10-22 EP EP10833742.9A patent/EP2491116A4/en not_active Ceased
- 2010-10-22 US US13/503,214 patent/US20120251509A1/en not_active Abandoned
- 2010-10-22 JP JP2012535411A patent/JP5955771B2/ja active Active
-
2014
- 2014-11-20 US US14/548,544 patent/US20150079053A1/en not_active Abandoned
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