JP2013507349A5 - - Google Patents
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- Publication number
- JP2013507349A5 JP2013507349A5 JP2012532660A JP2012532660A JP2013507349A5 JP 2013507349 A5 JP2013507349 A5 JP 2013507349A5 JP 2012532660 A JP2012532660 A JP 2012532660A JP 2012532660 A JP2012532660 A JP 2012532660A JP 2013507349 A5 JP2013507349 A5 JP 2013507349A5
- Authority
- JP
- Japan
- Prior art keywords
- sucrose
- reaction mixture
- organotin
- ester
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 18
- 239000011541 reaction mixture Substances 0.000 claims 9
- 230000010933 acylation Effects 0.000 claims 6
- 238000005917 acylation reaction Methods 0.000 claims 6
- 239000003880 polar aprotic solvent Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical group CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical group CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 claims 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- NOGFHTGYPKWWRX-UHFFFAOYSA-N 2,2,6,6-tetramethyloxan-4-one Chemical group CC1(C)CC(=O)CC(C)(C)O1 NOGFHTGYPKWWRX-UHFFFAOYSA-N 0.000 claims 1
- CZFRZPMJNNTNDS-UHFFFAOYSA-L CCCC[Sn](O)(CCCC)O[Sn](CCCC)(CCCC)OC(C)=O Chemical group CCCC[Sn](O)(CCCC)O[Sn](CCCC)(CCCC)OC(C)=O CZFRZPMJNNTNDS-UHFFFAOYSA-L 0.000 claims 1
- 239000004376 Sucralose Substances 0.000 claims 1
- AFHCRQREQZIDSI-OVUASUNJSA-N [(2r,3s,4s,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl benzoate Chemical group O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(=O)C=2C=CC=CC=2)O1 AFHCRQREQZIDSI-OVUASUNJSA-N 0.000 claims 1
- JLHADLTXDDGZFX-UHFFFAOYSA-L [[acetyloxy(dibutyl)stannyl]oxy-dibutylstannyl] acetate Chemical group CCCC[Sn](CCCC)(OC(C)=O)O[Sn](CCCC)(CCCC)OC(C)=O JLHADLTXDDGZFX-UHFFFAOYSA-L 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 238000010923 batch production Methods 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 238000010924 continuous production Methods 0.000 claims 1
- 239000006184 cosolvent Substances 0.000 claims 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims 1
- 235000019408 sucralose Nutrition 0.000 claims 1
- AFHCRQREQZIDSI-UHFFFAOYSA-N sucrose-6-benzoate Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC(=O)C=2C=CC=CC=2)O1 AFHCRQREQZIDSI-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25068109P | 2009-10-12 | 2009-10-12 | |
| US61/250,681 | 2009-10-12 | ||
| PCT/GB2010/001904 WO2011045566A1 (en) | 2009-10-12 | 2010-10-12 | Low temperature, single solvent process for the production of sucrose-6-ester |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013507349A JP2013507349A (ja) | 2013-03-04 |
| JP2013507349A5 true JP2013507349A5 (enExample) | 2013-08-29 |
| JP5726195B2 JP5726195B2 (ja) | 2015-05-27 |
Family
ID=41565635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532660A Expired - Fee Related JP5726195B2 (ja) | 2009-10-12 | 2010-10-12 | スクロース−６−エステルを生成する低温単一溶媒方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8921540B2 (enExample) |
| EP (1) | EP2488541A1 (enExample) |
| JP (1) | JP5726195B2 (enExample) |
| KR (1) | KR20120089718A (enExample) |
| CN (1) | CN102639550B (enExample) |
| GB (1) | GB2474311B (enExample) |
| IE (1) | IE86139B1 (enExample) |
| WO (1) | WO2011045566A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201110520D0 (en) * | 2011-05-10 | 2011-08-03 | Tate & Lyle Technology Ltd | Extraction of carboxylic acids with tin compounds |
| CN104098617A (zh) * | 2013-04-08 | 2014-10-15 | 南京工业大学 | 一种蔗糖-6-乙酸酯的制备方法 |
| US10047038B2 (en) | 2013-11-27 | 2018-08-14 | Tate & Lyle Technology Limited | Waste treatment process |
| US10227367B2 (en) | 2013-12-16 | 2019-03-12 | Tate & Lyle Technology Limited | Chlorination of sucrose-6-esters |
| GB2544217B (en) | 2014-08-08 | 2020-03-25 | Tate & Lyle Tech Ltd | Chlorination of sucrose-6-esters |
| CN104774226A (zh) * | 2015-04-08 | 2015-07-15 | 常州市牛塘化工厂有限公司 | 一种蔗糖-6-乙酯的制备方法 |
| CN105254684B (zh) * | 2015-11-03 | 2019-01-01 | 浙江新和成股份有限公司 | 一种蔗糖-6-乙酸酯的制备方法 |
| GB2551591B (en) | 2016-06-23 | 2019-08-07 | Tate & Lyle Tech Ltd | Liquid-liquid extraction of DMF |
| CN106349300B (zh) * | 2016-08-30 | 2019-02-26 | 安徽金禾实业股份有限公司 | 三氯蔗糖酯化单溶剂反应方法 |
| CN108558962B (zh) | 2018-05-22 | 2020-06-30 | 山东新和成精化科技有限公司 | 一种用于合成蔗糖-6-酯的方法 |
| CN109438533A (zh) * | 2018-12-10 | 2019-03-08 | 安徽金禾实业股份有限公司 | 一种三氯蔗糖生产中高温连续酰化的方法 |
| CN109575069A (zh) * | 2018-12-10 | 2019-04-05 | 安徽金禾实业股份有限公司 | 一种三氯蔗糖生产中催化剂的回收方法 |
| CN112973166B (zh) * | 2019-12-17 | 2024-04-30 | 无锡弘鼎华化工设备有限公司 | 一种三氯蔗糖中和液溶剂的回收装置及方法 |
| CN111574572A (zh) * | 2020-05-22 | 2020-08-25 | 安徽金禾实业股份有限公司 | 一种三氯蔗糖生产中有机锡催化剂连续性制备补充的方法 |
| WO2022051988A1 (zh) | 2020-09-10 | 2022-03-17 | 安徽金禾实业股份有限公司 | 一种蔗糖-6-酯的制备方法 |
| CN112808048B (zh) * | 2021-01-04 | 2022-05-31 | 安徽金禾实业股份有限公司 | 蔗糖-6-酯的制造设备及制造方法 |
| US12434171B2 (en) * | 2021-02-19 | 2025-10-07 | Anhui Jinhe Industrial Co., Ltd. | Production apparatus and production method of sucrose-6-ester |
| EP4163001B1 (en) * | 2021-02-19 | 2024-12-11 | Anhui Jinhe Industrial Co., Ltd. | Production apparatus and production method for sucrose-6-ester |
| CN112933634B (zh) * | 2021-03-04 | 2022-04-08 | 安徽金禾实业股份有限公司 | 一种环列式的蔗糖-6-酯连续生产设备及生产工艺流程 |
| CN112973164B (zh) * | 2021-03-04 | 2022-09-02 | 安徽金禾实业股份有限公司 | 一种高效率的蔗糖6酯连续生产设备及方法 |
| WO2024082175A1 (zh) | 2022-10-19 | 2024-04-25 | 安徽金禾实业股份有限公司 | 一种三氯蔗糖精品的制备方法 |
| CN115894579A (zh) * | 2022-11-17 | 2023-04-04 | 安徽金禾实业股份有限公司 | 一种三氯蔗糖生产中b糖的处理方法 |
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| CN101253189A (zh) | 2005-08-30 | 2008-08-27 | 法马德医疗保险私人有限公司 | 基于从反应混合物中直接萃取到有机溶剂中随后蒸除溶剂的纯化三氯半乳蔗糖的方法 |
| US20070100139A1 (en) * | 2005-10-31 | 2007-05-03 | Healthy Brands, Llc | Methods for chlorinating sucrose-6-ester |
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| CN100418976C (zh) * | 2006-04-03 | 2008-09-17 | 广州科宏食品添加物有限公司 | 一种三氯蔗糖的制备方法 |
| GB0702854D0 (en) | 2007-01-09 | 2007-03-28 | Tate & Lyle Plc | Method for the synthesis of sucrose-6-esters |
| US20090076261A1 (en) * | 2007-09-13 | 2009-03-19 | Polymed Therapeutics, Inc. | Novel process for preparing sucrose-6-esters |
-
2009
- 2009-11-20 GB GB0920385.2A patent/GB2474311B/en active Active
-
2010
- 2010-10-11 US US12/901,808 patent/US8921540B2/en active Active
- 2010-10-12 CN CN201080054223.6A patent/CN102639550B/zh active Active
- 2010-10-12 JP JP2012532660A patent/JP5726195B2/ja not_active Expired - Fee Related
- 2010-10-12 KR KR1020127012141A patent/KR20120089718A/ko not_active Ceased
- 2010-10-12 WO PCT/GB2010/001904 patent/WO2011045566A1/en not_active Ceased
- 2010-10-12 EP EP10766092A patent/EP2488541A1/en not_active Withdrawn
- 2010-10-12 IE IE20100653A patent/IE86139B1/en not_active IP Right Cessation
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