CN102639550B - 用于生产蔗糖-6-酯的低温、单一溶剂方法 - Google Patents

用于生产蔗糖-6-酯的低温、单一溶剂方法 Download PDF

Info

Publication number
CN102639550B
CN102639550B CN201080054223.6A CN201080054223A CN102639550B CN 102639550 B CN102639550 B CN 102639550B CN 201080054223 A CN201080054223 A CN 201080054223A CN 102639550 B CN102639550 B CN 102639550B
Authority
CN
China
Prior art keywords
sucrose
reaction mixture
ester
polar aprotic
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201080054223.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN102639550A (zh
Inventor
爱德华·米钦斯基
戴维·克尔曼
詹姆斯·埃德温·威利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tate and Lyle PLC
Original Assignee
Tate and Lyle PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tate and Lyle PLC filed Critical Tate and Lyle PLC
Publication of CN102639550A publication Critical patent/CN102639550A/zh
Application granted granted Critical
Publication of CN102639550B publication Critical patent/CN102639550B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2224—Compounds having one or more tin-oxygen linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201080054223.6A 2009-10-12 2010-10-12 用于生产蔗糖-6-酯的低温、单一溶剂方法 Active CN102639550B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25068109P 2009-10-12 2009-10-12
US61/250,681 2009-10-12
PCT/GB2010/001904 WO2011045566A1 (en) 2009-10-12 2010-10-12 Low temperature, single solvent process for the production of sucrose-6-ester

Publications (2)

Publication Number Publication Date
CN102639550A CN102639550A (zh) 2012-08-15
CN102639550B true CN102639550B (zh) 2016-01-27

Family

ID=41565635

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080054223.6A Active CN102639550B (zh) 2009-10-12 2010-10-12 用于生产蔗糖-6-酯的低温、单一溶剂方法

Country Status (8)

Country Link
US (1) US8921540B2 (enExample)
EP (1) EP2488541A1 (enExample)
JP (1) JP5726195B2 (enExample)
KR (1) KR20120089718A (enExample)
CN (1) CN102639550B (enExample)
GB (1) GB2474311B (enExample)
IE (1) IE86139B1 (enExample)
WO (1) WO2011045566A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106349300A (zh) * 2016-08-30 2017-01-25 安徽金禾实业股份有限公司 三氯蔗糖酯化单溶剂反应方法

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201110520D0 (en) * 2011-05-10 2011-08-03 Tate & Lyle Technology Ltd Extraction of carboxylic acids with tin compounds
CN104098617A (zh) * 2013-04-08 2014-10-15 南京工业大学 一种蔗糖-6-乙酸酯的制备方法
US10047038B2 (en) 2013-11-27 2018-08-14 Tate & Lyle Technology Limited Waste treatment process
US10227367B2 (en) 2013-12-16 2019-03-12 Tate & Lyle Technology Limited Chlorination of sucrose-6-esters
GB2544217B (en) 2014-08-08 2020-03-25 Tate & Lyle Tech Ltd Chlorination of sucrose-6-esters
CN104774226A (zh) * 2015-04-08 2015-07-15 常州市牛塘化工厂有限公司 一种蔗糖-6-乙酯的制备方法
CN105254684B (zh) * 2015-11-03 2019-01-01 浙江新和成股份有限公司 一种蔗糖-6-乙酸酯的制备方法
GB2551591B (en) 2016-06-23 2019-08-07 Tate & Lyle Tech Ltd Liquid-liquid extraction of DMF
CN108558962B (zh) 2018-05-22 2020-06-30 山东新和成精化科技有限公司 一种用于合成蔗糖-6-酯的方法
CN109438533A (zh) * 2018-12-10 2019-03-08 安徽金禾实业股份有限公司 一种三氯蔗糖生产中高温连续酰化的方法
CN109575069A (zh) * 2018-12-10 2019-04-05 安徽金禾实业股份有限公司 一种三氯蔗糖生产中催化剂的回收方法
CN112973166B (zh) * 2019-12-17 2024-04-30 无锡弘鼎华化工设备有限公司 一种三氯蔗糖中和液溶剂的回收装置及方法
CN111574572A (zh) * 2020-05-22 2020-08-25 安徽金禾实业股份有限公司 一种三氯蔗糖生产中有机锡催化剂连续性制备补充的方法
WO2022051988A1 (zh) 2020-09-10 2022-03-17 安徽金禾实业股份有限公司 一种蔗糖-6-酯的制备方法
CN112808048B (zh) * 2021-01-04 2022-05-31 安徽金禾实业股份有限公司 蔗糖-6-酯的制造设备及制造方法
US12434171B2 (en) * 2021-02-19 2025-10-07 Anhui Jinhe Industrial Co., Ltd. Production apparatus and production method of sucrose-6-ester
EP4163001B1 (en) * 2021-02-19 2024-12-11 Anhui Jinhe Industrial Co., Ltd. Production apparatus and production method for sucrose-6-ester
CN112933634B (zh) * 2021-03-04 2022-04-08 安徽金禾实业股份有限公司 一种环列式的蔗糖-6-酯连续生产设备及生产工艺流程
CN112973164B (zh) * 2021-03-04 2022-09-02 安徽金禾实业股份有限公司 一种高效率的蔗糖6酯连续生产设备及方法
WO2024082175A1 (zh) 2022-10-19 2024-04-25 安徽金禾实业股份有限公司 一种三氯蔗糖精品的制备方法
CN115894579A (zh) * 2022-11-17 2023-04-04 安徽金禾实业股份有限公司 一种三氯蔗糖生产中b糖的处理方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023329A (en) * 1990-04-23 1991-06-11 Noramco, Inc. Sucrose-6-ester production process
US5470969A (en) * 1990-08-27 1995-11-28 Mcneil-Ppc, Inc. Catalyzed sucrose-6-ester process
CN1316428A (zh) * 2001-04-12 2001-10-10 河南兴泰科技实业有限公司 三氯蔗糖－6－酯制备新工艺
CN1446223A (zh) * 2000-07-31 2003-10-01 塔特和莱利有限公司 用于合成蔗糖－6－酯类的改进方法
CN1453284A (zh) * 2003-05-23 2003-11-05 广东省食品工业研究所 一种三氯蔗糖的合成方法

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3062467D1 (en) * 1979-12-20 1983-04-28 Tate & Lyle Plc Process for the preparation of 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose
EP0043649B1 (en) 1980-07-08 1984-09-12 TATE & LYLE PUBLIC LIMITED COMPANY Process for the preparation of 4, 1',6'-trichloro-4,1',6'-trideoxygalactosucrose (tgs)
CA1183133A (en) * 1980-10-28 1985-02-26 Tate & Lyle Public Limited Company Sweet chlorine-substituted disaccharides
GB8525954D0 (en) * 1985-10-21 1985-11-27 Mcneilab Inc Chlorination of carbohydrates &c alcohols
GB8525871D0 (en) * 1985-10-21 1985-11-27 Tate & Lyle Plc Chemical compound
GB8622345D0 (en) * 1986-09-17 1986-10-22 Tate & Lyle Plc Sucrose derivatives
US4950746A (en) * 1988-07-18 1990-08-21 Noramco, Inc. Process for synthesizing sucrose derivatives by regioselective reaction
GB8822673D0 (en) * 1988-09-27 1988-11-02 Tate & Lyle Plc Selective acylation of sugars
GB8822674D0 (en) * 1988-09-27 1988-11-02 Tate & Lyle Plc Preparation of acylated sucrose derivatives
NZ234143A (en) * 1989-06-28 1991-10-25 Mcneil Ppc Inc Aqueous pharmaceutical suspension formulation for administering substantially insoluble pharmaceutical agents
US4980463A (en) 1989-07-18 1990-12-25 Noramco, Inc. Sucrose-6-ester chlorination
US5089608A (en) * 1990-03-23 1992-02-18 Mcneil-Ppc, Inc. Selective 6-acylation of sucrose mediated by cyclic adducts of dialkyltin oxides and diols
US5034551A (en) * 1990-04-23 1991-07-23 Noramco, Inc. Process for recovery of organotin esters from reaction mixtures containing the same and re-use of the recovered organotin compounds
GR910100356A (el) * 1990-08-27 1992-08-31 Mcneil Ppc Inc Καταλυόμενη μέ?οδος εστέρος-6-σακχαρόζης.
NZ240818A (en) * 1990-12-14 1993-08-26 Mcneil Ppc Inc Liquid sucralose concentrate compositions containing preservative, buffer and liquid
GB9110931D0 (en) * 1991-05-21 1991-07-10 Tate & Lyle Plc Process for the preparation of sucrose 6-esters
US5272137A (en) * 1992-02-14 1993-12-21 Mcneil-Pfc, Inc. Aqueous pharmaceutical suspension for pharmaceutical actives
US5270071A (en) * 1992-06-18 1993-12-14 Mcneil-Ppc, Inc. Reduced calorie fruit spreads
US5397588A (en) * 1992-06-18 1995-03-14 Mcneil-Ppc, Inc. Reduced calorie fruit spreads
US5354902A (en) * 1992-10-26 1994-10-11 Mcneil-Ppc, Inc. Stabilized sorbic acid or salt thereof
CA2110313C (en) * 1992-12-01 2004-10-26 Edward John Roche Pharmaceutical compositions containing a guanidinothiazole compound and antacids
US5298611A (en) * 1993-03-12 1994-03-29 Mcneil-Ppc, Inc. Sucralose pentaester production
US5530106A (en) * 1993-03-12 1996-06-25 Mcneil-Ppc, Inc. Recovery of sucralose intermediates
NO941358L (no) * 1993-04-16 1994-10-17 Mcneil Ppc Inc Vandig farmasöytisk suspensjon og fremgangsmåte for fremstilling derav
CA2128820A1 (en) * 1993-07-27 1995-01-28 Walter G. Gowan, Jr. Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof
US5674522A (en) * 1993-10-07 1997-10-07 Mcneil-Ppc, Inc. Beverage concentrate for drug delivery
DE4429134A1 (de) * 1994-08-17 1996-02-22 Henkel Kgaa Verfahren zur Herstellung von Alkyl- und/oder Alkenyloligoglykosiden
US5498709A (en) 1994-10-17 1996-03-12 Mcneil-Ppc, Inc. Production of sucralose without intermediate isolation of crystalline sucralose-6-ester
US5593696A (en) * 1994-11-21 1997-01-14 Mcneil-Ppc, Inc. Stabilized composition of famotidine and sucralfate for treatment of gastrointestinal disorders
RU2159773C2 (ru) * 1995-11-28 2000-11-27 МакНЕЙЛ-ППС, ИНК. Способы получения сложного эфира сахарозы по положению 6
US5902628A (en) * 1996-11-14 1999-05-11 Pepsico., Inc. Beverage with reduction of lingering sweet aftertaste of sucralose
WO1998035974A1 (en) * 1997-02-13 1998-08-20 Mcneil-Ppc Inc. Chromatographic purification of chlorinated sucrose
AU753587B2 (en) * 1997-11-14 2002-10-24 Johnson & Johnson Consumer Companies, Inc. Highly flavored dental floss
US6394230B1 (en) * 1997-12-16 2002-05-28 Cognis Corporation Sterol esters as food additives
MXPA01000309A (es) * 1998-07-07 2002-10-17 Johnson & Johnson Metodo para mejorar el suministro de edulcoracion de sacarosa.
US6090401A (en) * 1999-03-31 2000-07-18 Mcneil-Ppc, Inc. Stable foam composition
US6211246B1 (en) * 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions
DE19938980A1 (de) * 1999-08-19 2001-02-22 Basf Ag Verfahren zur Herstellung von 2-Keto-L-gulonsäureestern
US6277409B1 (en) * 2000-02-11 2001-08-21 Mcneil-Ppc, Inc. Protective coating for tablet
US6258381B1 (en) * 2000-02-11 2001-07-10 Mcneil-Ppc, Inc. Tablet and process for making the same
WO2002040495A2 (en) * 2000-11-17 2002-05-23 Mcneil-Ppc, Inc. Improved sucralose composition and process for the crystallization thereof
US6998480B2 (en) 2002-03-08 2006-02-14 Tate & Lyle Public Limited Company Process for improving sucralose purity and yield
US7049435B2 (en) * 2002-03-08 2006-05-23 Tate & Lyle Public Limited Company Extractive methods for purifying sucralose
US6890581B2 (en) * 2002-04-05 2005-05-10 Tate & Lyle Public Limited Company Methods for buffer stabilized aqueous deacylation
US20040030124A1 (en) * 2002-08-06 2004-02-12 Catani Steven J. Process for recovering chlorosucrose compounds
US6943248B2 (en) * 2003-04-30 2005-09-13 Tate & Lyle Public Limited Company Crystalline form of sucralose, and method for producing it
DE602004032578D1 (de) 2004-03-19 2011-06-16 Vb Medicare Pvt Ltd Verbessertes verfahren zur herstellung von chlorierter saccharose
WO2005090376A1 (en) 2004-03-19 2005-09-29 Pharmed Medicare Private Limited An improved process for producing chlorinated sucrose
CN101098972A (zh) * 2004-12-10 2008-01-02 法马德医疗保险私人有限公司 硅烷化硅胶色谱纯化6-乙酰基-4,1',6'三氯半乳蔗糖和4,1',6'三氯半乳蔗糖的改良方法
US20080125584A1 (en) 2004-12-10 2008-05-29 Rakesh Ratnam Salts Assisted Selective Extraction Of 6-Acetyl- 4,1' , 6' Trichlorogalactosucrose And 4,1', 6' Trichlorogalactosucrosse From Aqueous Reaction Mixture
US20060188629A1 (en) * 2005-01-21 2006-08-24 Greg Liesen Method for the purification of sucralose
US20090105470A1 (en) * 2005-02-22 2009-04-23 Pharmed Medicare Private Limited , A Corporation Tin Mediated Regioselective Synthesis of Sucrose-6-Esters
US20060205936A1 (en) * 2005-03-14 2006-09-14 Sl Laboratories, Llc Chlorination of Sucrose-6-esters
KR20080016826A (ko) 2005-06-01 2008-02-22 팜드 메디케어 프리베이트 리미티드 용매 추출에 의한 염소화 수크로스 유도체의 정제 방법
US20060276639A1 (en) 2005-06-01 2006-12-07 Healthy Brands, Llc Conversion of sucralose-6-ester to sucralose
US20100197906A1 (en) 2005-06-06 2010-08-05 Pharmed Medicare Private Limited Method for purification of chlorinated sucrose derivatives from reaction mixture by chromatography
CN101253189A (zh) 2005-08-30 2008-08-27 法马德医疗保险私人有限公司 基于从反应混合物中直接萃取到有机溶剂中随后蒸除溶剂的纯化三氯半乳蔗糖的方法
US20070100139A1 (en) * 2005-10-31 2007-05-03 Healthy Brands, Llc Methods for chlorinating sucrose-6-ester
US7741477B2 (en) * 2006-01-10 2010-06-22 Alembic Limited Process for purification of sucralose
CN100418976C (zh) * 2006-04-03 2008-09-17 广州科宏食品添加物有限公司 一种三氯蔗糖的制备方法
GB0702854D0 (en) 2007-01-09 2007-03-28 Tate & Lyle Plc Method for the synthesis of sucrose-6-esters
US20090076261A1 (en) * 2007-09-13 2009-03-19 Polymed Therapeutics, Inc. Novel process for preparing sucrose-6-esters

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023329A (en) * 1990-04-23 1991-06-11 Noramco, Inc. Sucrose-6-ester production process
US5470969A (en) * 1990-08-27 1995-11-28 Mcneil-Ppc, Inc. Catalyzed sucrose-6-ester process
CN1446223A (zh) * 2000-07-31 2003-10-01 塔特和莱利有限公司 用于合成蔗糖－6－酯类的改进方法
CN1316428A (zh) * 2001-04-12 2001-10-10 河南兴泰科技实业有限公司 三氯蔗糖－6－酯制备新工艺
CN1453284A (zh) * 2003-05-23 2003-11-05 广东省食品工业研究所 一种三氯蔗糖的合成方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106349300A (zh) * 2016-08-30 2017-01-25 安徽金禾实业股份有限公司 三氯蔗糖酯化单溶剂反应方法
CN106349300B (zh) * 2016-08-30 2019-02-26 安徽金禾实业股份有限公司 三氯蔗糖酯化单溶剂反应方法

Also Published As

Publication number Publication date
GB2474311B (en) 2012-10-17
EP2488541A1 (en) 2012-08-22
GB0920385D0 (en) 2010-01-06
KR20120089718A (ko) 2012-08-13
CN102639550A (zh) 2012-08-15
JP5726195B2 (ja) 2015-05-27
US8921540B2 (en) 2014-12-30
IE20100653A1 (en) 2011-05-11
GB2474311A (en) 2011-04-13
JP2013507349A (ja) 2013-03-04
WO2011045566A1 (en) 2011-04-21
US20110087018A1 (en) 2011-04-14
IE86139B1 (en) 2013-02-27

Similar Documents

Publication Publication Date Title
CN102639550B (zh) 用于生产蔗糖-6-酯的低温、单一溶剂方法
US9073959B2 (en) Process for the production of sucrose-6-ester
JP3012355B2 (ja) サツカロース−６−エステルの製造法
JP2882548B2 (ja) 有機錫エステルを含む反応混合物から同化合物の回収法及び回収した有機錫化合物の再使用
US5298611A (en) Sucralose pentaester production
JPH04225993A (ja) サツカロース−６−エステルの製造法
CN103648602B (zh) 用锡化合物提取羧酸
JP5586683B2 (ja) スズスクロース付加物の塩基を利用した形成
JP5653416B2 (ja) ジメチルアミンを除去するプロセス
CN101981044B (zh) 碳水化合物浓度对三氯半乳蔗糖萃取效率的影响
JPH04225992A (ja) 新規白金錯体

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant