JP2013505062A - 医療装置用の抗感染性潤滑剤およびその調製方法 - Google Patents
医療装置用の抗感染性潤滑剤およびその調製方法 Download PDFInfo
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- JP2013505062A JP2013505062A JP2012529769A JP2012529769A JP2013505062A JP 2013505062 A JP2013505062 A JP 2013505062A JP 2012529769 A JP2012529769 A JP 2012529769A JP 2012529769 A JP2012529769 A JP 2012529769A JP 2013505062 A JP2013505062 A JP 2013505062A
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/452—Lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
Abstract
Description
Claims (20)
- 抗菌剤と、
前記抗菌剤を溶解することができる第1の溶媒であって、水、炭素原子数が1のアルコール、および炭素原子数が2のアルコールからなる群から選択される第1の溶媒と、
潤滑性剤と、
前記潤滑性剤を溶解することができる第2の溶媒と
を含み、前記第1の溶媒と前記第2の溶媒は相互に混和性であることを特徴とする抗菌剤組成物。 - 前記潤滑性剤がシリコーン油であることを特徴とする請求項1に記載の組成物。
- 前記第2の溶媒が、炭化水素、ケトン、ハロゲン化炭化水素および炭素原子数が少なくとも3のアルコールのうちの少なくとも1種であることを特徴とする請求項1に記載の組成物。
- 前記第2の溶媒がポリエトキシル化界面活性剤であることを特徴とする請求項1に記載の組成物。
- 前記抗菌剤が、クロルヘキシジン二酢酸塩、クロルヘキシジングルコン酸塩、トリクロサン、塩化ベンザルコニウムおよびパラクロロメタキシレノール(PCMX)のうちの少なくとも1種であることを特徴とする請求項1に記載の組成物。
- 前記シリコーン油が、ジメチルシロキサンおよびトリフルオロプロピルメチルシロキサンのうちの少なくとも1種であることを特徴とする請求項2に記載の組成物。
- 前記第2の溶媒が、2種以上の炭化水素、ケトン、ハロゲン化炭化水素、炭素原子数が少なくとも3のアルコールおよびそれらの組合せを含むことを特徴とする請求項3に記載の組成物。
- 抗菌剤組成物を製造するための方法であって、
抗菌剤を選択するステップと、
前記抗菌剤を溶解することができる第1の溶媒を選択するステップであって、前記第1の溶媒が水、炭素原子数が1のアルコール、および炭素原子数が2のアルコールからなる群から選択されるステップと、
前記抗菌剤を前記第1の溶媒に溶解させて、第1の混和性溶液を生成するステップと、
潤滑性剤を選択するステップと、
前記潤滑性剤を溶解することができる第2の溶媒を選択するステップと、
前記潤滑性剤を前記第2の溶媒に溶解させて、第2の混和性溶液を生成するステップと、
前記第1の混和性溶液と前記第2の混和性溶液とを均一に混合するステップと、
を含むことを特徴とする方法。 - 前記潤滑性剤がシリコーン油であることを特徴とする請求項8に記載の方法。
- 前記第2の溶媒が、炭化水素、ケトン、ハロゲン化炭化水素および炭素原子数が少なくとも3のアルコールのうちの少なくとも1種であることを特徴とする請求項8に記載の方法。
- 前記第2の溶媒がポリエトキシル化界面活性剤であることを特徴とする請求項8に記載の方法。
- 前記抗菌剤が、クロルヘキシジン二酢酸塩、クロルヘキシジングルコン酸塩、トリクロサン、塩化ベンザルコニウムおよびパラクロロメタキシレノール(PCMX)のうちの少なくとも1種であることを特徴とする請求項8に記載の方法。
- 前記シリコーン油が、ジメチルシロキサンおよびトリフルオロプロピルメチルシロキサンのうちの少なくとも1種であることを特徴とする請求項9に記載の方法。
- 前記第2の溶媒が、2種以上の炭化水素、ケトン、ハロゲン化炭化水素、炭素原子数が少なくとも3のアルコールおよびそれらの組合せを含むことを特徴とする請求項10に記載の方法。
- カテーテル関連血流感染症を防止するための血管内システムであって、
外表面を有する血管アクセス装置と、
前記外表面に適用された抗菌性コーティングであって、
抗菌剤と、
前記抗菌剤を溶解することができる第1の溶媒であって、水、C1アルコールおよびC2アルコールからなる群から選択される第1の溶媒と、
潤滑性剤と、
前記潤滑性剤を溶解することができる第2の溶媒と
を含み、前記第1の溶媒と第2の溶媒が相互に混和性である抗菌性コーティングと、
を含むことを特徴とするシステム。 - 前記潤滑性剤がシリコーン油であることを特徴とする請求項15に記載のシステム。
- 前記血管アクセス装置が注射器をさらに含むことを特徴とする請求項15に記載のシステム。
- 前記第2の溶媒が、炭化水素、ケトン、ハロゲン化炭化水素および炭素原子数が少なくとも3のアルコールのうちの少なくとも1種であることを特徴とする請求項15に記載のシステム。
- 前記第2の溶媒がポリエトキシル化界面活性剤であることを特徴とする請求項15に記載のシステム。
- 前記シリコーン油が、ジメチルシロキサンおよびトリフルオロプロピルメチルシロキサンのうちの少なくとも1種であることを特徴とする請求項16に記載のシステム。
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US12/561,863 US20110065798A1 (en) | 2009-09-17 | 2009-09-17 | Anti-infective lubricant for medical devices and methods for preparing the same |
PCT/US2010/045616 WO2011034675A2 (en) | 2009-09-17 | 2010-08-16 | Anti-infective lubricant for medical devices and methods for preparing the same |
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Also Published As
Publication number | Publication date |
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BR112012005874A2 (pt) | 2016-02-16 |
WO2011034675A2 (en) | 2011-03-24 |
US20150079144A1 (en) | 2015-03-19 |
CN102497894A (zh) | 2012-06-13 |
ES2615493T3 (es) | 2017-06-07 |
AU2010295926B2 (en) | 2015-02-12 |
AU2010295926A1 (en) | 2012-03-22 |
US20110065798A1 (en) | 2011-03-17 |
EP2477670B1 (en) | 2016-11-23 |
BR112012005874B1 (pt) | 2018-10-09 |
EP2477670A2 (en) | 2012-07-25 |
WO2011034675A3 (en) | 2011-05-19 |
JP5868323B2 (ja) | 2016-02-24 |
IN2012DN02024A (ja) | 2015-07-31 |
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