JP2013504331A5 - - Google Patents
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- JP2013504331A5 JP2013504331A5 JP2012528991A JP2012528991A JP2013504331A5 JP 2013504331 A5 JP2013504331 A5 JP 2013504331A5 JP 2012528991 A JP2012528991 A JP 2012528991A JP 2012528991 A JP2012528991 A JP 2012528991A JP 2013504331 A5 JP2013504331 A5 JP 2013504331A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- protein
- biomarker
- tau
- gfap
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 16
- 239000000090 biomarker Substances 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 239000007857 degradation product Substances 0.000 claims 9
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 claims 6
- 102100039289 Glial fibrillary acidic protein Human genes 0.000 claims 6
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 claims 6
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 claims 6
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 claims 6
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 5
- 238000003776 cleavage reaction Methods 0.000 claims 5
- 230000007017 scission Effects 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- 108090000371 Esterases Proteins 0.000 claims 3
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims 3
- 102100031874 Spectrin alpha chain, non-erythrocytic 1 Human genes 0.000 claims 3
- 101710157175 Spectrin alpha chain, non-erythrocytic 1 Proteins 0.000 claims 3
- 102000044159 Ubiquitin Human genes 0.000 claims 3
- 108090000848 Ubiquitin Proteins 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 3
- 102000057063 human MAPT Human genes 0.000 claims 3
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 claims 2
- 102100028652 Gamma-enolase Human genes 0.000 claims 2
- 101000979001 Homo sapiens Methionine aminopeptidase 2 Proteins 0.000 claims 2
- 101000969087 Homo sapiens Microtubule-associated protein 2 Proteins 0.000 claims 2
- 102000009664 Microtubule-Associated Proteins Human genes 0.000 claims 2
- 108010020004 Microtubule-Associated Proteins Proteins 0.000 claims 2
- 102100021118 Microtubule-associated protein 2 Human genes 0.000 claims 2
- 102100023057 Neurofilament light polypeptide Human genes 0.000 claims 2
- 108010019965 Spectrin Proteins 0.000 claims 2
- 102000005890 Spectrin Human genes 0.000 claims 2
- 108010055170 Synaptotagmin I Proteins 0.000 claims 2
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- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
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- 108010026424 tau Proteins Proteins 0.000 claims 2
- 102000013498 tau Proteins Human genes 0.000 claims 2
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- 108091006112 ATPases Proteins 0.000 claims 1
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- 101000934069 Homo sapiens Calpain-1 catalytic subunit Proteins 0.000 claims 1
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- 101000979333 Homo sapiens Neurofilament light polypeptide Proteins 0.000 claims 1
- 101000979321 Homo sapiens Neurofilament medium polypeptide Proteins 0.000 claims 1
- 101000673946 Homo sapiens Synaptotagmin-like protein 1 Proteins 0.000 claims 1
- 102100025087 Insulin receptor substrate 1 Human genes 0.000 claims 1
- 101710201824 Insulin receptor substrate 1 Proteins 0.000 claims 1
- 108091028080 MiR-132 Proteins 0.000 claims 1
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- 108091028049 Mir-221 microRNA Proteins 0.000 claims 1
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- 102100030610 Mothers against decapentaplegic homolog 5 Human genes 0.000 claims 1
- 101710143113 Mothers against decapentaplegic homolog 5 Proteins 0.000 claims 1
- 102100024007 Neurofilament heavy polypeptide Human genes 0.000 claims 1
- 101710159895 Neurofilament heavy polypeptide Proteins 0.000 claims 1
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- 102100023206 Neuromodulin Human genes 0.000 claims 1
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- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 102000008880 Peptidase C12, ubiquitin carboxyl-terminal hydrolases Human genes 0.000 claims 1
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- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 claims 1
- 101100480719 Rattus norvegicus Mapt gene Proteins 0.000 claims 1
- 102000013008 Semaphorin-3A Human genes 0.000 claims 1
- 108010090319 Semaphorin-3A Proteins 0.000 claims 1
- 102000017299 Synapsin-1 Human genes 0.000 claims 1
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- 102100040541 Synaptotagmin-like protein 1 Human genes 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 102100035071 Vimentin Human genes 0.000 claims 1
- 108010065472 Vimentin Proteins 0.000 claims 1
- 108010011385 alpha-internexin Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
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- 208000029028 brain injury Diseases 0.000 claims 1
- 108010044208 calpastatin Proteins 0.000 claims 1
- ZXJCOYBPXOBJMU-HSQGJUDPSA-N calpastatin peptide Ac 184-210 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C1=CC=C(O)C=C1 ZXJCOYBPXOBJMU-HSQGJUDPSA-N 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 230000000593 degrading effect Effects 0.000 claims 1
- 102000051520 human GFAP Human genes 0.000 claims 1
- 210000005049 internexin Anatomy 0.000 claims 1
- 230000004807 localization Effects 0.000 claims 1
- 108091055434 miR-124a stem-loop Proteins 0.000 claims 1
- 108091082871 miR-124a-2 stem-loop Proteins 0.000 claims 1
- 108091050112 miR-124a-4 stem-loop Proteins 0.000 claims 1
- 108091054623 miR-124a-5 stem-loop Proteins 0.000 claims 1
- 108091024680 miR-124a-6 stem-loop Proteins 0.000 claims 1
- 108091024609 miR-124b stem-loop Proteins 0.000 claims 1
- 108091081188 miR-124b-1 stem-loop Proteins 0.000 claims 1
- 108091060300 miR-124b-2 stem-loop Proteins 0.000 claims 1
- 108091044988 miR-125a stem-loop Proteins 0.000 claims 1
- 108091049513 miR-125a-1 stem-loop Proteins 0.000 claims 1
- 108091040046 miR-125a-2 stem-loop Proteins 0.000 claims 1
- 108091070946 miR-128 stem-loop Proteins 0.000 claims 1
- 108091029379 miR-139 stem-loop Proteins 0.000 claims 1
- 108091033783 miR-153 stem-loop Proteins 0.000 claims 1
- 108091029500 miR-183 stem-loop Proteins 0.000 claims 1
- 108091058965 miR-218a stem-loop Proteins 0.000 claims 1
- 108091063841 miR-219 stem-loop Proteins 0.000 claims 1
- 108091080321 miR-222 stem-loop Proteins 0.000 claims 1
- 108091074487 miR-34 stem-loop Proteins 0.000 claims 1
- 108091092493 miR-34-1 stem-loop Proteins 0.000 claims 1
- 108091059780 miR-34-2 stem-loop Proteins 0.000 claims 1
- 108091055813 miR-6 stem-loop Proteins 0.000 claims 1
- 108091065445 miR-6-4 stem-loop Proteins 0.000 claims 1
- 108091053743 miR-6-5 stem-loop Proteins 0.000 claims 1
- 108091055911 miR-6-6 stem-loop Proteins 0.000 claims 1
- 108091047084 miR-9 stem-loop Proteins 0.000 claims 1
- 108091038507 miR-92b stem-loop Proteins 0.000 claims 1
- 108091081014 miR-92b-1 stem-loop Proteins 0.000 claims 1
- 108091032846 miR-92b-2 stem loop Proteins 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 208000037890 multiple organ injury Diseases 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 108010080874 neuroserpin Proteins 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 102000000568 rho-Associated Kinases Human genes 0.000 claims 1
- 108010041788 rho-Associated Kinases Proteins 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 102000003137 synaptotagmin Human genes 0.000 claims 1
- 108060008004 synaptotagmin Proteins 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 210000005048 vimentin Anatomy 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24212309P | 2009-09-14 | 2009-09-14 | |
| US61/242,123 | 2009-09-14 | ||
| US35450410P | 2010-06-14 | 2010-06-14 | |
| US61/354,504 | 2010-06-14 | ||
| US35577910P | 2010-06-17 | 2010-06-17 | |
| US61/355,779 | 2010-06-17 | ||
| US38015810P | 2010-09-03 | 2010-09-03 | |
| US61/380,158 | 2010-09-03 | ||
| PCT/US2010/048789 WO2011032155A2 (en) | 2009-09-14 | 2010-09-14 | Micro-rna, autoantibody and protein markers for diagnosis of neuronal injury |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253708A Division JP2016105097A (ja) | 2009-09-14 | 2015-12-25 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013504331A JP2013504331A (ja) | 2013-02-07 |
| JP2013504331A5 true JP2013504331A5 (OSRAM) | 2013-12-19 |
| JP5909447B2 JP5909447B2 (ja) | 2016-04-26 |
Family
ID=43733138
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528991A Active JP5909447B2 (ja) | 2009-09-14 | 2010-09-14 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| JP2015253708A Pending JP2016105097A (ja) | 2009-09-14 | 2015-12-25 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| JP2017111070A Active JP6469760B2 (ja) | 2009-09-14 | 2017-06-05 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253708A Pending JP2016105097A (ja) | 2009-09-14 | 2015-12-25 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| JP2017111070A Active JP6469760B2 (ja) | 2009-09-14 | 2017-06-05 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20130022982A1 (OSRAM) |
| EP (1) | EP2478360B1 (OSRAM) |
| JP (3) | JP5909447B2 (OSRAM) |
| AU (2) | AU2010291933B2 (OSRAM) |
| CA (1) | CA2774173A1 (OSRAM) |
| ES (1) | ES2687469T3 (OSRAM) |
| HU (1) | HUE040281T2 (OSRAM) |
| WO (1) | WO2011032155A2 (OSRAM) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8492107B2 (en) | 2004-04-15 | 2013-07-23 | University Of Florida Research Foundation, Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| AU2009282117B2 (en) | 2008-08-11 | 2016-05-12 | Banyan Biomarkers, Inc. | Biomarker detection process and assay of neurological condition |
| CA2766057A1 (en) * | 2009-06-19 | 2010-12-23 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| US20170315136A9 (en) * | 2009-06-19 | 2017-11-02 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| JP5909447B2 (ja) | 2009-09-14 | 2016-04-26 | バンヤン・バイオマーカーズ・インコーポレーテッド | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| WO2012045324A1 (en) * | 2010-10-07 | 2012-04-12 | Mediagnost Gesellschaft Fur Forschung Und Herstellung Von Diagnostika Gmbh | Method for detecting a parkinson's disease and test system |
| US9746481B2 (en) | 2010-10-14 | 2017-08-29 | The Johns Hopkins University | Biomarkers of brain injury |
| DE102011011280A1 (de) * | 2011-02-15 | 2012-08-16 | Euroimmun Medizinische Labordiagnostika Ag | Diagnosekit sowie ein Verfahren zur Untersuchung einer menschlichen Patientenprobe auf das Vorhandensein von Neuromyelitis-optica-spezifischen Antikörpern |
| US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
| GB201111361D0 (en) * | 2011-07-04 | 2011-08-17 | Nordic Bioscience As | Biochemical markers for neurodegenerative conditions |
| WO2013024469A1 (en) * | 2011-08-16 | 2013-02-21 | Rosetta Genomics Ltd. | Methods and compositions for diagnosis of alzheimer's desease |
| EP2825893A4 (en) | 2012-03-13 | 2016-03-16 | Univ Johns Hopkins | CITRILLINATED BRAIN AND NERVE PROTEINS AS A BIOMARKER OF BRAIN INJURY OR NERVOUS GENERATION |
| WO2013173596A1 (en) * | 2012-05-16 | 2013-11-21 | Trustees Of Boston University | Chronic traumatic encephalopathy in blast-exposed individuals |
| MY171473A (en) * | 2012-07-03 | 2019-10-15 | Univ Washington | Antibodies to tau |
| US9856532B2 (en) * | 2012-09-07 | 2018-01-02 | Institute For Systems Biology | Markers and methods for detecting posttraumatic stress disorder (PTSD) |
| US20140073524A1 (en) * | 2012-09-07 | 2014-03-13 | Institute For Systems Biology | Markers and methods for detecting posttraumatic stress disorder (ptsd) |
| EP3022322A4 (en) | 2013-07-17 | 2017-05-17 | The Johns Hopkins University | A multi-protein biomarker assay for brain injury detection and outcome |
| GB201319761D0 (en) * | 2013-11-08 | 2013-12-25 | Nordic Bioscience As | Biomarkers of disease progression |
| CN103656685B (zh) * | 2014-01-10 | 2016-01-13 | 厦门大学 | microRNA-219在制备抗癫痫药物中的应用 |
| WO2015134551A1 (en) * | 2014-03-03 | 2015-09-11 | Banyan Biomarkers, Inc. | Micro rna markers for diagnosis of a neurological condition |
| US9605315B2 (en) * | 2014-03-26 | 2017-03-28 | The University Of Montana | Detection of traumatic brain injury |
| WO2015157300A1 (en) * | 2014-04-07 | 2015-10-15 | Iron Horse Diagnostics, Inc | Traumatic brain injury and neurodegenerative biomarkers, methods, and systems |
| EP3663764B1 (en) * | 2014-04-08 | 2023-11-01 | University of Florida Research Foundation, Inc. | Protein biomarkers for acute, subacute and chronic traumatic injuries of the central nervous system |
| WO2015160391A1 (en) * | 2014-04-15 | 2015-10-22 | The Government Of The United States, As Represented By The Secretary Of The Army, On Behalf Of Walter Reed Army Institute Of Research | Diagnosis and treatment of tauopathy and chronic traumatic encephalopathy |
| WO2015196191A1 (en) * | 2014-06-20 | 2015-12-23 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Microrna biomarkers for traumatic brain injury and methods of use thereof |
| EP3198013B1 (en) * | 2014-09-26 | 2019-06-12 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Microrna biomarkers for posttraumatic stress disorder and methods of use thereof |
| AU2015330355B2 (en) * | 2014-10-06 | 2021-09-23 | Fundacio Hospital Universitari Vall D'hebron - Institut De Recerca | Markers and their use in brain injury |
| EP3254106A4 (en) | 2015-02-05 | 2018-10-03 | Immunarray USA, Inc. | Methods and compositions for diagnosing brain injury or neurodegeneration |
| WO2016205730A1 (en) * | 2015-06-18 | 2016-12-22 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Citrullinated proteins and their breakdown products as tbi biomarkers |
| EP3329005B1 (en) * | 2015-07-29 | 2020-05-13 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Microrna biomarkers for traumatic brain injury and methods of use thereof |
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| GB201603967D0 (en) * | 2016-03-08 | 2016-04-20 | Univ Birmingham | Biomarkers of traumatic brain injury |
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| EP3452832A4 (en) * | 2016-05-06 | 2020-04-22 | Duke University | METHODS AND KITS FOR DIAGNOSIS AND TREATMENT OF DISEASES OR INJURIES OF THE NERVOUS SYSTEM |
| EP3509646A4 (en) * | 2016-09-09 | 2020-06-17 | Mayo Foundation for Medical Education and Research | METHOD AND MATERIALS FOR IDENTIFYING AND TREATING AUTOIMMUNE GFAP ASTROCYTOPATHY |
| IT201600093825A1 (it) * | 2016-09-19 | 2018-03-19 | Fondazione St Italiano Tecnologia | Composizione farmaceutica di miRNA e suoi usi terapeutici. |
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| AU2018275236B2 (en) | 2017-05-30 | 2024-11-07 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin I |
| CN110998321A (zh) * | 2017-06-02 | 2020-04-10 | 约翰霍普金斯大学 | 帕金森氏症患者脑脊液中par的检测方法 |
| WO2018223003A1 (en) | 2017-06-02 | 2018-12-06 | The John Hopkins University | Detection of par in the csf of patients with parkinson's disease |
| WO2018236590A1 (en) * | 2017-06-19 | 2018-12-27 | St. John's University | Circulating serum microrna biomarkers and methods for determining the progression rate of parkinson's disease |
| JP7454945B2 (ja) | 2017-07-03 | 2024-03-25 | アボット・ラボラトリーズ | 血液中のユビキチンカルボキシ末端ヒドロラーゼｌ１レベルを測定するための、改善された方法 |
| TWI827557B (zh) | 2017-10-25 | 2024-01-01 | 美商健生醫藥公司 | Ｔａｕ胜肽之組成物及其用途 |
| JP6942036B2 (ja) * | 2017-11-30 | 2021-09-29 | 藤倉化成株式会社 | 脳梗塞の発症リスクを高感度に検出する体液抗体バイオマーカー |
| EP3721233A2 (en) | 2017-12-09 | 2020-10-14 | Abbott Laboratories | Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (tbi), using glial fibrillary acidic protein (gfap) and/or ubiquitin carboxy-terminal hydrolase l1 (uch-l1) |
| CA3067055A1 (en) | 2017-12-09 | 2019-06-13 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of gfap and uch-l1 |
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