HUE040281T2 - Autoantitest markerek traumás agysérülés diagnózisára - Google Patents
Autoantitest markerek traumás agysérülés diagnózisáraInfo
- Publication number
- HUE040281T2 HUE040281T2 HUE10816275A HUE10816275A HUE040281T2 HU E040281 T2 HUE040281 T2 HU E040281T2 HU E10816275 A HUE10816275 A HU E10816275A HU E10816275 A HUE10816275 A HU E10816275A HU E040281 T2 HUE040281 T2 HU E040281T2
- Authority
- HU
- Hungary
- Prior art keywords
- diagnosis
- brain injury
- traumatic brain
- autoantibody markers
- autoantibody
- Prior art date
Links
- 208000030886 Traumatic Brain injury Diseases 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 230000009529 traumatic brain injury Effects 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Rehabilitation Therapy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24212309P | 2009-09-14 | 2009-09-14 | |
| US35450410P | 2010-06-14 | 2010-06-14 | |
| US35577910P | 2010-06-17 | 2010-06-17 | |
| US38015810P | 2010-09-03 | 2010-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE040281T2 true HUE040281T2 (hu) | 2019-03-28 |
Family
ID=43733138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE10816275A HUE040281T2 (hu) | 2009-09-14 | 2010-09-14 | Autoantitest markerek traumás agysérülés diagnózisára |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20130022982A1 (OSRAM) |
| EP (1) | EP2478360B1 (OSRAM) |
| JP (3) | JP5909447B2 (OSRAM) |
| AU (2) | AU2010291933B2 (OSRAM) |
| CA (1) | CA2774173A1 (OSRAM) |
| ES (1) | ES2687469T3 (OSRAM) |
| HU (1) | HUE040281T2 (OSRAM) |
| WO (1) | WO2011032155A2 (OSRAM) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8492107B2 (en) | 2004-04-15 | 2013-07-23 | University Of Florida Research Foundation, Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| JP5781436B2 (ja) | 2008-08-11 | 2015-09-24 | バンヤン・バイオマーカーズ・インコーポレーテッド | 神経学的状態のバイオマーカー検出方法およびアッセイ |
| US20170315136A9 (en) * | 2009-06-19 | 2017-11-02 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| EP3355059A3 (en) * | 2009-06-19 | 2018-09-26 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| CA2774173A1 (en) | 2009-09-14 | 2011-03-17 | Banyan Biomarkers, Inc. | Micro-rna, autoantibody and protein markers for diagnosis of neuronal injury |
| WO2012045324A1 (en) * | 2010-10-07 | 2012-04-12 | Mediagnost Gesellschaft Fur Forschung Und Herstellung Von Diagnostika Gmbh | Method for detecting a parkinson's disease and test system |
| EP2628013B1 (en) | 2010-10-14 | 2019-06-12 | The Johns Hopkins University | Biomarkers of brain injury |
| DE102011011280A1 (de) * | 2011-02-15 | 2012-08-16 | Euroimmun Medizinische Labordiagnostika Ag | Diagnosekit sowie ein Verfahren zur Untersuchung einer menschlichen Patientenprobe auf das Vorhandensein von Neuromyelitis-optica-spezifischen Antikörpern |
| US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
| GB201111361D0 (en) | 2011-07-04 | 2011-08-17 | Nordic Bioscience As | Biochemical markers for neurodegenerative conditions |
| US20140206777A1 (en) * | 2011-08-16 | 2014-07-24 | Rosetta Genomics Ltd. | Methods and compositions for diagnosis of alzheimer's disease |
| WO2013138509A1 (en) * | 2012-03-13 | 2013-09-19 | The Johns Hopkins University | Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration |
| WO2013173596A1 (en) * | 2012-05-16 | 2013-11-21 | Trustees Of Boston University | Chronic traumatic encephalopathy in blast-exposed individuals |
| EP3838921A3 (en) * | 2012-07-03 | 2021-09-01 | Washington University | Antibodies to tau |
| US20140073524A1 (en) * | 2012-09-07 | 2014-03-13 | Institute For Systems Biology | Markers and methods for detecting posttraumatic stress disorder (ptsd) |
| US9856532B2 (en) * | 2012-09-07 | 2018-01-02 | Institute For Systems Biology | Markers and methods for detecting posttraumatic stress disorder (PTSD) |
| US10534003B2 (en) | 2013-07-17 | 2020-01-14 | The Johns Hopkins University | Multi-protein biomarker assay for brain injury detection and outcome |
| GB201319761D0 (en) * | 2013-11-08 | 2013-12-25 | Nordic Bioscience As | Biomarkers of disease progression |
| CN103656685B (zh) * | 2014-01-10 | 2016-01-13 | 厦门大学 | microRNA-219在制备抗癫痫药物中的应用 |
| WO2015134551A1 (en) * | 2014-03-03 | 2015-09-11 | Banyan Biomarkers, Inc. | Micro rna markers for diagnosis of a neurological condition |
| US9605315B2 (en) * | 2014-03-26 | 2017-03-28 | The University Of Montana | Detection of traumatic brain injury |
| US20170023591A1 (en) * | 2014-04-07 | 2017-01-26 | Iron Horse Diagnostics, Inc. | Traumatic Brain Injury and Neurodegenerative Biomarkers, Methods, and Systems |
| EP3663764B1 (en) * | 2014-04-08 | 2023-11-01 | University of Florida Research Foundation, Inc. | Protein biomarkers for acute, subacute and chronic traumatic injuries of the central nervous system |
| WO2015160391A1 (en) * | 2014-04-15 | 2015-10-22 | The Government Of The United States, As Represented By The Secretary Of The Army, On Behalf Of Walter Reed Army Institute Of Research | Diagnosis and treatment of tauopathy and chronic traumatic encephalopathy |
| WO2015196191A1 (en) * | 2014-06-20 | 2015-12-23 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Microrna biomarkers for traumatic brain injury and methods of use thereof |
| WO2016049429A1 (en) * | 2014-09-26 | 2016-03-31 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Microrna biomarkers for posttraumatic stress disorder and methods of use thereof |
| EP3204778A2 (en) * | 2014-10-06 | 2017-08-16 | Université de Genève | Markers and their use in brain injury |
| JP2018510359A (ja) * | 2015-02-05 | 2018-04-12 | イミューンアレイ ユーエスエイ インコーポレイテッド | 脳損傷または神経変性を診断するための方法および組成物 |
| WO2016205730A1 (en) * | 2015-06-18 | 2016-12-22 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Citrullinated proteins and their breakdown products as tbi biomarkers |
| JP2018522558A (ja) * | 2015-07-29 | 2018-08-16 | ザ ヘンリー エム. ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | 外傷性脳損傷のためのマイクロrnaバイオマーカー、及びその使用方法 |
| US11053545B2 (en) | 2015-09-08 | 2021-07-06 | The Translational Genomics Research Institute | Biomarkers and methods of diagnosing and prognosing mild traumatic brain injuries |
| EP3377074B1 (en) * | 2015-11-18 | 2024-01-03 | Dignity Health | Methods of diagnosing post traumatic epilepsy |
| GB201603967D0 (en) * | 2016-03-08 | 2016-04-20 | Univ Birmingham | Biomarkers of traumatic brain injury |
| EP3450540A4 (en) * | 2016-04-28 | 2020-04-08 | The Foundation for the Promotion of Industrial Science | Device for culturing nerve cell, method for culturing nerve cell, cultured nerve cell, method for analyzing and identifying protein in axon bundle, and method for using nerve cell |
| JP2019521319A (ja) * | 2016-05-06 | 2019-07-25 | デューク ユニバーシティ | 神経系疾患または損傷を診断および治療するための方法並びにキット |
| EP3509646A4 (en) * | 2016-09-09 | 2020-06-17 | Mayo Foundation for Medical Education and Research | METHOD AND MATERIALS FOR IDENTIFYING AND TREATING AUTOIMMUNE GFAP ASTROCYTOPATHY |
| IT201600093825A1 (it) * | 2016-09-19 | 2018-03-19 | Fondazione St Italiano Tecnologia | Composizione farmaceutica di miRNA e suoi usi terapeutici. |
| CN110366558A (zh) | 2016-10-28 | 2019-10-22 | 班扬生物标记公司 | 针对泛素c末端水解酶l1(uch-l1)和胶质纤维酸性蛋白(gfap)的抗体及相关方法 |
| WO2018096049A1 (en) * | 2016-11-23 | 2018-05-31 | Randox Laboratories Ltd | Gfap derivatives for stroke diagnostics |
| WO2018148294A2 (en) * | 2017-02-07 | 2018-08-16 | Bioregency, Inc. | S100β AND ISOFORMS FOR DETECTION OF NEUROLOGICAL CONDITIONS |
| WO2018152359A1 (en) | 2017-02-17 | 2018-08-23 | Denali Therapeutics Inc. | Anti-tau antibodies and methods of use thereof |
| US11016092B2 (en) | 2017-03-23 | 2021-05-25 | Abbott Laboratories | Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase L1 |
| JP7067800B2 (ja) * | 2017-04-12 | 2022-05-16 | 国立大学法人九州大学 | 神経障害性疼痛マーカー及びその使用 |
| US10877048B2 (en) | 2017-04-15 | 2020-12-29 | Abbott Laboratories | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers |
| AU2018256845B2 (en) | 2017-04-28 | 2024-03-14 | Abbott Laboratories | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject |
| WO2018218169A1 (en) | 2017-05-25 | 2018-11-29 | Abbott Laboratories | Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers |
| BR112019025387A2 (pt) | 2017-05-30 | 2020-07-07 | Abbott Laboratories | métodos para auxiliar no diagnóstico e avaliação de uma lesão traumática cerebral branda em um indivíduo humano com o uso de troponina cardíaca i e biomarcadores precoces |
| WO2018223003A1 (en) | 2017-06-02 | 2018-12-06 | The John Hopkins University | Detection of par in the csf of patients with parkinson's disease |
| EP3631448A4 (en) * | 2017-06-02 | 2021-03-03 | The Johns Hopkins University | DETECTION OF PAR IN THE CSF OF PATIENTS WITH PARKINSON'S DISEASE |
| EP4410998A3 (en) * | 2017-06-19 | 2024-10-23 | St. John's University | Circulating serum microrna biomarkers and methods for determining the progression rate of parkinson's disease |
| EP3649474A1 (en) | 2017-07-03 | 2020-05-13 | Abbott Laboratories | Improved methods for measuring ubiquitin carboxy-terminal hydrolase l1 levels in blood |
| TW202333768A (zh) | 2017-10-25 | 2023-09-01 | 美商健生醫藥公司 | Tau胜肽之組成物及其用途 |
| JP6942036B2 (ja) * | 2017-11-30 | 2021-09-29 | 藤倉化成株式会社 | 脳梗塞の発症リスクを高感度に検出する体液抗体バイオマーカー |
| CN111094983A (zh) | 2017-12-09 | 2020-05-01 | 雅培实验室 | 使用胶质细胞原纤维酸性蛋白(gfap)和/或泛素羧基末端水解酶l1(uch-l1)帮助诊断和评价已遭受骨科损伤并已遭受或可能已遭受头部损伤诸如轻度创伤性脑损伤(tbi)的患者的方法 |
| US11016105B2 (en) | 2017-12-09 | 2021-05-25 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of GFAP and UCH-L1 |
| CA3084064A1 (en) | 2017-12-29 | 2019-07-04 | Abbott Laboratories | Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury |
| KR102026675B1 (ko) * | 2018-02-12 | 2019-09-30 | 강원대학교산학협력단 | miR-135a-5p 및 p62에 의한 알레르기 반응 조절 메커니즘 및 이의 이용 |
| EP3762729A1 (en) * | 2018-03-08 | 2021-01-13 | Meso Scale Technologies, LLC | Genetic marker and/or biomarkers for traumatic brain injury, and ultrasensitive assays for biomarkers of traumatic brain injury |
| JP6499342B2 (ja) * | 2018-03-19 | 2019-04-10 | 隆樹 日和佐 | 脳梗塞の診断マーカー |
| WO2019207159A1 (en) * | 2018-04-27 | 2019-10-31 | Fondazione Ebri Rita Levi-Montalcini | Antibody directed against a tau-derived neurotoxic peptide and uses thereof |
| WO2020023789A2 (en) * | 2018-07-25 | 2020-01-30 | Srnalytics, Inc. | Small rna predictors for alzheimer's disease |
| CN110824156B (zh) * | 2018-08-14 | 2023-08-11 | 欧蒙医学诊断(中国)有限公司 | 神经自身免疫疾病的诊断 |
| WO2020037311A1 (en) * | 2018-08-17 | 2020-02-20 | University Of Florida Research Foundation, Inc. | Protein and peptide biomarkers for traumatic injury to the central nervous system |
| CA3116860A1 (en) * | 2018-10-17 | 2020-04-23 | Ochsner Health System | Plasma and cerebrospinal fluid mirna biomarkers in intracerebral and subarachnoid hemorrhage |
| CN109266739A (zh) * | 2018-11-29 | 2019-01-25 | 成都仕康美生物科技有限公司 | 一种检测脑损伤的miRNA标志物、试剂盒、应用 |
| WO2020113271A1 (en) * | 2018-12-04 | 2020-06-11 | La Trobe University | Methods of diagnosing a disease state |
| JOP20210211A1 (ar) | 2019-02-08 | 2023-01-30 | Janssen Pharmaceuticals Inc | طريقة إعطاء دواء آمنة للقاح ببتيد تاو المفسفر |
| PL3924518T3 (pl) * | 2019-02-14 | 2025-08-11 | Marker Diagnostics Uk Limited | Obecne w ślinie biomarkery urazu mózgu |
| GB201909393D0 (en) | 2019-06-28 | 2019-08-14 | Gen2 Neuroscience Ltd | Tau epitope and binding molecules |
| CN110551809A (zh) * | 2019-08-21 | 2019-12-10 | 昆明医科大学第一附属医院 | miR-124在脊髓损伤修复中的用途 |
| US11644463B2 (en) * | 2019-08-30 | 2023-05-09 | Euroimmun Medizinische Labordiagnostika Ag | Detection of an autoantibody |
| WO2022011269A2 (en) * | 2020-07-09 | 2022-01-13 | University Of Florida Research Foundation, Incorporated | Biofluid-based protein and mirna biomarkers for neonatal hypoxic-ischemic encephalopathy |
| JP2023538975A (ja) * | 2020-08-24 | 2023-09-12 | マラバイオ システムズ,インク. | 母体自己抗体を減少させる方法 |
| KR102357260B1 (ko) * | 2020-12-10 | 2022-02-08 | 주식회사 레피겐엠디 | 마이크로rna를 이용한 당뇨병성 신경병증의 예측 및 진단 방법 및 이를 위한 키트 |
| CN113238045B (zh) * | 2021-04-27 | 2021-12-28 | 南方医科大学南方医院 | Crmp2及抗crmp2抗体的应用 |
| KR102759445B1 (ko) * | 2021-11-16 | 2025-01-24 | 한국한의학연구원 | 치료에 따른 보행 장애 개선 판별용 바이오마커 및 이의 용도 |
| TWI853766B (zh) * | 2022-12-22 | 2024-08-21 | 國立臺灣大學 | 用於心跳停止病患頭部電腦斷層之灰白質比率自動計算方法 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5637459A (en) | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| ATE318832T1 (de) | 1990-06-11 | 2006-03-15 | Gilead Sciences Inc | Verfahren zur vervendung von nukleinsäureliganden |
| US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
| US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
| US5683867A (en) | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
| US5707796A (en) | 1990-06-11 | 1998-01-13 | Nexstar Pharmaceuticals, Inc. | Method for selecting nucleic acids on the basis of structure |
| AU2414092A (en) * | 1991-08-01 | 1993-03-02 | Paul H. Voorheis | Diagnostic method for alzheimer's disease |
| US5731410A (en) | 1994-11-28 | 1998-03-24 | University Of Utah Research Foundation | Peptide for blocking autoantibody-evoked activation of glutamate receptor type 3 (GLUR3) |
| JP4624559B2 (ja) * | 1998-09-08 | 2011-02-02 | イノジェネティックス・ナムローゼ・フェンノートシャップ | 初期cnsダメージのマーカーとしてのタウ |
| US20020002270A1 (en) | 1999-06-16 | 2002-01-03 | Raymond P. Zinkowski | Purified antigen for alzheimer's disease, and methods of obtaining and using same |
| US6589746B1 (en) * | 1999-10-21 | 2003-07-08 | University Of Cincinnati | Method of detecting axonally-derived protein tau in patients with traumatic CNS injury |
| US20030199000A1 (en) | 2001-08-20 | 2003-10-23 | Valkirs Gunars E. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| US20040203083A1 (en) | 2001-04-13 | 2004-10-14 | Biosite, Inc. | Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases |
| US20040253637A1 (en) | 2001-04-13 | 2004-12-16 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| US7427490B2 (en) | 2001-08-20 | 2008-09-23 | Biosite Incorporated | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| US7713705B2 (en) | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| US20020172676A1 (en) * | 2001-05-16 | 2002-11-21 | George Jackowski | Method of treatment of alzheimer's disease and device therefor |
| US7144708B2 (en) | 2001-06-25 | 2006-12-05 | The Cleveland Clinic Foundation | Markers of blood barrier disruption and methods of using same |
| WO2003032894A2 (en) | 2001-10-12 | 2003-04-24 | Pfizer Products Inc. | Method of monitoring neuroprotective treatment |
| AU2003243563A1 (en) | 2002-06-12 | 2004-09-28 | The Cleveland Clinic Foundation | Markers of blood barrier permeability and methods of using same |
| EP2211176A3 (en) | 2002-09-11 | 2010-12-08 | University Of Florida | Analyzing nerve cell damage |
| JP2006526140A (ja) | 2002-12-24 | 2006-11-16 | バイオサイト インコーポレイテッド | 鑑別診断のためのマーカーおよびその使用方法 |
| DK2357477T3 (en) | 2003-09-20 | 2018-02-05 | Electrophoretics Ltd | Diagnostic approach for brain injury-related disorders based on detection of NDKA |
| EP1519194A1 (en) | 2003-09-24 | 2005-03-30 | Roche Diagnostics GmbH | Use of gfap for identification of intracerebral hemorrhage |
| AU2005238446B2 (en) | 2004-04-15 | 2009-07-30 | Banyan Biomarkers Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| EP1747282B1 (en) * | 2004-04-15 | 2011-06-08 | University of Florida Research Foundation, Inc. | Map-2 proteolytic breakdown products as diagnostic biomarkers for neural injury |
| US8492107B2 (en) | 2004-04-15 | 2013-07-23 | University Of Florida Research Foundation, Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| US20140303041A1 (en) | 2004-04-15 | 2014-10-09 | University Of Florida Research Foundation Inc. | In vitro diagnostic devices for nervous system injury and other neural disorders |
| GB2428240A (en) * | 2005-07-14 | 2007-01-24 | Univ Gen Ve | Diagnostic method for brain damage-related disorders |
| EP1949103A2 (en) | 2005-10-20 | 2008-07-30 | Biosite Incorporated | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| JP5266459B2 (ja) | 2006-02-15 | 2013-08-21 | 国立大学法人三重大学 | 診断用組換えプロテオリポソームの作製法 |
| WO2007136617A2 (en) * | 2006-05-18 | 2007-11-29 | Walter Reed Army Institute Of Research (Wrair) | Endothelial-monocyte activating polypeptide ii, a biomarker for use in diagnosis of brain injury |
| WO2007140188A2 (en) | 2006-05-26 | 2007-12-06 | Biosite Incorporated | Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases |
| JP2011511301A (ja) * | 2008-02-04 | 2011-04-07 | バンヤン・バイオマーカーズ・インコーポレイテッド | 脳損傷を診断または治療するための方法 |
| EP2143735A1 (en) | 2008-07-10 | 2010-01-13 | Institut Pasteur | Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins |
| US20140342381A1 (en) | 2008-08-11 | 2014-11-20 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of neurological condition |
| JP5781436B2 (ja) | 2008-08-11 | 2015-09-24 | バンヤン・バイオマーカーズ・インコーポレーテッド | 神経学的状態のバイオマーカー検出方法およびアッセイ |
| US20120094295A1 (en) | 2008-11-21 | 2012-04-19 | The Johns Hopkins University | Neurodegenerative disease diagnostic compositions and methods of use |
| US20170315136A9 (en) | 2009-06-19 | 2017-11-02 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| EP3355059A3 (en) * | 2009-06-19 | 2018-09-26 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| WO2011011334A2 (en) | 2009-07-18 | 2011-01-27 | Banyan Biomarkers, Inc. | SYNERGISTIC BIOMARKER ASSAY OF NEUROLGICAL CONDITION USING S-100β |
| CA2774173A1 (en) | 2009-09-14 | 2011-03-17 | Banyan Biomarkers, Inc. | Micro-rna, autoantibody and protein markers for diagnosis of neuronal injury |
| US20130029362A1 (en) | 2010-04-01 | 2013-01-31 | Andreas Jeromin | Markers and assays for detection of neurotoxicity |
| WO2011160096A2 (en) | 2010-06-17 | 2011-12-22 | Banyan Biomarkers, Inc. | Glial fibrillary acidic protein, autoantigens and autoantibodies thereto as biomarkers of neural injury or neurological disorder or condition |
| WO2013040502A2 (en) | 2011-09-14 | 2013-03-21 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Processes and kits to detect and monitor for diagnostic biomarkers for post traumatic stress disorder (ptsd) and to differentiate between suicidal and non-suicidal form of the disorder |
| US20140024053A1 (en) | 2012-07-20 | 2014-01-23 | Banyan Biomarkers, Inc. | Methods, kits and devices for detecting bii-spectrin, and breakdown products thereof, as biomarkers for the diagnosis of neural injury |
| US20140275294A1 (en) | 2013-03-15 | 2014-09-18 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of liver injury |
| WO2014194329A1 (en) | 2013-05-31 | 2014-12-04 | Banyan Biomarkers, Inc. | NEURAL SPECIFIC S100β FOR BIOMARKER ASSAYS AND DEVICES FOR DETECTION OF A NEUROLOGICAL CONDITION |
-
2010
- 2010-09-14 CA CA2774173A patent/CA2774173A1/en not_active Abandoned
- 2010-09-14 US US13/395,931 patent/US20130022982A1/en not_active Abandoned
- 2010-09-14 ES ES10816275T patent/ES2687469T3/es active Active
- 2010-09-14 JP JP2012528991A patent/JP5909447B2/ja active Active
- 2010-09-14 HU HUE10816275A patent/HUE040281T2/hu unknown
- 2010-09-14 EP EP10816275.1A patent/EP2478360B1/en not_active Revoked
- 2010-09-14 AU AU2010291933A patent/AU2010291933B2/en not_active Expired - Fee Related
- 2010-09-14 WO PCT/US2010/048789 patent/WO2011032155A2/en not_active Ceased
-
2015
- 2015-12-25 JP JP2015253708A patent/JP2016105097A/ja active Pending
-
2016
- 2016-12-07 AU AU2016269481A patent/AU2016269481B2/en not_active Ceased
- 2016-12-27 US US15/391,755 patent/US10041959B2/en active Active
-
2017
- 2017-06-05 JP JP2017111070A patent/JP6469760B2/ja active Active
-
2018
- 2018-08-01 US US16/052,512 patent/US20190064188A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2478360A4 (en) | 2013-04-03 |
| JP2013504331A (ja) | 2013-02-07 |
| CA2774173A1 (en) | 2011-03-17 |
| AU2010291933B2 (en) | 2016-09-08 |
| AU2016269481A1 (en) | 2016-12-22 |
| JP2017181518A (ja) | 2017-10-05 |
| AU2016269481B2 (en) | 2018-08-30 |
| US20190064188A1 (en) | 2019-02-28 |
| JP2016105097A (ja) | 2016-06-09 |
| AU2010291933A1 (en) | 2012-05-10 |
| JP6469760B2 (ja) | 2019-02-13 |
| US10041959B2 (en) | 2018-08-07 |
| WO2011032155A3 (en) | 2011-10-06 |
| JP5909447B2 (ja) | 2016-04-26 |
| EP2478360A2 (en) | 2012-07-25 |
| WO2011032155A2 (en) | 2011-03-17 |
| EP2478360B1 (en) | 2018-06-27 |
| US20130022982A1 (en) | 2013-01-24 |
| ES2687469T3 (es) | 2018-10-25 |
| US20170242041A1 (en) | 2017-08-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUE040281T2 (hu) | Autoantitest markerek traumás agysérülés diagnózisára | |
| IL225731B (en) | Biomarkers for brain injury | |
| IL221330A0 (en) | Medical neurological instrument | |
| GB2479176B (en) | Surgical instrument | |
| PL2488190T3 (pl) | Zmniejszanie ryzyka patologicznych skutków urazowego uszkodzenia mózgu | |
| IL215767A0 (en) | Methods of treatment for solid tumors | |
| IL226392A0 (en) | Emotion to acquire physiological signals | |
| IL196456A0 (en) | Uderbelly of armord vehicle | |
| IL222328A (en) | Tissue microabulation system | |
| IL253293A0 (en) | Desferrioxamine complexes of metals for the treatment of diseases related to the immune system | |
| SG2014014724A (en) | METHODS FOR THE TREATMENT OF IL-1ß RELATED CONDITIONS | |
| EP2542163A4 (en) | SURGICAL INSTRUMENT | |
| PT2576825T (pt) | Métodos para avaliar a receptividade do endométrio de uma doente | |
| EP2564796A4 (en) | MEDICAL INSTRUMENT | |
| EP2641560A4 (en) | SURGICAL PAD | |
| EP2646821A4 (en) | NEOANTIC BODY FOR THE DIAGNOSIS OF TISSUE INJURY | |
| GB201008109D0 (en) | Surgical forceps for wire introduction | |
| GB201017027D0 (en) | Distal radius fixation system | |
| GB0911643D0 (en) | Surgical instrument | |
| PL2477656T3 (pl) | Leczenie stanów neurologicznych | |
| GB0913561D0 (en) | Brain cooling device | |
| GB0914839D0 (en) | Treatment of oil | |
| HU0900199D0 (en) | Diagnosis of gluten-induced autoimmune diseases | |
| GB0905594D0 (en) | Surgical instrument | |
| GB201016461D0 (en) | Medical instrument |