JP2013503205A5 - - Google Patents
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- JP2013503205A5 JP2013503205A5 JP2012527108A JP2012527108A JP2013503205A5 JP 2013503205 A5 JP2013503205 A5 JP 2013503205A5 JP 2012527108 A JP2012527108 A JP 2012527108A JP 2012527108 A JP2012527108 A JP 2012527108A JP 2013503205 A5 JP2013503205 A5 JP 2013503205A5
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- composition
- polypeptide
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- transplant
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- 229920001184 polypeptide Polymers 0.000 claims 14
- 102000037240 fusion proteins Human genes 0.000 claims 9
- 108020001507 fusion proteins Proteins 0.000 claims 9
- 102000004965 antibodies Human genes 0.000 claims 7
- 108090001123 antibodies Proteins 0.000 claims 7
- 230000002401 inhibitory effect Effects 0.000 claims 7
- 206010018651 Graft versus host disease Diseases 0.000 claims 6
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 6
- 230000037361 pathway Effects 0.000 claims 6
- 210000000056 organs Anatomy 0.000 claims 5
- 210000001519 tissues Anatomy 0.000 claims 5
- 230000002708 enhancing Effects 0.000 claims 4
- 102000018358 Immunoglobulins Human genes 0.000 claims 2
- 108060003951 Immunoglobulins Proteins 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000001185 Bone Marrow Anatomy 0.000 claims 1
- 229960003957 Dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N Dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- MGNNYOODZCAHBA-GQKYHHCASA-N Fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 1
- 101700086956 IFNG Proteins 0.000 claims 1
- 102100016020 IFNG Human genes 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims 1
- 210000003491 Skin Anatomy 0.000 claims 1
- 210000000447 Th1 Cells Anatomy 0.000 claims 1
- 210000000068 Th17 Cells Anatomy 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
- 230000000735 allogeneic Effects 0.000 claims 1
- 229960004729 colecalciferol Drugs 0.000 claims 1
- 229960002714 fluticasone Drugs 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 229960004017 salmeterol Drugs 0.000 claims 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 1
- 229940021056 vitamin D3 Drugs 0.000 claims 1
- 235000005282 vitamin D3 Nutrition 0.000 claims 1
- 239000011647 vitamin D3 Substances 0.000 claims 1
Claims (13)
- 被験体における移植組織または移植器官の拒絶反応を阻害または軽減するための組成物であって、
前記組成物は、第２のポリペプチドに融合した、または第２のポリペプチドに融合したリンカーペプチドに融合した、配列番号６３または配列番号６４のＩｇＶドメインを含むＢ７−Ｈ４ポリペプチドを含む融合タンパク質を含み、
前記融合タンパク質は、前記被験体においてＴｈ１経路またはＴｈ１７経路に対するＴｒｅｇの抑制効果を増強し、前記被験体における移植された組織または器官の拒絶反応を軽減するのに有効な量で存在する、
組成物。 - 被験体における移植組織または移植器官の拒絶反応を阻害または軽減するための組成物であって、
前記組成物は、第２のポリペプチドに融合した、または第２のポリペプチドに融合したリンカーペプチドに融合した、配列番号６３または配列番号６４のＩｇＶドメインを含むＢ７−Ｈ４ポリペプチドを含む融合タンパク質を含み、
前記第２のポリペプチドは、ヒトＩｇＧ１免疫グロブリンのヒンジ領域、ＣＨ２領域およびＣＨ３領域を含み、
前記融合タンパク質は、前記被験体においてＴｈ１経路またはＴｈ１７経路に対するＴｒｅｇの抑制効果を増強し、前記被験体における移植された組織または器官の拒絶反応を軽減するのに有効な量で存在する、
組成物。 - 前記融合タンパク質が、前記被験体において前記Ｔｈ１７経路に対するＴｒｅｇの抑制効果を増強するのに有効な量で存在する、請求項１または２に記載の組成物。
- 前記被験体においてＴｈ１７細胞の数を低減させる、請求項１〜３のいずれか一項に記載の組成物。
- 前記被験体においてＴｈ１細胞の数を低減させる、請求項１〜４のいずれか一項に記載の組成物。
- 前記被験体においてＩＬ−１７のレベルを低減させる、請求項１〜５のいずれか一項に記載の組成物。
- 第２の治療剤をさらに含む、請求項１〜６のいずれか一項に記載の組成物。
- 前記第２の治療剤が、グルココルチコイド、フルチカゾン、サルメテロール（ｓａｌｍｅｔｅｒｏａｌ）；ＩＬ−１２に対する抗体、ＩＬ−６に対する抗体、ＩＦＮ−γに対する抗体、ＩＬ−２３に対する抗体、ＩＬ−２２に対する抗体、ＩＬ−２１に対する抗体、およびＩＬ−４に対する抗体；ビタミンＤ３；ＣＴＬＡ−４−Ｉｇ、ベラタセプト；デキサメタゾン、ならびにその組合せからなる群から選択される、請求項７に記載の組成物。
- 前記移植が、同種異系移植である、請求項１〜８のいずれか一項に記載の組成物。
- 前記移植が、皮膚移植、組織移植、臓器移植、または骨髄移植である、請求項１〜９のいずれか一項に記載の組成物。
- 被験体における移植片対宿主病（ＧＶＨＤ）の１または複数の症状を処置するための組成物であって、
前記組成物は、第２のポリペプチドに融合した、または第２のポリペプチドに融合したリンカーペプチドに融合した、配列番号６３または配列番号６４のＩｇＶドメインを含むＢ７−Ｈ４ポリペプチドを含む融合タンパク質を含み、
前記融合タンパク質は、前記被験体においてＧＶＨＤの１または複数の症状を緩和するのに有効な量で存在する、
組成物。 - 被験体における移植片対宿主病（ＧＶＨＤ）の１または複数の症状を処置するための組成物であって、
前記組成物は、第２のポリペプチドに融合した、または第２のポリペプチドに融合したリンカーペプチドに融合した、配列番号６３または配列番号６４のＩｇＶドメインを含むＢ７−Ｈ４ポリペプチドを含む融合タンパク質を含み、
前記第２のポリペプチドは、ヒトＩｇＧ１免疫グロブリンのヒンジ領域、ＣＨ２領域およびＣＨ３領域を含み、
前記融合タンパク質は、前記被験体においてＧＶＨＤの１または複数の症状を緩和するのに有効な量で存在する、
組成物。 - 前記Ｔｈ１７経路に対するＴｒｅｇの抑制効果を増強することによって、被験体における移植拒絶反応を阻害する方法で使用するための、請求項１〜１２のいずれか一項に記載の組成物。
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23860509P | 2009-08-31 | 2009-08-31 | |
| US61/238,605 | 2009-08-31 | ||
| US25493009P | 2009-10-26 | 2009-10-26 | |
| US61/254,930 | 2009-10-26 | ||
| US26685409P | 2009-12-04 | 2009-12-04 | |
| US61/266,854 | 2009-12-04 | ||
| US28653709P | 2009-12-15 | 2009-12-15 | |
| US61/286,537 | 2009-12-15 | ||
| US37836110P | 2010-08-30 | 2010-08-30 | |
| US61/378,361 | 2010-08-30 | ||
| PCT/US2010/047384 WO2011026132A2 (en) | 2009-08-31 | 2010-08-31 | Methods and compositions for the inhibition of transplant rejection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013503205A JP2013503205A (ja) | 2013-01-31 |
| JP2013503205A5 true JP2013503205A5 (ja) | 2013-10-17 |
Family
ID=42990231
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527101A Pending JP2013503204A (ja) | 2009-08-31 | 2010-08-31 | Ｂ７−ｈ４融合タンパク質およびその使用方法 |
| JP2012527108A Pending JP2013503205A (ja) | 2009-08-31 | 2010-08-31 | 移植拒絶反応を阻害するための方法および組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527101A Pending JP2013503204A (ja) | 2009-08-31 | 2010-08-31 | Ｂ７−ｈ４融合タンパク質およびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US9005616B2 (ja) |
| EP (2) | EP2473523A2 (ja) |
| JP (2) | JP2013503204A (ja) |
| CN (2) | CN102741279A (ja) |
| AU (2) | AU2010286361A1 (ja) |
| CA (2) | CA2772199A1 (ja) |
| IN (2) | IN2012DN02753A (ja) |
| WO (2) | WO2011026132A2 (ja) |
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- 2010-08-31 AU AU2010286361A patent/AU2010286361A1/en not_active Abandoned
- 2010-08-31 WO PCT/US2010/047384 patent/WO2011026132A2/en active Application Filing
- 2010-08-31 CN CN2010800488674A patent/CN102741279A/zh active Pending
- 2010-08-31 CN CN2010800488477A patent/CN102666581A/zh active Pending
- 2010-08-31 CA CA2772199A patent/CA2772199A1/en not_active Abandoned
- 2010-08-31 JP JP2012527101A patent/JP2013503204A/ja active Pending
- 2010-08-31 JP JP2012527108A patent/JP2013503205A/ja active Pending
- 2010-08-31 IN IN2753DEN2012 patent/IN2012DN02753A/en unknown
- 2010-08-31 WO PCT/US2010/047366 patent/WO2011026122A2/en active Application Filing
- 2010-08-31 AU AU2010286351A patent/AU2010286351A1/en not_active Abandoned
- 2010-08-31 US US13/392,811 patent/US9011853B2/en active Active
- 2010-08-31 CA CA2772204A patent/CA2772204A1/en not_active Abandoned
- 2010-08-31 IN IN2764DEN2012 patent/IN2012DN02764A/en unknown
-
2015
- 2015-04-06 US US14/679,505 patent/US20160039906A1/en not_active Abandoned
- 2015-04-06 US US14/679,497 patent/US9957312B2/en active Active
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