JP2013502393A - ３−アミノ−５−フェニル−５，６−ジヒドロ−２ｈ−［１，４］オキサジン誘導体 - Google Patents

３−アミノ−５−フェニル−５，６−ジヒドロ−２ｈ−［１，４］オキサジン誘導体 Download PDF

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Publication number
JP2013502393A
JP2013502393A JP2012525154A JP2012525154A JP2013502393A JP 2013502393 A JP2013502393 A JP 2013502393A JP 2012525154 A JP2012525154 A JP 2012525154A JP 2012525154 A JP2012525154 A JP 2012525154A JP 2013502393 A JP2013502393 A JP 2013502393A
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Japan
Prior art keywords
phenyl
methyl
amino
dihydro
oxazin
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Pending
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JP2012525154A
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Japanese (ja)
Inventor
アンドレイニ，マッテオ
バナー，デービッド
ガベリエリ，エマヌエレ
グーバ，ヴォルフガンク
ヒルペルト，ハンス
マウザー，ハーラルト
マイヴェーク，アレクサンダー・ファオ
ナルキジアン，ロベール
パワー，イアン
ロジャース−エバンス，マーク
トラヴァグリ，マッシミリアノ
ヴァラッチ，ミケラ
ヴォルテリング，トーマス
ヴォストル，ヴォルフガンク
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F Hoffmann La Roche AG
Siena Biotech SpA
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F Hoffmann La Roche AG
Siena Biotech SpA
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Application filed by F Hoffmann La Roche AG, Siena Biotech SpA filed Critical F Hoffmann La Roche AG
Publication of JP2013502393A publication Critical patent/JP2013502393A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Hematology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Transplantation (AREA)
  • Toxicology (AREA)
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  • Psychiatry (AREA)
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  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012525154A 2009-08-19 2010-08-16 ３−アミノ−５−フェニル−５，６−ジヒドロ−２ｈ−［１，４］オキサジン誘導体 Pending JP2013502393A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09168132.0 2009-08-19
EP09168132 2009-08-19
PCT/EP2010/061875 WO2011020806A1 (en) 2009-08-19 2010-08-16 3-amino-5-phenyl-5,6-dihydro-2h-[1,4]oxazine derivatives

Publications (1)

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JP2013502393A true JP2013502393A (ja) 2013-01-24

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JP2012525154A Pending JP2013502393A (ja) 2009-08-19 2010-08-16 ３−アミノ−５−フェニル−５，６−ジヒドロ−２ｈ−［１，４］オキサジン誘導体

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US (3) US8188079B2 (enExample)
EP (1) EP2467368A1 (enExample)
JP (1) JP2013502393A (enExample)
KR (1) KR20120068870A (enExample)
CN (1) CN102639516A (enExample)
AR (1) AR077935A1 (enExample)
AU (1) AU2010285005A1 (enExample)
BR (1) BR112012003704A2 (enExample)
CA (1) CA2768341A1 (enExample)
IL (1) IL217918A0 (enExample)
IN (1) IN2012DN00766A (enExample)
MX (1) MX2012001985A (enExample)
SG (1) SG178442A1 (enExample)
TW (1) TW201111373A (enExample)
WO (1) WO2011020806A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015500257A (ja) * 2011-12-06 2015-01-05 ヤンセン ファーマシューティカ エヌ．ベー． ５−（３−アミノフェニル）−５−アルキル−５，６−ジヒドロ−２ｈ−［１，４］オキサジン−３−アミン誘導体
JP2015500223A (ja) * 2011-12-05 2015-01-05 ヤンセン ファーマシューティカ エヌ．ベー． ６−ジフルオロメチル−５，６−ジヒドロ−２ｈ−［１，４］オキサジン−３−アミン誘導体

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JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
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BR112013017988A2 (pt) * 2011-01-13 2019-09-24 Novartis Ag inibidores de bace-2 para o tratamento de distúrbios metabólicos
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US9067924B2 (en) * 2011-03-04 2015-06-30 Hoffmann-La Roche Inc. 1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors
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JPWO2012147763A1 (ja) * 2011-04-26 2014-07-28 塩野義製薬株式会社 オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤
US9493451B2 (en) 2011-05-16 2016-11-15 Bionomics Limited Amine derivatives as potassium channel blockers
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CN103608344B (zh) * 2011-06-07 2016-11-23 霍夫曼-拉罗奇有限公司 [1,3]噁嗪类
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