JP2013501817A5 - - Google Patents
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- JP2013501817A5 JP2013501817A5 JP2012524911A JP2012524911A JP2013501817A5 JP 2013501817 A5 JP2013501817 A5 JP 2013501817A5 JP 2012524911 A JP2012524911 A JP 2012524911A JP 2012524911 A JP2012524911 A JP 2012524911A JP 2013501817 A5 JP2013501817 A5 JP 2013501817A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
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- polynucleotide encoding
- signal peptide
- individual
- Prior art date
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- 102000003812 Interleukin-15 Human genes 0.000 claims description 51
- 102000040430 polynucleotide Human genes 0.000 claims description 15
- 108091033319 polynucleotide Proteins 0.000 claims description 15
- 239000002157 polynucleotide Substances 0.000 claims description 15
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 10
- 239000013598 vector Substances 0.000 claims description 10
- 206010025327 Lymphopenia Diseases 0.000 claims description 8
- 231100001023 lymphopenia Toxicity 0.000 claims description 6
- 239000000833 heterodimer Substances 0.000 claims description 5
- 229920001184 polypeptide Polymers 0.000 claims description 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 5
- 239000002246 antineoplastic agent Substances 0.000 claims description 4
- 229940041181 antineoplastic drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 102000008616 interleukin-15 receptor activity proteins Human genes 0.000 claims 1
- 108040002039 interleukin-15 receptor activity proteins Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 description 50
- 210000001519 tissue Anatomy 0.000 description 10
- 230000002093 peripheral effect Effects 0.000 description 8
- 210000003563 lymphoid tissue Anatomy 0.000 description 6
- 230000002992 thymic effect Effects 0.000 description 4
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000011748 cell maturation Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23415509P | 2009-08-14 | 2009-08-14 | |
| US23415209P | 2009-08-14 | 2009-08-14 | |
| US61/234,155 | 2009-08-14 | ||
| US61/234,152 | 2009-08-14 | ||
| PCT/US2010/045511 WO2011020047A1 (en) | 2009-08-14 | 2010-08-13 | Use of il-15 to increase thymic output and to treat lymphopenia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015041346A Division JP6162167B2 (ja) | 2009-08-14 | 2015-03-03 | 胸腺産出の増大およびリンパ球減少症の治療のためのｉｌ−１５の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013501817A JP2013501817A (ja) | 2013-01-17 |
| JP2013501817A5 true JP2013501817A5 (https=) | 2013-09-19 |
Family
ID=42813425
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012524911A Pending JP2013501817A (ja) | 2009-08-14 | 2010-08-13 | 胸腺産出の増大およびリンパ球減少症の治療のためのｉｌ−１５の使用 |
| JP2015041346A Active JP6162167B2 (ja) | 2009-08-14 | 2015-03-03 | 胸腺産出の増大およびリンパ球減少症の治療のためのｉｌ−１５の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015041346A Active JP6162167B2 (ja) | 2009-08-14 | 2015-03-03 | 胸腺産出の増大およびリンパ球減少症の治療のためのｉｌ−１５の使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US8871191B2 (https=) |
| EP (2) | EP2464377B1 (https=) |
| JP (2) | JP2013501817A (https=) |
| AU (2) | AU2010282280B2 (https=) |
| CA (1) | CA2768965C (https=) |
| ES (1) | ES2598005T3 (https=) |
| NZ (1) | NZ714757A (https=) |
| WO (1) | WO2011020047A1 (https=) |
Families Citing this family (98)
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| EP3263581B2 (en) | 2005-05-17 | 2025-07-09 | University of Connecticut | Compositions and methods for immunomodulation in an organism |
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| NZ569541A (en) | 2006-01-13 | 2012-05-25 | Us Gov Health & Human Serv | Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells |
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| ES2598005T3 (es) * | 2009-08-14 | 2017-01-24 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Uso de IL-15 para aumentar la salida del timo y para tratar la linfopenia |
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