JP2013501056A - ウイルス感染およびウイルス誘発腫瘍を治療する組成物および方法 - Google Patents

ウイルス感染およびウイルス誘発腫瘍を治療する組成物および方法 Download PDF

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JP2013501056A
JP2013501056A JP2012523680A JP2012523680A JP2013501056A JP 2013501056 A JP2013501056 A JP 2013501056A JP 2012523680 A JP2012523680 A JP 2012523680A JP 2012523680 A JP2012523680 A JP 2012523680A JP 2013501056 A JP2013501056 A JP 2013501056A
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alkynyl
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cmx001
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JP2013501056A5 (enExample
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ラニア,アーネスト・アール
ペインター,ジョージ・アール
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キメリクス,インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/6512Six-membered rings having the nitrogen atoms in positions 1 and 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2012523680A 2009-08-03 2010-08-02 ウイルス感染およびウイルス誘発腫瘍を治療する組成物および方法 Pending JP2013501056A (ja)

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US23093109P 2009-08-03 2009-08-03
US61/230,931 2009-08-03
PCT/US2010/044093 WO2011017253A1 (en) 2009-08-03 2010-08-02 Composition and methods of treating viral infections and viral induced tumors

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JP2013501056A true JP2013501056A (ja) 2013-01-10
JP2013501056A5 JP2013501056A5 (enExample) 2013-09-12

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US (1) US20120164104A1 (enExample)
EP (1) EP2462152A4 (enExample)
JP (1) JP2013501056A (enExample)
AU (1) AU2010279678B2 (enExample)
BR (1) BR112012002551A2 (enExample)
CA (1) CA2770282A1 (enExample)
WO (1) WO2011017253A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
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JP2016515128A (ja) * 2013-03-15 2016-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 非環式ヌクレオシドホスホン酸ジエステル
JP2018522836A (ja) * 2015-06-01 2018-08-16 エクイガーミナル エスエー 抗ウイルス組成物
WO2024047811A1 (ja) * 2022-08-31 2024-03-07 シンバイオ製薬株式会社 リンパ腫の治療用医薬組成物
WO2024048657A1 (ja) * 2022-08-31 2024-03-07 シンバイオ製薬株式会社 リンパ腫の治療用医薬組成物
WO2024219491A1 (ja) * 2023-04-21 2024-10-24 シンバイオ製薬株式会社 神経膠腫の治療用医薬組成物
JP2025065589A (ja) * 2022-08-31 2025-04-22 シンバイオ製薬株式会社 リンパ腫の治療用医薬組成物

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US8524248B2 (en) 2007-12-14 2013-09-03 University of Pittsburgh—of the Commonwealth System of Higher Education Methods to diagnose and immunize against the virus causing human Merkel cell carcinoma
MX2010008148A (es) 2008-01-25 2010-10-20 Chimerix Inc Métodos de tratamiento de infecciones virales.
WO2009111486A2 (en) * 2008-03-04 2009-09-11 The Regents Of The University Of California Reversing the immune decline of aging by a nutraceutical antioxidant in mice
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
CA2779473C (en) * 2009-10-30 2016-08-16 Chimerix, Inc. Methods of treating viral associated diseases
WO2011100698A2 (en) 2010-02-12 2011-08-18 Chimerix, Inc. Methods of treating viral infection
EP2563367A4 (en) 2010-04-26 2013-12-04 Chimerix Inc Methods of treating retroviral infections and related dosage regimes
CN103209985B (zh) * 2010-08-31 2016-08-24 奇默里克斯公司 膦酸酯衍生物及其合成方法
EP2770834A4 (en) * 2011-10-26 2015-11-25 Chimerix Inc Hexadecyloxypropyl cidofovir for the treatment of double-stranded dna virus infection
US9593137B2 (en) 2011-12-22 2017-03-14 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
WO2014146218A1 (zh) * 2013-03-22 2014-09-25 当代绿能科技股份有限公司 马替麦考酚酯或其盐类用于制备抗流感病毒之药物的用途
WO2015073148A1 (en) * 2013-11-15 2015-05-21 Chimerix Inc. Morphic forms of hexadecyloxypropyl-phosphonate esters
CN112898345A (zh) 2014-09-15 2021-06-04 加利福尼亚大学董事会 核苷酸类似物
US10160778B2 (en) 2014-10-27 2018-12-25 Concert Pharmaceuticals, Inc. Pyrimidine phosphonic acid esters
EP3350191B9 (en) 2015-09-15 2021-12-22 The Regents of the University of California Nucleotide analogs
CN118416082A (zh) 2016-06-28 2024-08-02 应急生物防御行动兰辛有限责任公司 布林西多福韦的制剂
AU2020334152A1 (en) 2019-08-22 2022-03-24 Emory University Nucleoside prodrugs and uses related thereto
CN113288896A (zh) * 2021-05-28 2021-08-24 成都中医药大学 槐定碱在制备抗疱疹病毒的药物中的用途
CA3262284A1 (en) 2022-07-21 2024-01-25 Antiva Biosciences Inc Pharmaceutical compositions and forms for the treatment of human papillomavirus (HPV) infection and HPV-induced neoplasm
CN119080836B (zh) * 2024-11-07 2025-04-15 上海柯君医药科技有限公司 一种正痘病毒抑制剂及其应用

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016515128A (ja) * 2013-03-15 2016-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 非環式ヌクレオシドホスホン酸ジエステル
JP2019069984A (ja) * 2013-03-15 2019-05-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 非環式ヌクレオシドホスホン酸ジエステル
JP2018522836A (ja) * 2015-06-01 2018-08-16 エクイガーミナル エスエー 抗ウイルス組成物
WO2024047811A1 (ja) * 2022-08-31 2024-03-07 シンバイオ製薬株式会社 リンパ腫の治療用医薬組成物
WO2024048657A1 (ja) * 2022-08-31 2024-03-07 シンバイオ製薬株式会社 リンパ腫の治療用医薬組成物
JP2025065589A (ja) * 2022-08-31 2025-04-22 シンバイオ製薬株式会社 リンパ腫の治療用医薬組成物
WO2024219491A1 (ja) * 2023-04-21 2024-10-24 シンバイオ製薬株式会社 神経膠腫の治療用医薬組成物

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CA2770282A1 (en) 2011-02-10
US20120164104A1 (en) 2012-06-28
EP2462152A4 (en) 2013-02-13
BR112012002551A2 (pt) 2017-06-13
EP2462152A1 (en) 2012-06-13
WO2011017253A1 (en) 2011-02-10
AU2010279678B2 (en) 2015-09-10
AU2010279678A1 (en) 2012-03-01

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