JP2013500012A5 - - Google Patents

Info

Publication number

JP2013500012A5

JP2013500012A5 JP2012521750A JP2012521750A JP2013500012A5 JP 2013500012 A5 JP2013500012 A5 JP 2013500012A5 JP 2012521750 A JP2012521750 A JP 2012521750A JP 2012521750 A JP2012521750 A JP 2012521750A JP 2013500012 A5 JP2013500012 A5 JP 2013500012A5

Authority

JP

Japan

Prior art keywords

cell

endothelial cells

cells

reduce

expression

Prior art date

2010-07-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 210000004027 cell Anatomy 0.000 claims description 41
• 210000002889 endothelial cell Anatomy 0.000 claims description 28
• 238000000034 method Methods 0.000 claims description 26
• 102000004127 Cytokines Human genes 0.000 claims description 12
• 108090000695 Cytokines Proteins 0.000 claims description 12
• 108010067225 Cell Adhesion Molecules Proteins 0.000 claims description 10
• 102000016289 Cell Adhesion Molecules Human genes 0.000 claims description 10
• 230000004913 activation Effects 0.000 claims description 10
• 230000001404 mediated effect Effects 0.000 claims description 10
• 210000003716 mesoderm Anatomy 0.000 claims description 9
• 206010015866 Extravasation Diseases 0.000 claims description 8
• 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims description 8
• 101710150336 Protein Rex Proteins 0.000 claims description 8
• 108010017842 Telomerase Proteins 0.000 claims description 8
• 210000003981 ectoderm Anatomy 0.000 claims description 8
• 210000001900 endoderm Anatomy 0.000 claims description 8
• 210000003989 endothelium vascular Anatomy 0.000 claims description 8
• 230000036251 extravasation Effects 0.000 claims description 8
• 210000004602 germ cell Anatomy 0.000 claims description 8
• 210000000265 leukocyte Anatomy 0.000 claims description 8
• 230000023404 leukocyte cell-cell adhesion Effects 0.000 claims description 8
• 230000000694 effects Effects 0.000 claims description 6
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 4
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 4
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 4
• 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims description 4
• 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims description 4
• 206010061218 Inflammation Diseases 0.000 claims description 2
• 102100037850 Interferon gamma Human genes 0.000 claims description 2
• 108010074328 Interferon-gamma Proteins 0.000 claims description 2
• 108010002352 Interleukin-1 Proteins 0.000 claims description 2
• 238000007876 drug discovery Methods 0.000 claims description 2
• 230000004054 inflammatory process Effects 0.000 claims description 2
• 108090000184 Selectins Proteins 0.000 claims 4
• 102000003800 Selectins Human genes 0.000 claims 4
• 230000000735 allogeneic effect Effects 0.000 claims 1
• 210000001161 mammalian embryo Anatomy 0.000 claims 1
• 108010024212 E-Selectin Proteins 0.000 description 2
• 102100023471 E-selectin Human genes 0.000 description 2
• 108010035766 P-Selectin Proteins 0.000 description 2
• 102100023472 P-selectin Human genes 0.000 description 2
• 239000003795 chemical substances by application Substances 0.000 description 1
• 230000003247 decreasing effect Effects 0.000 description 1
• 230000001225 therapeutic effect Effects 0.000 description 1