JP2013227300A5 - - Google Patents
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- Publication number
- JP2013227300A5 JP2013227300A5 JP2013068407A JP2013068407A JP2013227300A5 JP 2013227300 A5 JP2013227300 A5 JP 2013227300A5 JP 2013068407 A JP2013068407 A JP 2013068407A JP 2013068407 A JP2013068407 A JP 2013068407A JP 2013227300 A5 JP2013227300 A5 JP 2013227300A5
- Authority
- JP
- Japan
- Prior art keywords
- aqueous composition
- fatty acid
- polyoxyethylene sorbitan
- sorbitan fatty
- acid ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 35
- 229920001214 Polysorbate 60 Polymers 0.000 claims 14
- 235000014113 dietary fatty acids Nutrition 0.000 claims 14
- 239000000194 fatty acid Substances 0.000 claims 14
- 229930195729 fatty acid Natural products 0.000 claims 14
- -1 fatty acid ester Chemical class 0.000 claims 14
- 229960000686 benzalkonium chloride Drugs 0.000 claims 12
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 12
- ZBPLOVFIXSTCRZ-UHFFFAOYSA-N bromfenac Chemical compound NC1=C(CC(O)=O)C=CC=C1C(=O)C1=CC=C(Br)C=C1 ZBPLOVFIXSTCRZ-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 2
- 229930182566 Gentamicin Natural products 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 229910021538 borax Inorganic materials 0.000 claims 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 2
- 239000004327 boric acid Substances 0.000 claims 2
- 239000003889 eye drop Substances 0.000 claims 2
- 229960002518 gentamicin Drugs 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000004328 sodium tetraborate Substances 0.000 claims 2
- 235000010339 sodium tetraborate Nutrition 0.000 claims 2
- 229960000707 tobramycin Drugs 0.000 claims 2
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims 2
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 239000003221 ear drop Substances 0.000 claims 1
- 239000003978 infusion fluid Substances 0.000 claims 1
- 239000007923 nasal drop Substances 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- YBCAZPLXEGKKFM-UHFFFAOYSA-K ruthenium(iii) chloride Chemical compound [Cl-].[Cl-].[Cl-].[Ru+3] YBCAZPLXEGKKFM-UHFFFAOYSA-K 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013068407A JP5922609B2 (ja) | 2012-03-28 | 2013-03-28 | ２−アミノ−３−（４−ブロモベンゾイル）フェニル酢酸含有水性組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012073181 | 2012-03-28 | ||
| JP2012073181 | 2012-03-28 | ||
| JP2013068407A JP5922609B2 (ja) | 2012-03-28 | 2013-03-28 | ２−アミノ−３−（４−ブロモベンゾイル）フェニル酢酸含有水性組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013227300A JP2013227300A (ja) | 2013-11-07 |
| JP2013227300A5 true JP2013227300A5 (OSRAM) | 2016-02-04 |
| JP5922609B2 JP5922609B2 (ja) | 2016-05-24 |
Family
ID=49260248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013068407A Expired - Fee Related JP5922609B2 (ja) | 2012-03-28 | 2013-03-28 | ２−アミノ−３−（４−ブロモベンゾイル）フェニル酢酸含有水性組成物 |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JP5922609B2 (OSRAM) |
| KR (1) | KR20140139501A (OSRAM) |
| CN (1) | CN104203224A (OSRAM) |
| IN (1) | IN2014DN07767A (OSRAM) |
| MY (1) | MY170840A (OSRAM) |
| PH (1) | PH12014502171A1 (OSRAM) |
| SG (1) | SG11201405837YA (OSRAM) |
| TW (1) | TWI604858B (OSRAM) |
| WO (1) | WO2013147000A1 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016199854A1 (ja) * | 2015-06-10 | 2016-12-15 | 参天製薬株式会社 | 点眼剤、及び点眼剤防腐効力維持方法 |
| CN111712238A (zh) * | 2017-12-14 | 2020-09-25 | 参天制药株式会社 | 含有2-氨基-3-（4-溴苯甲酰基）苯乙酸或其盐的滴眼剂 |
| CN114224830A (zh) * | 2021-12-24 | 2022-03-25 | 辰欣药业股份有限公司 | 一种单剂量无抑菌剂的眼用制剂及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002308764A (ja) * | 2001-02-09 | 2002-10-23 | Taisho Pharmaceut Co Ltd | 眼科用医薬組成物 |
| US7829544B2 (en) * | 2003-11-14 | 2010-11-09 | Senju Pharmaceutical Co., Ltd. | Aqueous solution preparation containing aminoglycoside antibiotic and bromfenac |
| CN1823754A (zh) * | 2006-03-28 | 2006-08-30 | 卢秀莲 | 溴芬酸钠滴眼液及其制备方法 |
| CN101313899B (zh) * | 2007-06-01 | 2012-02-29 | 北京德众万全药物技术开发有限公司 | 一种含有溴芬酸钠的眼用药物组合物 |
| WO2009105534A2 (en) * | 2008-02-21 | 2009-08-27 | Ista Pharmaceuticals | Ophthalmic nsaids as adjuvants |
| CN101322683B (zh) * | 2008-07-30 | 2013-01-16 | 浙江三叶药业有限公司 | 一种含有溴芬酸钠水合物的眼用凝胶剂及其制备方法 |
| BR112013018025A2 (pt) * | 2011-01-18 | 2020-10-27 | Senju Pharmaceutical Co., Ltd | composição de bromfenac líquida aquosa método para reforçar a eficácia conservante de uma solução aquosa |
| JP6012231B2 (ja) * | 2011-04-08 | 2016-10-25 | ロート製薬株式会社 | ブロムフェナク含有組成物 |
-
2013
- 2013-03-27 TW TW102110918A patent/TWI604858B/zh not_active IP Right Cessation
- 2013-03-28 MY MYPI2014702590A patent/MY170840A/en unknown
- 2013-03-28 KR KR1020147025807A patent/KR20140139501A/ko not_active Abandoned
- 2013-03-28 JP JP2013068407A patent/JP5922609B2/ja not_active Expired - Fee Related
- 2013-03-28 CN CN201380014630.8A patent/CN104203224A/zh active Pending
- 2013-03-28 SG SG11201405837YA patent/SG11201405837YA/en unknown
- 2013-03-28 IN IN7767DEN2014 patent/IN2014DN07767A/en unknown
- 2013-03-28 WO PCT/JP2013/059211 patent/WO2013147000A1/ja not_active Ceased
-
2014
- 2014-09-26 PH PH12014502171A patent/PH12014502171A1/en unknown
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