JP2013227300A5 - - Google Patents
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- Publication number
- JP2013227300A5 JP2013227300A5 JP2013068407A JP2013068407A JP2013227300A5 JP 2013227300 A5 JP2013227300 A5 JP 2013227300A5 JP 2013068407 A JP2013068407 A JP 2013068407A JP 2013068407 A JP2013068407 A JP 2013068407A JP 2013227300 A5 JP2013227300 A5 JP 2013227300A5
- Authority
- JP
- Japan
- Prior art keywords
- aqueous composition
- fatty acid
- polyoxyethylene sorbitan
- sorbitan fatty
- acid ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 35
- 229920001214 Polysorbate 60 Polymers 0.000 claims 14
- 235000014113 dietary fatty acids Nutrition 0.000 claims 14
- 239000000194 fatty acid Substances 0.000 claims 14
- -1 fatty acid ester Chemical class 0.000 claims 14
- 229960000686 Benzalkonium Chloride Drugs 0.000 claims 12
- ZBPLOVFIXSTCRZ-UHFFFAOYSA-N Bromfenac Chemical compound NC1=C(CC(O)=O)C=CC=C1C(=O)C1=CC=C(Br)C=C1 ZBPLOVFIXSTCRZ-UHFFFAOYSA-N 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- KGBXLFKZBHKPEV-UHFFFAOYSA-N Boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 2
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- NLVFBUXFDBBNBW-PBSUHMDJSA-N Tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims 2
- 229960000707 Tobramycin Drugs 0.000 claims 2
- 239000004327 boric acid Substances 0.000 claims 2
- 239000003889 eye drop Substances 0.000 claims 2
- 229960002518 gentamicin Drugs 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000004328 sodium tetraborate Substances 0.000 claims 2
- 235000010339 sodium tetraborate Nutrition 0.000 claims 2
- SJSYJHLLBBSLIH-SDNWHVSQSA-N (E)-3-(2-methoxyphenyl)-2-phenylprop-2-enoic acid Chemical compound COC1=CC=CC=C1\C=C(\C(O)=O)C1=CC=CC=C1 SJSYJHLLBBSLIH-SDNWHVSQSA-N 0.000 claims 1
- WLJVXDMOQOGPHL-UHFFFAOYSA-N Phenylacetic acid Natural products OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims 1
- 229940068968 Polysorbate 80 Drugs 0.000 claims 1
- YBCAZPLXEGKKFM-UHFFFAOYSA-K Ruthenium(III) chloride Chemical compound [Cl-].[Cl-].[Cl-].[Ru+3] YBCAZPLXEGKKFM-UHFFFAOYSA-K 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 239000003221 ear drop Substances 0.000 claims 1
- 239000003978 infusion fluid Substances 0.000 claims 1
- 239000007923 nasal drop Substances 0.000 claims 1
- 229960003424 phenylacetic acid Drugs 0.000 claims 1
- 239000003279 phenylacetic acid Substances 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
Claims (25)
０≦A＜１のとき、０≦B＜９６A＋５
A=１のとき、１＜B≦１００
１＜A＜３のとき、５＜B≦１００
３≦A≦１０のとき、２０＜B≦１００
の範囲内である、水性組成物、但し
ゲンタマイシン塩酸塩またはトブラマイシンを含有しない。 An aqueous composition comprising 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof, and optionally benzalkonium chloride and / or polyoxyethylene sorbitan fatty acid ester, comprising 2-amino-3 The content A (parts by mass) of benzalkonium chloride and the content B (parts by mass) of polyoxyethylene sorbitan fatty acid ester with respect to 100 parts by mass of-(4-bromobenzoyl) phenylacetic acid,
When 0 ≦ A <1, 0 ≦ B <96A + 5
When A = 1, 1 <B ≦ 100
When 1 <A <3, 5 <B ≦ 100
When 3 ≦ A ≦ 10, 20 <B ≦ 100
An aqueous composition , wherein
Contains no gentamicin hydrochloride or tobramycin .
０≦A＜１のとき、０≦B＜２６A＋５
A=１のとき、２≦B≦３０
１＜A＜３のとき、５＜B≦３０
３≦A≦５のとき、２０＜B≦３０
の範囲内である、請求項１記載の水性組成物。 Benzalkonium chloride content A and polyoxyethylene sorbitan fatty acid ester content B
When 0 ≦ A <1, 0 ≦ B <26A + 5
When A = 1, 2 ≦ B ≦ 30
When 1 <A <3, 5 <B ≦ 30
When 3 ≦ A ≦ 5, 20 <B ≦ 30
The aqueous composition of claim 1, which is within the range of
１＜A＜３、及び５＜B≦３０
の範囲内である、請求項１記載の水性組成物。 Benzalkonium chloride content A and polyoxyethylene sorbitan fatty acid ester content B
1 <A <3 and 5 <B ≦ 30
The aqueous composition of claim 1, which is within the range of
１．２≦A≦２．５、及び７≦B≦２０
の範囲内である、請求項１記載の水性組成物。 Benzalkonium chloride content A and polyoxyethylene sorbitan fatty acid ester content B
1.2 ≦ A ≦ 2.5 and 7 ≦ B ≦ 20
The aqueous composition of claim 1, which is within the range of
A=０、及びB=０である、請求項１記載の水性組成物。 The aqueous composition of claim 1, wherein A = 0 and B = 0.
０≦X＜０．００１のとき、０≦Y＜９６X＋０．００５
X=０．００１のとき、０．００１＜Y≦０．１
０．００１＜X＜０．００３のとき、０．００５＜Y≦０．１
０．００３≦X≦０．０１のとき、０．０２＜Y≦０．１
の範囲内である、水性組成物、但し
ゲンタマイシン塩酸塩またはトブラマイシンを含有しない。 An aqueous composition comprising 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof, and optionally benzalkonium chloride and / or polyoxyethylene sorbitan fatty acid ester, comprising benzalkonium chloride Concentration X (w / v%) and polyoxyethylene sorbitan fatty acid ester concentration Y (w / v%)
When 0 ≦ X <0.001, 0 ≦ Y <96X + 0.005
When X = 0.001, 0.001 <Y ≦ 0.1
When 0.001 <X <0.003, 0.005 <Y ≦ 0.1
When 0.003 ≦ X ≦ 0.01, 0.02 <Y ≦ 0.1
An aqueous composition , wherein
Contains no gentamicin hydrochloride or tobramycin .
０≦X＜０．００１のとき、０≦Y＜２６X＋０．００５
X=０．００１のとき、０．００２≦Y≦０．０３
０．００１＜X＜０．００３のとき、０．００５＜Y≦０．０３
０．００３≦X≦０．００５のとき、０．０２＜Y≦０．０３
の範囲内である、請求項６記載の水性組成物。 Benzalkonium chloride concentration X and polyoxyethylene sorbitan fatty acid ester concentration Y
When 0 ≦ X <0.001, 0 ≦ Y <26X + 0.005
When X = 0.001, 0.002 ≦ Y ≦ 0.03
When 0.001 <X <0.003, 0.005 <Y ≦ 0.03
When 0.003 ≦ X ≦ 0.005, 0.02 <Y ≦ 0.03
The aqueous composition of claim 6 , which is within the range of
０．００１＜X＜０．００３、及び０．００５＜Y≦０．０３
の範囲内である、請求項６記載の水性組成物。 Benzalkonium chloride concentration X and polyoxyethylene sorbitan fatty acid ester concentration Y
0.001 <X <0.003 and 0.005 <Y ≦ 0.03
The aqueous composition of claim 6 , which is within the range of
０．００１２≦X≦０．００２５、及び０．００８≦Y≦０．０２
の範囲内である、請求項６記載の水性組成物。 Benzalkonium chloride concentration X and polyoxyethylene sorbitan fatty acid ester concentration Y
0.0012 ≦ X ≦ 0.0025 and 0.008 ≦ Y ≦ 0.02
The aqueous composition of claim 6 , which is within the range of
X=０、及びY=０である、請求項６記載の水性組成物。 The aqueous composition according to claim 6, wherein X = 0 and Y = 0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013068407A JP5922609B2 (en) | 2012-03-28 | 2013-03-28 | Aqueous composition containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012073181 | 2012-03-28 | ||
| JP2012073181 | 2012-03-28 | ||
| JP2013068407A JP5922609B2 (en) | 2012-03-28 | 2013-03-28 | Aqueous composition containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013227300A JP2013227300A (en) | 2013-11-07 |
| JP2013227300A5 true JP2013227300A5 (en) | 2016-02-04 |
| JP5922609B2 JP5922609B2 (en) | 2016-05-24 |
Family
ID=49260248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013068407A Expired - Fee Related JP5922609B2 (en) | 2012-03-28 | 2013-03-28 | Aqueous composition containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JP5922609B2 (en) |
| KR (1) | KR20140139501A (en) |
| CN (1) | CN104203224A (en) |
| IN (1) | IN2014DN07767A (en) |
| MY (1) | MY170840A (en) |
| PH (1) | PH12014502171A1 (en) |
| SG (1) | SG11201405837YA (en) |
| TW (1) | TWI604858B (en) |
| WO (1) | WO2013147000A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016199854A1 (en) * | 2015-06-10 | 2016-12-15 | 参天製薬株式会社 | Ophthalmic solution and method for maintaining preservative efficacy of ophthalmic solution |
| WO2019117252A1 (en) * | 2017-12-14 | 2019-06-20 | 参天製薬株式会社 | Eye drop containing 2-amino-3-(4-bromobenzoyl) phenylacetic acid or salt thereof |
| CN114224830A (en) * | 2021-12-24 | 2022-03-25 | 辰欣药业股份有限公司 | Single-dose bacteriostatic-free ophthalmic preparation and preparation method thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002308764A (en) * | 2001-02-09 | 2002-10-23 | Taisho Pharmaceut Co Ltd | Pharmaceutical composition for ophthalmic use |
| WO2005046700A1 (en) * | 2003-11-14 | 2005-05-26 | Senju Pharmaceutical Co., Ltd. | Aqueous solution preparation containing aminoglycoside antibiotic and bromfenac |
| CN1823754A (en) * | 2006-03-28 | 2006-08-30 | 卢秀莲 | Sodium bromophenolate eye drops and its preparation method |
| CN101313899B (en) * | 2007-06-01 | 2012-02-29 | 北京德众万全药物技术开发有限公司 | Medicament composition for eyes containing sodium bromfenac |
| BRPI0908502A2 (en) * | 2008-02-21 | 2017-05-23 | Ista Pharmaceuticals | ophthalmic aines as adjuvants |
| CN101322683B (en) * | 2008-07-30 | 2013-01-16 | 浙江三叶药业有限公司 | Gel for eye containing bromfenac sodium hydrate and preparation thereof |
| WO2012099142A1 (en) * | 2011-01-18 | 2012-07-26 | 千寿製薬株式会社 | Bromfenac aqueous liquid composition having preservative efficiency |
| JP6012231B2 (en) * | 2011-04-08 | 2016-10-25 | ロート製薬株式会社 | Bromfenac-containing composition |
-
2013
- 2013-03-27 TW TW102110918A patent/TWI604858B/en not_active IP Right Cessation
- 2013-03-28 WO PCT/JP2013/059211 patent/WO2013147000A1/en active Application Filing
- 2013-03-28 CN CN201380014630.8A patent/CN104203224A/en active Pending
- 2013-03-28 IN IN7767DEN2014 patent/IN2014DN07767A/en unknown
- 2013-03-28 SG SG11201405837YA patent/SG11201405837YA/en unknown
- 2013-03-28 JP JP2013068407A patent/JP5922609B2/en not_active Expired - Fee Related
- 2013-03-28 MY MYPI2014702590A patent/MY170840A/en unknown
- 2013-03-28 KR KR1020147025807A patent/KR20140139501A/en active IP Right Grant
-
2014
- 2014-09-26 PH PH12014502171A patent/PH12014502171A1/en unknown
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