JP2011251985A5 - - Google Patents
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- Publication number
- JP2011251985A5 JP2011251985A5 JP2011157930A JP2011157930A JP2011251985A5 JP 2011251985 A5 JP2011251985 A5 JP 2011251985A5 JP 2011157930 A JP2011157930 A JP 2011157930A JP 2011157930 A JP2011157930 A JP 2011157930A JP 2011251985 A5 JP2011251985 A5 JP 2011251985A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrate
- pharmaceutically acceptable
- acceptable salt
- hydroxamic acid
- batch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 8
- 239000002245 particle Substances 0.000 claims 6
- WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 6
- 229960000237 vorinostat Drugs 0.000 claims 6
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003931 anilides Chemical class 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68287505P | 2005-05-20 | 2005-05-20 | |
| US60/682,875 | 2005-05-20 | ||
| US69312805P | 2005-06-23 | 2005-06-23 | |
| US60/693,128 | 2005-06-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540436A Division JP5264174B2 (ja) | 2005-05-20 | 2006-05-16 | スベロイルアニリドヒドロキサム酸の製剤及びこれを作製するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011251985A JP2011251985A (ja) | 2011-12-15 |
| JP2011251985A5 true JP2011251985A5 (OSRAM) | 2012-10-04 |
| JP5308486B2 JP5308486B2 (ja) | 2013-10-09 |
Family
ID=37452585
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540436A Active JP5264174B2 (ja) | 2005-05-20 | 2006-05-16 | スベロイルアニリドヒドロキサム酸の製剤及びこれを作製するための方法 |
| JP2011157930A Active JP5308486B2 (ja) | 2005-05-20 | 2011-07-19 | スベロイルアニリドヒドロキサム酸の製剤及びこれを作製するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540436A Active JP5264174B2 (ja) | 2005-05-20 | 2006-05-16 | スベロイルアニリドヒドロキサム酸の製剤及びこれを作製するための方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8093295B2 (OSRAM) |
| EP (2) | EP1853245A2 (OSRAM) |
| JP (2) | JP5264174B2 (OSRAM) |
| KR (2) | KR100884500B1 (OSRAM) |
| AR (1) | AR055953A1 (OSRAM) |
| AU (3) | AU2006249440C1 (OSRAM) |
| BR (1) | BRPI0605893A (OSRAM) |
| CA (1) | CA2580367C (OSRAM) |
| CR (1) | CR8912A (OSRAM) |
| DO (1) | DOP2006000113A (OSRAM) |
| EC (1) | ECSP077263A (OSRAM) |
| IL (1) | IL181070A0 (OSRAM) |
| MA (1) | MA28804B1 (OSRAM) |
| MX (1) | MX2007002047A (OSRAM) |
| MY (1) | MY144613A (OSRAM) |
| NI (1) | NI200700031A (OSRAM) |
| NZ (2) | NZ553204A (OSRAM) |
| PE (1) | PE20061390A1 (OSRAM) |
| TW (2) | TWI415603B (OSRAM) |
| WO (2) | WO2006127321A2 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI415603B (zh) * | 2005-05-20 | 2013-11-21 | Merck Sharp & Dohme | 1,8-辛二醯基苯胺羥胺酸(suberoylanilide hydroxamic acid)之調配物及其製配方法 |
| AU2009305214B2 (en) | 2008-10-15 | 2015-06-25 | Generics [Uk] Limited | Process for the preparation of vorinostat |
| NZ593585A (en) * | 2008-11-26 | 2012-12-21 | Generics Uk Ltd | Crystalline forms of vorinostat (suberoylanilide hydroxamic acid) |
| EP2362870A2 (en) * | 2008-11-26 | 2011-09-07 | Generics [UK] Limited | Novel processes and pure polymorphs |
| US20110313044A1 (en) * | 2010-06-18 | 2011-12-22 | Urquima S.A. | Polymorphs of Suberoylanilide Hydroxamic Acid |
| WO2018011811A2 (en) * | 2016-07-13 | 2018-01-18 | Rappaport Family Institute For Research In The Medical Sciences | Inhibitors of cytoplasmic histone deacetylase 4 complex for treating or preventing vascular or valve calcification |
| CN107362148B (zh) * | 2017-07-27 | 2020-04-21 | 东曜药业有限公司 | 一种治疗肿瘤的药物组合物及其制备方法和应用 |
| EP4007585A4 (en) | 2019-08-02 | 2023-11-08 | OneHealthCompany, Inc. | TREATMENT OF CANINE CANCERS |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| JPS61176523A (ja) * | 1985-01-30 | 1986-08-08 | Teruhiko Beppu | 制癌剤 |
| US5608108A (en) * | 1988-11-14 | 1997-03-04 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
| US5055608A (en) * | 1988-11-14 | 1991-10-08 | Sloan-Kettering Institute For Cancer Research | Novel potent inducers of thermal differentiation and method of use thereof |
| US5175191A (en) * | 1988-11-14 | 1992-12-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| USRE38506E1 (en) * | 1991-10-04 | 2004-04-20 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| US5369108A (en) * | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| US5700811A (en) | 1991-10-04 | 1997-12-23 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
| US5635532A (en) * | 1991-10-21 | 1997-06-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia |
| JP3170069B2 (ja) * | 1992-10-06 | 2001-05-28 | 日水製薬株式会社 | 徐放性顆粒剤 |
| US6030961A (en) | 1997-03-11 | 2000-02-29 | Bar-Ilan Research & Development Co., Ltd. | Oxyalkylene phosphate compounds and uses thereof |
| US6043389A (en) * | 1997-03-11 | 2000-03-28 | Mor Research Applications, Ltd. | Hydroxy and ether-containing oxyalkylene esters and uses thereof |
| US6124495A (en) | 1997-03-11 | 2000-09-26 | Beacon Laboratories, Inc. | Unsaturated oxyalkylene esters and uses thereof |
| US6231880B1 (en) * | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
| AUPO721997A0 (en) | 1997-06-06 | 1997-07-03 | Queensland Institute Of Medical Research, The | Anticancer compounds |
| US6262116B1 (en) * | 1998-01-23 | 2001-07-17 | Sloan-Kettering Institute For Cancer Research | Transcription therapy for cancers |
| IL142531A0 (en) | 1998-10-13 | 2002-03-10 | Fujisawa Pharmaceutical Co | Cyclic peptide compound, processes for the preparation thereof and pharmaceutical compositions containing the same |
| JP2003500052A (ja) | 1999-05-03 | 2003-01-07 | メチルジーン インコーポレイテッド | ヒストン脱アセチル酵素の抑制 |
| JP2001081031A (ja) | 1999-08-30 | 2001-03-27 | Schering Ag | 溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤 |
| TR200201052T2 (tr) | 1999-09-08 | 2003-01-21 | Sloan-Kettering Institute For Cancer Research | Yeni hücre farklılaştırıcı ajanlar sınıfı ve hıstone deacetylase inhibitörleri, ve burada kullanım yöntemleri |
| DK1233958T3 (da) | 1999-11-23 | 2011-10-17 | Methylgene Inc | Hæmmere af histondeacetylase |
| WO2001070675A2 (en) | 2000-03-24 | 2001-09-27 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| WO2002015921A2 (en) | 2000-08-18 | 2002-02-28 | The Governement Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Methods of treating cutaneous and peripheral t-cell lymphoma by a histone deacetylase inhibitor |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| EP2292593A3 (en) | 2000-09-29 | 2011-05-25 | TopoTarget UK Limited | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors |
| AU2002243231A1 (en) * | 2000-11-21 | 2002-07-24 | Wake Forest University | Method of treating autoimmune diseases |
| AR035659A1 (es) | 2000-12-07 | 2004-06-23 | Hoffmann La Roche | Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos |
| US6495719B2 (en) * | 2001-03-27 | 2002-12-17 | Circagen Pharmaceutical | Histone deacetylase inhibitors |
| US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| EP1532244A4 (en) * | 2001-06-14 | 2005-12-14 | Bristol Myers Squibb Co | NEW HISTONIC HUMAN DEACETYLASES |
| EP2269609A3 (en) * | 2001-10-16 | 2012-07-11 | Sloan-Kettering Institute for Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain with SAHA |
| US20040132643A1 (en) * | 2002-01-09 | 2004-07-08 | Fojo Antonio Tito | Histone deacelylase inhibitors in diagnosis and treatment of thyroid neoplasms |
| WO2003070188A2 (en) * | 2002-02-15 | 2003-08-28 | Sloan-Kettering Institute For Cancer Research | Method of treating trx mediated diseases |
| MXPA04008577A (es) * | 2002-03-04 | 2005-07-13 | Aton Pharma Inc | Metodos para inducir diferenciacion terminal. |
| US20060276547A1 (en) * | 2002-03-04 | 2006-12-07 | Bacopoulos Nicholas G | Methods of treating cancer with HDAC inhibitors |
| US7148257B2 (en) * | 2002-03-04 | 2006-12-12 | Merck Hdac Research, Llc | Methods of treating mesothelioma with suberoylanilide hydroxamic acid |
| US20070060614A1 (en) * | 2002-03-04 | 2007-03-15 | Bacopoulos Nicholas G | Methods of treating cancer with hdac inhibitors |
| US20040132825A1 (en) * | 2002-03-04 | 2004-07-08 | Bacopoulos Nicholas G. | Methods of treating cancer with HDAC inhibitors |
| US7456219B2 (en) * | 2002-03-04 | 2008-11-25 | Merck Hdac Research, Llc | Polymorphs of suberoylanilide hydroxamic acid |
| AU2003226408B2 (en) * | 2002-04-15 | 2007-06-14 | Sloan-Kettering Institute For Cancer Research | Combination therapy for the treatment of cancer |
| DE10218106A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen von Arzneimittelwirkstoffen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
| EP1567142A4 (en) * | 2002-11-20 | 2005-12-14 | Errant Gene Therapeutics Llc | TREATMENT OF PULMONARY CELLS WITH HISTONE DEACETYLASE INHIBITORS |
| CA2520611A1 (en) * | 2003-04-01 | 2004-10-21 | Memorial Sloan-Kettering Cancer Center | Hydroxamic acid compounds and methods of use thereof |
| PL379887A1 (pl) * | 2003-08-26 | 2006-11-27 | Merck Hdac Research, Llc | Sposób leczenia raka inhibitorami HDAC |
| TWI415603B (zh) * | 2005-05-20 | 2013-11-21 | Merck Sharp & Dohme | 1,8-辛二醯基苯胺羥胺酸(suberoylanilide hydroxamic acid)之調配物及其製配方法 |
| EP1933825A2 (en) | 2005-08-18 | 2008-06-25 | Merck and Co., Inc. | Combination methods of saha and targretin for treating cancer |
| US20070117815A1 (en) | 2005-11-04 | 2007-05-24 | James Pluda | Method of treating cancers with SAHA and pemetrexed |
| WO2007056162A2 (en) | 2005-11-04 | 2007-05-18 | Merck & Co., Inc. | Methods of treating cancers with saha, carboplatin, and paclitaxel and other combination therapies |
| US20070197568A1 (en) * | 2005-11-04 | 2007-08-23 | Paul Bunn | Methods of using SAHA and Erlotinib for treating cancer |
-
2006
- 2006-05-11 TW TW099119337A patent/TWI415603B/zh not_active IP Right Cessation
- 2006-05-11 TW TW095116824A patent/TWI365068B/zh not_active IP Right Cessation
- 2006-05-15 DO DO2006000113A patent/DOP2006000113A/es unknown
- 2006-05-16 WO PCT/US2006/018795 patent/WO2006127321A2/en not_active Ceased
- 2006-05-16 EP EP06759843A patent/EP1853245A2/en not_active Ceased
- 2006-05-16 AU AU2006249440A patent/AU2006249440C1/en active Active
- 2006-05-16 BR BRPI0605893-0A patent/BRPI0605893A/pt not_active IP Right Cessation
- 2006-05-16 KR KR1020077003998A patent/KR100884500B1/ko not_active Expired - Fee Related
- 2006-05-16 PE PE2006000515A patent/PE20061390A1/es not_active Application Discontinuation
- 2006-05-16 NZ NZ553204A patent/NZ553204A/en not_active IP Right Cessation
- 2006-05-16 KR KR1020087030074A patent/KR100993135B1/ko not_active Expired - Fee Related
- 2006-05-16 US US11/663,165 patent/US8093295B2/en active Active
- 2006-05-16 NZ NZ594669A patent/NZ594669A/xx not_active IP Right Cessation
- 2006-05-16 JP JP2007540436A patent/JP5264174B2/ja active Active
- 2006-05-16 WO PCT/US2006/018737 patent/WO2006127319A2/en not_active Ceased
- 2006-05-16 MX MX2007002047A patent/MX2007002047A/es active IP Right Grant
- 2006-05-16 CA CA2580367A patent/CA2580367C/en active Active
- 2006-05-16 EP EP10183861A patent/EP2292221A3/en not_active Withdrawn
- 2006-05-17 AR ARP060101986A patent/AR055953A1/es not_active Application Discontinuation
- 2006-05-17 MY MYPI20062258A patent/MY144613A/en unknown
-
2007
- 2007-01-30 IL IL181070A patent/IL181070A0/en unknown
- 2007-02-02 NI NI200700031A patent/NI200700031A/es unknown
- 2007-02-07 CR CR8912A patent/CR8912A/es unknown
- 2007-02-16 MA MA29685A patent/MA28804B1/fr unknown
- 2007-02-16 EC EC2007007263A patent/ECSP077263A/es unknown
-
2009
- 2009-04-27 AU AU2009201650A patent/AU2009201650B2/en not_active Ceased
- 2009-04-27 AU AU2009201652A patent/AU2009201652B2/en not_active Ceased
-
2010
- 2010-01-13 US US12/686,830 patent/US20100113829A1/en not_active Abandoned
- 2010-01-13 US US12/686,843 patent/US8450372B2/en active Active
- 2010-01-13 US US12/686,812 patent/US8288440B2/en active Active
-
2011
- 2011-07-19 JP JP2011157930A patent/JP5308486B2/ja active Active
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