TWI365068B - Formulations of suberoylanilide hydroxamic acid and methods for producing same - Google Patents

Formulations of suberoylanilide hydroxamic acid and methods for producing same

Info

Publication number
TWI365068B
TWI365068B TW095116824A TW95116824A TWI365068B TW I365068 B TWI365068 B TW I365068B TW 095116824 A TW095116824 A TW 095116824A TW 95116824 A TW95116824 A TW 95116824A TW I365068 B TWI365068 B TW I365068B
Authority
TW
Taiwan
Prior art keywords
formulations
methods
hydroxamic acid
producing same
suberoylanilide hydroxamic
Prior art date
Application number
TW095116824A
Other languages
English (en)
Other versions
TW200727892A (en
Inventor
Thomas A Miller
Kimberly Gallagher
Craig Ikeda
Justin Moser
Pavol Rajniak
Qingxi Wang
Brian Sell
Vincent R Capodanno
Benjamin Max Cohen
Robert A Reed
Jeannie Chow Wong
Aaron S Cote
Erik A Dienemann
Cindy Starbuck
Hsien-Hsin Tung
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37452585&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI365068(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of TW200727892A publication Critical patent/TW200727892A/zh
Application granted granted Critical
Publication of TWI365068B publication Critical patent/TWI365068B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW095116824A 2005-05-20 2006-05-11 Formulations of suberoylanilide hydroxamic acid and methods for producing same TWI365068B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68287505P 2005-05-20 2005-05-20
US69312805P 2005-06-23 2005-06-23

Publications (2)

Publication Number Publication Date
TW200727892A TW200727892A (en) 2007-08-01
TWI365068B true TWI365068B (en) 2012-06-01

Family

ID=37452585

Family Applications (2)

Application Number Title Priority Date Filing Date
TW099119337A TWI415603B (zh) 2005-05-20 2006-05-11 １，８－辛二醯基苯胺羥胺酸（ｓｕｂｅｒｏｙｌａｎｉｌｉｄｅ ｈｙｄｒｏｘａｍｉｃ ａｃｉｄ）之調配物及其製配方法
TW095116824A TWI365068B (en) 2005-05-20 2006-05-11 Formulations of suberoylanilide hydroxamic acid and methods for producing same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TW099119337A TWI415603B (zh) 2005-05-20 2006-05-11 １，８－辛二醯基苯胺羥胺酸（ｓｕｂｅｒｏｙｌａｎｉｌｉｄｅ ｈｙｄｒｏｘａｍｉｃ ａｃｉｄ）之調配物及其製配方法

Country Status (20)

Country Link
US (4) US8093295B2 (zh)
EP (2) EP1853245A2 (zh)
JP (2) JP5264174B2 (zh)
KR (2) KR100993135B1 (zh)
AR (1) AR055953A1 (zh)
AU (3) AU2006249440C1 (zh)
BR (1) BRPI0605893A (zh)
CA (1) CA2580367C (zh)
CR (1) CR8912A (zh)
DO (1) DOP2006000113A (zh)
EC (1) ECSP077263A (zh)
IL (1) IL181070A0 (zh)
MA (1) MA28804B1 (zh)
MX (1) MX2007002047A (zh)
MY (1) MY144613A (zh)
NI (1) NI200700031A (zh)
NZ (2) NZ553204A (zh)
PE (1) PE20061390A1 (zh)
TW (2) TWI415603B (zh)
WO (2) WO2006127321A2 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI415603B (zh) * 2005-05-20 2013-11-21 Merck Sharp & Dohme １，８－辛二醯基苯胺羥胺酸（ｓｕｂｅｒｏｙｌａｎｉｌｉｄｅ ｈｙｄｒｏｘａｍｉｃ ａｃｉｄ）之調配物及其製配方法
US8883851B2 (en) 2008-10-15 2014-11-11 Generics [Uk] Limited Process for the preparation of vorinostat
CA2744458A1 (en) * 2008-11-26 2010-06-03 Generics [Uk] Limited Novel processes and pure polymorphs
US8754129B2 (en) 2008-11-26 2014-06-17 Generics [Uk] Limited Crystalline vorinostat form VI
US20110313044A1 (en) * 2010-06-18 2011-12-22 Urquima S.A. Polymorphs of Suberoylanilide Hydroxamic Acid
WO2018011811A2 (en) * 2016-07-13 2018-01-18 Rappaport Family Institute For Research In The Medical Sciences Inhibitors of cytoplasmic histone deacetylase 4 complex for treating or preventing vascular or valve calcification
CN107362148B (zh) * 2017-07-27 2020-04-21 东曜药业有限公司 一种治疗肿瘤的药物组合物及其制备方法和应用

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Also Published As

Publication number Publication date
BRPI0605893A (pt) 2007-12-18
US20100113829A1 (en) 2010-05-06
US8288440B2 (en) 2012-10-16
WO2006127319A3 (en) 2007-03-29
TW201034660A (en) 2010-10-01
US20100112046A1 (en) 2010-05-06
ECSP077263A (zh) 2007-04-26
US20100119596A1 (en) 2010-05-13
US20080132575A1 (en) 2008-06-05
WO2006127319A2 (en) 2006-11-30
NZ594669A (en) 2013-02-22
JP2011251985A (ja) 2011-12-15
MX2007002047A (es) 2007-04-12
DOP2006000113A (es) 2006-10-31
NZ553204A (en) 2011-09-30
CR8912A (es) 2008-02-21
TWI415603B (zh) 2013-11-21
AU2010201359A1 (en) 2010-04-29
JP5264174B2 (ja) 2013-08-14
EP1853245A2 (en) 2007-11-14
WO2006127321A2 (en) 2006-11-30
KR100884500B1 (ko) 2009-02-20
AU2006249440B2 (en) 2009-03-12
US8093295B2 (en) 2012-01-10
CA2580367C (en) 2012-08-21
NI200700031A (es) 2008-03-03
KR20080113135A (ko) 2008-12-26
AU2009201652B2 (en) 2011-10-06
AU2009201650B2 (en) 2011-09-15
AU2006249440C1 (en) 2009-08-13
US8450372B2 (en) 2013-05-28
MY144613A (en) 2011-10-04
AR055953A1 (es) 2007-09-12
CA2580367A1 (en) 2006-11-30
KR100993135B1 (ko) 2010-11-10
MA28804B1 (fr) 2007-08-01
JP5308486B2 (ja) 2013-10-09
IL181070A0 (en) 2007-07-04
AU2009201652A1 (en) 2009-05-21
EP2292221A3 (en) 2011-08-10
PE20061390A1 (es) 2007-01-15
KR20070062505A (ko) 2007-06-15
TW200727892A (en) 2007-08-01
WO2006127321A3 (en) 2007-03-22
EP2292221A2 (en) 2011-03-09
AU2006249440A1 (en) 2006-11-30
AU2009201650A1 (en) 2009-05-21
JP2008519081A (ja) 2008-06-05

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