JP2013181034A5 - - Google Patents
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- JP2013181034A5 JP2013181034A5 JP2013107244A JP2013107244A JP2013181034A5 JP 2013181034 A5 JP2013181034 A5 JP 2013181034A5 JP 2013107244 A JP2013107244 A JP 2013107244A JP 2013107244 A JP2013107244 A JP 2013107244A JP 2013181034 A5 JP2013181034 A5 JP 2013181034A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- composition
- antigenic peptide
- molecule
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 230000003053 immunization Effects 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 15
- 230000000890 antigenic effect Effects 0.000 claims 13
- 238000002649 immunization Methods 0.000 claims 9
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 8
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 8
- 238000003776 cleavage reaction Methods 0.000 claims 8
- 230000007017 scission Effects 0.000 claims 8
- 239000003981 vehicle Substances 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 4
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 4
- 241000724791 Filamentous phage Species 0.000 claims 3
- 238000009825 accumulation Methods 0.000 claims 3
- 239000000412 dendrimer Substances 0.000 claims 3
- 229920000736 dendritic polymer Polymers 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims 2
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims 2
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims 2
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- JKHXYJKMNSSFFL-IUCAKERBSA-N Val-Lys Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN JKHXYJKMNSSFFL-IUCAKERBSA-N 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000001588 bifunctional effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 108010073969 valyllysine Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36134402P | 2002-03-05 | 2002-03-05 | |
| US60/361,344 | 2002-03-05 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010114047A Division JP2010248197A (ja) | 2002-03-05 | 2010-05-18 | 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ切断部位に対する免疫応答を誘発するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013181034A JP2013181034A (ja) | 2013-09-12 |
| JP2013181034A5 true JP2013181034A5 (enExample) | 2014-07-10 |
| JP5717210B2 JP5717210B2 (ja) | 2015-05-13 |
Family
ID=27805031
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003574670A Pending JP2005532276A (ja) | 2002-03-05 | 2003-03-04 | 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ開裂部位に対する免疫応答を誘発する方法 |
| JP2010114047A Pending JP2010248197A (ja) | 2002-03-05 | 2010-05-18 | 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ切断部位に対する免疫応答を誘発するための方法 |
| JP2013107244A Expired - Fee Related JP5717210B2 (ja) | 2002-03-05 | 2013-05-21 | 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ切断部位に対する免疫応答を誘発するための方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003574670A Pending JP2005532276A (ja) | 2002-03-05 | 2003-03-04 | 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ開裂部位に対する免疫応答を誘発する方法 |
| JP2010114047A Pending JP2010248197A (ja) | 2002-03-05 | 2010-05-18 | 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ切断部位に対する免疫応答を誘発するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7494655B2 (enExample) |
| EP (2) | EP1480666B1 (enExample) |
| JP (3) | JP2005532276A (enExample) |
| AU (1) | AU2003225636A1 (enExample) |
| CA (1) | CA2477675C (enExample) |
| ES (1) | ES2392247T3 (enExample) |
| IL (3) | IL163812A0 (enExample) |
| WO (1) | WO2003076455A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1398019A1 (de) | 2002-09-13 | 2004-03-17 | Cognis France S.A. | Verfahren zum Schutz und zur Modulation von Dermal Epidermal Junctions |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| WO2005033278A2 (en) * | 2003-09-30 | 2005-04-14 | Ludwig Institute For Cancer Research | In vivo efficacy of ny-eso-1 plus iscom |
| BRPI0516674A (pt) * | 2004-10-28 | 2008-09-16 | Sanko Junyaku Kk | método de análise de mal de alzheimer e reagente de diagnóstico |
| AR054729A1 (es) | 2005-10-18 | 2007-07-11 | Starpharma Pty Ltd | Sistema de administracion |
| CA2626865C (en) | 2005-10-25 | 2014-12-30 | Starpharma Pty Limited | Macromolecular compounds having controlled stoichiometry |
| KR20080090408A (ko) | 2005-11-30 | 2008-10-08 | 아보트 러보러터리즈 | 항-Ａβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법 |
| SG10201706600VA (en) | 2005-11-30 | 2017-09-28 | Abbvie Inc | Monoclonal antibodies and uses thereof |
| CA2636599C (en) | 2006-01-20 | 2014-07-15 | Starpharma Pty Limited | Modified macromolecule |
| US8193248B2 (en) | 2006-03-22 | 2012-06-05 | Starpharma Pty Limited | Contraceptive composition |
| CN101553567A (zh) * | 2006-07-21 | 2009-10-07 | 台拉维夫大学拉莫特 | 抑制或治疗与细胞内形成蛋白纤维状内含体或聚集体相关的疾病的方法 |
| PL2052011T3 (pl) | 2006-08-11 | 2021-03-08 | Starpharma Pty Limited | Nakierowany środek terapeutyczny będący dendrymerem polilizynowym |
| AU2007327546B2 (en) * | 2006-11-28 | 2013-11-21 | Alzhyme Pty Ltd | Improved peptide composition |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| EP2199391B1 (en) | 2007-09-27 | 2015-11-11 | Japan Tobacco, Inc. | Factor involved in latent infection with herpesvirus, and use thereof |
| GB0720912D0 (en) * | 2007-10-25 | 2007-12-05 | Univ Cardiff | Monoclonal Anitbody for APP |
| KR101397554B1 (ko) * | 2007-11-09 | 2014-05-21 | 재단법인서울대학교산학협력재단 | 치매(알츠하이머 병)의 진단, 예방, 치료제 및 이들의스크리닝 방법 |
| MX2010006422A (es) | 2007-12-11 | 2010-06-25 | Glaxo Group Ltd | Proteinas de union a antigenos. |
| WO2009124119A2 (en) * | 2008-04-01 | 2009-10-08 | The Trustes of Columbia University in the City of New York | Phosphodiesterase inhibitors and uses thereof |
| WO2009155538A1 (en) * | 2008-06-20 | 2009-12-23 | Merck & Co., Inc. | Compositions and methods of depleting amyloid-beta peptides from cerebrospinal fluid to treat alzheimer's disease |
| TW201438738A (zh) | 2008-09-16 | 2014-10-16 | Genentech Inc | 治療進展型多發性硬化症之方法 |
| AU2009316326A1 (en) * | 2008-11-24 | 2010-05-27 | Ramot At Tel-Aviv University Ltd. | Method for treating Parkinson' s disease using filamentous bacteriophage |
| EP2379076B1 (en) | 2008-12-23 | 2014-11-12 | The Trustees of Columbia University in the City of New York | Phosphodiesterase inhibitors and uses thereof |
| WO2011031720A1 (en) * | 2009-09-11 | 2011-03-17 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Bispecific nanobodies as a therapeutic for alzheimer's disease |
| EP2558494B1 (en) | 2010-04-15 | 2018-05-23 | AbbVie Inc. | Amyloid-beta binding proteins |
| US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| JP6608818B2 (ja) * | 2014-06-27 | 2019-11-20 | 日本たばこ産業株式会社 | 気分障害を診断、治療又は予防する方法 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN106349334A (zh) * | 2015-07-15 | 2017-01-25 | 韩震 | 一种多肽化合物及其制备方法与应用 |
| US10539578B2 (en) | 2015-12-28 | 2020-01-21 | Japan Tobacco Inc. | Method for diagnosing, treating, or preventing mood disorders |
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| US12281166B2 (en) | 2020-05-26 | 2025-04-22 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking Galectin-3 |
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| GB0720912D0 (en) * | 2007-10-25 | 2007-12-05 | Univ Cardiff | Monoclonal Anitbody for APP |
-
2003
- 2003-03-04 AU AU2003225636A patent/AU2003225636A1/en not_active Abandoned
- 2003-03-04 IL IL16381203A patent/IL163812A0/xx unknown
- 2003-03-04 WO PCT/US2003/006388 patent/WO2003076455A2/en not_active Ceased
- 2003-03-04 US US10/506,665 patent/US7494655B2/en not_active Expired - Fee Related
- 2003-03-04 EP EP03744143A patent/EP1480666B1/en not_active Expired - Lifetime
- 2003-03-04 ES ES03744143T patent/ES2392247T3/es not_active Expired - Lifetime
- 2003-03-04 CA CA2477675A patent/CA2477675C/en not_active Expired - Fee Related
- 2003-03-04 JP JP2003574670A patent/JP2005532276A/ja active Pending
- 2003-03-04 EP EP10185941A patent/EP2292247A3/en not_active Withdrawn
-
2004
- 2004-08-30 IL IL163812A patent/IL163812A/en not_active IP Right Cessation
-
2007
- 2007-04-03 US US11/695,948 patent/US7854931B2/en not_active Expired - Fee Related
-
2010
- 2010-05-18 JP JP2010114047A patent/JP2010248197A/ja active Pending
- 2010-12-06 US US12/961,248 patent/US8613928B2/en not_active Expired - Fee Related
-
2011
- 2011-05-08 IL IL212752A patent/IL212752A/en not_active IP Right Cessation
-
2013
- 2013-05-21 JP JP2013107244A patent/JP5717210B2/ja not_active Expired - Fee Related
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