JP2013181034A5 - - Google Patents

Info

Publication number

JP2013181034A5

JP2013181034A5 JP2013107244A JP2013107244A JP2013181034A5 JP 2013181034 A5 JP2013181034 A5 JP 2013181034A5 JP 2013107244 A JP2013107244 A JP 2013107244A JP 2013107244 A JP2013107244 A JP 2013107244A JP 2013181034 A5 JP2013181034 A5 JP 2013181034A5

Authority

JP

Japan

Prior art keywords

seq

composition

antigenic peptide

molecule

peptide

Prior art date

2013-05-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 claims 17
• 230000003053 immunization Effects 0.000 claims 15
• 239000000203 mixture Substances 0.000 claims 15
• 230000000890 antigenic effect Effects 0.000 claims 13
• 238000002649 immunization Methods 0.000 claims 9
• 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 8
• 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 8
• 238000003776 cleavage reaction Methods 0.000 claims 8
• 230000007017 scission Effects 0.000 claims 8
• 239000003981 vehicle Substances 0.000 claims 6
• 239000000427 antigen Substances 0.000 claims 5
• 102000036639 antigens Human genes 0.000 claims 5
• 108091007433 antigens Proteins 0.000 claims 5
• 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 4
• 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 4
• 239000002671 adjuvant Substances 0.000 claims 4
• 241000724791 Filamentous phage Species 0.000 claims 3
• 238000009825 accumulation Methods 0.000 claims 3
• 239000000412 dendrimer Substances 0.000 claims 3
• 229920000736 dendritic polymer Polymers 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims 2
• 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims 2
• 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims 2
• DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 2
• 239000003085 diluting agent Substances 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 125000000524 functional group Chemical group 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• 230000003612 virological effect Effects 0.000 claims 2
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
• 239000004472 Lysine Substances 0.000 claims 1
• JKHXYJKMNSSFFL-IUCAKERBSA-N Val-Lys Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN JKHXYJKMNSSFFL-IUCAKERBSA-N 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 230000001588 bifunctional effect Effects 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 239000002502 liposome Substances 0.000 claims 1
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
• 108010073969 valyllysine Proteins 0.000 claims 1