JP2013085485A5 - - Google Patents
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- Publication number
- JP2013085485A5 JP2013085485A5 JP2011226233A JP2011226233A JP2013085485A5 JP 2013085485 A5 JP2013085485 A5 JP 2013085485A5 JP 2011226233 A JP2011226233 A JP 2011226233A JP 2011226233 A JP2011226233 A JP 2011226233A JP 2013085485 A5 JP2013085485 A5 JP 2013085485A5
- Authority
- JP
- Japan
- Prior art keywords
- cyp3a
- mouse
- immunostaining
- liver
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 210000003494 hepatocyte Anatomy 0.000 description 2
- 238000012744 immunostaining Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 102100033421 Keratin, type I cytoskeletal 18 Human genes 0.000 description 1
- 102100023972 Keratin, type II cytoskeletal 8 Human genes 0.000 description 1
- 108010066327 Keratin-18 Proteins 0.000 description 1
- 108010070511 Keratin-8 Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- WDVSHHCDHLJJJR-UHFFFAOYSA-N Proflavine Chemical compound C1=CC(N)=CC2=NC3=CC(N)=CC=C3C=C21 WDVSHHCDHLJJJR-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
Images
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011226233A JP5883265B2 (ja) | 2011-10-13 | 2011-10-13 | ヒト肝細胞を担持するキメラ非ヒト動物 |
| EP12840420.9A EP2767160B1 (en) | 2011-10-13 | 2012-10-12 | Chimeric non-human animal carrying human hepatocyte |
| CA2851997A CA2851997C (en) | 2011-10-13 | 2012-10-12 | Chimeric non-human animal carrying human hepatocyte |
| US14/351,481 US9420769B2 (en) | 2011-10-13 | 2012-10-12 | Chimeric non-human animal carrying human hepatocyte |
| PCT/JP2012/077019 WO2013054949A1 (ja) | 2011-10-13 | 2012-10-12 | ヒト肝細胞を担持するキメラ非ヒト動物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011226233A JP5883265B2 (ja) | 2011-10-13 | 2011-10-13 | ヒト肝細胞を担持するキメラ非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013085485A JP2013085485A (ja) | 2013-05-13 |
| JP2013085485A5 true JP2013085485A5 (cg-RX-API-DMAC7.html) | 2014-10-30 |
| JP5883265B2 JP5883265B2 (ja) | 2016-03-09 |
Family
ID=48081988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011226233A Expired - Fee Related JP5883265B2 (ja) | 2011-10-13 | 2011-10-13 | ヒト肝細胞を担持するキメラ非ヒト動物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9420769B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2767160B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5883265B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2851997C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013054949A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6496107B2 (ja) * | 2014-05-08 | 2019-04-03 | 株式会社フェニックスバイオ | 高尿酸血症モデル |
| WO2018005471A1 (en) | 2016-06-27 | 2018-01-04 | Baylor College Of Medicine | Human liver chimeric non-human animal with deficient p450 oxidoreductase and methods of using same |
| KR20220035926A (ko) * | 2019-07-26 | 2022-03-22 | 앰비스 메디신즈 인코포레이티드 | 간세포 생성을 위한 방법 및 조성물 |
| JP7037789B2 (ja) * | 2019-12-23 | 2022-03-17 | 積水メディカル株式会社 | ヒト肝細胞キメラ動物におけるヒト肝細胞置換率の測定方法 |
| EP4408169A4 (en) * | 2021-09-30 | 2025-10-29 | Univ Southern California | Human hepatocyte culture medium and conditioned medium of in vitro cultured human hepatocyte cells and their uses |
| CN118265448A (zh) * | 2021-09-30 | 2024-06-28 | 南加州大学 | 人肝细胞培养基和体外培养的人肝细胞的条件化培养基及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3266766B2 (ja) | 1994-08-23 | 2002-03-18 | 科学技術振興事業団 | ローン性増殖能を有する肝実質細胞とその取得方法、並びにその継代培養方法 |
| JP3211941B2 (ja) | 1996-12-26 | 2001-09-25 | 科学技術振興事業団 | ヒト小型肝細胞の取得方法と、この細胞の初代培養および継代培養方法 |
| WO2001011951A1 (fr) * | 1999-08-13 | 2001-02-22 | Kirin Beer Kabushiki Kaisha | Souris renfermant un cytochrome p450 humain |
| US6995299B2 (en) * | 1999-11-02 | 2006-02-07 | University Of Connecticut | Propagation of human hepatocytes in non-human animals |
| US6509514B1 (en) | 2000-03-17 | 2003-01-21 | Kmt Hepatech, Inc. | Chimeric animal model susceptible to human hepatitis C virus infection |
| JP2002045087A (ja) | 2000-05-19 | 2002-02-12 | Japan Science & Technology Corp | キメラ動物 |
| EP1496066A4 (en) * | 2002-03-25 | 2006-09-13 | Japan Science & Tech Agency | ANTIBODY RECOGNIZING PROLIFERATIVE HUMAN LIVER CELLS, PROLIFERATIVE HUMAN LIVER CELLS, AND FUNCTIONAL HUMAN LIVER CELLS |
| WO2008001614A1 (fr) | 2006-06-29 | 2008-01-03 | Hiroshima Industrial Promotion Organization | Modèle animalier de stéatohépatite non alcoolique et modèle animalier de stéatose hépatique |
| GB0720552D0 (en) * | 2007-10-19 | 2007-11-28 | Iti Scotland Ltd | Multiple cluster knockout |
| JP4997544B2 (ja) * | 2007-11-14 | 2012-08-08 | 国立大学法人鳥取大学 | ヒトチトクロームｐ４５０遺伝子（クラスター）を含む哺乳動物人工染色体ベクター及びそれを保持する非ヒト哺乳動物 |
| JP5557217B2 (ja) * | 2010-01-06 | 2014-07-23 | 国立大学法人鳥取大学 | マウス人工染色体ベクター |
| KR20110116817A (ko) | 2010-04-20 | 2011-10-26 | 삼성전기주식회사 | 열전 모듈을 이용한 건축용 단열재 |
-
2011
- 2011-10-13 JP JP2011226233A patent/JP5883265B2/ja not_active Expired - Fee Related
-
2012
- 2012-10-12 CA CA2851997A patent/CA2851997C/en not_active Expired - Fee Related
- 2012-10-12 WO PCT/JP2012/077019 patent/WO2013054949A1/ja not_active Ceased
- 2012-10-12 EP EP12840420.9A patent/EP2767160B1/en not_active Not-in-force
- 2012-10-12 US US14/351,481 patent/US9420769B2/en not_active Expired - Fee Related
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