JP2012531897A5 - - Google Patents
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- JP2012531897A5 JP2012531897A5 JP2012517843A JP2012517843A JP2012531897A5 JP 2012531897 A5 JP2012531897 A5 JP 2012531897A5 JP 2012517843 A JP2012517843 A JP 2012517843A JP 2012517843 A JP2012517843 A JP 2012517843A JP 2012531897 A5 JP2012531897 A5 JP 2012531897A5
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- 229920001184 polypeptide Polymers 0.000 claims description 148
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 148
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 148
- 210000004027 cell Anatomy 0.000 claims description 57
- 238000006467 substitution reaction Methods 0.000 claims description 53
- 150000001413 amino acids Chemical group 0.000 claims description 32
- 150000007523 nucleic acids Chemical class 0.000 claims description 27
- 108020004707 nucleic acids Proteins 0.000 claims description 22
- 102000039446 nucleic acids Human genes 0.000 claims description 22
- 229940024606 amino acid Drugs 0.000 claims description 13
- 239000013604 expression vector Substances 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 5
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 5
- 239000004474 valine Substances 0.000 claims description 5
- 102000018697 Membrane Proteins Human genes 0.000 claims description 4
- 108010052285 Membrane Proteins Proteins 0.000 claims description 4
- 108020003175 receptors Proteins 0.000 claims description 4
- 102000005962 receptors Human genes 0.000 claims description 4
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 3
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 3
- 229960000310 isoleucine Drugs 0.000 claims description 3
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 3
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims description 2
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims description 2
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims description 2
- 102000004278 Receptor Protein-Tyrosine Kinases Human genes 0.000 claims description 2
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- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 description 3
- 102100029206 Low affinity immunoglobulin gamma Fc region receptor II-c Human genes 0.000 description 3
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 description 3
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- 108020004414 DNA Proteins 0.000 description 2
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- 108090000790 Enzymes Proteins 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
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- 238000001042 affinity chromatography Methods 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- 102000000844 Cell Surface Receptors Human genes 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
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- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
- 102000034287 fluorescent proteins Human genes 0.000 description 1
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- 238000010438 heat treatment Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22199909P | 2009-06-30 | 2009-06-30 | |
| US61/221,999 | 2009-06-30 | ||
| PCT/US2010/040304 WO2011008517A2 (en) | 2009-06-30 | 2010-06-29 | Immunoglobulin fc polypeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012531897A JP2012531897A (ja) | 2012-12-13 |
| JP2012531897A5 true JP2012531897A5 (enExample) | 2013-07-18 |
| JP5683581B2 JP5683581B2 (ja) | 2015-03-11 |
Family
ID=43381018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012517843A Expired - Fee Related JP5683581B2 (ja) | 2009-06-30 | 2010-06-29 | 免疫グロブリンＦｃポリペプチド |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8679493B2 (enExample) |
| EP (1) | EP2448972A4 (enExample) |
| JP (1) | JP5683581B2 (enExample) |
| CN (1) | CN102549016B (enExample) |
| AU (1) | AU2010273763B2 (enExample) |
| CA (1) | CA2766065C (enExample) |
| WO (1) | WO2011008517A2 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008453B2 (en) * | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
| CA2780069C (en) | 2009-12-08 | 2018-07-17 | Abbott Gmbh & Co. Kg | Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration |
| AU2012214643B2 (en) * | 2011-02-07 | 2016-12-15 | Research Development Foundation | Engineered immunoglobulin Fc polypeptides |
| KR20230005405A (ko) | 2011-02-25 | 2023-01-09 | 추가이 세이야쿠 가부시키가이샤 | ＦｃγＲＩＩｂ 특이적 Ｆｃ 항체 |
| US10654916B2 (en) | 2011-04-21 | 2020-05-19 | The Regents Of The University Of California, A California Corporation | Compositions and methods for the treatment of neuromyelitis optica |
| KR102049122B1 (ko) | 2011-06-30 | 2019-11-26 | 추가이 세이야쿠 가부시키가이샤 | 헤테로이량화 폴리펩티드 |
| US20150050269A1 (en) | 2011-09-30 | 2015-02-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
| AU2012317395B2 (en) * | 2011-09-30 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule inducing immune response to target antigen |
| CN113416257A (zh) | 2011-11-30 | 2021-09-21 | 中外制药株式会社 | 包含进入细胞内以形成免疫复合体的搬运体(载体)的药物 |
| US20130330347A1 (en) | 2012-01-27 | 2013-12-12 | Abbvie Inc. | Composition and method for the diagnosis and treatment of diseases associated with neurite degeneration |
| SG11201508170TA (en) | 2013-04-02 | 2015-11-27 | Chugai Pharmaceutical Co Ltd | Fc REGION VARIANT |
| CA2904805A1 (en) | 2013-04-29 | 2014-11-06 | F. Hoffmann-La Roche Ag | Fc-receptor binding modified asymmetric antibodies and methods of use |
| CN103524625B (zh) * | 2013-09-24 | 2015-03-18 | 众森源生物技术（江苏）有限公司 | 一种新型诱导抗体产生的方法 |
| CN105916880B (zh) | 2014-01-15 | 2020-01-17 | 豪夫迈·罗氏有限公司 | 具有改善的蛋白A结合作用的Fc区变体 |
| EP3094647A1 (en) * | 2014-01-15 | 2016-11-23 | F. Hoffmann-La Roche AG | Fc-region variants with modified fcrn- and maintained protein a-binding properties |
| WO2015164723A1 (en) | 2014-04-25 | 2015-10-29 | The Trustees Of The University Of Pennsylvania | Methods and compositions for treating metastatic breast cancer and other cancers in the brain |
| AU2015252866B2 (en) | 2014-05-02 | 2021-01-28 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered Fc constructs |
| MX2017005774A (es) | 2014-12-19 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso. |
| SI3250610T1 (sl) | 2015-01-30 | 2023-11-30 | Momenta Pharmaceuticals, Inc. | Protitelesa fcrn in načini njihove uporabe |
| MX2017008978A (es) | 2015-02-05 | 2017-10-25 | Chugai Pharmaceutical Co Ltd | Anticuerpos que comprenden un dominio de union al antigeno dependiente de la concentracion ionica, variantes de la region fc, antiocuerpor de union a interleucina 8 (il-8) y usos de los mismos. |
| JP6724023B2 (ja) | 2015-02-09 | 2020-07-15 | リサーチ ディベロップメント ファウンデーション | 改善された補体活性化を示す操作された免疫グロブリンｆｃポリペプチド |
| JP6665485B2 (ja) * | 2015-10-29 | 2020-03-13 | 東ソー株式会社 | 抗体依存性細胞傷害活性に基づく抗体の分析方法 |
| JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | 抗ミオスタチン抗体および使用方法 |
| EP3423572B1 (en) | 2016-03-02 | 2023-11-29 | Momenta Pharmaceuticals, Inc. | Methods related to engineered fc constructs |
| KR102697688B1 (ko) * | 2016-04-15 | 2024-08-21 | 바이오아트라, 인코퍼레이티드 | 항 Axl항체 및 이의 면역접합체와 이것들의 용도 |
| US11623964B2 (en) * | 2016-05-23 | 2023-04-11 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered Fc constructs |
| CN109689685A (zh) | 2016-07-08 | 2019-04-26 | 斯塔滕生物技术有限公司 | 抗apoc3抗体及其使用方法 |
| HRP20240048T1 (hr) | 2016-07-29 | 2024-03-29 | Momenta Pharmaceuticals, Inc. | Fcrn antitijela i postupci njihove uporabe |
| CN116251182A (zh) | 2016-08-05 | 2023-06-13 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| EP3526241A1 (en) | 2016-10-14 | 2019-08-21 | Xencor, Inc. | Il15/il15r heterodimeric fc-fusion proteins |
| CA3040823A1 (en) * | 2016-10-17 | 2018-04-26 | Vetoquinol Sa | Modified antibody constant region |
| US11220531B2 (en) | 2017-01-06 | 2022-01-11 | Janssen Biotech, Inc. | Engineered Fc constructs |
| CA3059133A1 (en) | 2017-04-21 | 2018-10-25 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
| MA49517A (fr) | 2017-06-30 | 2020-05-06 | Xencor Inc | Protéines de fusion fc hétérodimères ciblées contenant il-15/il-15ra et domaines de liaison à l'antigène |
| US11059892B2 (en) | 2017-08-11 | 2021-07-13 | Research Development Foundation | Engineered antibody Fc variants for enhanced serum half life |
| US10538583B2 (en) | 2017-10-31 | 2020-01-21 | Staten Biotechnology B.V. | Anti-APOC3 antibodies and compositions thereof |
| JP7039694B2 (ja) | 2017-10-31 | 2022-03-22 | スターテン・バイオテクノロジー・ベー・フェー | 抗ａｐｏｃ３抗体およびその使用方法 |
| EP4640703A2 (en) | 2017-11-14 | 2025-10-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-c1s antibodies and methods of use |
| CA3084315A1 (en) | 2017-12-11 | 2019-06-20 | Abalone Bio, Inc. | Yeast display of proteins in the periplasmic space |
| US11773168B2 (en) | 2017-12-13 | 2023-10-03 | Momenta Pharmaceuticals, Inc. | FcRn antibodies and methods of use thereof |
| CN108676094B (zh) * | 2017-12-31 | 2021-07-20 | 武汉班科生物技术股份有限公司 | 人IgG抗体Fc段CH2结构域突变体及制备方法与应用 |
| EP3768315A4 (en) * | 2018-03-21 | 2022-11-30 | Dana Farber Cancer Institute, Inc. | Fc variant compositions and methods of use thereof |
| JP2021521784A (ja) | 2018-04-18 | 2021-08-30 | ゼンコア インコーポレイテッド | ＩＬ−１５／ＩＬ−１５ＲａＦｃ融合タンパク質とＰＤ−１抗原結合ドメインを含むＰＤ−１標的化ヘテロダイマー融合タンパク質およびそれらの使用 |
| TWI851572B (zh) | 2018-04-18 | 2024-08-11 | 美商山可爾股份有限公司 | IL-15/IL-15Rα異二聚體Fc融合蛋白及其用途 |
| JP7366056B2 (ja) | 2018-04-18 | 2023-10-20 | ゼンコア インコーポレイテッド | ＩＬ－１５／ＩＬ－１５ＲＡ Ｆｃ融合タンパク質およびＬＡＧ－３抗原結合ドメインを含む、ＬＡＧ－３を標的とするヘテロ二量体融合タンパク質 |
| JP2021520829A (ja) | 2018-04-18 | 2021-08-26 | ゼンコア インコーポレイテッド | ＩＬ−１５／ＩＬ−１５ＲＡ Ｆｃ融合タンパク質およびＴＩＭ−３抗原結合ドメインを含む、ＴＩＭ−３標的化ヘテロ二量体融合タンパク質 |
| CA3105985A1 (en) * | 2018-07-11 | 2020-01-16 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc-antigen binding domain constructs targeted to ccr4 |
| CN118754986A (zh) | 2018-08-10 | 2024-10-11 | 中外制药株式会社 | 抗cd137抗原结合分子及其应用 |
| WO2020077297A1 (en) * | 2018-10-11 | 2020-04-16 | Valerion Therapeutics, Llc | Methods and compositions for treatment of protein aggregation-based disorders |
| PE20211055A1 (es) | 2018-10-12 | 2021-06-07 | Xencor Inc | Proteinas de fusion il-15 / il-15 ralpha f c dirigidas a pd-1 y usos en terapias de combinacion de las mismas |
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| AU2020248645A1 (en) * | 2019-03-27 | 2021-10-28 | Tigatx, Inc. | Engineered IgA antibodies and methods of use |
| EP3969475A4 (en) | 2019-05-15 | 2023-04-26 | Chugai Seiyaku Kabushiki Kaisha | An antigen-binding molecule, a pharmaceutical composition, and a method |
| TW202128757A (zh) | 2019-10-11 | 2021-08-01 | 美商建南德克公司 | 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白 |
| CN113121677B (zh) * | 2019-12-31 | 2023-06-27 | 周易 | 一种得到高纯度异源抗体的方法 |
| JP2023550043A (ja) * | 2020-11-12 | 2023-11-30 | バイオアトラ インコーポレイテッド | 抗Ａｘｌ抗体、抗体断片およびそれらの免疫コンジュゲートを用いたＡｘｌ発現癌の治療方法 |
| CN115466323B (zh) * | 2022-09-13 | 2025-07-01 | 宁波博睿瀚达生物科技有限公司 | 一种分离分泌性白细胞蛋白酶抑制因子的方法 |
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-
2010
- 2010-06-29 CN CN201080038758.4A patent/CN102549016B/zh not_active Expired - Fee Related
- 2010-06-29 CA CA2766065A patent/CA2766065C/en active Active
- 2010-06-29 AU AU2010273763A patent/AU2010273763B2/en not_active Ceased
- 2010-06-29 JP JP2012517843A patent/JP5683581B2/ja not_active Expired - Fee Related
- 2010-06-29 WO PCT/US2010/040304 patent/WO2011008517A2/en not_active Ceased
- 2010-06-29 EP EP10800284A patent/EP2448972A4/en not_active Withdrawn
- 2010-06-30 US US12/827,386 patent/US8679493B2/en active Active
-
2014
- 2014-02-14 US US14/181,594 patent/US20140235482A1/en not_active Abandoned
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