JP2012530509A5 - - Google Patents
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- Publication number
- JP2012530509A5 JP2012530509A5 JP2012516776A JP2012516776A JP2012530509A5 JP 2012530509 A5 JP2012530509 A5 JP 2012530509A5 JP 2012516776 A JP2012516776 A JP 2012516776A JP 2012516776 A JP2012516776 A JP 2012516776A JP 2012530509 A5 JP2012530509 A5 JP 2012530509A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- amino acid
- endolysin
- acid residues
- protein according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09163953 | 2009-06-26 | ||
| EP09163953.4 | 2009-06-26 | ||
| PCT/EP2010/059146 WO2010149792A2 (en) | 2009-06-26 | 2010-06-28 | Antimicrobial agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016113291A Division JP2017008033A (ja) | 2009-06-26 | 2016-06-07 | 抗微生物剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012530509A JP2012530509A (ja) | 2012-12-06 |
| JP2012530509A5 true JP2012530509A5 (https=) | 2013-08-15 |
| JP6034187B2 JP6034187B2 (ja) | 2016-11-30 |
Family
ID=42799668
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012516776A Active JP6034187B2 (ja) | 2009-06-26 | 2010-06-28 | 抗微生物剤 |
| JP2016113291A Pending JP2017008033A (ja) | 2009-06-26 | 2016-06-07 | 抗微生物剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016113291A Pending JP2017008033A (ja) | 2009-06-26 | 2016-06-07 | 抗微生物剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US8906365B2 (https=) |
| EP (3) | EP2445515B1 (https=) |
| JP (2) | JP6034187B2 (https=) |
| KR (2) | KR20170024129A (https=) |
| CN (2) | CN102458452B (https=) |
| AU (3) | AU2010264656B2 (https=) |
| BR (1) | BRPI1015192A2 (https=) |
| CA (1) | CA2764131C (https=) |
| DK (1) | DK2445515T3 (https=) |
| EA (1) | EA037202B1 (https=) |
| ES (1) | ES2579806T3 (https=) |
| IL (2) | IL217124A (https=) |
| MX (2) | MX360300B (https=) |
| PL (1) | PL2445515T3 (https=) |
| SG (1) | SG177370A1 (https=) |
| SI (1) | SI2445515T1 (https=) |
| WO (1) | WO2010149792A2 (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| KR101701890B1 (ko) | 2009-06-26 | 2017-02-02 | 뤼산도 아게 | 항균제 |
| DK2445515T3 (en) | 2009-06-26 | 2016-07-04 | Univ Leuven Kath | antimicrobial agents |
| SG178440A1 (en) | 2009-08-24 | 2012-04-27 | Univ Leuven Kath | New endolysin obpgplys |
| EA037276B1 (ru) * | 2010-04-27 | 2021-03-03 | Лисандо Аг | Способы устранения или уменьшения бактериальной биопленки |
| EP2468856A1 (en) * | 2010-12-23 | 2012-06-27 | Lysando Aktiengesellschaft | Antimicrobial Agents |
| CN103635584B (zh) | 2011-04-12 | 2017-10-27 | 冈戈根股份有限公司 | 嵌合抗菌多肽 |
| US9068204B2 (en) | 2013-03-15 | 2015-06-30 | The United States Of America, As Represented By The Secretary Of Agriculture | Peptidoglycan hydrolase antimicrobials for eradicating lactobacilli that contaminate and reduce ethanol yields in biofuel fermentation |
| WO2015070912A1 (en) * | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified el188 endolysin sequence |
| WO2015070911A1 (en) * | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified kz144 endolysin sequence |
| WO2015121443A1 (en) | 2014-02-14 | 2015-08-20 | Lysando Ag | Antimicrobial agents |
| CA2941426C (en) * | 2014-04-08 | 2022-09-27 | Lysando Ag | Pharmaceutical composition against chronic bacterial infections |
| AU2015279705B2 (en) * | 2014-06-26 | 2021-04-01 | The Rockefeller University | Acinetobacter lysins |
| CN105734029B (zh) * | 2014-12-12 | 2020-09-25 | 丰益(上海)生物技术研发中心有限公司 | 磷脂酶抗菌肽 |
| AU2016324307B2 (en) | 2015-09-17 | 2021-10-21 | Contrafect Corporation | Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby |
| CN105175509A (zh) * | 2015-10-19 | 2015-12-23 | 河南科技学院 | 一种抗菌肽xyz-1及其应用 |
| CA3014442A1 (en) * | 2016-02-29 | 2017-09-08 | Dana-Farber Cancer Institute, Inc. | Stapled intracellular-targeting antimicrobial peptides to treat infection |
| AU2017255962B2 (en) * | 2016-04-28 | 2023-02-23 | Lysando Ag | Antimicrobial agents against Salmonella bacteria |
| WO2018100408A1 (en) | 2016-11-30 | 2018-06-07 | Sasinapas Co.,Ltd. | Modified peptides |
| AU2017375050B2 (en) * | 2016-12-16 | 2021-07-22 | Universidade Do Minho | Novel endolysin |
| US20180208938A1 (en) * | 2017-01-23 | 2018-07-26 | Innate Immunity LLC | Compositions and Methods for Protecting Plants Against Bacterial Infections |
| AU2018248060B2 (en) * | 2017-04-03 | 2024-05-23 | Sasinapas Co., Ltd. | Engineered Gram-negative endolysins |
| AU2018304230A1 (en) | 2017-07-19 | 2020-02-06 | Dana-Farber Cancer Institute, Inc. | Stabilized anti-microbial peptides for the treatment of antibiotic-resistant bacterial infections |
| WO2019155002A1 (en) * | 2018-02-08 | 2019-08-15 | Institut Pasteur | Anti-prevotella bacteriocin methods and compositions |
| CN112368376A (zh) * | 2018-03-29 | 2021-02-12 | 康特拉费克特公司 | 溶素-抗微生物肽(amp)多肽构建体、溶素、其分离的编码多核苷酸及其用途 |
| WO2020046747A1 (en) * | 2018-08-23 | 2020-03-05 | Contrafect Corporation | Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
| CN108410840A (zh) * | 2018-04-03 | 2018-08-17 | 大连理工大学 | 一种铜绿假单胞菌噬菌体内溶素及其编码基因与应用 |
| JP6979210B2 (ja) * | 2018-04-26 | 2021-12-08 | 株式会社ニューギン | 遊技機 |
| EP3802620A1 (en) * | 2018-05-30 | 2021-04-14 | Lysando AG | Novel antimicrobial fusion proteins |
| US11958890B2 (en) | 2018-05-30 | 2024-04-16 | Lysando Ag | Antimicrobial proteins |
| WO2021007107A1 (en) * | 2019-07-05 | 2021-01-14 | Contrafect Corporation | Antimicrobial, bacteriophage-derived polypeptides and their use against gram-negative and acid-fast bacteria |
| MX2022011291A (es) | 2020-03-11 | 2022-12-08 | Telum Therapeutics S L | Nueva lisina recombinante y su uso en el tratamiento de infecciones por bacterias gramnegativas. |
| CA3171721A1 (en) | 2020-03-19 | 2021-09-23 | Fritz Eichenseher | A stabilized protein of interest |
| WO2021235876A1 (ko) * | 2020-05-22 | 2021-11-25 | 주식회사 라이센텍 | 신규한 폴리펩타이드, 융합 폴리펩타이드, 및 이를 포함하는 그람음성균에 대한 항생제 |
| KR102286544B1 (ko) * | 2021-02-10 | 2021-08-05 | 주식회사 라이센텍 | 융합 폴리펩타이드 및 이를 포함하는 그람음성균에 대한 항생제 |
| EP4182334A4 (en) * | 2020-07-17 | 2024-10-16 | The University Of Western Australia | COMPOSITIONS AND METHODS OF TREATMENT OF CANCER |
| CN111876400B (zh) * | 2020-08-06 | 2022-05-24 | 昆明理工大学 | 一种常温裂解酶Sly和编码此酶的多核苷酸 |
| SK289101B6 (sk) * | 2020-12-17 | 2023-08-09 | Ústav molekulárnej biológie Slovenskej akadémie vied, verejná výskumná inštitúcia | Antimikrobiálny proteín, antimikrobiálny rekombinantný proteín s lytickými vlastnosťami, expresný vektor, spôsob ich prípravy a použitie |
| US11548917B1 (en) * | 2021-11-24 | 2023-01-10 | Intron Biotechnology, Inc. | Antibacterial composition effective in treating gram negative bacterial infections and method for preparing the same |
| WO2024241070A1 (en) | 2023-05-22 | 2024-11-28 | L'oreal | Cosmetic composition comprising an endolysin and a polyvinyl alcohol |
| FR3149202B1 (fr) | 2023-06-02 | 2026-04-10 | Oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et une huile. |
| FR3152395A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et la 4-hydroxyacetophenone |
| FR3149205B1 (fr) | 2023-06-02 | 2026-04-24 | Oreal | Composition cosmétique comprenant une endolysine et un agent de charge organique |
| FR3149204B1 (fr) | 2023-06-02 | 2026-02-13 | Oreal | Composition cosmétique comprenant une endolysine et un tensioactif non ionique comprenant un résidu carbohydrate |
| FR3149209B1 (fr) | 2023-06-02 | 2026-04-03 | Oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un alcool aromatique |
| FR3149208B1 (fr) | 2023-06-02 | 2026-03-20 | Oreal | Composition cosmétique, notamment aqueuse, comprenant une endolysine et un pullulane |
| FR3149203B1 (fr) | 2023-06-02 | 2026-03-13 | Oreal | Composition anhydre comprenant une endolysine et de l’hydroxypropylmethylcellulose et/ou du pullulane |
| EP4719330A1 (en) | 2023-06-02 | 2026-04-08 | L'oreal | Cosmetic composition comprising an endolysin derived from a staphylococcus aureus phage and an aromatic alcohol |
| FR3149206B1 (fr) | 2023-06-02 | 2026-03-13 | Oreal | Composition cosmétique aqueuse comprenant une endolysine et du tréhalose |
| FR3149207B1 (fr) | 2023-06-02 | 2026-03-13 | Oreal | Composition cosmétique comprenant une endolysine et un composé de formule (I) |
| FR3152394B1 (fr) | 2023-08-28 | 2026-04-24 | Oreal | Composition cosmétique comprenant une endolysine et des particules d’aérogel de silice hydrophobe |
| FR3152396A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un polyhydroxyalcane |
| FR3152393B1 (fr) | 2023-08-28 | 2026-04-24 | Oreal | Composition cosmétique comprenant une endolysine dérivée d’un phage de Staphylococcus aureus et une charge minérale |
| WO2025093666A1 (en) | 2023-11-01 | 2025-05-08 | University Of Copenhagen | Treatment of lymphoma |
| CN117534733B (zh) * | 2024-01-10 | 2024-03-29 | 黑龙江八一农垦大学 | 抗菌肽cm24、重组基因、乳酸工程菌及其应用 |
| CN118895244B (zh) * | 2024-07-23 | 2025-06-20 | 浙江自贸区中航生物科技有限责任公司 | 一种提高nk细胞杀伤活性的多肽及其应用 |
| WO2026052743A1 (en) | 2024-09-04 | 2026-03-12 | Micreos Human Health B.V. | Reduction of trans-epidermal water loss by a polypeptide with antibacterial properties |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989000194A1 (en) * | 1987-07-06 | 1989-01-12 | Louisiana State University Agricultural And Mechan | Inhibition of eucaryotic pathogens and neoplasms and stimulation of fibroblasts and lymphocytes with lytic peptides |
| GB8816693D0 (en) | 1988-07-13 | 1988-08-17 | Agricultural & Food Res | Viral enzyme & gene |
| GB2255561B (en) | 1991-04-20 | 1995-06-21 | Agricultural & Food Res | Lysins from bacteriophages |
| ATE233817T1 (de) | 1992-08-21 | 2003-03-15 | Univ British Columbia | Kationische peptide und verfahren zu deren herstellung |
| ATE198119T1 (de) | 1994-09-01 | 2001-01-15 | Novo Nordisk As | Eine grundlegende proteinzusammensetzung zur abtötung oder inhibierung mikrobieller zellen |
| US6503881B2 (en) | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| US5997862A (en) | 1997-10-31 | 1999-12-07 | New Horizons Diagnostics Corporation | Therapeutic treatment of group A streptococcal infections |
| US20030113298A1 (en) * | 1997-10-31 | 2003-06-19 | Vincent Fischetti | Use of bacterial phage associated lysing proteins for the prophylactic and therapeutic treatment of various illnesses |
| US6428784B1 (en) | 1997-10-31 | 2002-08-06 | New Horizons Diagnostics Corp | Vaginal suppository for treating group B Streptococcus infection |
| US6288212B1 (en) * | 1998-08-28 | 2001-09-11 | The University Of British Columbia | Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor |
| US5993809A (en) | 1998-11-18 | 1999-11-30 | Children's Hospital Medical Center | Lysozyme fusion proteins in infections |
| EP1194570A1 (en) * | 1999-06-23 | 2002-04-10 | PPL Therapeutics (Scotland) Limited | Fusion proteins incorporating lysozyme |
| US7338936B2 (en) * | 2000-11-28 | 2008-03-04 | House Ear Institute | Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis |
| CA2482995C (en) | 2002-04-22 | 2013-01-29 | Dow Global Technologies Inc. | Low-cost production of peptides |
| US7566447B2 (en) * | 2003-05-15 | 2009-07-28 | Iogenetics, Llc | Biocides |
| JP2007504810A (ja) * | 2003-09-11 | 2007-03-08 | ノボザイムス アクティーゼルスカブ | 抗微生物剤の組換え製造 |
| WO2005108563A2 (en) | 2004-04-19 | 2005-11-17 | University Of Chicago | Peptidoglycan-hydrolyzing protein encoded by bacteriophage n4 |
| US20070207209A1 (en) * | 2004-08-27 | 2007-09-06 | Murphy Christopher J | Trophic factor combinations for nervous system treatment |
| US7572602B1 (en) | 2004-12-03 | 2009-08-11 | The United States Of America As Represented By The Secretary Of Agriculture | Nucleic acid encoding endolysin fusion protein |
| DE102005040347A1 (de) | 2005-08-25 | 2007-03-01 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von Listerien |
| US7943128B2 (en) | 2006-03-31 | 2011-05-17 | The University Court Of The University Of St Andrews | Anti-microbial compositions comprising a cationic peptide and a glycylglycine endopeptidase |
| DE102006061002A1 (de) | 2006-12-22 | 2008-06-26 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von gram-positiven Bakterien |
| US8586709B2 (en) * | 2007-09-25 | 2013-11-19 | Pastoral Greenhouse Research Limited | Cell-permeabilising peptides and polypeptides for microbial cells |
| AU2008328584A1 (en) | 2007-11-26 | 2009-06-04 | Plant Bioscience Limited | Novel polypeptides having endolysin activity and uses thereof |
| CA2736062A1 (en) | 2008-07-24 | 2010-01-28 | The United State Of America, As Represented By The Secretary Of Agricuure | Triple acting antimicrobials that are refractory to resistance development |
| EP2157100A1 (en) | 2008-08-19 | 2010-02-24 | Profos AG | Artificial peptidoglycan lysing enzymes and peptidoglycan binding proteins |
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| JP5654493B2 (ja) * | 2009-02-03 | 2015-01-14 | アプライド・バイオミメティック・エイ／エス | 重合プロテオリポソームを用いたナノ加工膜 |
| WO2010091294A2 (en) | 2009-02-05 | 2010-08-12 | The Regents Of The University Of California | New targeted antimicrobial moieties |
| US8383102B2 (en) | 2009-05-21 | 2013-02-26 | The United States Of America As Represented By The Secretary Of Agriculture | Fusion of peptidoglycan hydrolase enzymes to a protein transduction domain allows eradication of both extracellular and intracellular gram positive pathogens |
| DK2445515T3 (en) | 2009-06-26 | 2016-07-04 | Univ Leuven Kath | antimicrobial agents |
| KR101701890B1 (ko) | 2009-06-26 | 2017-02-02 | 뤼산도 아게 | 항균제 |
| SG178440A1 (en) | 2009-08-24 | 2012-04-27 | Univ Leuven Kath | New endolysin obpgplys |
| EA037276B1 (ru) | 2010-04-27 | 2021-03-03 | Лисандо Аг | Способы устранения или уменьшения бактериальной биопленки |
| WO2014001571A1 (en) | 2012-06-29 | 2014-01-03 | Lysando Ag | Composition for use in mycobacteria diagnosis |
-
2010
- 2010-06-28 DK DK10730139.2T patent/DK2445515T3/en active
- 2010-06-28 PL PL10730139.2T patent/PL2445515T3/pl unknown
- 2010-06-28 CN CN201080028371.0A patent/CN102458452B/zh active Active
- 2010-06-28 JP JP2012516776A patent/JP6034187B2/ja active Active
- 2010-06-28 EP EP10730139.2A patent/EP2445515B1/en active Active
- 2010-06-28 SI SI201031217A patent/SI2445515T1/sl unknown
- 2010-06-28 SG SG2011096310A patent/SG177370A1/en unknown
- 2010-06-28 WO PCT/EP2010/059146 patent/WO2010149792A2/en not_active Ceased
- 2010-06-28 US US13/380,312 patent/US8906365B2/en active Active
- 2010-06-28 ES ES10730139.2T patent/ES2579806T3/es active Active
- 2010-06-28 CA CA2764131A patent/CA2764131C/en active Active
- 2010-06-28 EA EA201270079A patent/EA037202B1/ru not_active IP Right Cessation
- 2010-06-28 CN CN201510751765.3A patent/CN105440139B/zh active Active
- 2010-06-28 EP EP16163433.2A patent/EP3058950B1/en active Active
- 2010-06-28 MX MX2015006025A patent/MX360300B/es unknown
- 2010-06-28 AU AU2010264656A patent/AU2010264656B2/en active Active
- 2010-06-28 KR KR1020177004886A patent/KR20170024129A/ko not_active Ceased
- 2010-06-28 KR KR1020127002107A patent/KR101711062B1/ko active Active
- 2010-06-28 MX MX2011013288A patent/MX2011013288A/es active IP Right Grant
- 2010-06-28 BR BRPI1015192A patent/BRPI1015192A2/pt not_active IP Right Cessation
- 2010-06-28 EP EP20158514.8A patent/EP3714895A3/en not_active Withdrawn
-
2011
- 2011-12-21 IL IL217124A patent/IL217124A/en active IP Right Grant
-
2014
- 2014-11-07 US US14/535,457 patent/US10137175B2/en active Active
-
2016
- 2016-04-13 AU AU2016202296A patent/AU2016202296B2/en active Active
- 2016-06-07 JP JP2016113291A patent/JP2017008033A/ja active Pending
-
2017
- 2017-03-05 IL IL250938A patent/IL250938B/en active IP Right Grant
-
2018
- 2018-03-16 AU AU2018201931A patent/AU2018201931B2/en active Active
- 2018-10-24 US US16/169,472 patent/US11052137B2/en active Active
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