JP2012530246A5 - - Google Patents
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- JP2012530246A5 JP2012530246A5 JP2012515162A JP2012515162A JP2012530246A5 JP 2012530246 A5 JP2012530246 A5 JP 2012530246A5 JP 2012515162 A JP2012515162 A JP 2012515162A JP 2012515162 A JP2012515162 A JP 2012515162A JP 2012530246 A5 JP2012530246 A5 JP 2012530246A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- sheath
- flow
- laminar flow
- sheath flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 114
- 239000012530 fluid Substances 0.000 claims description 61
- 210000004027 cell Anatomy 0.000 claims description 42
- 238000000926 separation method Methods 0.000 claims description 38
- 210000004881 tumor cell Anatomy 0.000 claims description 35
- 241000894007 species Species 0.000 claims description 19
- 239000006249 magnetic particle Substances 0.000 claims description 14
- 239000000872 buffer Substances 0.000 claims description 13
- 238000011282 treatment Methods 0.000 claims description 12
- 238000012512 characterization method Methods 0.000 claims description 10
- 238000011156 evaluation Methods 0.000 claims description 10
- 230000009871 nonspecific binding Effects 0.000 claims description 10
- 210000000130 stem cell Anatomy 0.000 claims description 10
- 238000011144 upstream manufacturing Methods 0.000 claims description 10
- 239000008280 blood Substances 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 8
- 238000011221 initial treatment Methods 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 8
- 239000007853 buffer solution Substances 0.000 claims description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- 238000002372 labelling Methods 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims description 4
- 238000009104 chemotherapy regimen Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 230000003287 optical effect Effects 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 238000012546 transfer Methods 0.000 claims description 3
- 108091023037 Aptamer Proteins 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- 206010064571 Gene mutation Diseases 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 239000011324 bead Substances 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 201000005787 hematologic cancer Diseases 0.000 claims description 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
- 230000002062 proliferating effect Effects 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 241001515965 unidentified phage Species 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000011269 treatment regimen Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 description 3
- 238000011519 second-line treatment Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18591909P | 2009-06-10 | 2009-06-10 | |
| US61/185,919 | 2009-06-10 | ||
| US31362510P | 2010-03-12 | 2010-03-12 | |
| US61/313,625 | 2010-03-12 | ||
| US12/813,285 US8263387B2 (en) | 2009-06-10 | 2010-06-10 | Sheath flow devices and methods |
| PCT/US2010/038229 WO2010144745A2 (en) | 2009-06-10 | 2010-06-10 | Sheath flow devices and methods |
| US12/813,285 | 2010-06-10 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012530246A JP2012530246A (ja) | 2012-11-29 |
| JP2012530246A5 true JP2012530246A5 (https=) | 2013-07-25 |
| JP5337912B2 JP5337912B2 (ja) | 2013-11-06 |
Family
ID=43309472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012515162A Expired - Fee Related JP5337912B2 (ja) | 2009-06-10 | 2010-06-10 | シース流装置及び方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8263387B2 (https=) |
| EP (1) | EP2440941B1 (https=) |
| JP (1) | JP5337912B2 (https=) |
| CN (1) | CN102713640B (https=) |
| DK (1) | DK2440941T3 (https=) |
| PL (1) | PL2440941T3 (https=) |
| PT (1) | PT2440941T (https=) |
| SM (1) | SMT201700421T1 (https=) |
| WO (1) | WO2010144745A2 (https=) |
Families Citing this family (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| AU2004285960A1 (en) | 2003-10-30 | 2005-05-12 | Cytonome/St, Llc | Multilayer hydrodynamic sheath flow structure |
| US10908066B2 (en) | 2010-11-16 | 2021-02-02 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
| JP5651485B2 (ja) * | 2011-01-14 | 2015-01-14 | 株式会社日立ハイテクノロジーズ | 核酸分析装置 |
| WO2012106748A1 (en) * | 2011-02-07 | 2012-08-16 | Empire Technology Development Llc | Cell sorting apparatus and method |
| CA2827226C (en) | 2011-04-27 | 2019-02-12 | Becton Dickinson And Company | Devices and methods for separating magnetically labeled moieties in a sample |
| JP5812469B2 (ja) * | 2011-05-18 | 2015-11-11 | 国立大学法人広島大学 | 細胞分離チップ |
| KR101970634B1 (ko) * | 2011-06-02 | 2019-04-19 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 생체외 조직 배양 시스템을 위한 방법 및 용도 |
| DE102011080012B4 (de) * | 2011-07-28 | 2015-09-10 | Siemens Aktiengesellschaft | Strömungsmechanische Zellführung für Durchflusszytometrie |
| WO2013033232A1 (en) * | 2011-08-29 | 2013-03-07 | The Charles Stark Draper Laboratory, Inc. | System and method for blood separation by microfluidic acoustic focusing |
| USD702364S1 (en) * | 2011-12-20 | 2014-04-08 | SYFR, Inc. | Auto-staining cartridge |
| JP2015503736A (ja) | 2011-12-29 | 2015-02-02 | ダンマークス テクニスク ユニバーシテット | 電磁放射を用いて微小物体を分類するためのシステム |
| KR101211862B1 (ko) | 2012-04-30 | 2012-12-12 | 한국기계연구원 | 자기장을 이용하는 자가 세포 추출장치 및 이를 이용하는 방법 |
| WO2014003689A1 (en) * | 2012-06-28 | 2014-01-03 | Nanyang Technological University | Detection device and method for detection of particles |
| US10130951B2 (en) | 2012-09-18 | 2018-11-20 | Cynvenio Biosystems, Inc. | Open-ended conical tube for recovering cells from a microfludic chip |
| US9802197B2 (en) * | 2012-09-18 | 2017-10-31 | Cynvenio Biosystems, Inc. | Fluid reservoir |
| EP2908140B1 (en) | 2012-10-15 | 2019-08-14 | National University Corporation Nagoya University | Microchannel chip for microparticle separation, microparticle separation method and system for microparticle separation using chip |
| WO2014066553A1 (en) | 2012-10-26 | 2014-05-01 | Becton, Dickinson And Company | Devices and methods for manipulating components in a fluid sample |
| US20140242603A1 (en) * | 2013-02-26 | 2014-08-28 | Glenn Yaguang Deng | Methods and apparatus for target cell magnetic enrichment, isolation and biological analysis |
| WO2014138739A1 (en) | 2013-03-08 | 2014-09-12 | The Charles Stark Draper Laboratory, Inc. | System and method for blood separation by microfluidic acoustic focusing |
| USD758372S1 (en) * | 2013-03-13 | 2016-06-07 | Nagrastar Llc | Smart card interface |
| US9888283B2 (en) | 2013-03-13 | 2018-02-06 | Nagrastar Llc | Systems and methods for performing transport I/O |
| WO2014143427A1 (en) * | 2013-03-14 | 2014-09-18 | The Regents Of The University Of California | In-vivo monitoring of molecular targets |
| NZ711384A (en) * | 2013-03-14 | 2018-06-29 | Cytonome St Llc | Hydrodynamic focusing apparatus and methods |
| US9279750B2 (en) | 2013-03-15 | 2016-03-08 | Iris International, Inc. | Method and composition for staining and sample processing |
| US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
| JP6523245B2 (ja) | 2013-03-15 | 2019-05-29 | アイリス インターナショナル， インコーポレイテッド | 血液試料における粒子分析のためのシース液システム及び方法 |
| US12590955B2 (en) | 2013-03-15 | 2026-03-31 | Zeon Corporation | Methods and systems for processing particles |
| EP3608022A1 (en) | 2013-03-15 | 2020-02-12 | The Trustees of Princeton University | Methods and devices for high throughput purification |
| EP3569313A1 (en) | 2013-03-15 | 2019-11-20 | GPB Scientific, LLC | On-chip microfluidic processing of particles |
| EP2995961A4 (en) * | 2013-05-08 | 2017-01-04 | Sony Corporation | Flow channel device, analytical apparatus, and fluid apparatus |
| US8961904B2 (en) | 2013-07-16 | 2015-02-24 | Premium Genetics (Uk) Ltd. | Microfluidic chip |
| CN110975947A (zh) * | 2013-07-16 | 2020-04-10 | Abs全球公司 | 识别流体混合物中的成分的设备和产生流体混合物的设备 |
| WO2015035467A1 (en) * | 2013-09-11 | 2015-03-19 | Active Magnetics Research Pty Ltd | Apparatus and method for entrapping magnetic material |
| EP3058316B1 (en) | 2013-10-18 | 2019-03-13 | The General Hospital Corporation | Microfluidic sorting using high gradient magnetic fields |
| GB2523293A (en) * | 2013-10-24 | 2015-08-26 | Vws Uk Ltd | Method and Apparatus for measuring fluorescence in organisms |
| US11796449B2 (en) | 2013-10-30 | 2023-10-24 | Abs Global, Inc. | Microfluidic system and method with focused energy apparatus |
| EP3570005A1 (en) * | 2013-10-30 | 2019-11-20 | ABS Global, Inc. | Microfluidic system and method with focused energy apparatus |
| US10746683B2 (en) | 2013-12-12 | 2020-08-18 | Altratech Limited | Capacitive sensor and method of use |
| US10359354B2 (en) * | 2013-12-18 | 2019-07-23 | Azure Biosystems, Inc. | Chip assembly, flow cell and flow cytometer for characterizing particles |
| US9835623B2 (en) * | 2014-01-15 | 2017-12-05 | Caliper Life Sciences, Inc. | Method and system of microfluidic immunoassay using magnetic beads |
| US10928404B2 (en) | 2014-02-26 | 2021-02-23 | The Brigham And Women's Hospital, Inc. | System and method for cell levitation and monitoring |
| US10578615B2 (en) * | 2014-04-08 | 2020-03-03 | Vanderbilt University | Low resource method and device for detecting analytes |
| JP6308525B2 (ja) * | 2014-04-11 | 2018-04-11 | 国立大学法人名古屋大学 | 微粒子分離用チップ、該微粒子分離用チップを用いた微粒子分離用システム及び微粒子分離方法 |
| DE102014106603A1 (de) * | 2014-05-12 | 2015-11-12 | Verein zur Förderung von Innovationen durch Forschung, Entwicklung und Technologietransfer e.V. (Verein INNOVENT e.V.) | Verfahren und Vorrichtung zur Abreicherung von zirkulierenden Tumorzellen aus einer Zellsuspension |
| US20170268037A1 (en) * | 2014-05-15 | 2017-09-21 | Fluxion Biosciences, Inc. | Methods and systems for cell separation using magnetic-and size-based separation |
| CN105530640B (zh) * | 2014-09-30 | 2019-02-22 | 国际商业机器公司 | 用于通信控制的方法和装置 |
| EP3259579B1 (en) | 2015-02-19 | 2022-09-14 | 1087 Systems, Inc. | Scanning infrared measurement system |
| KR20160120416A (ko) * | 2015-04-08 | 2016-10-18 | 인제대학교 산학협력단 | 분리 가능한 복수의 패널을 포함하는 미세 입자 분리 장치 어셈블리 |
| USD864968S1 (en) | 2015-04-30 | 2019-10-29 | Echostar Technologies L.L.C. | Smart card interface |
| US20160355777A1 (en) * | 2015-06-05 | 2016-12-08 | Novartis Ag | Flow-through paramagnetic particle-based cell separation and paramagnetic particle removal |
| JP6911021B2 (ja) | 2015-06-25 | 2021-07-28 | サイトノーム／エスティー・エルエルシー | 音響操作を用いるマイクロ流体デバイスおよびシステム |
| US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
| WO2017045703A1 (en) * | 2015-09-15 | 2017-03-23 | Siemens Healthcare Gmbh | A technique for focusing a sample in a flow |
| WO2017054075A1 (en) * | 2015-09-28 | 2017-04-06 | The Governing Council Of The University Of Toronto | Device for magnetic profiling of particles in a flow |
| EP3356820B1 (en) * | 2015-10-02 | 2026-03-11 | The Board of Trustees of the Leland Stanford Junior University | Sorting biological moieties using magnetic levitation |
| CN105435868B (zh) * | 2015-10-26 | 2017-11-28 | 深圳华迈兴微医疗科技有限公司 | 定量检测全血中肌钙蛋白i的磁微粒化学发光微流控芯片 |
| CN105597846B (zh) * | 2015-10-26 | 2017-11-28 | 深圳华迈兴微医疗科技有限公司 | 一种d‑二聚体定量检测的磁微粒化学发光微流控芯片 |
| WO2017083391A1 (en) | 2015-11-09 | 2017-05-18 | Georgia Tech Research Corporation | Microfluidic devices for cellular sorting |
| US20170259262A1 (en) * | 2016-03-09 | 2017-09-14 | Intelligent Bio-Systems, Inc. | Laminar fluidic separation in flowcells for minimal reagent usage |
| WO2017161201A1 (en) | 2016-03-16 | 2017-09-21 | Cynvenio Biosystems Inc. | Cancer detection assay and related compositions, methods and systems |
| FR3050664B1 (fr) * | 2016-04-27 | 2018-05-25 | Microfactory | Systeme d'evaluation in vitro de l'efficacite d'un deodorant. |
| CN107442186B (zh) * | 2016-05-31 | 2020-06-09 | 深圳汇芯生物医疗科技有限公司 | 微流控芯片、基于微流控芯片的分析装置及分析方法 |
| US20180093271A1 (en) * | 2016-09-30 | 2018-04-05 | The University Of Tokyo | Microdevice for Capturing Particles, and Method for Capturing, Concentrating, or Separating Particles Using the Same |
| IT201600104601A1 (it) | 2016-10-18 | 2018-04-18 | Menarini Silicon Biosystems Spa | Sistema microfluidico |
| MX2019015505A (es) | 2017-06-30 | 2020-07-28 | Inscripta Inc | Metodos, modulos, instrumentos y sistemas de procesamiento de celulas automatizados. |
| WO2019017726A2 (en) | 2017-07-21 | 2019-01-24 | Seegene, Inc. | MAGNETIC BALL TRANSFER MODULES, AUTOMATED SYSTEM COMPRISING SAME, AND PROCESS FOR EXTRACTING NUCLEIC ACIDS USING THE SAME |
| US11648559B2 (en) * | 2017-08-04 | 2023-05-16 | University Of Georgia Research Foundation, Inc. | Devices and methods for separating circulating tumor cells from biological samples |
| US10738327B2 (en) | 2017-08-28 | 2020-08-11 | Inscripta, Inc. | Electroporation cuvettes for automation |
| US11738344B2 (en) * | 2017-09-19 | 2023-08-29 | Hifibio Sas | Particle sorting in a microfluidic system |
| EP3710167A4 (en) * | 2017-11-14 | 2021-08-18 | University of Florida Research Foundation | MAGNETIC SEPARATION SYSTEM AND DEVICES |
| US11426724B2 (en) * | 2018-01-11 | 2022-08-30 | NanoCav, LLC | Microfluidic cellular device and methods of use thereof |
| US20190283022A1 (en) * | 2018-03-15 | 2019-09-19 | Behrad Vahidi | Highly parallel microfluidic blood separation device |
| WO2019190874A1 (en) | 2018-03-29 | 2019-10-03 | Inscripta, Inc. | Automated control of cell growth rates for induction and transformation |
| WO2019195934A1 (en) * | 2018-04-10 | 2019-10-17 | Xeinac Biotec Inc. | Microfluidic chip |
| US10376889B1 (en) | 2018-04-13 | 2019-08-13 | Inscripta, Inc. | Automated cell processing instruments comprising reagent cartridges |
| US10858761B2 (en) | 2018-04-24 | 2020-12-08 | Inscripta, Inc. | Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells |
| EP3796998A1 (en) | 2018-05-23 | 2021-03-31 | ABS Global, Inc. | Systems and methods for particle focusing in microchannels |
| AU2019292919A1 (en) | 2018-06-30 | 2021-03-11 | Inscripta, Inc. | Instruments, modules, and methods for improved detection of edited sequences in live cells |
| US11142740B2 (en) | 2018-08-14 | 2021-10-12 | Inscripta, Inc. | Detection of nuclease edited sequences in automated modules and instruments |
| US10532324B1 (en) | 2018-08-14 | 2020-01-14 | Inscripta, Inc. | Instruments, modules, and methods for improved detection of edited sequences in live cells |
| US10752874B2 (en) | 2018-08-14 | 2020-08-25 | Inscripta, Inc. | Instruments, modules, and methods for improved detection of edited sequences in live cells |
| EP3836943A4 (en) * | 2018-08-14 | 2022-10-19 | Inscripta, Inc. | ENHANCED DETECTION OF NUCLEASE-EDITED SEQUENCES IN AUTOMATED MODULES AND INSTRUMENTS THROUGH MASS CELL CULTURE |
| WO2020128561A1 (en) | 2018-12-21 | 2020-06-25 | Premium Genetics (Uk) Ltd. | System and methods for sub-population identification |
| PL3669982T3 (pl) * | 2018-12-21 | 2022-07-11 | Helmholtz-Zentrum Dresden - Rossendorf E.V. | Urządzenie mikroprzepływowe, urządzenie i sposób wzbogacania i rozcieńczania magnetycznych jednostek cząsteczkowych |
| CN109735430B (zh) * | 2019-01-28 | 2021-12-14 | 武汉纺织大学 | 一种三维磁泳分离的微流控芯片 |
| CN109746064B (zh) * | 2019-01-28 | 2021-10-15 | 武汉纺织大学 | 一种梯度磁场微流控芯片 |
| US10551313B1 (en) * | 2019-04-15 | 2020-02-04 | The Florida International University Board Of Trustees | Surface plasmon resonance based mechanical sensing of beating heart cells |
| EP3955735B1 (en) | 2019-04-18 | 2024-05-22 | ABS Global, Inc. | System and process for continuous addition of cryoprotectant |
| US10907125B2 (en) | 2019-06-20 | 2021-02-02 | Inscripta, Inc. | Flow through electroporation modules and instrumentation |
| US10920189B2 (en) | 2019-06-21 | 2021-02-16 | Inscripta, Inc. | Genome-wide rationally-designed mutations leading to enhanced lysine production in E. coli |
| US10927385B2 (en) | 2019-06-25 | 2021-02-23 | Inscripta, Inc. | Increased nucleic-acid guided cell editing in yeast |
| WO2021090555A1 (ja) * | 2019-11-05 | 2021-05-14 | ソニー株式会社 | 微小粒子分取用マイクロチップのプライミング方法、微小粒子分取方法、微小粒子分取装置、及びプログラム |
| WO2021097394A1 (en) * | 2019-11-15 | 2021-05-20 | Redbud Labs, Inc. | Microfluidic device for and methods of using surface-attached posts and capture beads in a microfluidic chamber |
| US12605525B2 (en) | 2019-12-04 | 2026-04-21 | Nextern Innovation, Llc | Focusing catheter |
| CN111088146A (zh) * | 2020-01-09 | 2020-05-01 | 天津大学 | 一种从胸腔积液中筛分肿瘤细胞的微流控芯片 |
| US10689669B1 (en) | 2020-01-11 | 2020-06-23 | Inscripta, Inc. | Automated multi-module cell processing methods, instruments, and systems |
| US11628439B2 (en) | 2020-01-13 | 2023-04-18 | Abs Global, Inc. | Single-sheath microfluidic chip |
| AU2021213705A1 (en) | 2020-01-27 | 2022-06-16 | Inscripta, Inc. | Electroporation modules and instrumentation |
| JP2021153445A (ja) * | 2020-03-26 | 2021-10-07 | 株式会社エンプラス | 液体取扱装置および液体取扱方法 |
| US20210332388A1 (en) | 2020-04-24 | 2021-10-28 | Inscripta, Inc. | Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells |
| CN111621416A (zh) * | 2020-05-14 | 2020-09-04 | 南京大学 | 一种基于移动磁网的生物磁性分离方法 |
| US11787841B2 (en) | 2020-05-19 | 2023-10-17 | Inscripta, Inc. | Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli |
| CN111721705A (zh) * | 2020-06-12 | 2020-09-29 | 迪瑞医疗科技股份有限公司 | 一种妇科分泌物分析仪器用层流液及其制备方法 |
| US20220008922A1 (en) * | 2020-07-08 | 2022-01-13 | Lumacyte, LLC | Sampling device and systems |
| EP4232601A4 (en) | 2020-10-21 | 2024-10-09 | ABS Global, Inc. | METHODS AND SYSTEMS FOR PROCESSING GENETIC SAMPLES TO DETERMINE IDENTITY OR DETECT CONTAMINATION |
| CN112372584B (zh) * | 2020-10-23 | 2021-12-03 | 浦江县颐硕科技开发有限公司 | 一种双头非牛顿式敲击锤及其调节方法 |
| CN116472118A (zh) * | 2020-11-19 | 2023-07-21 | Dh科技发展私人贸易有限公司 | 用于处理流体样品的系统和方法 |
| JP7633402B2 (ja) | 2020-11-23 | 2025-02-19 | エイビーエス グローバル、インコーポレイテッド | モジュール式フロー・サイトメトリ・システム及びサンプル処理方法 |
| USD1118965S1 (en) | 2021-11-12 | 2026-03-17 | Abs Global, Inc. | Flow cytometry device |
| EP4194542A1 (en) * | 2021-12-07 | 2023-06-14 | Fluigent | Apparatus for feeding a liquid medium to a fluidic system |
| WO2023141199A2 (en) * | 2022-01-21 | 2023-07-27 | Trustees Of Dartmouth College | Microtransfer patterning of magnetic materials for microfluidic applications |
| US12415172B2 (en) | 2022-12-22 | 2025-09-16 | Synthego Corporation | Systems and method for automated oligonucleotide synthesis |
| CN116338156A (zh) * | 2023-02-24 | 2023-06-27 | 桂林优利特医疗电子有限公司 | 一种应用多方法学进行微粒子分析的液路系统 |
| CN116410848B (zh) * | 2023-06-09 | 2023-08-11 | 四川大学 | 一种无标记的高侵袭性循环肿瘤细胞捕获、培养芯片 |
| CN119319034A (zh) * | 2023-07-17 | 2025-01-17 | 深圳赛桥生物创新技术有限公司 | 磁分选容器、装置、方法和介质 |
| CN116679043B (zh) * | 2023-08-03 | 2023-11-03 | 天津大学 | 适用于磁泳分析平台的机器人及制备方法、磁泳分析平台 |
| JP2025048837A (ja) * | 2023-09-20 | 2025-04-03 | ソフトバンクグループ株式会社 | システム |
| CN121016873B (zh) * | 2025-10-28 | 2026-01-30 | 北京芯迈微生物技术有限公司 | 一种可拓宽β-hCG定量分析范围的免疫微流控芯片及其应用 |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4894146A (en) * | 1986-01-27 | 1990-01-16 | University Of Utah | Thin channel split flow process and apparatus for particle fractionation |
| US5108933A (en) * | 1988-09-16 | 1992-04-28 | Immunicon Corporation | Manipulation of colloids for facilitating magnetic separations |
| US4893496A (en) * | 1988-10-14 | 1990-01-16 | Panametrics, Inc. | Torsional wave fluid sensor and system |
| US5770029A (en) * | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
| US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
| WO1994011078A1 (en) | 1992-11-16 | 1994-05-26 | Immunivest Corporation | Magnetic immobilization and manipulation of biological entities |
| US5622831A (en) * | 1990-09-26 | 1997-04-22 | Immunivest Corporation | Methods and devices for manipulation of magnetically collected material |
| US5466574A (en) * | 1991-03-25 | 1995-11-14 | Immunivest Corporation | Apparatus and methods for magnetic separation featuring external magnetic means |
| US5186827A (en) | 1991-03-25 | 1993-02-16 | Immunicon Corporation | Apparatus for magnetic separation featuring external magnetic means |
| US5795470A (en) * | 1991-03-25 | 1998-08-18 | Immunivest Corporation | Magnetic separation apparatus |
| US5646001A (en) | 1991-03-25 | 1997-07-08 | Immunivest Corporation | Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof |
| US6001229A (en) * | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
| DE19520298A1 (de) * | 1995-06-02 | 1996-12-05 | Bayer Ag | Sortiervorrichtung für biologische Zellen oder Viren |
| US5660990A (en) | 1995-08-18 | 1997-08-26 | Immunivest Corporation | Surface immobilization of magnetically collected materials |
| US20030215798A1 (en) * | 1997-06-16 | 2003-11-20 | Diversa Corporation | High throughput fluorescence-based screening for novel enzymes |
| EP0920627B1 (en) | 1996-06-07 | 2004-05-12 | Immunivest Corporation | Magnetic separation employing external and internal gradients |
| US6890426B2 (en) | 1996-06-07 | 2005-05-10 | Immunivest Corporation | Magnetic separation apparatus and methods |
| US6660159B1 (en) * | 1996-06-07 | 2003-12-09 | Immunivest Corporation | Magnetic separation apparatus and methods |
| US7666308B2 (en) * | 1996-06-07 | 2010-02-23 | Veridex, Llc. | Magnetic separation apparatus and methods |
| JP2002503334A (ja) * | 1996-09-04 | 2002-01-29 | テクニカル ユニバーシティ オブ デンマーク | 粒子の分離と分析用のマイクロフローシステム |
| US6686208B2 (en) * | 1997-03-18 | 2004-02-03 | Institut Fur Chemo- Und Biosensorik Munster E.V. | Device and method for carrying out fluoresence immunotests |
| EP0970365B1 (en) * | 1997-03-25 | 2003-10-01 | Immunivest Corporation | Apparatus and methods for capture and analysis of particulate entities |
| JP2002507750A (ja) | 1998-03-25 | 2002-03-12 | トリオン ダイアグノスティクス アクティー ゼルスカブ | 場による粒子操作のためのマイクロシステムおよび方法 |
| DE19815882A1 (de) * | 1998-04-08 | 1999-10-14 | Fuhr Guenther | Verfahren und Vorrichtung zur Manipulierung von Mikropartikeln in Fluidströmungen |
| US6250475B1 (en) * | 1998-05-01 | 2001-06-26 | Magnetic Products, Inc. | Permanent magnet separator having moveable stripper plate |
| ATE404269T1 (de) | 1998-11-30 | 2008-08-15 | Immunivest Corp | Verfahren und vorrichtung zur magnetischen trennung |
| US6858439B1 (en) * | 1999-03-15 | 2005-02-22 | Aviva Biosciences | Compositions and methods for separation of moieties on chips |
| JP2001137613A (ja) * | 1999-11-11 | 2001-05-22 | Kawamura Inst Of Chem Res | 抽出機構を有する微小ケミカルデバイス |
| JP2003523185A (ja) | 2000-01-13 | 2003-08-05 | イムニベスト・コーポレイション | 強磁性流体に基づくアレイ |
| WO2001087458A1 (en) * | 2000-05-12 | 2001-11-22 | University Of Cincinnati | Magnetic bead-based arrays |
| US6828098B2 (en) * | 2000-05-20 | 2004-12-07 | The Regents Of The University Of Michigan | Method of producing a DNA library using positional amplification based on the use of adaptors and nick translation |
| WO2001096857A2 (en) | 2000-06-14 | 2001-12-20 | Board Of Regents, The University Of Texas System | Method and apparatus for combined magnetophoretic and dielectrophoretic manipulation of analyte mixtures |
| EP1340082A2 (en) * | 2000-08-23 | 2003-09-03 | Imego AB | Microfluidic device and method with transport of magnetic particles into and out of wells |
| US6833542B2 (en) * | 2000-11-13 | 2004-12-21 | Genoptix, Inc. | Method for sorting particles |
| US6736978B1 (en) * | 2000-12-13 | 2004-05-18 | Iowa State University Research Foundation, Inc. | Method and apparatus for magnetoresistive monitoring of analytes in flow streams |
| EP1356420B1 (en) | 2001-01-05 | 2006-10-11 | Immunivest Corporation | Devices and methods to image objects |
| US7223363B2 (en) * | 2001-03-09 | 2007-05-29 | Biomicro Systems, Inc. | Method and system for microfluidic interfacing to arrays |
| US20020166760A1 (en) * | 2001-05-11 | 2002-11-14 | Prentiss Mara G. | Micromagentic systems and methods for microfluidics |
| US7075162B2 (en) * | 2001-08-30 | 2006-07-11 | Fluidigm Corporation | Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes |
| KR100442836B1 (ko) * | 2001-11-10 | 2004-08-02 | 삼성전자주식회사 | 생화학 유체를 온도가 다른 폐쇄된 챔버 구간을 따라 회전이동시키는 폐쇄 유체 회로 시스템 |
| US20030186465A1 (en) | 2001-11-27 | 2003-10-02 | Kraus Robert H. | Apparatus used in identification, sorting and collection methods using magnetic microspheres and magnetic microsphere kits |
| US7232691B2 (en) * | 2001-11-27 | 2007-06-19 | Los Alamos National Security, Llc | Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres |
| AU2002358552A1 (en) * | 2001-11-27 | 2003-06-10 | Gnothis Holding Sa | Nanostructure, in particular for analysing individual molecules |
| GB2383127B (en) * | 2001-12-12 | 2004-10-20 | Proimmune Ltd | Device and method for investigating analytes in liquid suspension or solution |
| US7318902B2 (en) * | 2002-02-04 | 2008-01-15 | Colorado School Of Mines | Laminar flow-based separations of colloidal and cellular particles |
| US7764821B2 (en) * | 2002-02-14 | 2010-07-27 | Veridex, Llc | Methods and algorithms for cell enumeration in a low-cost cytometer |
| US20030175980A1 (en) * | 2002-03-14 | 2003-09-18 | Hayenga Jon W. | Ribbon flow cytometry and cell sorting |
| US7312085B2 (en) * | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
| US20040018611A1 (en) * | 2002-07-23 | 2004-01-29 | Ward Michael Dennis | Microfluidic devices for high gradient magnetic separation |
| US7118676B2 (en) | 2003-09-04 | 2006-10-10 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| US20040043506A1 (en) * | 2002-08-30 | 2004-03-04 | Horst Haussecker | Cascaded hydrodynamic focusing in microfluidic channels |
| US7371051B2 (en) * | 2002-09-09 | 2008-05-13 | The Trustees Of The University Of Pennsylvania | Controlled magnetohydrodynamic fluidic networks and stirrers |
| US6919637B2 (en) * | 2002-09-30 | 2005-07-19 | Intel Corporation | Interconnect structure for an integrated circuit and method of fabrication |
| US20040121413A1 (en) * | 2002-12-20 | 2004-06-24 | Aebersold Rudolf H. | Androgen-regulated genes and uses for diagnosis, prognosis and treatment of prostate neoplastic conditions |
| US7282180B2 (en) * | 2003-07-02 | 2007-10-16 | Immunivest Corporation | Devices and methods to image objects |
| US20050079591A1 (en) * | 2003-07-08 | 2005-04-14 | Reich Daniel H. | Method and magnetic microarray system for trapping and manipulating cells |
| JP2005030906A (ja) * | 2003-07-11 | 2005-02-03 | Mitsubishi Chemicals Corp | 分析用チップ及び分析方法 |
| AU2004285960A1 (en) * | 2003-10-30 | 2005-05-12 | Cytonome/St, Llc | Multilayer hydrodynamic sheath flow structure |
| JP4617779B2 (ja) * | 2003-11-25 | 2011-01-26 | 豊田合成株式会社 | キャップ装置 |
| WO2005065267A2 (en) * | 2003-12-24 | 2005-07-21 | Massachusetts Institute Of Technology | Magnetophoretic cell clarification |
| WO2005084374A2 (en) * | 2004-03-03 | 2005-09-15 | The General Hospital Corporation | Magnetic device for isolation of cells and biomolecules in a microfluidic environment |
| US7442339B2 (en) * | 2004-03-31 | 2008-10-28 | Intel Corporation | Microfluidic apparatus, Raman spectroscopy systems, and methods for performing molecular reactions |
| WO2005099419A2 (en) * | 2004-04-13 | 2005-10-27 | President And Fellows Of Harvard College | Manipulation and/or detection of biological samples or other objects |
| US20050274650A1 (en) * | 2004-06-09 | 2005-12-15 | Georgia Tech Research Corporation | Blood separation systems in micro device format and fabrication methods |
| DE102004040785B4 (de) * | 2004-08-23 | 2006-09-21 | Kist-Europe Forschungsgesellschaft Mbh | Mikrofluidisches System zur Isolierung biologischer Partikel unter Verwendung der immunomagnetischen Separation |
| US7824620B2 (en) | 2004-09-21 | 2010-11-02 | The Trustees Of The University Of Pennsylvania | Nano- and micro-scale structures: methods, devices and applications thereof |
| US20060177815A1 (en) * | 2004-11-29 | 2006-08-10 | The Regents Of The University Of California | Dielectrophoretic particle sorter |
| US20070196820A1 (en) * | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| US7749445B2 (en) * | 2005-05-02 | 2010-07-06 | Bioscale, Inc. | Method and apparatus for analyzing bioprocess fluids |
| US20090201504A1 (en) * | 2005-08-09 | 2009-08-13 | Maxwell Sensors, Inc. | Hydrodynamic focusing for analyzing rectangular microbeads |
| US9220831B2 (en) * | 2005-10-06 | 2015-12-29 | Children's Medical Center Corporation | Device and method for combined microfluidic-micromagnetic separation of material in continuous flow |
| GB0523631D0 (en) * | 2005-11-21 | 2005-12-28 | Univ Cambridge Tech | Magnetic tagging techniques |
| US7807454B2 (en) | 2006-10-18 | 2010-10-05 | The Regents Of The University Of California | Microfluidic magnetophoretic device and methods for using the same |
| US8586385B2 (en) * | 2006-12-28 | 2013-11-19 | Intel Corporation | Method and device for biomolecule preparation and detection using magnetic array |
| US7412131B2 (en) * | 2007-01-02 | 2008-08-12 | General Electric Company | Multilayer optic device and system and method for making same |
| US8551333B2 (en) * | 2007-04-05 | 2013-10-08 | The Regents Of The University Of California | Particle-based microfluidic device for providing high magnetic field gradients |
| US20100233694A1 (en) * | 2007-04-16 | 2010-09-16 | On-O-ity, Inc | Devices and methods for diagnosing, prognosing, or theranosing a condition by enriching rare cells |
| US20080302732A1 (en) * | 2007-05-24 | 2008-12-11 | Hyongsok Soh | Integrated fluidics devices with magnetic sorting |
| WO2009026566A1 (en) * | 2007-08-23 | 2009-02-26 | Cynvenio Biosystems, Llc | Trapping magnetic sorting system for target species |
| US7736891B2 (en) * | 2007-09-11 | 2010-06-15 | University Of Washington | Microfluidic assay system with dispersion monitoring |
| US9480935B2 (en) * | 2008-02-01 | 2016-11-01 | Lawrence Livermore National Security, Llc | Systems and methods for separating particles and/or substances from a sample fluid |
| WO2009117611A2 (en) * | 2008-03-19 | 2009-09-24 | Cynvenio Biosystems, Llc | Trapping magnetic cell sorting system |
| US20110137018A1 (en) * | 2008-04-16 | 2011-06-09 | Cynvenio Biosystems, Inc. | Magnetic separation system with pre and post processing modules |
| US8154273B2 (en) * | 2008-10-10 | 2012-04-10 | Beckman Coulter, Inc. | Detecting and handling coincidence in particle analysis |
| WO2010053796A2 (en) * | 2008-10-28 | 2010-05-14 | The Regents Of The University Of Colorado, A Body Corporate | Microfluidic cell sorter utilizing broadband coherent anti-stokes raman scattering |
-
2010
- 2010-06-10 PL PL10786873T patent/PL2440941T3/pl unknown
- 2010-06-10 DK DK10786873.9T patent/DK2440941T3/en active
- 2010-06-10 JP JP2012515162A patent/JP5337912B2/ja not_active Expired - Fee Related
- 2010-06-10 EP EP10786873.9A patent/EP2440941B1/en not_active Not-in-force
- 2010-06-10 WO PCT/US2010/038229 patent/WO2010144745A2/en not_active Ceased
- 2010-06-10 PT PT107868739T patent/PT2440941T/pt unknown
- 2010-06-10 SM SM20170421T patent/SMT201700421T1/it unknown
- 2010-06-10 CN CN201080035957.XA patent/CN102713640B/zh active Active
- 2010-06-10 US US12/813,285 patent/US8263387B2/en active Active
-
2012
- 2012-08-03 US US13/566,930 patent/US20120301883A1/en not_active Abandoned
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