JP2012530246A5 - - Google Patents
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- JP2012530246A5 JP2012530246A5 JP2012515162A JP2012515162A JP2012530246A5 JP 2012530246 A5 JP2012530246 A5 JP 2012530246A5 JP 2012515162 A JP2012515162 A JP 2012515162A JP 2012515162 A JP2012515162 A JP 2012515162A JP 2012530246 A5 JP2012530246 A5 JP 2012530246A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- sheath
- flow
- laminar flow
- sheath flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 114
- 239000012530 fluid Substances 0.000 claims description 61
- 210000004027 cell Anatomy 0.000 claims description 42
- 238000000926 separation method Methods 0.000 claims description 38
- 210000004881 tumor cell Anatomy 0.000 claims description 35
- 241000894007 species Species 0.000 claims description 19
- 239000006249 magnetic particle Substances 0.000 claims description 14
- 239000000872 buffer Substances 0.000 claims description 13
- 238000011282 treatment Methods 0.000 claims description 12
- 238000012512 characterization method Methods 0.000 claims description 10
- 238000011156 evaluation Methods 0.000 claims description 10
- 230000009871 nonspecific binding Effects 0.000 claims description 10
- 210000000130 stem cell Anatomy 0.000 claims description 10
- 238000011144 upstream manufacturing Methods 0.000 claims description 10
- 239000008280 blood Substances 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 8
- 238000011221 initial treatment Methods 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 8
- 239000007853 buffer solution Substances 0.000 claims description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- 238000002372 labelling Methods 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims description 4
- 238000009104 chemotherapy regimen Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 230000003287 optical effect Effects 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 238000012546 transfer Methods 0.000 claims description 3
- 108091023037 Aptamer Proteins 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- 206010064571 Gene mutation Diseases 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 239000011324 bead Substances 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 201000005787 hematologic cancer Diseases 0.000 claims description 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
- 230000002062 proliferating effect Effects 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 241001515965 unidentified phage Species 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000011269 treatment regimen Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 description 3
- 238000011519 second-line treatment Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18591909P | 2009-06-10 | 2009-06-10 | |
| US61/185,919 | 2009-06-10 | ||
| US31362510P | 2010-03-12 | 2010-03-12 | |
| US61/313,625 | 2010-03-12 | ||
| PCT/US2010/038229 WO2010144745A2 (en) | 2009-06-10 | 2010-06-10 | Sheath flow devices and methods |
| US12/813,285 | 2010-06-10 | ||
| US12/813,285 US8263387B2 (en) | 2009-06-10 | 2010-06-10 | Sheath flow devices and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012530246A JP2012530246A (ja) | 2012-11-29 |
| JP2012530246A5 true JP2012530246A5 (https=) | 2013-07-25 |
| JP5337912B2 JP5337912B2 (ja) | 2013-11-06 |
Family
ID=43309472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012515162A Expired - Fee Related JP5337912B2 (ja) | 2009-06-10 | 2010-06-10 | シース流装置及び方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8263387B2 (https=) |
| EP (1) | EP2440941B1 (https=) |
| JP (1) | JP5337912B2 (https=) |
| CN (1) | CN102713640B (https=) |
| DK (1) | DK2440941T3 (https=) |
| PL (1) | PL2440941T3 (https=) |
| PT (1) | PT2440941T (https=) |
| SM (1) | SMT201700421T1 (https=) |
| WO (1) | WO2010144745A2 (https=) |
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2010
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- 2010-06-10 DK DK10786873.9T patent/DK2440941T3/en active
- 2010-06-10 SM SM20170421T patent/SMT201700421T1/it unknown
- 2010-06-10 CN CN201080035957.XA patent/CN102713640B/zh active Active
- 2010-06-10 PT PT107868739T patent/PT2440941T/pt unknown
- 2010-06-10 JP JP2012515162A patent/JP5337912B2/ja not_active Expired - Fee Related
- 2010-06-10 EP EP10786873.9A patent/EP2440941B1/en not_active Not-in-force
- 2010-06-10 WO PCT/US2010/038229 patent/WO2010144745A2/en not_active Ceased
- 2010-06-10 US US12/813,285 patent/US8263387B2/en active Active
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2012
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