JP2012529912A5 - - Google Patents
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- JP2012529912A5 JP2012529912A5 JP2012516171A JP2012516171A JP2012529912A5 JP 2012529912 A5 JP2012529912 A5 JP 2012529912A5 JP 2012516171 A JP2012516171 A JP 2012516171A JP 2012516171 A JP2012516171 A JP 2012516171A JP 2012529912 A5 JP2012529912 A5 JP 2012529912A5
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- 229920001184 polypeptide Polymers 0.000 claims description 53
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 53
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 53
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 34
- 238000006243 chemical reaction Methods 0.000 claims description 26
- 230000000813 microbial effect Effects 0.000 claims description 26
- 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 claims description 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
- 150000001413 amino acids Chemical class 0.000 claims description 18
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 18
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 18
- 102000018659 1-Acylglycerophosphocholine O-Acyltransferase Human genes 0.000 claims description 17
- 108010052187 1-Acylglycerophosphocholine O-Acyltransferase Proteins 0.000 claims description 17
- 125000002252 acyl group Chemical group 0.000 claims description 17
- 230000000694 effects Effects 0.000 claims description 17
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims description 17
- 102000040430 polynucleotide Human genes 0.000 claims description 17
- 108091033319 polynucleotide Proteins 0.000 claims description 17
- 239000002157 polynucleotide Substances 0.000 claims description 17
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 16
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 16
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 16
- 230000001105 regulatory effect Effects 0.000 claims description 12
- 102000004223 1-acyl-sn-glycerol-3-phosphate acyltransferase Human genes 0.000 claims description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 6
- 229930195729 fatty acid Natural products 0.000 claims description 6
- 239000000194 fatty acid Substances 0.000 claims description 6
- 150000004665 fatty acids Chemical class 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 101710124165 1-acyl-sn-glycerol-3-phosphate acyltransferase Proteins 0.000 claims description 4
- 101710097496 Lysophospholipid acyltransferase Proteins 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 108700013165 1-acyl-sn-glycerol-3-phosphate acyltransferase family Proteins 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 description 50
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 8
- 241000235015 Yarrowia lipolytica Species 0.000 description 5
- 244000005700 microbiome Species 0.000 description 3
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 description 1
- BBWMTEYXFFWPIF-CJBMEHDJSA-N (2e,4e,6e)-icosa-2,4,6-trienoic acid Chemical compound CCCCCCCCCCCCC\C=C\C=C\C=C\C(O)=O BBWMTEYXFFWPIF-CJBMEHDJSA-N 0.000 description 1
- FPRKGXIOSIUDSE-SYACGTDESA-N (2z,4z,6z,8z)-docosa-2,4,6,8-tetraenoic acid Chemical compound CCCCCCCCCCCCC\C=C/C=C\C=C/C=C\C(O)=O FPRKGXIOSIUDSE-SYACGTDESA-N 0.000 description 1
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 description 1
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 description 1
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 description 1
- 235000021294 Docosapentaenoic acid Nutrition 0.000 description 1
- 235000021292 Docosatetraenoic acid Nutrition 0.000 description 1
- 235000021297 Eicosadienoic acid Nutrition 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 description 1
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18735909P | 2009-06-16 | 2009-06-16 | |
| US61/187,359 | 2009-06-16 | ||
| PCT/US2010/038527 WO2010147900A1 (en) | 2009-06-16 | 2010-06-14 | IMPROVEMENT OF LONG CHAIN OMEGA-3 AND OMEGA-6 POLYUNSATURATED FATTY ACID BIOSYNTHESIS BY EXPRESSION OF ACYL-CoA LYSOPHOSPHOLIPID ACYLTRANSFERASES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012529912A JP2012529912A (ja) | 2012-11-29 |
| JP2012529912A5 true JP2012529912A5 (enExample) | 2013-08-01 |
| JP5931721B2 JP5931721B2 (ja) | 2016-06-08 |
Family
ID=43356702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012516171A Expired - Fee Related JP5931721B2 (ja) | 2009-06-16 | 2010-06-14 | アシルＣｏＡリゾリン脂質アシルトランスフェラーゼの発現による長鎖オメガ−３及びオメガ−６多価不飽和脂肪酸生合成の改良 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2443248B1 (enExample) |
| JP (1) | JP5931721B2 (enExample) |
| CN (1) | CN102459627B (enExample) |
| AU (1) | AU2010260227B2 (enExample) |
| BR (1) | BRPI1009690A2 (enExample) |
| CA (1) | CA2763424C (enExample) |
| CL (1) | CL2011003161A1 (enExample) |
| DK (1) | DK2443248T3 (enExample) |
| NO (1) | NO2443248T3 (enExample) |
| WO (1) | WO2010147900A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010147907A1 (en) | 2009-06-16 | 2010-12-23 | E. I. Du Pont De Nemours And Company | High eicosapentaenoic acid oils from improved optimized strains of yarrowia lipolytica |
| KR102602204B1 (ko) | 2012-02-17 | 2023-11-15 | 알크레스타, 인크. | 식이 지방산 수요를 공급하기 위한 방법들, 조성물들 및 디바이스들 |
| HUE033766T2 (en) | 2012-06-15 | 2018-01-29 | Commw Scient Ind Res Org | Production of long chain polyunsaturated fatty acids in plant cells |
| WO2013192007A1 (en) * | 2012-06-19 | 2013-12-27 | E. I. Du Pont De Nemours And Company | MUTANT ACYL-CoA:LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASES |
| EA037817B1 (ru) | 2013-12-18 | 2021-05-25 | Коммонвелт Сайнтифик Энд Индастриэл Рисерч Организэйшн | Экстрагированный растительный липид, содержащий длинноцепочечные полиненасыщенные жирные кислоты |
| CA2953008C (en) * | 2014-06-27 | 2024-03-19 | Nuseed Pty Ltd | Lipid comprising docosapentaenoic acid |
| EA037184B1 (ru) * | 2014-06-27 | 2021-02-16 | Коммонвелт Сайнтифик Энд Индастриэл Рисерч Организэйшн | Липид, содержащий докозапентаеновую кислоту |
| CN117305343A (zh) * | 2014-06-27 | 2023-12-29 | 联邦科学技术研究组织 | 包含二十二碳五烯酸的提取的植物脂质 |
| US10258590B2 (en) | 2015-10-14 | 2019-04-16 | Alcresta Therapeutics, Inc. | Enteral feeding device and related methods of use |
| JP7097014B2 (ja) * | 2018-02-13 | 2022-07-07 | 国立大学法人富山大学 | 藻類及びその使用 |
| EP3586640A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| EP3586642A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Ala enriched polyunsaturated fatty acid compositions |
| AU2021323515A1 (en) * | 2020-08-11 | 2023-03-09 | Viva Star Biosciences Limited | Triazole-pyridinyl substituted azacyclohexyl acetic acid compounds as LPA receptor antagonists |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4792523A (en) | 1984-08-31 | 1988-12-20 | Cetus Corporation | 3'Expression enhancing fragments and method |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| TWI324181B (en) | 2001-04-16 | 2010-05-01 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| ATE517984T1 (de) * | 2003-02-27 | 2011-08-15 | Basf Plant Science Gmbh | Verfahren zur herstellung mehrfach ungesättigter fettsäuren |
| EP3121269A1 (de) | 2003-03-31 | 2017-01-25 | University Of Bristol | Neue pflanzliche acyltransferase spezifisch für langkettige mehrfach ungesättigte fettsäuren |
| US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7504259B2 (en) | 2003-11-12 | 2009-03-17 | E. I. Du Pont De Nemours And Company | Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast |
| US7550651B2 (en) | 2004-06-25 | 2009-06-23 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
| US7189559B2 (en) * | 2004-11-04 | 2007-03-13 | E. I. Du Pont De Nemours And Company | Mortierella alpina lysophosphatidic acid acyltransferase homolog for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| DE102004062294A1 (de) | 2004-12-23 | 2006-07-06 | Basf Plant Science Gmbh | Verfahren zur Herstellung von mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen |
| CN103589650A (zh) | 2005-03-18 | 2014-02-19 | 米克罗比亚公司 | 产油酵母和真菌中类胡萝卜素的产生 |
| US7470532B2 (en) | 2005-10-19 | 2008-12-30 | E.I. Du Pont De Nemours And Company | Mortierella alpina C16/18 fatty acid elongase |
| WO2007061742A1 (en) | 2005-11-23 | 2007-05-31 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| EP2090662A3 (en) * | 2006-04-05 | 2012-10-31 | Metanomics GmbH | Process for the production of a fine chemical |
| WO2008054565A1 (en) | 2006-10-30 | 2008-05-08 | E. I. Du Pont De Nemours And Company | Δ17 desaturase and its use in making polyunsaturated fatty acids |
| US7709239B2 (en) | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| US8846374B2 (en) | 2006-12-12 | 2014-09-30 | E I Du Pont De Nemours And Company | Carotenoid production in a recombinant oleaginous yeast |
| US7732155B2 (en) * | 2006-12-13 | 2010-06-08 | National Research Council Of Canada | Methods for identifying lysophosphatidylcholine acyltransferases |
| DK2129777T3 (en) | 2007-04-03 | 2016-01-25 | Du Pont | MULTIZYMER AND USE THEREOF FOR THE PRODUCTION OF polyunsaturated fatty acids |
| WO2009001315A2 (en) * | 2007-06-26 | 2008-12-31 | Staahl Ulf | Use of a class of genes encoding lysophospholipid acyl transferases for application in agriculture, biotechnology, and medicine |
| RU2496881C2 (ru) | 2007-07-23 | 2013-10-27 | Сантори Холдингз Лимитед | Композиции жирных кислот, имеющие новую пропорцию жирных кислот |
| US8323935B2 (en) * | 2007-10-03 | 2012-12-04 | E I Du Pont De Nemours And Company | Optimized strains of Yarrowia lipolytica for high eicosapentaenoic acid production |
| CA2701130A1 (en) | 2007-10-03 | 2009-04-09 | E.I. Du Pont De Nemours And Company | Peroxisome biogenesis factor protein (pex) disruptions for altering the content of polyunsaturated fatty acids and the total lipid content in oleaginous eukaryotic organisms |
-
2010
- 2010-06-14 BR BRPI1009690-6A patent/BRPI1009690A2/pt not_active Application Discontinuation
- 2010-06-14 CN CN201080026825.0A patent/CN102459627B/zh not_active Expired - Fee Related
- 2010-06-14 CA CA2763424A patent/CA2763424C/en not_active Expired - Fee Related
- 2010-06-14 NO NO10790004A patent/NO2443248T3/no unknown
- 2010-06-14 EP EP10790004.5A patent/EP2443248B1/en not_active Not-in-force
- 2010-06-14 JP JP2012516171A patent/JP5931721B2/ja not_active Expired - Fee Related
- 2010-06-14 DK DK10790004.5T patent/DK2443248T3/en active
- 2010-06-14 AU AU2010260227A patent/AU2010260227B2/en not_active Ceased
- 2010-06-14 WO PCT/US2010/038527 patent/WO2010147900A1/en not_active Ceased
-
2011
- 2011-12-15 CL CL2011003161A patent/CL2011003161A1/es unknown
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