CL2011003161A1 - Celula huesped microbiana oleaginosa recombinante para la produccion mejorada de acido eicosapentaenoico, la que codifica un polipeptido con actividad acil coa lisofosfolipido, metodo para elaborar aceite que comprende dicho acido graso de cadena larga. - Google Patents
Celula huesped microbiana oleaginosa recombinante para la produccion mejorada de acido eicosapentaenoico, la que codifica un polipeptido con actividad acil coa lisofosfolipido, metodo para elaborar aceite que comprende dicho acido graso de cadena larga.Info
- Publication number
- CL2011003161A1 CL2011003161A1 CL2011003161A CL2011003161A CL2011003161A1 CL 2011003161 A1 CL2011003161 A1 CL 2011003161A1 CL 2011003161 A CL2011003161 A CL 2011003161A CL 2011003161 A CL2011003161 A CL 2011003161A CL 2011003161 A1 CL2011003161 A1 CL 2011003161A1
- Authority
- CL
- Chile
- Prior art keywords
- polypeptide
- activity
- host cell
- encodes
- microbial host
- Prior art date
Links
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 title abstract 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 title abstract 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000813 microbial effect Effects 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 125000002252 acyl group Chemical group 0.000 title 1
- 150000004668 long chain fatty acids Chemical class 0.000 title 1
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 abstract 2
- 235000020669 docosahexaenoic acid Nutrition 0.000 abstract 1
- 229940090949 docosahexaenoic acid Drugs 0.000 abstract 1
- 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6481—Phosphoglycerides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6431—Linoleic acids [18:2[n-6]]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18735909P | 2009-06-16 | 2009-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2011003161A1 true CL2011003161A1 (es) | 2012-05-25 |
Family
ID=43356702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011003161A CL2011003161A1 (es) | 2009-06-16 | 2011-12-15 | Celula huesped microbiana oleaginosa recombinante para la produccion mejorada de acido eicosapentaenoico, la que codifica un polipeptido con actividad acil coa lisofosfolipido, metodo para elaborar aceite que comprende dicho acido graso de cadena larga. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2443248B1 (enExample) |
| JP (1) | JP5931721B2 (enExample) |
| CN (1) | CN102459627B (enExample) |
| AU (1) | AU2010260227B2 (enExample) |
| BR (1) | BRPI1009690A2 (enExample) |
| CA (1) | CA2763424C (enExample) |
| CL (1) | CL2011003161A1 (enExample) |
| DK (1) | DK2443248T3 (enExample) |
| NO (1) | NO2443248T3 (enExample) |
| WO (1) | WO2010147900A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2442666T3 (da) | 2009-06-16 | 2015-07-13 | Du Pont | Olier med højt indhold af eicosapentaensyre fra forbedrede og optimerede stammer af yarrowia lipolytica |
| NZ629943A (en) | 2012-02-17 | 2016-06-24 | Alcresta Inc | Methods, compositions, and devices for supplying dietary fatty acid needs |
| BR122019026149A8 (pt) | 2012-06-15 | 2022-06-28 | Commw Scient Ind Res Org | Célula hospedeira, processo de produzir um lipídio de planta extraído, método de produzir semente, farinha de semente, método para produzir um produto alimentício, uso e processo para produzir ésteres de etila |
| CA2877279A1 (en) * | 2012-06-19 | 2013-12-27 | E. I. Du Pont De Nemours And Company | Improved production of polyunsaturated fatty acids by coexpression of acyl-coa:lysophosphatidylcholine acyltransferases and phospholipid:diacylglycerol acyltransferases |
| PE20170253A1 (es) * | 2013-12-18 | 2017-04-14 | Nuseed Pty Ltd | Lipido que comprende acidos grasos poliinsaturados de cadena larga |
| AU2015281791A1 (en) * | 2014-06-27 | 2017-01-12 | Commonwealth Scientific And Industrial Research Organisation | Lipid comprising docosapentaenoic acid |
| UA122770C2 (uk) * | 2014-06-27 | 2021-01-06 | Коммонвелз Сайнтіфік Енд Індастріал Рисерч Организейшн | Ліпід, що містить докозапентаєнову кислоту |
| EA037184B1 (ru) * | 2014-06-27 | 2021-02-16 | Коммонвелт Сайнтифик Энд Индастриэл Рисерч Организэйшн | Липид, содержащий докозапентаеновую кислоту |
| US10258590B2 (en) | 2015-10-14 | 2019-04-16 | Alcresta Therapeutics, Inc. | Enteral feeding device and related methods of use |
| JP7097014B2 (ja) * | 2018-02-13 | 2022-07-07 | 国立大学法人富山大学 | 藻類及びその使用 |
| EP3586642A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Ala enriched polyunsaturated fatty acid compositions |
| EP3586641A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| EP3586640A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| EP3586643A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| IL300525A (en) * | 2020-08-11 | 2023-04-01 | Viva Star Biosciences Ltd | Triazole-pyridinyl-substituted azacyclohexyl acetic acid compounds as LPA receptor antagonists |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4792523A (en) | 1984-08-31 | 1988-12-20 | Cetus Corporation | 3'Expression enhancing fragments and method |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| TWI324181B (en) | 2001-04-16 | 2010-05-01 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| ATE517984T1 (de) * | 2003-02-27 | 2011-08-15 | Basf Plant Science Gmbh | Verfahren zur herstellung mehrfach ungesättigter fettsäuren |
| US7855321B2 (en) | 2003-03-31 | 2010-12-21 | University Of Bristol | Plant acyltransferases specific for long-chained, multiply unsaturated fatty acids |
| US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7504259B2 (en) | 2003-11-12 | 2009-03-17 | E. I. Du Pont De Nemours And Company | Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast |
| WO2006012325A1 (en) | 2004-06-25 | 2006-02-02 | E.I. Dupont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7189559B2 (en) * | 2004-11-04 | 2007-03-13 | E. I. Du Pont De Nemours And Company | Mortierella alpina lysophosphatidic acid acyltransferase homolog for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US7588931B2 (en) * | 2004-11-04 | 2009-09-15 | E. I. Du Pont De Nemours And Company | High arachidonic acid producing strains of Yarrowia lipolytica |
| DE102004062294A1 (de) | 2004-12-23 | 2006-07-06 | Basf Plant Science Gmbh | Verfahren zur Herstellung von mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen |
| EP2371967B1 (en) | 2005-03-18 | 2015-06-03 | DSM IP Assets B.V. | Production of carotenoids in oleaginous yeast and fungi |
| US7470532B2 (en) | 2005-10-19 | 2008-12-30 | E.I. Du Pont De Nemours And Company | Mortierella alpina C16/18 fatty acid elongase |
| KR20080071190A (ko) | 2005-11-23 | 2008-08-01 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 델타-９ 일롱가제, 및 다중불포화 지방산 생성에 있어서의이들의 용도 |
| CA2644273A1 (en) * | 2006-04-05 | 2008-03-27 | Metanomics Gmbh | Process for the production of a fine chemical |
| EP2087105B1 (en) | 2006-10-30 | 2015-02-25 | E.I. Du Pont De Nemours And Company | Delta 17 desaturase and its use in making polyunsaturated fatty acids |
| US7709239B2 (en) | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| US8846374B2 (en) | 2006-12-12 | 2014-09-30 | E I Du Pont De Nemours And Company | Carotenoid production in a recombinant oleaginous yeast |
| US7732155B2 (en) * | 2006-12-13 | 2010-06-08 | National Research Council Of Canada | Methods for identifying lysophosphatidylcholine acyltransferases |
| MX2009010574A (es) | 2007-04-03 | 2009-10-22 | Du Pont | Multienzimas y su uso en la fabricacion de acidos grasos poliinsaturados. |
| WO2009001315A2 (en) * | 2007-06-26 | 2008-12-31 | Staahl Ulf | Use of a class of genes encoding lysophospholipid acyl transferases for application in agriculture, biotechnology, and medicine |
| US8551744B2 (en) | 2007-07-23 | 2013-10-08 | Suntory Holdings Limited | Method of preparing a fatty acid composition |
| CA2701130A1 (en) | 2007-10-03 | 2009-04-09 | E.I. Du Pont De Nemours And Company | Peroxisome biogenesis factor protein (pex) disruptions for altering the content of polyunsaturated fatty acids and the total lipid content in oleaginous eukaryotic organisms |
| JP5711968B2 (ja) * | 2007-10-03 | 2015-05-07 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | 高エイコサペンタエン酸を生成するためのヤロウィア・リポリティカ（ＹａｒｒｏｗｉａＬｉｐｏｌｙｔｉｃａ）の最適化株 |
-
2010
- 2010-06-14 AU AU2010260227A patent/AU2010260227B2/en not_active Ceased
- 2010-06-14 BR BRPI1009690-6A patent/BRPI1009690A2/pt not_active Application Discontinuation
- 2010-06-14 CA CA2763424A patent/CA2763424C/en not_active Expired - Fee Related
- 2010-06-14 NO NO10790004A patent/NO2443248T3/no unknown
- 2010-06-14 EP EP10790004.5A patent/EP2443248B1/en not_active Not-in-force
- 2010-06-14 CN CN201080026825.0A patent/CN102459627B/zh not_active Expired - Fee Related
- 2010-06-14 WO PCT/US2010/038527 patent/WO2010147900A1/en not_active Ceased
- 2010-06-14 DK DK10790004.5T patent/DK2443248T3/en active
- 2010-06-14 JP JP2012516171A patent/JP5931721B2/ja not_active Expired - Fee Related
-
2011
- 2011-12-15 CL CL2011003161A patent/CL2011003161A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2443248A1 (en) | 2012-04-25 |
| NO2443248T3 (enExample) | 2018-05-26 |
| DK2443248T3 (en) | 2018-03-12 |
| WO2010147900A1 (en) | 2010-12-23 |
| EP2443248B1 (en) | 2017-12-27 |
| AU2010260227A1 (en) | 2011-11-10 |
| CN102459627A (zh) | 2012-05-16 |
| JP5931721B2 (ja) | 2016-06-08 |
| CA2763424A1 (en) | 2010-12-23 |
| CN102459627B (zh) | 2015-07-29 |
| CA2763424C (en) | 2018-06-12 |
| AU2010260227B2 (en) | 2015-01-29 |
| EP2443248A4 (en) | 2013-07-10 |
| JP2012529912A (ja) | 2012-11-29 |
| BRPI1009690A2 (pt) | 2015-08-25 |
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