JP2012529523A5 - - Google Patents
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- JP2012529523A5 JP2012529523A5 JP2012515079A JP2012515079A JP2012529523A5 JP 2012529523 A5 JP2012529523 A5 JP 2012529523A5 JP 2012515079 A JP2012515079 A JP 2012515079A JP 2012515079 A JP2012515079 A JP 2012515079A JP 2012529523 A5 JP2012529523 A5 JP 2012529523A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- composition according
- liver
- ornithine
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 14
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims 8
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 7
- 229960003104 ornithine Drugs 0.000 claims 7
- OBKXEAXTFZPCHS-UHFFFAOYSA-N 4-phenylbutyric acid Chemical compound OC(=O)CCCC1=CC=CC=C1 OBKXEAXTFZPCHS-UHFFFAOYSA-N 0.000 claims 6
- IPBVNPXQWQGGJP-UHFFFAOYSA-N acetic acid phenyl ester Natural products CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 claims 6
- 229940049953 phenylacetate Drugs 0.000 claims 6
- 229950009215 phenylbutanoic acid Drugs 0.000 claims 6
- 210000004185 liver Anatomy 0.000 claims 5
- 208000019423 liver disease Diseases 0.000 claims 5
- 208000007232 portal hypertension Diseases 0.000 claims 5
- 208000007788 Acute Liver Failure Diseases 0.000 claims 4
- 206010000804 Acute hepatic failure Diseases 0.000 claims 4
- 231100000836 acute liver failure Toxicity 0.000 claims 4
- 230000003908 liver function Effects 0.000 claims 4
- 208000032843 Hemorrhage Diseases 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 230000000740 bleeding effect Effects 0.000 claims 3
- 238000001990 intravenous administration Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- LRSYFEZBIMVWRY-VWMHFEHESA-N (2s)-2,5-diaminopentanoic acid;2-phenylacetic acid Chemical compound NCCC[C@H](N)C(O)=O.OC(=O)CC1=CC=CC=C1 LRSYFEZBIMVWRY-VWMHFEHESA-N 0.000 claims 1
- 206010003445 Ascites Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 102000008052 Nitric Oxide Synthase Type III Human genes 0.000 claims 1
- 108010075520 Nitric Oxide Synthase Type III Proteins 0.000 claims 1
- 206010046996 Varicose vein Diseases 0.000 claims 1
- 206010065441 Venous haemorrhage Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 208000034158 bleeding Diseases 0.000 claims 1
- 230000006931 brain damage Effects 0.000 claims 1
- 231100000874 brain damage Toxicity 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 229960003424 phenylacetic acid Drugs 0.000 claims 1
- 239000003279 phenylacetic acid Substances 0.000 claims 1
- 230000000770 proinflammatory effect Effects 0.000 claims 1
- 229960002232 sodium phenylbutyrate Drugs 0.000 claims 1
- VPZRWNZGLKXFOE-UHFFFAOYSA-M sodium phenylbutyrate Chemical compound [Na+].[O-]C(=O)CCCC1=CC=CC=C1 VPZRWNZGLKXFOE-UHFFFAOYSA-M 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18515809P | 2009-06-08 | 2009-06-08 | |
| US61/185,158 | 2009-06-08 | ||
| US24074809P | 2009-09-09 | 2009-09-09 | |
| US61/240,748 | 2009-09-09 | ||
| US29637710P | 2010-01-19 | 2010-01-19 | |
| US61/296,377 | 2010-01-19 | ||
| PCT/US2010/037838 WO2010144498A2 (en) | 2009-06-08 | 2010-06-08 | Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015098205A Division JP6250588B2 (ja) | 2009-06-08 | 2015-05-13 | Ｌ−オルニチンフェニル酢酸塩を用いる門脈圧亢進の治療及び肝機能の修復 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012529523A JP2012529523A (ja) | 2012-11-22 |
| JP2012529523A5 true JP2012529523A5 (OSRAM) | 2013-07-18 |
| JP5749255B2 JP5749255B2 (ja) | 2015-07-15 |
Family
ID=43309444
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012515079A Active JP5749255B2 (ja) | 2009-06-08 | 2010-06-08 | Ｌ−オルニチンフェニル酢酸塩を用いる門脈圧亢進の治療及び肝機能の修復 |
| JP2015098205A Active JP6250588B2 (ja) | 2009-06-08 | 2015-05-13 | Ｌ−オルニチンフェニル酢酸塩を用いる門脈圧亢進の治療及び肝機能の修復 |
| JP2016238546A Active JP6527497B2 (ja) | 2009-06-08 | 2016-12-08 | Ｌ−オルニチンフェニル酢酸塩を用いる門脈圧亢進の治療及び肝機能の修復 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015098205A Active JP6250588B2 (ja) | 2009-06-08 | 2015-05-13 | Ｌ−オルニチンフェニル酢酸塩を用いる門脈圧亢進の治療及び肝機能の修復 |
| JP2016238546A Active JP6527497B2 (ja) | 2009-06-08 | 2016-12-08 | Ｌ−オルニチンフェニル酢酸塩を用いる門脈圧亢進の治療及び肝機能の修復 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20120157526A1 (OSRAM) |
| EP (3) | EP2440200B8 (OSRAM) |
| JP (3) | JP5749255B2 (OSRAM) |
| KR (2) | KR20170026672A (OSRAM) |
| CN (2) | CN102625699B (OSRAM) |
| AU (1) | AU2010258888B2 (OSRAM) |
| BR (1) | BRPI1012956A8 (OSRAM) |
| CA (2) | CA2764587C (OSRAM) |
| DK (2) | DK2440200T3 (OSRAM) |
| EA (2) | EA025735B1 (OSRAM) |
| ES (2) | ES2728948T3 (OSRAM) |
| IL (2) | IL216811A (OSRAM) |
| MX (3) | MX375116B (OSRAM) |
| NZ (2) | NZ615091A (OSRAM) |
| PL (1) | PL2440200T3 (OSRAM) |
| SG (1) | SG176675A1 (OSRAM) |
| WO (1) | WO2010144498A2 (OSRAM) |
| ZA (1) | ZA201108988B (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2448549T3 (es) | 2004-11-26 | 2014-03-14 | Ucl Business Plc | Composiciones que comprenden ornitina y fenilacetato o fenilbutirato para tratar encefalopatía hepática |
| ES2652187T3 (es) | 2009-04-03 | 2018-01-31 | Ocera Therapeutics, Inc. | Fenilacetato de l-ornitina y métodos para elaborar el mismo |
| EP2440200B8 (en) | 2009-06-08 | 2014-10-15 | UCL Business PLC | Treatment of portal hypertension using l-ornithine phenylacetate |
| EP2625162B1 (en) | 2010-10-06 | 2019-03-13 | Ocera Therapeutics, Inc. | Methods of making l-ornithine phenyl acetate |
| CN102993037B (zh) * | 2012-11-20 | 2015-03-04 | 南京工业大学 | 一种l-鸟氨酸苯乙酸盐的制备方法 |
| SI3099306T1 (sl) | 2014-01-29 | 2019-03-29 | Umecrine Cognition Ab | Steroidna spojina za uporabo v zdravljenju hepatične encefalopatije |
| CN107206049B (zh) | 2014-10-24 | 2021-12-07 | 马林克罗特医疗产品知识产权公司 | 治疗患1型肝肾综合征的患者的方法 |
| KR102487376B1 (ko) | 2014-11-24 | 2023-01-10 | 유씨엘 비즈니스 리미티드 | 암모니아-저감 치료를 이용한 간성상세포 활성화와 연관된 질병의 치료 |
| TWI748936B (zh) | 2015-01-12 | 2021-12-11 | 瑞典商優鎂奎認知Ａｂ公司 | 新穎化合物 |
| EP4205735A1 (en) * | 2015-04-20 | 2023-07-05 | Ocera Therapeutics, Inc. | Formulations of l-ornithine phenylacetate |
| JP2017014206A (ja) * | 2015-06-30 | 2017-01-19 | ナノアンティバイオティクス，インコーポレイテッド | 腹水の治療 |
| JP6990170B2 (ja) * | 2015-08-18 | 2022-01-12 | オセラ セラピューティクス， インコーポレイテッド | Ｌ－オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる筋肉喪失の治療および予防 |
| EP3352748A4 (en) * | 2015-09-25 | 2019-06-05 | Ocera Therapeutics, Inc. | TREATMENT AND PREVENTION OF NEURONAL CELL LOSS BY L-ORNITHIN IN COMBINATION WITH AT LEAST ONE PHENYL ACETATE AND PHENYL BUTYRATE |
| SG11201802987UA (en) * | 2015-11-13 | 2018-05-30 | Ocera Therapeutics Inc | Formulation of l-ornithine phenylacetate |
| US11219611B2 (en) | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
| CN106109429A (zh) * | 2016-07-26 | 2016-11-16 | 北京百奥药业有限责任公司 | 一种苯丁酸钠片剂及其制备方法 |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| US11160826B1 (en) | 2017-03-03 | 2021-11-02 | United States Government As Represented By The Department Of Veterans Affairs | Cholesterol lowering drugs for the treatment of hepatic encephalopathy |
| CN110740988A (zh) | 2017-05-11 | 2020-01-31 | 欧塞拉治疗有限公司 | 制备l-鸟氨酸苯乙酸盐的方法 |
| SG11202001142VA (en) | 2017-08-14 | 2020-03-30 | Axcella Health Inc | Amino acid compositions for the treatment of liver disease |
| WO2019173148A1 (en) * | 2018-03-05 | 2019-09-12 | The United States Government As Represented By The United States Department Of Veterans Affairs | Cholesterol lowering drugs for the treatment of hepatic encephalopathy |
| US10596136B2 (en) | 2018-06-20 | 2020-03-24 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
| AU2020270106A1 (en) | 2019-05-09 | 2021-11-18 | Ocera Therapeutics, Inc. | Methods of assessing and treating hepatic encephalopathy |
| KR20220011697A (ko) | 2019-05-22 | 2022-01-28 | 바이오비에 아이앤씨. | 테를리프레신 제형 |
| KR102237526B1 (ko) * | 2019-11-07 | 2021-04-07 | 한국식품연구원 | 오르니틴 생성능이 우수한 락토바실러스 브레비스 wikim47를 이용한 마늘 발효 조성물 |
| WO2024261477A1 (en) | 2023-06-20 | 2024-12-26 | Yaqrit Limited | Combination of tlr4 antagonist, ornithine and phenylacetate or phenylbutyrate |
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| KR102487376B1 (ko) | 2014-11-24 | 2023-01-10 | 유씨엘 비즈니스 리미티드 | 암모니아-저감 치료를 이용한 간성상세포 활성화와 연관된 질병의 치료 |
| EP4205735A1 (en) | 2015-04-20 | 2023-07-05 | Ocera Therapeutics, Inc. | Formulations of l-ornithine phenylacetate |
| JP6990170B2 (ja) | 2015-08-18 | 2022-01-12 | オセラ セラピューティクス， インコーポレイテッド | Ｌ－オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる筋肉喪失の治療および予防 |
| EP3352748A4 (en) | 2015-09-25 | 2019-06-05 | Ocera Therapeutics, Inc. | TREATMENT AND PREVENTION OF NEURONAL CELL LOSS BY L-ORNITHIN IN COMBINATION WITH AT LEAST ONE PHENYL ACETATE AND PHENYL BUTYRATE |
| US11219611B2 (en) | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
-
2010
- 2010-06-08 EP EP10786721.0A patent/EP2440200B8/en active Active
- 2010-06-08 ES ES14175859T patent/ES2728948T3/es active Active
- 2010-06-08 KR KR1020177005930A patent/KR20170026672A/ko not_active Ceased
- 2010-06-08 CN CN201080035200.0A patent/CN102625699B/zh active Active
- 2010-06-08 MX MX2015012475A patent/MX375116B/es unknown
- 2010-06-08 JP JP2012515079A patent/JP5749255B2/ja active Active
- 2010-06-08 CN CN201410350083.7A patent/CN104434894A/zh active Pending
- 2010-06-08 DK DK10786721.0T patent/DK2440200T3/en active
- 2010-06-08 MX MX2011013129A patent/MX2011013129A/es active IP Right Grant
- 2010-06-08 BR BRPI1012956A patent/BRPI1012956A8/pt active Search and Examination
- 2010-06-08 EA EA201171396A patent/EA025735B1/ru not_active IP Right Cessation
- 2010-06-08 CA CA2764587A patent/CA2764587C/en active Active
- 2010-06-08 KR KR1020127000293A patent/KR101715008B1/ko active Active
- 2010-06-08 EP EP14175859.9A patent/EP2799067B1/en active Active
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